The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription
Schwab, Rebekka A., Nieminuszczy, Jadwiga, Shah, Fenil, Langton, Jamie, Lopez Martinez, David, Liang, Chih-Chao, Cohn, Martin A., Gibbons, Richard J., Deans, Andrew J., Niedzwiedz, Wojciech
Published in Molecular cell (05.11.2015)
Published in Molecular cell (05.11.2015)
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ATRX plays a key role in maintaining silencing at interstitial heterochromatic loci and imprinted genes
Voon, Hsiao P.J, Hughes, Jim R., Rode, Christina, De La Rosa-Velázquez, Inti A., Jenuwein, Thomas, Feil, Robert, Higgs, Douglas R., Gibbons, Richard J.
Published in Cell reports (Cambridge) (21.04.2015)
Published in Cell reports (Cambridge) (21.04.2015)
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Induction of the alternative lengthening of telomeres pathway by trapping of proteins on DNA
Rose, Anna M, Goncalves, Tomas, Cunniffe, Siobhan, Geiller, Helene E B, Kent, Thomas, Shepherd, Sam, Ratnaweera, Malitha, O’Sullivan, Roderick J, Gibbons, Richard J, Clynes, David
Published in Nucleic acids research (21.07.2023)
Published in Nucleic acids research (21.07.2023)
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Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia
Mettananda, Sachith, Fisher, Chris A, Hay, Deborah, Badat, Mohsin, Quek, Lynn, Clark, Kevin, Hublitz, Philip, Downes, Damien, Kerry, Jon, Gosden, Matthew, Telenius, Jelena, Sloane-Stanley, Jackie A, Faustino, Paula, Coelho, Andreia, Doondeea, Jessica, Usukhbayar, Batchimeg, Sopp, Paul, Sharpe, Jacqueline A, Hughes, Jim R, Vyas, Paresh, Gibbons, Richard J, Higgs, Douglas R
Published in Nature communications (04.09.2017)
Published in Nature communications (04.09.2017)
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A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker
Bozhilov, Yavor K, Downes, Damien J, Telenius, Jelena, Marieke Oudelaar, A, Olivier, Emmanuel N, Mountford, Joanne C, Hughes, Jim R, Gibbons, Richard J, Higgs, Douglas R
Published in Nature communications (21.06.2021)
Published in Nature communications (21.06.2021)
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Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin
Higgs, Douglas R, Neuhaus, David, Eustermann, Sebastian, Yang, Ji-Chun, Law, Martin J, Amos, Rachel, Chapman, Lynda M, Jelinska, Clare, Garrick, David, Clynes, David, Gibbons, Richard J, Rhodes, Daniela
Published in Nature structural & molecular biology (01.07.2011)
Published in Nature structural & molecular biology (01.07.2011)
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The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin
Truch, Julia, Downes, Damien J, Scott, Caroline, Gür, E Ravza, Telenius, Jelena M, Repapi, Emmanouela, Schwessinger, Ron, Gosden, Matthew, Brown, Jill M, Taylor, Stephen, Cheong, Pak Leng, Hughes, Jim R, Higgs, Douglas R, Gibbons, Richard J
Published in Nature communications (17.06.2022)
Published in Nature communications (17.06.2022)
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Journal Article
ATRX dysfunction induces replication defects in primary mouse cells
Clynes, David, Jelinska, Clare, Xella, Barbara, Ayyub, Helena, Taylor, Stephen, Mitson, Matthew, Bachrati, Csanád Z, Higgs, Douglas R, Gibbons, Richard J
Published in PloS one (20.03.2014)
Published in PloS one (20.03.2014)
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An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment
Lynch, Magnus D, Smith, Andrew J H, De Gobbi, Marco, Flenley, Maria, Hughes, Jim R, Vernimmen, Douglas, Ayyub, Helena, Sharpe, Jacqueline A, Sloane-Stanley, Jacqueline A, Sutherland, Linda, Meek, Stephen, Burdon, Tom, Gibbons, Richard J, Garrick, David, Higgs, Douglas R
Published in The EMBO journal (18.01.2012)
Published in The EMBO journal (18.01.2012)
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ATRX Contributes to MeCP2-Mediated Pericentric Heterochromatin Organization during Neural Differentiation
Marano, Domenico, Fioriniello, Salvatore, Fiorillo, Francesca, Gibbons, Richard J, D'Esposito, Maurizio, Della Ragione, Floriana
Published in International journal of molecular sciences (29.10.2019)
Published in International journal of molecular sciences (29.10.2019)
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Mutant IDH1 Promotes Glioma Formation In Vivo
Philip, Beatrice, Yu, Diana X., Silvis, Mark R., Shin, Clifford H., Robinson, James P., Robinson, Gemma L., Welker, Adam E., Angel, Stephanie N., Tripp, Sheryl R., Sonnen, Joshua A., VanBrocklin, Matthew W., Gibbons, Richard J., Looper, Ryan E., Colman, Howard, Holmen, Sheri L.
Published in Cell reports (Cambridge) (01.05.2018)
Published in Cell reports (Cambridge) (01.05.2018)
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Intragenic Enhancers Act as Alternative Promoters
Kowalczyk, Monika S., Hughes, Jim R., Garrick, David, Lynch, Magnus D., Sharpe, Jacqueline A., Sloane-Stanley, Jacqueline A., McGowan, Simon J., De Gobbi, Marco, Hosseini, Mona, Vernimmen, Douglas, Brown, Jill M., Gray, Nicola E., Collavin, Licio, Gibbons, Richard J., Flint, Jonathan, Taylor, Stephen, Buckle, Veronica J., Milne, Thomas A., Wood, William G., Higgs, Douglas R.
Published in Molecular cell (24.02.2012)
Published in Molecular cell (24.02.2012)
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Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia
Mettananda, Sachith, Fisher, Christopher A, Sloane-Stanley, Jackie A, Taylor, Stephen, Oppermann, Udo, Gibbons, Richard J, Higgs, Douglas R
Published in Haematologica (Roma) (01.03.2017)
Published in Haematologica (Roma) (01.03.2017)
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Mutations in Krüppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression
Viprakasit, Vip, Ekwattanakit, Supachai, Riolueang, Suchada, Chalaow, Nipon, Fisher, Chris, Lower, Karen, Kanno, Hitoshi, Tachavanich, Kalaya, Bejrachandra, Sasithorn, Saipin, Jariya, Juntharaniyom, Monthana, Sanpakit, Kleebsabai, Tanphaichitr, Voravarn S., Songdej, Duantida, Babbs, Christian, Gibbons, Richard J., Philipsen, Sjaak, Higgs, Douglas R.
Published in Blood (06.03.2014)
Published in Blood (06.03.2014)
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JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response
Chen, Edwin, Ahn, Jong Sook, Massie, Charlie E., Clynes, David, Godfrey, Anna L., Li, Juan, Park, Hyun Jung, Nangalia, Jyoti, Silber, Yvonne, Mullally, Ann, Gibbons, Richard J., Green, Anthony R.
Published in Proceedings of the National Academy of Sciences - PNAS (21.10.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (21.10.2014)
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A Comparison of Structural Variant Calling from Short-Read and Nanopore-Based Whole-Genome Sequencing Using Optical Genome Mapping as a Benchmark
Pei, Yang, Tanguy, Melanie, Giess, Adam, Dixit, Abhijit, Wilson, Louise C, Gibbons, Richard J, Twigg, Stephen R F, Elgar, Greg, Wilkie, Andrew O M
Published in Genes (01.07.2024)
Published in Genes (01.07.2024)
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Mutations in the chromatin-associated protein ATRX
Gibbons, Richard J, Wada, Takahito, Fisher, Christopher A, Malik, Nicola, Mitson, Matthew J, Steensma, David P, Fryer, Alan, Goudie, David R, Krantz, Ian D, Traeger-Synodinos, Joanne
Published in Human mutation (01.06.2008)
Published in Human mutation (01.06.2008)
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Regulatory SNP Causes a Human Genetic Disease by Creating a New Transcriptional Promoter
De Gobbi, Marco, Viprakasit, Vip, Hughes, Jim R, Fisher, Chris, Buckle, Veronica J, Ayyub, Helena, Gibbons, Richard J, Vernimmen, Douglas, Yoshinaga, Yuko, de Jong, Pieter, Cheng, Jan-Fang, Rubin, Edward M, Wood, William G, Bowden, Don, Higgs, Douglas R
Published in Science (American Association for the Advancement of Science) (26.05.2006)
Published in Science (American Association for the Advancement of Science) (26.05.2006)
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Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX
Argentaro, Anthony, Yang, Ji-Chun, Chapman, Lynda, Kowalczyk, Monika S, Gibbons, Richard J, Higgs, Douglas R, Neuhaus, David, Rhodes, Daniela
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2007)
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Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition
Lower, Karen M, Hughes, Jim R, De Gobbi, Marco, Henderson, Shirley, Viprakasit, Vip, Fisher, Chris, Goriely, Anne, Ayyub, Helena, Sloane-Stanley, Jackie, Vernimmen, Douglas, Langford, Cordelia, Garrick, David, Gibbons, Richard J, Higgs, Douglas R
Published in Proceedings of the National Academy of Sciences - PNAS (22.12.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (22.12.2009)
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