RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers
Nichols, Robert J, Haderk, Franziska, Stahlhut, Carlos, Schulze, Christopher J, Hemmati, Golzar, Wildes, David, Tzitzilonis, Christos, Mordec, Kasia, Marquez, Abby, Romero, Jason, Hsieh, Tientien, Zaman, Aubhishek, Olivas, Victor, McCoach, Caroline, Blakely, Collin M, Wang, Zhengping, Kiss, Gert, Koltun, Elena S, Gill, Adrian L, Singh, Mallika, Goldsmith, Mark A, Smith, Jacqueline A M, Bivona, Trever G
Published in Nature cell biology (01.09.2018)
Published in Nature cell biology (01.09.2018)
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Journal Article
A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development
Gill, Adrian L, Verdonk, Marcel, Boyle, Robert G, Taylor, Richard
Published in Current topics in medicinal chemistry (01.07.2007)
Published in Current topics in medicinal chemistry (01.07.2007)
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Journal Article
Allosteric Inhibition of SHP2 Stimulates Antitumor Immunity by Transforming the Immunosuppressive Environment
Quintana, Elsa, Schulze, Christopher J., Myers, Darienne R., Choy, Tiffany J., Mordec, Kasia, Wildes, David, Shifrin, Nataliya Tobvis, Belwafa, Amira, Koltun, Elena S., Gill, Adrian L., Singh, Mallika, Kelsey, Stephen, Goldsmith, Mark A., Nichols, Robert, Smith, Jacqueline A.M.
Published in Cancer research (Chicago, Ill.) (01.07.2020)
Published in Cancer research (Chicago, Ill.) (01.07.2020)
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Journal Article
Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS
Schulze, Christopher J., Seamon, Kyle J., Zhao, Yulei, Yang, Yu C., Cregg, Jim, Kim, Dongsung, Tomlinson, Aidan, Choy, Tiffany J., Wang, Zhican, Sang, Ben, Pourfarjam, Yasin, Lucas, Jessica, Cuevas-Navarro, Antonio, Ayala-Santos, Carlos, Vides, Alberto, Li, Chuanchuan, Marquez, Abby, Zhong, Mengqi, Vemulapalli, Vidyasiri, Weller, Caroline, Gould, Andrea, Whalen, Daniel M., Salvador, Anthony, Milin, Anthony, Saldajeno-Concar, Mae, Dinglasan, Nuntana, Chen, Anqi, Evans, Jim, Knox, John E., Koltun, Elena S., Singh, Mallika, Nichols, Robert, Wildes, David, Gill, Adrian L., Smith, Jacqueline A. M., Lito, Piro
Published in Science (American Association for the Advancement of Science) (18.08.2023)
Published in Science (American Association for the Advancement of Science) (18.08.2023)
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Journal Article
Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors
Burnett, G. Leslie, Yang, Yu C., Aggen, James B., Pitzen, Jennifer, Gliedt, Micah K., Semko, Chris M., Marquez, Abby, Evans, James W., Wang, Gang, Won, Walter S., Tomlinson, Aidan C. A., Kiss, Gert, Tzitzilonis, Christos, Thottumkara, Arun P., Cregg, James, Mellem, Kevin T., Choi, Jong S., Lee, Julie C., Zhao, Yongyuan, Lee, Bianca J., Meyerowitz, Justin G., Knox, John E., Jiang, Jingjing, Wang, Zhican, Wildes, David, Wang, Zhengping, Singh, Mallika, Smith, Jacqueline A. M., Gill, Adrian L.
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
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Journal Article
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth
Lee, Bianca J., Boyer, Jacob A., Burnett, G. Leslie, Thottumkara, Arun P., Tibrewal, Nidhi, Wilson, Stacy L., Hsieh, Tientien, Marquez, Abby, Lorenzana, Edward G., Evans, James W., Hulea, Laura, Kiss, Gert, Liu, Hui, Lee, Dong, Larsson, Ola, McLaughlan, Shannon, Topisirovic, Ivan, Wang, Zhengping, Wang, Zhican, Zhao, Yongyuan, Wildes, David, Aggen, James B., Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A. M., Rosen, Neal
Published in Nature chemical biology (01.10.2021)
Published in Nature chemical biology (01.10.2021)
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Journal Article
Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity
Howard, Steven, Berdini, Valerio, Boulstridge, John A, Carr, Maria G, Cross, David M, Curry, Jayne, Devine, Lindsay A, Early, Theresa R, Fazal, Lynsey, Gill, Adrian L, Heathcote, Michelle, Maman, Sarita, Matthews, Julia E, McMenamin, Rachel L, Navarro, Eva F, O’Brien, Michael A, O’Reilly, Marc, Rees, David C, Reule, Matthias, Tisi, Dominic, Williams, Glyn, Vinković, Mladen, Wyatt, Paul G
Published in Journal of medicinal chemistry (22.01.2009)
Published in Journal of medicinal chemistry (22.01.2009)
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Journal Article
Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Jiang, Jingjing, Jiang, Lingyan, Maldonato, Benjamin J, Wang, Yingyun, Holderfield, Matthew, Aronchik, Ida, Winters, Ian P, Salman, Zeena, Blaj, Cristina, Menard, Marie, Brodbeck, Jens, Chen, Zhe, Wei, Xing, Rosen, Michael J, Gindin, Yevgeniy, Lee, Bianca J, Evans, James W, Chang, Stephanie, Wang, Zhican, Seamon, Kyle J, Parsons, Dylan, Cregg, James, Marquez, Abby, Tomlinson, Aidan C A, Yano, Jason K, Knox, John E, Quintana, Elsa, Aguirre, Andrew J, Arbour, Kathryn C, Reed, Abby, Gustafson, W Clay, Gill, Adrian L, Koltun, Elena S, Wildes, David, Smith, Jacqueline A M, Wang, Zhengping, Singh, Mallika
Published in Cancer discovery (03.06.2024)
Published in Cancer discovery (03.06.2024)
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Journal Article
Automated iterative Csp3–C bond formation
Blair, Daniel J., Chitti, Sriyankari, Trobe, Melanie, Kostyra, David M., Haley, Hannah M. S., Hansen, Richard L., Ballmer, Steve G., Woods, Toby J., Wang, Wesley, Mubayi, Vikram, Schmidt, Michael J., Pipal, Robert W., Morehouse, Greg. F., Palazzolo Ray, Andrea M. E., Gray, Danielle L., Gill, Adrian L., Burke, Martin D.
Published in Nature (London) (07.04.2022)
Published in Nature (London) (07.04.2022)
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Journal Article
Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth
Lee, Bianca J., Boyer, Jacob A., Burnett, G. Leslie, Thottumkara, Arun P., Tibrewal, Nidhi, Wilson, Stacy L., Hsieh, Tientien, Marquez, Abby, Lorenzana, Edward G., Evans, James W., Hulea, Laura, Kiss, Gert, Liu, Hui, Lee, Dong, Larsson, Ola, McLaughlan, Shannon, Topisirovic, Ivan, Wang, Zhengping, Wang, Zhican, Zhao, Yongyuan, Wildes, David, Aggen, James B., Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A. M., Rosen, Neal
Published in Nature chemical biology (01.08.2021)
Published in Nature chemical biology (01.08.2021)
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Journal Article
Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth
Lee, Bianca J., Boyer, Jacob A., Burnett, G. Leslie, Thottumkara, Arun P., Tibrewal, Nidhi, Wilson, Stacy L., Hsieh, Tientien, Marquez, Abby, Lorenzana, Edward G., Evans, James W., Hulea, Laura, Kiss, Gert, Liu, Hui, Lee, Dong, Larsson, Ola, McLaughlan, Shannon, Topisirovic, Ivan, Wang, Zhengping, Wang, Zhican, Zhao, Yongyuan, Wildes, David, Aggen, James B., Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A. M., Rosen, Neal
Published in Nature chemical biology (01.11.2021)
Published in Nature chemical biology (01.11.2021)
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Journal Article
A general approach to the galanthamine ring system
Parsons, Philip J, Charles, Mark D, Harvey, Darren M, Sumoreeah, L.Ravi, Shell, Adrian, Spoors, Grant, Gill, Adrian L, Smith, Steve
Published in Tetrahedron letters (11.03.2001)
Published in Tetrahedron letters (11.03.2001)
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Journal Article
Identification of Novel p38α MAP Kinase Inhibitors Using Fragment-Based Lead Generation
Gill, Adrian L, Frederickson, Martyn, Cleasby, Anne, Woodhead, Steven J, Carr, Maria G, Woodhead, Andrew J, Walker, Margaret T, Congreve, Miles S, Devine, Lindsay A, Tisi, Dominic, O'Reilly, Marc, Seavers, Lisa C. A, Davis, Deborah J, Curry, Jayne, Anthony, Rachel, Padova, Alessandro, Murray, Christopher W, Carr, Robin A. E, Jhoti, Harren
Published in Journal of medicinal chemistry (27.01.2005)
Published in Journal of medicinal chemistry (27.01.2005)
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Journal Article
Optimisation of pharmacokinetic properties in a neutral series of 11β-HSD1 inhibitors
Scott, James S., Gill, Adrian L., Godfrey, Linda, Groombridge, Sam D., Rees, Amanda, Revill, John, Schofield, Paul, Sörme, Pernilla, Stocker, Andrew, Swales, John G., Whittamore, Paul R.O.
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
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Journal Article
RAS 억제제
BURNETT G. LESLIE, KOLTUN ELENA S, GILL ADRIAN L, CREGG JAMES, LIU YANG, KNOX JOHN E
Year of Publication 11.01.2024
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Year of Publication 11.01.2024
Patent
RAS 억제제
BUCKL ANDREAS, EDWARDS ANNE V, BURNETT G. LESLIE, KOLTUN ELENA S, SEMKO CHRISTOPHER, GILL ADRIAN L, CREGG JAMES, LIU YANG, KNOX JOHN E
Year of Publication 28.05.2024
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Year of Publication 28.05.2024
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암의 치료를 위한 RAS 억제제
BUCKL ANDREAS, EDWARDS ANNE V, BURNETT G. LESLIE, KOLTUN ELENA S, SEMKO CHRISTOPHER, GILL ADRIAN L, CREGG JAMES, PITZEN JENNIFER, KNOX JOHN E
Year of Publication 08.02.2024
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Year of Publication 08.02.2024
Patent
RAS 억제제
BUCKL ANDREAS, BURNETT G. LESLIE, KOLTUN ELENA S, GILL ADRIAN L, CREGG JAMES, PITZEN JENNIFER, LIU YANG, KNOX JOHN E, AGGEN JAMES
Year of Publication 04.08.2022
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Year of Publication 04.08.2022
Patent
RAS 억제제
BUCKL ANDREAS, BURNETT G. LESLIE, WHALEN DANIEL M, KOLTUN ELENA S, GILL ADRIAN L, CREGG JAMES, AAY NAING, PITZEN JENNIFER, LIU YANG, KNOX JOHN E, AGGEN JAMES
Year of Publication 04.08.2022
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Year of Publication 04.08.2022
Patent