pegIT - a web-based design tool for prime editing
Anderson, Mads Valdemar, Haldrup, Jakob, Thomsen, Emil Aagaard, Wolff, Jonas Holst, Mikkelsen, Jacob Giehm
Published in Nucleic acids research (02.07.2021)
Published in Nucleic acids research (02.07.2021)
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Journal Article
Lentiviral vectors for cutaneous RNA managing
Primo, Maria Nascimento, Bak, Rasmus O., Mikkelsen, Jacob Giehm
Published in Experimental dermatology (01.03.2012)
Published in Experimental dermatology (01.03.2012)
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Journal Article
Induction of Atherosclerosis in Mice and Hamsters Without Germline Genetic Engineering
Bjørklund, Martin Mæng, Hollensen, Anne Kruse, Hagensen, Mette Kallestrup, Dagnæs-Hansen, Frederik, Christoffersen, Christina, Mikkelsen, Jacob Giehm, Bentzon, Jacob Fog
Published in Circulation research (23.05.2014)
Published in Circulation research (23.05.2014)
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Journal Article
Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection
Thomsen, Martin K., Nandakumar, Ramya, Stadler, Daniela, Malo, Antje, Valls, Roser Marin, Wang, Fan, Reinert, Line S., Dagnæs‐Hansen, Frederik, Hollensen, Anne Kruse, Mikkelsen, Jacob Giehm, Protzer, Ulrike, Paludan, Søren R.
Published in Hepatology (Baltimore, Md.) (01.09.2016)
Published in Hepatology (Baltimore, Md.) (01.09.2016)
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Journal Article
Engineered lentivirus-derived nanoparticles (LVNPs) for delivery of CRISPR/Cas ribonucleoprotein complexes supporting base editing, prime editing and in vivo gene modification
Haldrup, Jakob, Andersen, Sofie, Labial, Alexander Rafael LaVilla, Wolff, Jonas Holst, Frandsen, Frederik Plum, Skov, Thomas Wisbech, Rovsing, Anne Bruun, Nielsen, Ian, Jakobsen, Thomas Stax, Askou, Anne Louise, Thomsen, Martin K, Corydon, Thomas J, Thomsen, Emil Aagaard, Mikkelsen, Jacob Giehm
Published in Nucleic acids research (13.10.2023)
Published in Nucleic acids research (13.10.2023)
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Journal Article
Targeted Knockout of the Vegfa Gene in the Retina by Subretinal Injection of RNP Complexes Containing Cas9 Protein and Modified sgRNAs
Holmgaard, Andreas Braae, Askou, Anne Louise, Jensen, Emilie Grarup, Alsing, Sidsel, Bak, Rasmus O., Mikkelsen, Jacob Giehm, Corydon, Thomas J.
Published in Molecular therapy (06.01.2021)
Published in Molecular therapy (06.01.2021)
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Journal Article
Dominant-negative SERPING1 variants cause intracellular retention of C1 inhibitor in hereditary angioedema
Haslund, Didde, Ryø, Laura Barrett, Seidelin Majidi, Sara, Rose, Iben, Skipper, Kristian Alsbjerg, Fryland, Tue, Bohn, Anja Bille, Koch, Claus, Thomsen, Martin K, Palarasah, Yaseelan, Corydon, Thomas J, Bygum, Anette, Nejsum, Lene N, Mikkelsen, Jacob Giehm
Published in The Journal of clinical investigation (01.01.2019)
Published in The Journal of clinical investigation (01.01.2019)
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Journal Article
Sustained transgene expression from sleeping beauty DNA transposons containing a core fragment of the HNRPA2B1-CBX3 ubiquitous chromatin opening element (UCOE)
Skipper, Kristian Alsbjerg, Hollensen, Anne Kruse, Antoniou, Michael N, Mikkelsen, Jacob Giehm
Published in BMC biotechnology (09.11.2019)
Published in BMC biotechnology (09.11.2019)
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Journal Article
Suppression of Choroidal Neovascularization by AAV-Based Dual-Acting Antiangiogenic Gene Therapy
Askou, Anne Louise, Alsing, Sidsel, Benckendorff, Josephine N.E., Holmgaard, Andreas, Mikkelsen, Jacob Giehm, Aagaard, Lars, Bek, Toke, Corydon, Thomas J.
Published in Molecular therapy. Nucleic acids (07.06.2019)
Published in Molecular therapy. Nucleic acids (07.06.2019)
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Journal Article
Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus
Rasmussen, Tue Kruse, Andersen, Thomas, Bak, Rasmus Otkjær, Yiu, Gloria, Sørensen, Christian Møller, Stengaard-Pedersen, Kristian, Mikkelsen, Jacob Giehm, Utz, Paul Joseph, Holm, Christian Kanstrup, Deleuran, Bent
Published in Arthritis research & therapy (09.06.2015)
Published in Arthritis research & therapy (09.06.2015)
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Journal Article
DNA transposon-based gene vehicles - scenes from an evolutionary drive
Skipper, Kristian Alsbjerg, Andersen, Peter Refsing, Sharma, Nynne, Mikkelsen, Jacob Giehm
Published in Journal of biomedical science (09.12.2013)
Published in Journal of biomedical science (09.12.2013)
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Journal Article
In Vivo Knockout of the Vegfa Gene by Lentiviral Delivery of CRISPR/Cas9 in Mouse Retinal Pigment Epithelium Cells
Holmgaard, Andreas, Askou, Anne Louise, Benckendorff, Josephine Natalia Esther, Thomsen, Emil Aagaard, Cai, Yujia, Bek, Toke, Mikkelsen, Jacob Giehm, Corydon, Thomas J.
Published in Molecular therapy. Nucleic acids (15.12.2017)
Published in Molecular therapy. Nucleic acids (15.12.2017)
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Journal Article
Identification of BLNK and BTK as mediators of rituximab‐induced programmed cell death by CRISPR screens in GCB‐subtype diffuse large B‐cell lymphoma
Thomsen, Emil Aagaard, Rovsing, Anne Bruun, Anderson, Mads Valdemar, Due, Hanne, Huang, Jinrong, Luo, Yonglun, Dybkær, Karen, Mikkelsen, Jacob Giehm
Published in Molecular oncology (01.09.2020)
Published in Molecular oncology (01.09.2020)
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Journal Article
CRISPR-Cas9-directed gene tagging using a single integrase-defective lentiviral vector carrying a transposase-based Cas9 off switch
Thomsen, Emil Aagaard, Skipper, Kristian Alsbjerg, Andersen, Sofie, Haslund, Didde, Skov, Thomas Wisbech, Mikkelsen, Jacob Giehm
Published in Molecular therapy. Nucleic acids (13.09.2022)
Published in Molecular therapy. Nucleic acids (13.09.2022)
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Journal Article
Potent microRNA suppression by RNA Pol II-transcribed 'Tough Decoy' inhibitors
Bak, Rasmus O, Hollensen, Anne Kruse, Primo, Maria Nascimento, Sørensen, Camilla Darum, Mikkelsen, Jacob Giehm
Published in RNA (Cambridge) (01.02.2013)
Published in RNA (Cambridge) (01.02.2013)
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Journal Article
Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles
Nielsen, Ian Helstrup, Rovsing, Anne Bruun, Janns, Jacob Hørlück, Thomsen, Emil Aagaard, Ruzo, Albert, Bøggild, Andreas, Nedergaard, Frederikke, Møller, Charlotte Thornild, Boesen, Thomas, Degn, Søren Egedal, Shah, Jagesh V., Mikkelsen, Jacob Giehm
Published in Molecular therapy. Nucleic acids (10.12.2024)
Published in Molecular therapy. Nucleic acids (10.12.2024)
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Journal Article