The Importance of Hydrogen Bonding and Aromatic Stacking to the Affinity and Efficacy of Cannabinoid Receptor CB2 Antagonist, 5‑(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]‑N‑[(1S,2S,4R)‑1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide (SR144528)
Kotsikorou, Evangelia, Navas, Frank, Roche, Michael J, Gilliam, Anne F, Thomas, Brian F, Seltzman, Herbert H, Kumar, Pritesh, Song, Zhao-Hui, Hurst, Dow P, Lynch, Diane L, Reggio, Patricia H
Published in Journal of medicinal chemistry (12.09.2013)
Published in Journal of medicinal chemistry (12.09.2013)
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Journal Article
Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents
Walentiny, D. Matthew, Vann, Robert E., Warner, Jonathan A., King, Lindsey S., Seltzman, Herbert H., Navarro, Hernán A., Twine, Charles E., Thomas, Brian F., Gilliam, Anne F., Gilmour, Brian P., Carroll, F. Ivy, Wiley, Jenny L.
Published in Psychopharmacology (01.06.2010)
Published in Psychopharmacology (01.06.2010)
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Comparative Receptor Binding Analyses of Cannabinoid Agonists and Antagonists
Thomas, B F, Gilliam, A F, Burch, D F, Roche, M J, Seltzman, H H
Published in The Journal of pharmacology and experimental therapeutics (01.04.1998)
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Published in The Journal of pharmacology and experimental therapeutics (01.04.1998)
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Synthesis and Structure−Activity Relationships of Amide and Hydrazide Analogues of the Cannabinoid CB1 Receptor Antagonist N-(Piperidinyl)- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716)
Francisco, Ma. Elena Y, Seltzman, Herbert H, Gilliam, Anne F, Mitchell, René A, Rider, Sharyl L, Pertwee, Roger G, Stevenson, Lesley A, Thomas, Brian F
Published in Journal of medicinal chemistry (20.06.2002)
Published in Journal of medicinal chemistry (20.06.2002)
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Journal Article
Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activities
THOMAS, Brian F, FRANCISCO, Ma. Elena Y, SELTZMAN, Herbert H, THOMAS, James B, FIX, Scott E, SCHULZ, Anne-Kathrin, GILLIAM, Anne F, PERTWEE, Roger G, STEVENSON, Leslie A
Published in Bioorganic & medicinal chemistry (15.09.2005)
Published in Bioorganic & medicinal chemistry (15.09.2005)
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The Bioactive Conformation of Aminoalkylindoles at the Cannabinoid CB1 and CB2 Receptors: Insights Gained from (E)- and (Z)-Naphthylidene Indenes
Reggio, Patricia H, Basu-Dutt, Sharmista, Barnett-Norris, Judy, Castro, Marie T, Hurst, Dow P, Seltzman, Herbert H, Roche, Michael J, Gilliam, Anne F, Thomas, Brian F, Stevenson, L. A, Pertwee, Roger G, Abood, Mary E
Published in Journal of medicinal chemistry (17.12.1998)
Published in Journal of medicinal chemistry (17.12.1998)
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Synthesis and Pharmacological Comparison of Dimethylheptyl and Pentyl Analogs of Anandamide
Seltzman, Herbert H, Fleming, Denise N, Thomas, Brian F, Gilliam, Anne F, McCallion, Deirdre S, Pertwee, Roger G, Compton, David R, Martin, Billy R
Published in Journal of medicinal chemistry (24.10.1997)
Published in Journal of medicinal chemistry (24.10.1997)
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Journal Article
The Importance of Hydrogen Bonding and Aromatic Stacking to the Affinity and Efficacy of Cannabinoid Receptor CB2 Antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyn-N-[(15,2S,4R)-1, 3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide (SR144528)
Kotsikorou, Evangelia, Navas, Frank, Roche, Michael J., Gilliam, Anne F., Thomas, Brian F., Seltzman, Herbert H., Kumar, Pritesh, Song, Zhao-Hui, Hurst, Dow P., Lynch, Diane L., Reggio, Patricia H.
Published in Journal of medicinal chemistry (12.09.2013)
Published in Journal of medicinal chemistry (12.09.2013)
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Journal Article
The Importance of Hydrogen Bonding and Aromatic Stacking to the Affinity and Efficacy of Cannabinoid Receptor CB 2 Antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]- N -[(1 S ,2 S ,4 R )-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide (SR144528)
Kotsikorou, Evangelia, Navas, Frank, Roche, Michael J., Gilliam, Anne F., Thomas, Brian F., Seltzman, Herbert H., Kumar, Pritesh, Song, Zhao-Hui, Hurst, Dow P., Lynch, Diane L., Reggio, Patricia H.
Published in Journal of medicinal chemistry (12.09.2013)
Published in Journal of medicinal chemistry (12.09.2013)
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Journal Article
The Importance of Hydrogen Bonding and Aromatic Stacking to the Affinity and Efficacy of Cannabinoid Receptor CB2 Antagonist, 5-(4-Chloro-3-methyl-phenyl)-1-(4-methyl-benzyl)-1H-pyrazole-3-carboxylic acid (1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-amide (SR144528)
Kotsikorou, Evangelia, Navas, Frank, Roche, Michael J., Gilliam, Anne F., Thomas, Brian, Seltzman, Herbert H., Kumar, Pritesh, Song, Zhao-Hui, Hurst, Dow P., Lynch, Diane L., Reggio, Patricia H.
Published in Journal of medicinal chemistry (14.08.2013)
Published in Journal of medicinal chemistry (14.08.2013)
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Journal Article
Reproductive Toxicity Evaluation of Methylethyl Ketoxime by Gavage in CD Rats
TYL, ROCHELLE W., GERHART, JAMES M., MYERS, CHRISTINA B., MARR, MELISSA C., BRINE, DOLORES R., GILLIAM, ANNE F., SEELY, JOHN C., DERELANKO, MICHAEL J., RINEHART, WILLIAM E.
Published in Toxicological sciences (1996)
Published in Toxicological sciences (1996)
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Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents: Special Issue on Kappa-Opioids
WALENTINY, D. Matthew, VANN, Robert E, CARROLL, F. Ivy, WILEY, Jenny L, WARNER, Jonathan A, KING, Lindsey S, SELTZMAN, Herbert H, NAVARRO, Hernán A, TWINE, Charles E, THOMAS, Brian F, GILLIAM, Anne F, GILMOUR, Brian P
Published in Psychopharmacologia (2010)
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Published in Psychopharmacologia (2010)
Journal Article
Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1 H-pyrazole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activities
Thomas, Brian F., Francisco, Ma. Elena Y., Seltzman, Herbert H., Thomas, James B., Fix, Scott E., Schulz, Anne-Kathrin, Gilliam, Anne F., Pertwee, Roger G., Stevenson, Leslie A.
Published in Bioorganic & medicinal chemistry (2005)
Published in Bioorganic & medicinal chemistry (2005)
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Journal Article
Structure elucidation of a novel ring‐constrained biaryl pyrazole CB 1 cannabinoid receptor antagonist
Francisco, Ma. Elena Y., Burgess, Jason P., George, Clifford, Bailey, Gregory S., Gilliam, Anne F., Seltzman, Herbert H., Thomas, Brian F.
Published in Magnetic resonance in chemistry (01.04.2003)
Published in Magnetic resonance in chemistry (01.04.2003)
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Journal Article
Synthesis and structure-activity relationships of amide and hydrazide analogues of the cannabinoid CB(1) receptor antagonist N-(piperidinyl)- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716)
Francisco, Maria Elena Y, Seltzman, Herbert H, Gilliam, Anne F, Mitchell, René A, Rider, Sharyl L, Pertwee, Roger G, Stevenson, Lesley A, Thomas, Brian F
Published in Journal of medicinal chemistry (20.06.2002)
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Published in Journal of medicinal chemistry (20.06.2002)
Journal Article
Synthesis and Structure−Activity Relationships of Amide and Hydrazide Analogues of the Cannabinoid CB 1 Receptor Antagonist N -(Piperidinyl)- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1 H -pyrazole-3-carboxamide (SR141716)
Francisco, Ma. Elena Y., Seltzman, Herbert H., Gilliam, Anne F., Mitchell, René A., Rider, Sharyl L., Pertwee, Roger G., Stevenson, Lesley A., Thomas, Brian F.
Published in Journal of medicinal chemistry (01.06.2002)
Published in Journal of medicinal chemistry (01.06.2002)
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Journal Article
Structure elucidation of a novel ring-constrained biaryl pyrazole CB1 cannabinoid receptor antagonist
Francisco, Ma. Elena Y., Burgess, Jason P., George, Clifford, Bailey, Gregory S., Gilliam, Anne F., Seltzman, Herbert H., Thomas, Brian F.
Published in Magnetic resonance in chemistry (01.04.2003)
Published in Magnetic resonance in chemistry (01.04.2003)
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Journal Article
Genetic monitoring of inbred rodents from controlled production colonies through biochemical markers and skin grafting procedures
Whitmore, S.P, Gilliam, A.F, Hendren, R.W, Lewis, S.E, Rao, G.N, Whisnant, C.C
Published in Laboratory animal science (Chicago) (01.10.1996)
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Published in Laboratory animal science (Chicago) (01.10.1996)
Journal Article
Reproductive Toxicity Evaluation of Methylethyl Ketoxime by Gavage in CD Rats
Tyl, Rochelle W., Gerhart, James M., Myers, Christina B., Marr, Melissa C., Brine, Dolores R., Gilliam, Anne F., Seely, John C., Derelanko, Michael J., Rinehart, William E.
Published in Fundamental and applied toxicology (01.06.1996)
Published in Fundamental and applied toxicology (01.06.1996)
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