Evaluation of Clinically Relevant Drug–Drug Interactions and Population Pharmacokinetics of Darolutamide in Patients with Nonmetastatic Castration-Resistant Prostate Cancer: Results of Pre-Specified and Post Hoc Analyses of the Phase III ARAMIS Trial
Shore, Neal, Zurth, Christian, Fricke, Robert, Gieschen, Hille, Graudenz, Kristina, Koskinen, Mikko, Ploeger, Bart, Moss, Jonathan, Prien, Olaf, Borghesi, Gustavo, Petrenciuc, Oana, Tammela, Teuvo L., Kuss, Iris, Verholen, Frank, Smith, Matthew R., Fizazi, Karim
Published in Targeted oncology (01.10.2019)
Published in Targeted oncology (01.10.2019)
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Drug–Drug Interaction Potential of Darolutamide: In Vitro and Clinical Studies
Zurth, Christian, Koskinen, Mikko, Fricke, Robert, Prien, Olaf, Korjamo, Timo, Graudenz, Kristina, Denner, Karsten, Bairlein, Michaela, von Bühler, Clemens-Jeremias, Wilkinson, Gary, Gieschen, Hille
Published in European journal of drug metabolism and pharmacokinetics (01.12.2019)
Published in European journal of drug metabolism and pharmacokinetics (01.12.2019)
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Higher blood–brain barrier penetration of [ 14 C]apalutamide and [ 14 C]enzalutamide compared to [ 14 C]darolutamide in rats using whole-body autoradiography
Zurth, Christian, Sandman, Steffen, Trummel, Dagmar, Seidel, Dietrich, Nubbemeyer, Reinhard, Gieschen, Hille
Published in Journal of clinical oncology (01.03.2019)
Published in Journal of clinical oncology (01.03.2019)
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Characterization of new estrogen receptor destabilizing compounds: Effects on estrogen-sensitive and tamoxifen-resistant breast cancer
HOFFMANN, Jens, BOHLMANN, Rolf, GIESCHEN, Hille, ULBRICH, Hannes-F, SCHNEIDER, Martin R, HEINRICH, Nikolaus, HOFMEISTER, Helmut, KROLL, Jörg, KÜNZER, Hermann, LICHTNER, Rosemarie B, NISHINO, Yuki, PARCZYK, Karsten, SAUER, Gerhard
Published in JNCI : Journal of the National Cancer Institute (04.02.2004)
Published in JNCI : Journal of the National Cancer Institute (04.02.2004)
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Absorption, distribution, metabolism and excretion of darolutamide (a novel non-steroidal androgen receptor antagonist) in rats
Taavitsainen, Päivi, Gieschen, Hille, Korjamo, Timo, Kähkönen, Marja, Malmström, Chira, Prien, Olaf, Niehues, Michael, Sandmann, Steffen, Janssen, Wiebke, Koskinen, Mikko
Published in Xenobiotica (02.08.2020)
Published in Xenobiotica (02.08.2020)
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Metabolism and Mass Balance of the Novel Nonsteroidal Androgen Receptor Inhibitor Darolutamide in Humans
Taavitsainen, Päivi, Prien, Olaf, Kähkönen, Marja, Niehues, Michael, Korjamo, Timo, Denner, Karsten, Nykänen, Pirjo, Vuorela, Annamari, Jungmann, Natalia A, von Bühler, Clemens-Jeremias, Koskinen, Mikko, Zurth, Christian, Gieschen, Hille
Published in Drug metabolism and disposition (01.06.2021)
Published in Drug metabolism and disposition (01.06.2021)
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Improving the ex vivo stability of drug ester compounds in rat and dog serum: Inhibition of the specific esterases and implications on their identity
Koitka, Matthias, Höchel, Joachim, Gieschen, Hille, Borchert, Hans-Hubert
Published in Journal of pharmaceutical and biomedical analysis (05.02.2010)
Published in Journal of pharmaceutical and biomedical analysis (05.02.2010)
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Determination of rat serum esterase activities by an HPLC method using S-acetylthiocholine iodide and p-nitrophenyl acetate
Koitka, Matthias, Höchel, Joachim, Obst, Detlev, Rottmann, Antje, Gieschen, Hille, Borchert, Hans-Hubert
Published in Analytical biochemistry (01.10.2008)
Published in Analytical biochemistry (01.10.2008)
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The bioavailability of oral fludarabine phosphate is unaffected by food
Oscier, D, Orchard, J A, Culligan, D, Cunningham, D, Johnson, S, Parker, A, Klein, M, Gieschen, H
Published in The hematology journal : the official journal of the European Haematology Association (2001)
Published in The hematology journal : the official journal of the European Haematology Association (2001)
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Development of a V79 cell line expressing human cytochrome P450 2D6 and its application as a metabolic screening tool
Rauschenbach, Reimund, Gieschen, Hille, Salomon, Birgit, Kraus, Christian, Kühne, Gerhard, Hildebrand, Michael
Published in Environmental toxicology and pharmacology (15.02.1997)
Published in Environmental toxicology and pharmacology (15.02.1997)
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Stable expression of human cytochrome P450 3A4 in V79 cells and its application for metabolic profiling of ergot derivatives
Rauschenbach, Reimund, Gieschen, Hille, Husemann, Manfred, Salomon, Birgit, Hildebrand, Michael
Published in European journal of pharmacology. Environmental toxicology and pharmacology section (06.10.1995)
Published in European journal of pharmacology. Environmental toxicology and pharmacology section (06.10.1995)
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