Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial
Zakrzewska, Joanna M, Prof, Palmer, Joanne, PhD, Morisset, Valerie, PhD, Giblin, Gerard MP, PhD, Obermann, Mark, MD, Ettlin, Dominik A, MD, Cruccu, Giorgio, Prof, Bendtsen, Lars, MD, Estacion, Mark, PhD, Derjean, Dominique, PhD, Waxman, Stephen G, Prof, Layton, Gary, MSc, Gunn, Kevin, MD, Tate, Simon, PhD
Published in Lancet neurology (01.04.2017)
Published in Lancet neurology (01.04.2017)
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Journal Article
Novel design for a phase IIa placebo-controlled, double-blind randomized withdrawal study to evaluate the safety and efficacy of CNV1014802 in patients with trigeminal neuralgia
Zakrzewska, Joanna M, Palmer, Joanne, Ettlin, Dominik A, Obermann, Mark, Giblin, Gerard M P, Morisset, Valerie, Tate, Simon, Gunn, Kevin
Published in Trials (23.11.2013)
Published in Trials (23.11.2013)
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Journal Article
Piperidine-derived g-secretase modulators
Hall, Adrian, Elliott, Richard L, Giblin, Gerard MP, Hussain, Ishrut, Musgrave, James, Naylor, Alan, Sasse, Rosemary, Smith, Beverley
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Journal Article
Discovery of a novel series of nonacidic benzofuran EP sub(1 receptor antagonists)
Allan, Amanda C, Billinton, Andy, Brown, Susan H, Chowdhury, Anita, Eatherton, Andrew J, Fieldhouse, Charlotte, Giblin, Gerard MP, Goldsmith, Paul, Hall, Adrian, Hurst, David N, Naylor, Alan, Rawlings, DAnthony, Sime, Mairi, Scoccitti, Tiziana, Theobald, Pamela J
Published in Bioorganic & medicinal chemistry letters (15.07.2011)
Published in Bioorganic & medicinal chemistry letters (15.07.2011)
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Journal Article
Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPAR[gamma] partial agonist
Sime, Mairi, Allan, Amanda C, Chapman, Paul, Fieldhouse, Charlotte, Giblin, Gerard MP, Healy, Mark P, Lambert, Millard H, Leesnitzer, Lisa M, Lewis, Ann, Merrihew, Raymond V, Rutter, Richard A, Sasse, Rosemary, Shearer, Barry G, Wilson, Timothy M, Xu, Robert X, Virley, David J
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Journal Article
Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB sub(2) agonists for the treatment of inflammatory pain
Gleave, Robert J, Beswick, Paul J, Brown, Andrew J, Giblin, Gerard MP, Goldsmith, Paul, Haslam, Carl P, Mitchell, William L, Nicholson, Neville H, Page, Lee W, Patel, Sadhana, Roomans, Susan, Slingsby, Brian P, Swarbrick, Martin E
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Journal Article
Discovery of a novel indole series of EP sub(1) receptor antagonists by scaffold hopping
Hall, Adrian, Billinton, Andy, Brown, Susan H, Chowdhury, Anita, Giblin, Gerard MP, Goldsmith, Paul, Hurst, David N, Naylor, Alan, Patel, Sadhana, Scoccitti, Tiziana, Theobald, Pamela J
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
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Journal Article
Novel methylene-linked heterocyclic EP sub(1) receptor antagonists
Hall, Adrian, Bit, Rino A, Brown, Susan H, Chowdhury, Anita, Giblin, Gerard MP, Hurst, David N, Kilford, Ian R, Lewell, Xiao, Naylor, Alan, Scoccitti, Tiziana
Published in Bioorganic & medicinal chemistry (01.03.2008)
Published in Bioorganic & medicinal chemistry (01.03.2008)
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Journal Article
Discovery of brain penetrant, soluble, pyrazole amide EP sub(1) receptor antagonists
Hall, Adrian, Billinton, Andy, Bristow, Alan K, Brown, Susan H, Chowdhury, Anita, Cutler, Leanne, Giblin, Gerard MP, Goldsmith, Paul, Hayhow, Thomas G, Kilford, Ian R, Naylor, Alan, Passingham, Barry, Rawlings, DAnthony
Published in Bioorganic & medicinal chemistry (01.07.2008)
Published in Bioorganic & medicinal chemistry (01.07.2008)
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Journal Article
Non-acidic pyrazole EP sub(1) receptor antagonists with in vivo analgesic efficacy
Hall, Adrian, Billinton, Andy, Brown, Susan H, Clayton, Nicholas M, Chowdhury, Anita, Giblin, Gerard MP, Goldsmith, Paul, Hayhow, Thomas G, Hurst, David N, Kilford, Ian R, Naylor, Alan, Passingham, Barry, Winyard, Lisa
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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Journal Article
Pyridine-3-carboxamides as novel CB sub(2) agonists for analgesia
Mitchell, William L, Giblin, Gerard MP, Naylor, Alan, Eatherton, Andrew J, Slingsby, Brian P, Rawlings, Anthony D, Jandu, Karamjit S, Haslam, Carl P, Brown, Andrew J, Goldsmith, Paul, Clayton, Nick M, Wilson, Alex W, Chessell, Iain P, Green, Richard H, Whittington, Andrew R, Wall, Ian D
Published in Bioorganic & medicinal chemistry letters (01.01.2009)
Published in Bioorganic & medicinal chemistry letters (01.01.2009)
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Journal Article
Identification and optimization of novel 1,3,4-oxadiazole EP sub(1) receptor antagonists
Hall, Adrian, Brown, Susan H, Chowdhury, Anita, Giblin, Gerard MP, Gibson, Mairi, Healy, Mark P, Livermore, David G, Wilson, Richard JMcArthur, Naylor, Alan, Rawlings, DAnthony, Roman, Shilina, Ward, Emma, Willay, Caroline
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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Journal Article
Identification of novel pyrazole acid antagonists for the EP sub(1) receptor
McKeown, Stephen C, Hall, Adrian, Giblin, Gerard MP, Lorthioir, Olivier, Blunt, Richard, Lewell, Xiao Q, Wilson, Richard J, Brown, Susan H, Chowdhury, Anita, Coleman, Tanya, Watson, Stephen P, Chessell, Iain P, Pipe, Adrian, Clayton, Nick, Goldsmith, Paul
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
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Journal Article
Identification of novel glycine sulfonamide antagonists for the EP sub(1) receptor
McKeown, Stephen C, Hall, Adrian, Blunt, Richard, Brown, Susan H, Chessell, Iain P, Chowdhury, Anita, Giblin, Gerard MP, Healy, Mark P, Johnson, Matthew R, Lorthioir, Olivier, Michel, Anton D, Naylor, Alan, Lewell, Xiao, Roman, Shilina, Watson, Stephen P, Winchester, Wendy J, Wilson, Richard J
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
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Journal Article
1,5-Biaryl pyrrole derivatives as EP sub(1) receptor antagonists: Structure-activity relationships of 4- and 5-substituted benzoic acid derivatives
Hall, Adrian, Brown, Susan H, Chessell, Iain P, Chowdhury, Anita, Clayton, Nicholas M, Coleman, Tanya, Giblin, Gerard MP, Hammond, Beverley, Healy, Mark P, Johnson, Matthew R, Metcalf, Ann, Michel, Anton D, Naylor, Alan, Novelli, Riccardo, Spalding, David J, Sweeting, Jennifer
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
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Journal Article
1,5-Biaryl pyrrole derivatives as EP sub(1) receptor antagonists. Structure- activity relationships of 6-substituted and 5,6-disubstituted benzoic acid derivatives
Hall, Adrian, Brown, Susan H, Chessell, Iain P, Chowdhury, Anita, Clayton, Nicholas M, Coleman, Tanya, Giblin, Gerard MP, Hammond, Beverley, Healy, Mark P, Johnson, Matthew R, Metcalf, Ann, Michel, Anton D, Naylor, Alan, Novelli, Riccardo, Spalding, David J, Sweeting, Jennifer, Winyard, Lisa
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
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Journal Article
Structure-activity relationships of 1,5-biaryl pyrroles as EP sub(1) receptor antagonists
Hall, Adrian, Atkinson, Stephen, Brown, Susan H, Chessell, Iain P, Chowdhury, Anita, Clayton, Nicholas M, Coleman, Tanya, Giblin, Gerard MP, Gleave, Robert J, Hammond, Beverley, Healy, Mark P, Johnson, Matthew R, Michel, Anton D, Naylor, Alan, Novelli, Riccardo, Spalding, David J, Tang, Sac P
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
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Journal Article
Discovery of novel biaryl heterocyclic EP sub(1) receptor antagonists
Hall, Adrian, Bit, Rino A, Brown, Susan H, Chaignot, Helene M, Chessell, Iain P, Coleman, Tanya, Giblin, Gerard MP, Hurst, David N, Kilford, Ian R, Lewell, Xiao Q, Michel, Anton D, Mohamed, Shiyam, Naylor, Alan, Novelli, Riccardo, Skinner, Lee, Spalding, David J, Tang, Sac P, Wilson, Richard J
Published in Bioorganic & medicinal chemistry letters (01.01.2006)
Published in Bioorganic & medicinal chemistry letters (01.01.2006)
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Journal Article
NOVEL COMPOUNDS
Giblin, Gerard MP, Stanway, Steven J, MacPherson, David T, Witty, David R
Year of Publication 02.10.2020
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Year of Publication 02.10.2020
Patent
7-METHYL-2-[4-METHYL-6-[4-(TRIFLUOROMETHYL)-PHENYL]PYRIMIDIN-2-YL]-1,7-DIAZASPIRO[4.4]NONAN-6-ONE
Giblin, Gerard MP, Stanway, Steven J, MacPherson, David T, Witty, David R
Year of Publication 27.01.2017
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Year of Publication 27.01.2017
Patent