Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor
Mbalaviele, Gabriel, Pauley, Adele M., Shaffer, Alexander F., Zweifel, Ben S., Mathialagan, Sumathy, Mnich, Stephen J., Nemirovskiy, Olga V., Carter, Jeff, Gierse, James K., Wang, Jane L., Vazquez, Michael L., Moore, William M., Masferrer, Jaime L.
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Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
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Published in Nature (London) (26.12.1996)
Published in Nature (London) (26.12.1996)
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Valdecoxib: Assessment of Cyclooxygenase-2 Potency and Selectivity
Gierse, James K, Zhang, Yan, Hood, William F, Walker, Mark C, Trigg, Jennifer S, Maziasz, Timothy J, Koboldt, Carol M, Muhammad, Jerry L, Zweifel, Ben S, Masferrer, Jaime L, Isakson, Peter C, Seibert, Karen
Published in The Journal of pharmacology and experimental therapeutics (01.03.2005)
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Characterization of Celecoxib and Valdecoxib Binding to Cyclooxygenase
Hood, William F, Gierse, James K, Isakson, Peter C, Kiefer, James R, Kurumbail, Ravi G, Seibert, Karen, Monahan, Joseph B
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Quantification of Peptide m/z Distributions from 13C‑Labeled Cultures with High-Resolution Mass Spectrometry
Allen, Doug K, Goldford, Joshua, Gierse, James K, Mandy, Dominic, Diepenbrock, Christine, Libourel, Igor G. L
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Development of a fluorescence-based enzyme assay of human 5-lipoxygenase
Pufahl, Robert A., Kasten, Thomas P., Hills, Rob, Gierse, James K., Reitz, Beverly A., Weinberg, Robin A., Masferrer, Jaime L.
Published in Analytical biochemistry (15.05.2007)
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Kinetic basis for selective inhibition of cyclo-oxygenases
Gierse, J K, Koboldt, C M, Walker, M C, Seibert, K, Isakson, P C
Published in Biochemical journal (01.05.1999)
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Structure-based parallel medicinal chemistry approach to improve metabolic stability of benzopyran COX-2 inhibitors
Xing, Li, Hamper, Bruce C., Fletcher, Theresa R., Wendling, Jay M., Carter, Jeffery, Gierse, James K., Liao, Subo
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
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Structural insights into the stereochemistry of the cyclooxygenase reaction
Kurumbail, Ravi G, Kiefer, James R, Pawlitz, Jennifer L, Moreland, Kirby T, Stegeman, Roderick A, Hood, William F, Gierse, James K, Stevens, Anna M, Goodwin, Douglas C, Rowlinson, Scott W, Marnett, Lawrence J, Stallings, William C
Published in Nature (London) (04.05.2000)
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Homo-timeric structural model of human microsomal prostaglandin E synthase-1 and characterization of its substrate/inhibitor binding interactions
Xing, Li, Kurumbail, Ravi G., Frazier, Ronald B., Davies, Michael S., Fujiwara, Hideji, Weinberg, Robin A., Gierse, James K., Caspers, Nicole, Carter, Jeffrey S., McDonald, Joseph J., Moore, William M., Vazquez, Michael L.
Published in Journal of computer-aided molecular design (2009)
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A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors
Walker, M C, Kurumbail, R G, Kiefer, J R, Moreland, K T, Koboldt, C M, Isakson, P C, Seibert, K, Gierse, J K
Published in Biochemical journal (01.08.2001)
Published in Biochemical journal (01.08.2001)
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Nitric Oxide Trapping of the Tyrosyl Radical of Prostaglandin H Synthase-2 Leads to Tyrosine Iminoxyl Radical and Nitrotyrosine Formation
Gunther, Michael R., Hsi, Linda C., Curtis, John F., Gierse, James K., Marnett, Lawrence J., Eling, Thomas E., Mason, Ronald P.
Published in The Journal of biological chemistry (04.07.1997)
Published in The Journal of biological chemistry (04.07.1997)
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A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and â2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors
Gierse, J K, McDonald, J J, Hauser, S D, Rangwala, S H, Koboldt, C M, Seibert, K
Published in The Journal of biological chemistry (28.06.1996)
Published in The Journal of biological chemistry (28.06.1996)
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Substrate specificity of recombinant human renal renin: effect of histidine in the P2 subsite of pH dependence
Green, David W, Aykent, Serdar, Gierse, James K, Zupec, Mark E
Published in Biochemistry (Easton) (01.03.1990)
Published in Biochemistry (Easton) (01.03.1990)
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Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase
PENNING, Thomas D, CHANDRAKUMAR, Nizal S, HARDING, Elizabeth I, HIGHKIN, Maureen K, KACHUR, James F, KIM, Suzanne H, VILLANI-PRICE, Doreen, PYLA, E. Yvonne, GHOREISHI-HAACK, Nayereh S, SMITH, Walter G, DESAI, Bipin N, DJURIC, Stevan W, GASIECKI, Alan F, MALECHA, James W, MIYASHIRO, Julie M, RUSSELL, Mark A, ASKONAS, Leslie J, GIERSE, James K
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
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Mutational Analysis of the Role of the Distal Histidine and Glutamine Residues of Prostaglandin-Endoperoxide Synthase-2 in Peroxidase Catalysis, Hydroperoxide Reduction, and Cyclooxygenase Activation
Landino, Lisa M., Crews, Brenda C., Gierse, James K., Hauser, Scott D., Marnett, Lawrence J.
Published in The Journal of biological chemistry (22.08.1997)
Published in The Journal of biological chemistry (22.08.1997)
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Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A4 hydrolase
PENNING, Thomas D, CHANDRAKUMAR, Nizal S, HARDING, Elizabeth I, HIGHKIN, Maureen K, KACHUR, James F, KIM, Suzanne H, VILLANI-PRICE, Doreen, PYLA, E. Yvonne, GHOREISHI-HAACK, Nayereh S, SMITH, Walter G, DESAI, Bipin N, DJURIC, Stevan W, GASIECKI, Alan F, LIANG, Chi-Dean, MIYASHIRO, Julie M, RUSSELL, Mark A, ASKONAS, Leslie J, GIERSE, James K
Published in Bioorganic & medicinal chemistry letters (01.12.2002)
Published in Bioorganic & medicinal chemistry letters (01.12.2002)
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A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors
WALKER, Mark C., KURUMBAIL, Ravi G., KIEFER, James R., MORELAND, Kirby T., KOBOLDT, Carol M., ISAKSON, Peter C., SEIBERT, Karen, GIERSE, James K.
Published in Biochemical journal (01.08.2001)
Published in Biochemical journal (01.08.2001)
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