Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs
DE BUCK, Stefan S, SINHA, Vikash K, FENU, Luca A, NIJSEN, Marjoleen J, MACKIE, Claire E, GILISSEN, Ron A. H. J
Published in Drug metabolism and disposition (01.10.2007)
Published in Drug metabolism and disposition (01.10.2007)
Get full text
Journal Article
Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
Johnson, Christopher N, Berdini, Valerio, Beke, Lijs, Bonnet, Pascal, Brehmer, Dirk, Coyle, Joseph E, Day, Phillip J, Frederickson, Martyn, Freyne, Eddy J. E, Gilissen, Ron A. H. J, Hamlett, Christopher C. F, Howard, Steven, Meerpoel, Lieven, McMenamin, Rachel, Patel, Sahil, Rees, David C, Sharff, Andrew, Sommen, François, Wu, Tongfei, Linders, Joannes T. M
Published in ACS medicinal chemistry letters (08.01.2015)
Published in ACS medicinal chemistry letters (08.01.2015)
Get full text
Journal Article
Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase
Johnson, Christopher N, Adelinet, Christophe, Berdini, Valerio, Beke, Lijs, Bonnet, Pascal, Brehmer, Dirk, Calo, Frederick, Coyle, Joseph E, Day, Phillip J, Frederickson, Martyn, Freyne, Eddy J. E, Gilissen, Ron A. H. J, Hamlett, Christopher C. F, Howard, Steven, Meerpoel, Lieven, Mevellec, Laurence, McMenamin, Rachel, Pasquier, Elisabeth, Patel, Sahil, Rees, David C, Linders, Joannes T. M
Published in ACS medicinal chemistry letters (08.01.2015)
Published in ACS medicinal chemistry letters (08.01.2015)
Get full text
Journal Article
Predicting Oral Clearance in Humans: How Close Can We Get with Allometry?
Sinha, Vikash K., De Buck, Stefan S., Fenu, Luca A., Smit, Johan W., Nijsen, Marjoleen, Gilissen, Ron A. H. J., Van Peer, Achiel, Lavrijsen, Karel, Mackie, Claire E.
Published in Clinical pharmacokinetics (2008)
Published in Clinical pharmacokinetics (2008)
Get full text
Journal Article
Towards a Better Prediction of Peak Concentration, Volume of Distribution and Half-Life after Oral Drug Administration in Man, Using Allometry
Sinha, Vikash K., Vaarties, Karin, De Buck, Stefan S., Fenu, Luca. A., Nijsen, Marjoleen, Gilissen, Ron A. H. J., Sanderson, Wendy, Uytsel, Kelly Van, Hoeben, Eva, Peer, Achiel Van, Mackie, Claire E., Smit, Johan W.
Published in Clinical pharmacokinetics (01.05.2011)
Published in Clinical pharmacokinetics (01.05.2011)
Get full text
Journal Article
Chiral capillary electrophoretic analysis of verapamil metabolism by cytochrome P450 3A4
Ha, Pham Thi Thanh, Sluyts, Inge, Dyck, Sigrid Van, Zhang, Jie, Gilissen, Ron A.H.J., Hoogmartens, Jos, Schepdael, Ann Van
Published in Journal of Chromatography A (07.07.2006)
Published in Journal of Chromatography A (07.07.2006)
Get full text
Journal Article
Conference Proceeding
Discovery of Potent, Orally Bioavailable Small-Molecule Inhibitors of the Human CCR2 Receptor
Doyon, Julien, Coesemans, Erwin, Boeckx, Staf, Buntinx, Mieke, Hermans, Bart, Van Wauwe, Jean P., Gilissen, Ron A. H. J., De Groot, Alex H. J., Corens, David, Van Lommen, Guy
Published in ChemMedChem (14.04.2008)
Published in ChemMedChem (14.04.2008)
Get full text
Journal Article
Cardio-vascular safety beyond hERG: in silico modelling of a guinea pig right atrium assay
Fenu, Luca A., Teisman, Ard, De Buck, Stefan S., Sinha, Vikash K., Gilissen, Ron A. H. J., Nijsen, Marjoleen J. M. A., Mackie, Claire E., Sanderson, Wendy E.
Published in Journal of computer-aided molecular design (01.12.2009)
Published in Journal of computer-aided molecular design (01.12.2009)
Get full text
Journal Article
Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients
de Witte, Wilhelmus E A, Wong, Yin Cheong, Nederpelt, Indira, Heitman, Laura H, Danhof, Meindert, van der Graaf, Piet H, Gilissen, Ron A H J, de Lange, Elizabeth C M
Published in Expert opinion on drug discovery (02.01.2016)
Published in Expert opinion on drug discovery (02.01.2016)
Get more information
Journal Article
Pharmacological Profile of JNJ-27141491 [(S)-3-[3,4-Difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxyl Acid Methyl Ester], as a Noncompetitive and Orally Active Antagonist of the Human Chemokine Receptor CCR2
Buntinx, Mieke, Hermans, Bart, Goossens, Jan, Moechars, Dieder, Gilissen, Ron A H J, Doyon, Julien, Boeckx, Staf, Coesemans, Erwin, Van Lommen, Guy, Van Wauwe, Jean P
Published in The Journal of pharmacology and experimental therapeutics (01.10.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2008)
Get full text
Journal Article
Simultaneous measurement of drug metabolic stability and identification of metabolites using ion-trap mass spectrometry
Kantharaj, E., Tuytelaars, An, Proost, Pascale E. A., Ongel, Zuleyha, van Assouw, Harrie P., Gilissen, Ron A. H. J.
Published in Rapid communications in mass spectrometry (01.01.2003)
Published in Rapid communications in mass spectrometry (01.01.2003)
Get full text
Journal Article
HERG mutation predicts short QT based on channel kinetics but causes long QT by heterotetrameric trafficking deficiency
PAULUSSEN, Aimée D. C, RAES, Adam, JONGBLOED, Roselie J, GILISSEN, Ron A. H. J, WILDE, Arthur A. M, SNYDERS, Dirk J, SMEETS, Hubert J. M, AERSSENS, Jeroen
Published in Cardiovascular research (15.08.2005)
Published in Cardiovascular research (15.08.2005)
Get full text
Journal Article
Simultaneous measurement of metabolic stability and metabolite identification of 7-methoxymethylthiazolo[3,2-a]pyrimidin-5-one derivatives in human liver microsomes using liquid chromatography/ion-trap mass spectrometry
Kantharaj, E., Ehmer, Peter B., Tuytelaars, An, Vlaslaer, Anne Van, Mackie, Claire, Gilissen, Ron A. H. J.
Published in Rapid communications in mass spectrometry (01.01.2005)
Published in Rapid communications in mass spectrometry (01.01.2005)
Get full text
Journal Article
The use of liquid chromatography-atmospheric pressure chemical ionization mass spectrometry to explore the in vitro metabolism of cyanoalkyl piperidine derivatives
Kantharaj, E., Ehmer, Peter B., De Wagter, Katie, Tuytelaars, An, Proost, Pascale E. A., Mackie, Claire, Gilissen, Ron A. H. J.
Published in Biomedical chromatography (01.04.2005)
Published in Biomedical chromatography (01.04.2005)
Get full text
Journal Article
Phenol sulphotransferase SULT1A1 polymorphism: molecular diagnosis and allele frequencies in Caucasian and African populations
COUGHTRIE, Michael W. H., GILISSEN, Ron A. H. J., SHEK, Benedicte, STRANGE, Richard C., FRYER, Anthony A., JONES, Peter W., BAMBER, Dianne E.
Published in Biochemical journal (01.01.1999)
Published in Biochemical journal (01.01.1999)
Get full text
Journal Article
Phenol sulphotransferase SULT1A11 genotype is associated with reduced risk of colorectal cancer
Bamber, D E, Fryer, A A, Strange, R C, Elder, J B, Deakin, M, Rajagopal, R, Fawole, A, Gilissen, R A, Campbell, F C, Coughtrie, M W
Published in Pharmacogenetics (London) (01.11.2001)
Published in Pharmacogenetics (London) (01.11.2001)
Get more information
Journal Article
Pharmacological Profile of JNJ-27141491 [( S )-3-[3,4-Difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1 H -imidazole-4-carboxyl Acid Methyl Ester], as a Noncompetitive and Orally Active Antagonist of the Human Chemokine Receptor CCR2
Buntinx, Mieke, Hermans, Bart, Goossens, Jan, Moechars, Dieder, Gilissen, Ron A. H. J., Doyon, Julien, Boeckx, Staf, Coesemans, Erwin, Van Lommen, Guy, Van Wauwe, Jean P.
Published in The Journal of pharmacology and experimental therapeutics (01.10.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2008)
Get full text
Journal Article
The use of liquid chromatography-atmospheric pressure chemical ionization mass spectrometry to explore thein vitro metabolism of cyanoalkyl piperidine derivatives
Kantharaj, E., Ehmer, Peter B., De Wagter, Katie, Tuytelaars, An, Proost, Pascale E. A., Mackie, Claire, Gilissen, Ron A. H. J.
Published in Biomedical chromatography (01.04.2005)
Published in Biomedical chromatography (01.04.2005)
Get full text
Journal Article