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Okumu, Denis O, East, Michael P, Levine, Merlin, Herring, Laura E, Zhang, Raymond, Gilbert, Thomas S K, Litchfield, David W, Zhang, Yanping, Graves, Lee M
Published in PloS one (16.05.2017)
Published in PloS one (16.05.2017)
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Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues
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Published in ACS chemical biology (17.05.2019)
Published in ACS chemical biology (17.05.2019)
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Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer
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Published in Science signaling (16.07.2019)
Published in Science signaling (16.07.2019)
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Kinome Profiling Identifies Druggable Targets for Novel Human Cytomegalovirus (HCMV) Antivirals
Arend, Kyle C., Lenarcic, Erik M., Vincent, Heather A., Rashid, Naim, Lazear, Eric, McDonald, Ian M., Gilbert, Thomas S.K., East, Michael P., Herring, Laura E., Johnson, Gary L., Graves, Lee M., Moorman, Nathaniel J.
Published in Molecular & cellular proteomics (01.04.2017)
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Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology
Da, Chenxiao, Zhang, Dehui, Stashko, Michael, Vasileiadi, Eleana, Parker, Rebecca E, Minson, Katherine A, Huey, Madeline G, Huelse, Justus M, Hunter, Debra, Gilbert, Thomas S. K, Norris-Drouin, Jacqueline, Miley, Michael, Herring, Laura E, Graves, Lee M, DeRyckere, Deborah, Earp, H. Shelton, Graham, Douglas K, Frye, Stephen V, Wang, Xiaodong, Kireev, Dmitri
Published in Journal of the American Chemical Society (02.10.2019)
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Dasatinib Is Preferentially Active in the Activated B‑Cell Subtype of Diffuse Large B‑Cell Lymphoma
Cann, Marissa L, Herring, Laura E, Haar, Lauren L, Gilbert, Thomas S. K, Goldfarb, Dennis, Richards, Kristy L, Graves, Lee M, Lawrence, David S
Published in Journal of proteome research (04.01.2019)
Published in Journal of proteome research (04.01.2019)
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KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
Vaseva, Angelina V., Blake, Devon R., Gilbert, Thomas S.K., Ng, Serina, Hostetter, Galen, Azam, Salma H., Ozkan-Dagliyan, Irem, Gautam, Prson, Bryant, Kirsten L., Pearce, Kenneth H., Herring, Laura E., Han, Haiyong, Graves, Lee M., Witkiewicz, Agnieszka K., Knudsen, Erik S., Pecot, Chad V., Rashid, Naim, Houghton, Peter J., Wennerberg, Krister, Cox, Adrienne D., Der, Channing J.
Published in Cancer cell (12.11.2018)
Published in Cancer cell (12.11.2018)
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The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer
Diehl, J. Nathaniel, Klomp, Jennifer E., Snare, Kayla R., Hibshman, Priya S., Blake, Devon R., Kaiser, Zane D., Gilbert, Thomas S.K., Baldelli, Elisa, Pierobon, Mariaelena, Papke, Björn, Yang, Runying, Hodge, Richard G., Rashid, Naim U., Petricoin, Emanuel F., Herring, Laura E., Graves, Lee M., Cox, Adrienne D., Der, Channing J.
Published in The Journal of biological chemistry (01.11.2021)
Published in The Journal of biological chemistry (01.11.2021)
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Mass spectrometry–based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells
McDonald, Ian M., Grant, Gavin D., East, Michael P., Gilbert, Thomas S.K., Wilkerson, Emily M., Goldfarb, Dennis, Beri, Joshua, Herring, Laura E., Vaziri, Cyrus, Cook, Jeanette Gowen, Emanuele, Michael J., Graves, Lee M.
Published in The Journal of biological chemistry (21.02.2020)
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Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals
Fritch, Ethan J., Mordant, Angie L., Gilbert, Thomas S.K., Wells, Carrow I., Yang, Xuan, Barker, Natalie K., Madden, Emily A., Dinnon, Kenneth H., Hou, Yixuan J., Tse, Longping V., Castillo, Izabella N., Sims, Amy C., Moorman, Nathaniel J., Lakshmanane, Premkumar, Willson, Timothy M., Herring, Laura E., Graves, Lee M., Baric, Ralph S.
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EPH receptor signaling as a novel therapeutic target in NF2-deficient meningioma
Angus, Steven P, Oblinger, Janet L, Stuhlmiller, Timothy J, DeSouza, Patrick A, Beauchamp, Roberta L, Witt, Luke, Chen, Xin, Jordan, Justin T, Gilbert, Thomas S K, Stemmer-Rachamimov, Anat, Gusella, James F, Plotkin, Scott R, Haggarty, Stephen J, Chang, Long-Sheng, Johnson, Gary L, Ramesh, Vijaya
Published in Neuro-oncology (Charlottesville, Va.) (02.08.2018)
Published in Neuro-oncology (Charlottesville, Va.) (02.08.2018)
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Correction to “Mitochondrial Protease ClpP Is a Target for the Anticancer Compounds ONC201 and Related Analogues”
Graves, Paul R., Aponte-Collazo, Lucas J., Fennell, Emily M. J., Graves, Adam C., Hale, Andrew E., Dicheva, Nedyalka, Herring, Laura E., Gilbert, Thomas S. K., East, Michael P., McDonald, Ian M., Lockett, Matthew R., Ashamalla, Hani, Moorman, Nathaniel J., Karanewsky, Donald S., Iwanowicz, Edwin J., Holmuhamedov, Ekhson, Graves, Lee M.
Published in ACS chemical biology (19.08.2022)
Published in ACS chemical biology (19.08.2022)
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Synthesis and Evaluation of Several New (2-Chloroethyl)nitrosocarbamates as Potential Anticancer Agents
Reynolds, Robert C, Tiwari, Anita, Harwell, Joyce E, Gordon, Deborah G, Garrett, Beverly D, Gilbert, Karen S, Schmid, Steven M, Waud, William R, Struck, Robert F
Published in Journal of medicinal chemistry (20.04.2000)
Published in Journal of medicinal chemistry (20.04.2000)
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Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis
Greer, Yoshimi Endo, Hernandez, Lidia, Fennell, Emily M J, Kundu, Manjari, Voeller, Donna, Chari, Raj, Gilbert, Samuel F, Gilbert, Thomas S K, Ratnayake, Shashikala, Tang, Binwu, Hafner, Markus, Chen, Qingrong, Meerzaman, Daoud, Iwanowicz, Edwin, Annunziata, Christina M, Graves, Lee M, Lipkowitz, Stanley
Published in Cancer research communications (10.10.2022)
Published in Cancer research communications (10.10.2022)
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Cytomegalovirus US28 regulates cellular EphA2 to maintain viral latency
Wass, Amanda B., Krishna, Benjamin A., Herring, Laura E., Gilbert, Thomas S. K., Nukui, Masatoshi, Groves, Ian J., Dooley, Abigail L., Kulp, Katherine H., Matthews, Stephen M., Rotroff, Daniel M., Graves, Lee M., O’Connor, Christine M.
Published in Science advances (28.10.2022)
Published in Science advances (28.10.2022)
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Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth
Krulikas, Linas J., McDonald, Ian M., Lee, Benjamin, Okumu, Denis O., East, Michael P., Gilbert, Thomas S. K., Herring, Laura E., Golitz, Brian T., Wells, Carrow I., Axtman, Allison D., Zuercher, William J., Willson, Timothy M., Kireev, Dmitri, Yeh, Jen Jen, Johnson, Gary L., Baines, Antonio T., Graves, Lee M.
Published in SLAS discovery (01.09.2018)
Published in SLAS discovery (01.09.2018)
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Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK
Chang, Long-Sheng, Oblinger, Janet L, Smith, Abbi E, Ferrer, Marc, Angus, Steven P, Hawley, Eric, Petrilli, Alejandra M, Beauchamp, Roberta L, Riecken, Lars Björn, Erdin, Serkan, Poi, Ming, Huang, Jie, Bessler, Waylan K, Zhang, Xiaohu, Guha, Rajarshi, Thomas, Craig, Burns, Sarah S, Gilbert, Thomas S. K, Jiang, Li, Li, Xiaohong, Lu, Qingbo, Yuan, Jin, He, Yongzheng, Dixon, Shelley A. H, Masters, Andrea, Jones, David R, Yates, Charles W, Haggarty, Stephen J, La Rosa, Salvatore, Welling, D. Bradley, Stemmer-Rachamimov, Anat O, Plotkin, Scott R, Gusella, James F, Guinney, Justin, Morrison, Helen, Ramesh, Vijaya, Fernandez-Valle, Cristina, Johnson, Gary L, Blakeley, Jaishri O, Clapp, D. Wade
Published in PloS one (15.07.2021)
Published in PloS one (15.07.2021)
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