BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection
Mills, Richard J., Humphrey, Sean J., Fortuna, Patrick R.J., Lor, Mary, Foster, Simon R., Quaife-Ryan, Gregory A., Johnston, Rebecca L., Dumenil, Troy, Bishop, Cameron, Rudraraju, Rajeev, Rawle, Daniel J., Le, Thuy, Zhao, Wei, Lee, Leo, Mackenzie-Kludas, Charley, Mehdiabadi, Neda R., Halliday, Christopher, Gilham, Dean, Fu, Li, Nicholls, Stephen J., Johansson, Jan, Sweeney, Michael, Wong, Norman C.W., Kulikowski, Ewelina, Sokolowski, Kamil A., Tse, Brian W.C., Devilée, Lynn, Voges, Holly K., Reynolds, Liam T., Krumeich, Sophie, Mathieson, Ellen, Abu-Bonsrah, Dad, Karavendzas, Kathy, Griffen, Brendan, Titmarsh, Drew, Elliott, David A., McMahon, James, Suhrbier, Andreas, Subbarao, Kanta, Porrello, Enzo R., Smyth, Mark J., Engwerda, Christian R., MacDonald, Kelli P.A., Bald, Tobias, James, David E., Hudson, James E.
Published in Cell (15.04.2021)
Published in Cell (15.04.2021)
Get full text
Journal Article
RVX-297, a BET Bromodomain Inhibitor, Has Therapeutic Effects in Preclinical Models of Acute Inflammation and Autoimmune Disease
Jahagirdar, Ravi, Attwell, Sarah, Marusic, Suzana, Bendele, Alison, Shenoy, Narmada, McLure, Kevin G, Gilham, Dean, Norek, Karen, Hansen, Henrik C, Yu, Raymond, Tobin, Jennifer, Wagner, Gregory S, Young, Peter R, Wong, Norman C W, Kulikowski, Ewelina
Published in Molecular pharmacology (01.12.2017)
Published in Molecular pharmacology (01.12.2017)
Get full text
Journal Article
Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators
Tsujikawa, Laura M., Kharenko, Olesya A., Stotz, Stephanie C., Rakai, Brooke D., Sarsons, Christopher D., Gilham, Dean, Wasiak, Sylwia, Fu, Li, Sweeney, Michael, Johansson, Jan O., Wong, Norman C.W., Kulikowski, Ewelina
Published in Biomedicine & pharmacotherapy (01.08.2022)
Published in Biomedicine & pharmacotherapy (01.08.2022)
Get full text
Journal Article
Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice
Labonté, Eric D, Camarota, Lisa M, Rojas, Juan C, Jandacek, Ronald J, Gilham, Dean E, Davies, Joanna P, Ioannou, Yiannis A, Tso, Patrick, Hui, David Y, Howles, Philip N
Published in American journal of physiology: Gastrointestinal and liver physiology (01.10.2008)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.10.2008)
Get full text
Journal Article
Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice
Hofmann, Susanna M, Zhou, Li, Perez-Tilve, Diego, Greer, Todd, Grant, Erin, Wancata, Lauren, Thomas, Andrew, Pfluger, Paul T, Basford, Joshua E, Gilham, Dean, Herz, Joachim, Tschöp, Matthias H, Hui, David Y
Published in The Journal of clinical investigation (01.11.2007)
Published in The Journal of clinical investigation (01.11.2007)
Get full text
Journal Article
Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro
Gilham, Dean, Smith, Audrey L, Fu, Li, Moore, Dalia Y, Muralidharan, Abenaya, Reid, St Patrick M, Stotz, Stephanie C, Johansson, Jan O, Sweeney, Michael, Wong, Norman C W, Kulikowski, Ewelina, El-Gamal, Dalia
Published in Biomedicines (18.04.2021)
Published in Biomedicines (18.04.2021)
Get full text
Journal Article
Apabetalone, a Clinical-Stage, Selective BET Inhibitor, Opposes DUX4 Target Gene Expression in Primary Human FSHD Muscle Cells
Sarsons, Christopher D, Gilham, Dean, Tsujikawa, Laura M, Wasiak, Sylwia, Fu, Li, Rakai, Brooke D, Stotz, Stephanie C, Carestia, Agostina, Sweeney, Michael, Kulikowski, Ewelina
Published in Biomedicines (30.09.2023)
Published in Biomedicines (30.09.2023)
Get full text
Journal Article
Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment
Gilham, Dean, Wasiak, Sylwia, Rakai, Brooke D, Fu, Li, Tsujikawa, Laura M, Sarsons, Christopher D, Carestia, Agostina, Lebioda, Kenneth, Johansson, Jan O, Sweeney, Michael, Kalantar-Zadeh, Kamyar, Kulikowski, Ewelina
Published in Biomedicines (01.06.2023)
Published in Biomedicines (01.06.2023)
Get full text
Journal Article
The BET inhibitor apabetalone decreases neuroendothelial proinflammatory activation in vitro and in a mouse model of systemic inflammation
Wasiak, Sylwia, Fu, Li, Daze, Emily, Gilham, Dean, Rakai, Brooke D., Stotz, Stephanie C., Tsujikawa, Laura M., Sarsons, Chris D., Studer, Deborah, Rinker, Kristina D., Jahagirdar, Ravi, Wong, Norman C. W., Sweeney, Michael, Johansson, Jan O., Kulikowski, Ewelina
Published in Translational neuroscience (01.01.2023)
Published in Translational neuroscience (01.01.2023)
Get full text
Journal Article
Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease
Sweeney, Michael, Johansson, Jan O., Wong, Norman C. W., Kulikowski, Ewelina, Fu, Li, Rakai, Brooke D., Stotz, Stephanie C., Halliday, Christopher, Tsujikawa, Laura M., Daze, Emily, Gilham, Dean, Wasiak, Sylwia, Jahagirdar, Ravi
Published in Cardiovascular therapeutics (2020)
Published in Cardiovascular therapeutics (2020)
Get full text
Journal Article
Benefit of Apabetalone on Plasma Proteins in Renal Disease
Wasiak, Sylwia, Tsujikawa, Laura M., Halliday, Christopher, Stotz, Stephanie C., Gilham, Dean, Jahagirdar, Ravi, Kalantar-Zadeh, Kamyar, Robson, Richard, Sweeney, Michael, Johansson, Jan O., Wong, Norman C., Kulikowski, Ewelina
Published in Kidney international reports (01.05.2018)
Published in Kidney international reports (01.05.2018)
Get full text
Journal Article
Metabolic control by S6 kinases depends on dietary lipids
Castañeda, Tamara R, Abplanalp, William, Um, Sung Hee, Pfluger, Paul T, Schrott, Brigitte, Brown, Kimberly, Grant, Erin, Carnevalli, Larissa, Benoit, Stephen C, Morgan, Donald A, Gilham, Dean, Hui, David Y, Rahmouni, Kamal, Thomas, George, Kozma, Sara C, Clegg, Deborah J, Tschöp, Matthias H
Published in PloS one (07.03.2012)
Published in PloS one (07.03.2012)
Get full text
Journal Article
Carboxyl Ester Lipase Deficiency Exacerbates Dietary Lipid Absorption Abnormalities and Resistance to Diet-induced Obesity in Pancreatic Triglyceride Lipase Knockout Mice
Gilham, Dean, Labonté, Eric D., Rojas, Juan C., Jandacek, Ronald J., Howles, Philip N., Hui, David Y.
Published in The Journal of biological chemistry (24.08.2007)
Published in The Journal of biological chemistry (24.08.2007)
Get full text
Journal Article
Data on gene and protein expression changes induced by apabetalone (RVX-208) in ex vivo treated human whole blood and primary hepatocytes
Wasiak, Sylwia, Gilham, Dean, Tsujikawa, Laura M., Halliday, Christopher, Norek, Karen, Patel, Reena G., McLure, Kevin G., Young, Peter R., Gordon, Allan, Kulikowski, Ewelina, Johansson, Jan, Sweeney, Michael, Wong, Norman C.
Published in Data in brief (01.09.2016)
Published in Data in brief (01.09.2016)
Get full text
Journal Article
Regulation of triacylglycerol hydrolase expression by dietary fatty acids and peroxisomal proliferator-activated receptors
Dolinsky, Vernon W., Gilham, Dean, Hatch, Grant M., Agellon, Luis B., Lehner, Richard, Vance, Dennis E.
Published in Biochimica et biophysica acta (30.11.2003)
Published in Biochimica et biophysica acta (30.11.2003)
Get full text
Journal Article
EPIGENETIC BET READER INHIBITOR APABETALONE / RVX-208 COUNTERS PROFIBROTIC AND CONTRACTILE ACTIVITY OF CARDIAC FIBROBLASTS WITH POTENTIAL BENEFIT FOR HEART FAILURE
Kulikowski, Ewelina, Wasiak, Sylwia, Tsujikawa, Laura, Fu, Li, Gilham, Dean, Sarsons, Christopher, Sweeney, Michael, Johansson, Jan
Published in Journal of the American College of Cardiology (07.03.2023)
Published in Journal of the American College of Cardiology (07.03.2023)
Get full text
Journal Article