Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform
Desai, Bimbisar, Dixon, Karen, Farrant, Elizabeth, Feng, Qixing, Gibson, Karl R, van Hoorn, Willem P, Mills, James, Morgan, Trevor, Parry, David M, Ramjee, Manoj K, Selway, Christopher N, Tarver, Gary J, Whitlock, Gavin, Wright, Adrian G
Published in Journal of medicinal chemistry (11.04.2013)
Published in Journal of medicinal chemistry (11.04.2013)
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Journal Article
The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain
Skerratt, Sarah E, Andrews, Mark, Bagal, Sharan K, Bilsland, James, Brown, David, Bungay, Peter J, Cole, Susan, Gibson, Karl R, Jones, Russell, Morao, Inaki, Nedderman, Angus, Omoto, Kiyoyuki, Robinson, Colin, Ryckmans, Thomas, Skinner, Kimberly, Stupple, Paul, Waldron, Gareth
Published in Journal of medicinal chemistry (23.11.2016)
Published in Journal of medicinal chemistry (23.11.2016)
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Journal Article
Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865)
Owen, Robert M, Blakemore, David, Cao, Lishuang, Flanagan, Neil, Fish, Rebecca, Gibson, Karl R, Gurrell, Rachel, Huh, Chan Woo, Kammonen, Juha, Mortimer-Cassen, Elisabeth, Nickolls, Sarah A, Omoto, Kiyoyuki, Owen, Dafydd, Pike, Andy, Pryde, David C, Reynolds, David S, Roeloffs, Rosemarie, Rose, Colin, Stead, Clara, Takeuchi, Mifune, Warmus, Joseph S, Watson, Christine
Published in Journal of medicinal chemistry (27.06.2019)
Published in Journal of medicinal chemistry (27.06.2019)
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Journal Article
Drugging DNA Damage Repair Pathways for Trinucleotide Repeat Expansion Diseases
Benn, Caroline L., Gibson, Karl R., Reynolds, David S.
Published in Journal of Huntington's Disease (01.01.2021)
Published in Journal of Huntington's Disease (01.01.2021)
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Book Review
Journal Article
In vitro and in vivo SAR of pyrido[3,4- d]pyramid-4-ylamine based mGluR1 antagonists
Mantell, Simon J., Gibson, Karl R., Osborne, Simon A., Maw, Graham N., Rees, Huw, Dodd, Peter G., Greener, Ben, Harbottle, Gareth W., Million, William A., Poinsard, Cedric, England, Steven, Carnell, Pauline, Betts, Alison M., Monhemius, Russell, Prime, Rebecca L.
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
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Journal Article
Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells
Ward, Jennifer A, McLellan, Lauren, Stockley, Martin, Gibson, Karl R, Whitlock, Gavin A, Knights, Charlotte, Harrigan, Jeanine A, Jacq, Xavier, Tate, Edward W
Published in ACS chemical biology (16.12.2016)
Published in ACS chemical biology (16.12.2016)
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Journal Article
Design and Identification of a Novel, Functionally Subtype Selective GABA(A) Positive Allosteric Modulator (PF-06372865)
Owen, Robert M., Blakemore, David, Cao, Lishuan, Flanagan, Neil, Fish, Rebecca, Gibson, Karl R., Gurrell, Rachel, Huh, Chan Woo, Kammonen, Juha, Mortimer-Cassen, Elisabeth, Nickolls, Sarah A., Omoto, Kiyoyuki, Owen, Dafydd, Pike, Andy, Pryde, David C., Reynolds, David S., Roeloffs, Rosemarie, Rose, Colin, Stead, Clara, Takeuchi, Mifune, Warmus, Joseph S., Watson, Christine
Published in Journal of medicinal chemistry (27.06.2019)
Published in Journal of medicinal chemistry (27.06.2019)
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Journal Article
Novel Amino-pyrazole Ureas with Potent In Vitro and In Vivo Antileishmanial Activity
Mowbray, Charles E, Braillard, Stéphanie, Speed, William, Glossop, Paul A, Whitlock, Gavin A, Gibson, Karl R, Mills, James E. J, Brown, Alan D, Gardner, J. Mark F, Cao, Yafeng, Hua, Wen, Morgans, Garreth L, Feijens, Pim-Bart, Matheeussen, An, Maes, Louis J
Published in Journal of medicinal chemistry (24.12.2015)
Published in Journal of medicinal chemistry (24.12.2015)
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Journal Article
Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin‑2 Receptor: Structure–Activity Relationships and Optimization
Zirimwabagabo, Jean-Olivier, Jailani, Ameera B. A, Avgoustou, Paris, Tozer, Matthew J, Gibson, Karl R, Glossop, Paul A, Mills, James E. J, Porter, Roderick A, Blaney, Paul, Wang, Ning, Skerry, Timothy M, Richards, Gareth O, Harrity, Joseph P. A
Published in Journal of medicinal chemistry (25.03.2021)
Published in Journal of medicinal chemistry (25.03.2021)
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Journal Article
Cligosiban, A Novel Brain-Penetrant, Selective Oxytocin Receptor Antagonist, Inhibits Ejaculatory Physiology in Rodents
Wayman, Chris, Russell, Rachel, Tang, Kim, Weibly, Laura, Gaboardi, Samantha, Fisher, Lucy, Allers, Kelly, Jackson, Margaret, Hawcock, Tony, Robinson, Nicola, Wilson, Lesley, Gupta, Julie, Casey, James, Gibson, Karl R.
Published in Journal of sexual medicine (01.12.2018)
Published in Journal of sexual medicine (01.12.2018)
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Journal Article
Synthesis and Conformational Dynamics of Tricyclic Pyridones Containing a Fused Seven-Membered Ring
Gibson, Karl R, Hitzel, Laure, Mortishire-Smith, Russell J, Gerhard, Ute, Jelley, Richard A, Reeve, Austin J, Rowley, Michael, Nadin, Alan, Owens, Andrew P
Published in Journal of organic chemistry (27.12.2002)
Published in Journal of organic chemistry (27.12.2002)
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Journal Article
Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain
Bagal, Sharan K., Bungay, Peter J., Denton, Stephen M., Gibson, Karl R., Glossop, Melanie S., Hay, Tanya L., Kemp, Mark I., Lane, Charlotte A. L., Lewis, Mark L., Maw, Graham N., Million, William A., Payne, C. Elizabeth, Poinsard, Cedric, Rawson, David J., Stammen, Blanda L., Stevens, Edward B., Thompson, Lisa R.
Published in ACS medicinal chemistry letters (11.06.2015)
Published in ACS medicinal chemistry letters (11.06.2015)
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Journal Article
Discovery of a First-in-Class Potent Small Molecule Antagonist against the Adrenomedullin‑2 Receptor
Avgoustou, Paris, Jailani, Ameera B. A, Zirimwabagabo, Jean-Olivier, Tozer, Matthew J, Gibson, Karl R, Glossop, Paul A, Mills, James E. J, Porter, Roderick A, Blaney, Paul, Bungay, Peter J, Wang, Ning, Shaw, Alice P, Bigos, Kamilla J. A, Holmes, Joseph L, Warrington, Jessica I, Skerry, Timothy M, Harrity, Joseph P. A, Richards, Gareth O
Published in ACS pharmacology & translational science (14.08.2020)
Published in ACS pharmacology & translational science (14.08.2020)
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Journal Article
Total Synthesis of cis-Sylvaticin
Brown, Lynda J, Spurr, Ian B, Kemp, Stephen C, Camp, Nicholas P, Gibson, Karl R, Brown, Richard C. D
Published in Organic letters (19.06.2008)
Published in Organic letters (19.06.2008)
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Journal Article
Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1
Paterson, Ian, Chen, David Y.-K., Coster, Mark J., Aceña, Jose L., Bach, Jordi, Gibson, Karl R., Keown, Linda E., Oballa, Renata M., Trieselmann, Thomas, Wallace, Debra J., Hodgson, Andrew P., Norcross, Roger D.
Published in Angewandte Chemie International Edition (05.11.2001)
Published in Angewandte Chemie International Edition (05.11.2001)
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Journal Article
The translational efficacy of a nonsteroidal progesterone receptor antagonist, 4-[3-cyclopropyl-1-(mesylmethyl)-5-methyl-1H-pyrazol-4-yl]oxy,-2,6-dimethylbenzonitrile (PF-02413873), on endometrial growth in macaque and human
Howe, David C, Mount, Natalie M, Bess, Kirsty, Brown, Amy, Bungay, Peter, Gibson, Karl R, Hawcock, Tony, Richard, Jacques, Jones, Gareth, Walley, Rosalind, McLeod, Alison, Apfeldorfer, Coralie, Ramsey, Simeon, Tweedy, Sarah, Pullen, Nick
Published in The Journal of pharmacology and experimental therapeutics (01.11.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2011)
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Journal Article
Microwave-assisted synthesis of mGluR1 ligands: carbon, nitrogen and oxygen linked derivatives of pyrido[3,4- d]pyrimidin-4-ylamines
Harbottle, Gareth W., Feeder, Neil, Gibson, Karl R., Glossop, Mel, Maw, Graham N., Million, William A., Morel, Florence F., Osborne, Simon, Poinsard, Cedric
Published in Tetrahedron letters (11.06.2007)
Published in Tetrahedron letters (11.06.2007)
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Journal Article
3-Substituted gem-cyclohexane sulfone based γ-secretase inhibitors for Alzheimer’s disease: Conformational analysis and biological activity
Jelley, Richard A., Elliott, Jason, Gibson, Karl R., Harrison, Timothy, Beher, Dirk, Clarke, Earl E., Lewis, Huw D., Shearman, Mark, Wrigley, Jonathan D.J.
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
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Journal Article