Acute Effects of Atypical Antipsychotics on Whole-Body Insulin Resistance in Rats: Implications for Adverse Metabolic Effects
HOUSEKNECHT, Karen L, ROBERTSON, Alan S, ZAVADOSKI, William, GIBBS, E. Michael, JOHNSON, David E, ROLLEMA, Hans
Published in Neuropsychopharmacology (New York, N.Y.) (01.02.2007)
Published in Neuropsychopharmacology (New York, N.Y.) (01.02.2007)
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The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents
DeNinno, Michael P., Andrews, Melissa, Bell, Andrew S., Chen, Yue, Eller-Zarbo, Cynthia, Eshelby, Nan, Etienne, John B., Moore, Dianna E., Palmer, Michael J., Visser, Michael S., Yu, Li J., Zavadoski, William J., Michael Gibbs, E.
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
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Identification of a novel glucose transporter-like protein---GLUT-12
Rogers, Suzanne, Macheda, Maria L, Docherty, Susan E, Carty, Maynard D, Henderson, Michael A, Soeller, Walter C, Gibbs, E. Michael, James, David E, Best, James D
Published in American journal of physiology: endocrinology and metabolism (01.03.2002)
Published in American journal of physiology: endocrinology and metabolism (01.03.2002)
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Defining the key pharmacophore elements of PF-04620110: Discovery of a potent, orally-active, neutral DGAT-1 inhibitor
Dow, Robert L., Andrews, Melissa P., Li, Jian-Cheng, Michael Gibbs, E., Guzman-Perez, Angel, LaPerle, Jennifer L., Li, Qifang, Mather, Dawn, Munchhof, Michael J., Niosi, Mark, Patel, Leena, Perreault, Christian, Tapley, Susan, Zavadoski, William J.
Published in Bioorganic & medicinal chemistry (01.09.2013)
Published in Bioorganic & medicinal chemistry (01.09.2013)
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Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3- d]pyrimidine core
Dow, Robert L., Andrews, Melissa, Aspnes, Gary E., Balan, Gayatri, Michael Gibbs, E., Guzman-Perez, Angel, Karki, Kapil, LaPerle, Jennifer L., Li, Jian-Cheng, Litchfield, John, Munchhof, Michael J., Perreault, Christian, Patel, Leena
Published in Bioorganic & medicinal chemistry letters (15.10.2011)
Published in Bioorganic & medicinal chemistry letters (15.10.2011)
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Modeling the mechanism of action of a DGAT1 inhibitor using a causal reasoning platform
Enayetallah, Ahmed E, Ziemek, Daniel, Leininger, Michael T, Randhawa, Ranjit, Yang, Jianxin, Manion, Tara B, Mather, Dawn E, Zavadoski, William J, Kuhn, Max, Treadway, Judith L, des Etages, Shelly Ann G, Gibbs, E Michael, Greene, Nigel, Steppan, Claire M
Published in PloS one (04.11.2011)
Published in PloS one (04.11.2011)
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Physiochemical drug properties associated with in vivo toxicological outcomes
Hughes, Jason D., Blagg, Julian, Price, David A., Bailey, Simon, DeCrescenzo, Gary A., Devraj, Rajesh V., Ellsworth, Edmund, Fobian, Yvette M., Gibbs, Michael E., Gilles, Richard W., Greene, Nigel, Huang, Enoch, Krieger-Burke, Teresa, Loesel, Jens, Wager, Travis, Whiteley, Larry, Zhang, Yao
Published in Bioorganic & medicinal chemistry (01.09.2008)
Published in Bioorganic & medicinal chemistry (01.09.2008)
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Establishment of Correlation between in Vitro Enzyme Binding Potency and in Vivo Pharmacological Activity: Application to Liver Glycogen Phosphorylase a Inhibitors
Yu, Li J, Chen, Yue, Treadway, Judith L, McPherson, R Kirk, McCoid, Scott C, Gibbs, E Michael, Hoover, Dennis J
Published in The Journal of pharmacology and experimental therapeutics (01.06.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2006)
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Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans
Maciejewski, Benjamin S, LaPerle, Jennifer L, Chen, Danny, Ghosh, Avijit, Zavadoski, William J, McDonald, Thomas S, Manion, Tara B, Mather, Dawn, Patterson, Terrell A, Hanna, Maya, Watkins, Steven, Gibbs, E Michael, Calle, Roberto A, Steppan, Claire M
Published in American journal of physiology: Gastrointestinal and liver physiology (01.06.2013)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.06.2013)
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Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase
Harwood, H. James, Petras, Stephen F., Hoover, Dennis J., Mankowski, Dayna C., Soliman, Victor F., Sugarman, Eliot D., Hulin, Bernard, Kwon, Younggil, Gibbs, E. Michael, Mayne, James T., Treadway, Judith L.
Published in Journal of lipid research (01.03.2005)
Published in Journal of lipid research (01.03.2005)
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The PPAR-γ Agonist, Darglitazone, Restores Acute Inflammatory Responses to Cerebral Hypoxia–Ischemia in the Diabetic ob/ob Mouse
Kumari, Rashmi, Willing, Lisa B, Patel, Shyama D, Krady, J Kyle, Zavadoski, William J, Gibbs, E Michael, Vannucci, Susan J, Simpson, Ian A
Published in Journal of cerebral blood flow and metabolism (01.02.2010)
Published in Journal of cerebral blood flow and metabolism (01.02.2010)
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Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1
Dow, Robert L, Li, Jian-Cheng, Pence, Michael P, Gibbs, E. Michael, LaPerle, Jennifer L, Litchfield, John, Piotrowski, David W, Munchhof, Michael J, Manion, Tara B, Zavadoski, William J, Walker, Gregory S, McPherson, R. Kirk, Tapley, Susan, Sugarman, Eliot, Guzman-Perez, Angel, DaSilva-Jardine, Paul
Published in ACS medicinal chemistry letters (12.05.2011)
Published in ACS medicinal chemistry letters (12.05.2011)
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Inhibitory effects of antipsychotics on carbachol-enhanced insulin secretion from perifused rat islets : Role of muscarinic antagonism in antipsychotic-induced diabetes and hyperglycemia
JOHNSON, David E, YAMAZAKI, Hanae, WARD, Karen M, SCHMIDT, Anne W, LEBEL, Wesley S, TREADWAY, Judith L, GIBBS, E. Michael, ZAWALICH, Walter S, ROLLEMA, Hans
Published in Diabetes (New York, N.Y.) (01.05.2005)
Published in Diabetes (New York, N.Y.) (01.05.2005)
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5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization
Wright, Stephen W., Rath, Virginia L., Genereux, Paul E., Hageman, David L., Levy, Carolyn B., McClure, Lester D., McCoid, Scott C., McPherson, R. Kirk, Schelhorn, Teresa M., Wilder, Donald E., Zavadoski, William J., Gibbs, E. Michael, Treadway, Judith L.
Published in Applied catalysis. B, Environmental (17.01.2005)
Published in Applied catalysis. B, Environmental (17.01.2005)
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GLUT4 Overexpression in db/db Mice Dose-Dependently Ameliorates Diabetes But Is Not a Lifelong Cure
BROZINICK, Joseph T, MCCOID, Scott C, REYNOLDS, Thomas H, NARDONE, Nancy A, HARGROVE, Diane M, STEVENSON, Ralph W, CUSHMAN, Samuel W, GIBBS, E. Michael
Published in Diabetes (New York, N.Y.) (01.03.2001)
Published in Diabetes (New York, N.Y.) (01.03.2001)
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Endogenous effectors of human liver glycogen phosphorylase modulate effects of indole-site inhibitors
Ercan-Fang, Nacide, Taylor, Miriam R, Treadway, Judith L, Levy, Carolyn B, Genereux, Paul E, Gibbs, E. Michael, Rath, Virginia L, Kwon, Younggil, Gannon, Mary C, Nuttall, Frank Q
Published in American journal of physiology: endocrinology and metabolism (01.09.2005)
Published in American journal of physiology: endocrinology and metabolism (01.09.2005)
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