Dual PI3Kδγ inhibition demonstrates potent anticancer effects in diffuse large B-cell lymphoma models: Discovery and preclinical characterization of LL-00084282
Verma, Mahip K., Samant, Charudatt, Kale, Ramesh, Patra, Sukanya, Mahajan, Nilesh, Gholve, Milind K., Marisetti, Ajitkumar, Sunkara, Brahmam, Naik, Aditya, Shingare, Manisha, Reddy, Madhusudhan, Bokare, Anand M., Akarte, Atul, Koul, Sarita, Nigade, Prashant B., Patil, Vinod B., Modi, Dipak, Ahirrao, Prajakta, Pawar, Shashikant, Kuldharan, Sandip, Dinchhana, Lal, Mehta, Maneesh, Gundu, Jayasagar, Jana, Nirmal, Vidhate, Prashant, Mahangare, Sachin Jaysing, Shukla, Manojkumar R., Goel, Rajan N., Bhonde, Mandar, Kamboj, Rajender Kumar, Palle, Venkata P.
Published in Biochemical and biophysical research communications (31.12.2022)
Published in Biochemical and biophysical research communications (31.12.2022)
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Discovery and pre-clinical characterization of a selective PI3Kδ inhibitor, LL-00071210 in rheumatoid arthritis
Kanoje, Vijay, Pandey, Dilip, Wagh, Akshaya, Patra, Sukanya, Kumar Marisetti, Ajit, Reddy, Madhusudhan, Samant, Charudatt, Mahajan, Nilesh, Gholve, Milind, Sabde, Sudeep, Trivedi, Sneha, Bhankhede, Trupti, Patil, Vinod, Nigade, Prashant, Modi, Dipak, Mehta, Maneesh, Ahirrao, Prajakta, Tota, Swathi, Nanda, Bidyut, Pawar, Shashikant, Polawar, Anuradha, Tamane, Kaustubh, Kuldharan, Sandip, Vishwase, Gururaj, Jana, Nirmal, Mahangare, Sachin J., Vidhate, Prashant, Lagad, Dipak, Gundu, Jayasagar, Phukan, Samiron, Shukla, Manojkumar, Narasimham, Lakshmi, Nemmani, Kumar V.S., Bhonde, Mandar, Sharma, Sharad, Kamboj, Rajender K., Palle, Venkata P.
Published in European journal of pharmacology (15.07.2022)
Published in European journal of pharmacology (15.07.2022)
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Discovery of a Potent and Selective PI3Kδ Inhibitor ( S )-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4 H -quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models
Shukla, Manojkumar R, Patra, Sukanya, Verma, Mahip, Sadasivam, Gayathri, Jana, Nirmal, Mahangare, Sachin J, Vidhate, Prashant, Lagad, Dipak, Tarage, Anand, Cheemala, Murthy, Kulkarni, Chaitanya, Bhagwat, Shankar, Chaudhari, Vinod D, Sayyed, Majid, Pachpute, Vipul, Phadtare, Ramesh, Gole, Gopal, Phukan, Samiron, Sunkara, Brahmam, Samant, Charudatt, Shingare, Manisha, Naik, Aditya, Trivedi, Sneha, Marisetti, Ajit Kumar, Reddy, Madhusudhan, Gholve, Milind, Mahajan, Nilesh, Sabde, Sudeep, Patil, Vinod, Modi, Dipak, Mehta, Maneesh, Nigade, Prashant, Tamane, Kaustubh, Tota, Swati, Goyal, Hemant, Volam, Harish, Pawar, Shashikant, Ahirrao, Prajakta, Dinchhana, Lal, Mallurwar, Sadanand, Akarte, Atul, Bokare, Anand, Kanhere, Rupesh, Reddy, Neetinkumar, Koul, Sarita, Dandekar, Manoj, Singh, Minakshi, Bernstein, Peter R, Narasimham, Lakshmi, Bhonde, Mandar, Gundu, Jayasagar, Goel, Rajan, Kulkarni, Sanjeev, Sharma, Sharad, Kamboj, Rajender Kumar, Palle, Venkata P
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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Journal Article
Discovery of a Potent and Selective PI3Kδ Inhibitor (S)‑2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl‑4H‑quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models
Shukla, Manojkumar R, Patra, Sukanya, Verma, Mahip, Sadasivam, Gayathri, Jana, Nirmal, Mahangare, Sachin J, Vidhate, Prashant, Lagad, Dipak, Tarage, Anand, Cheemala, Murthy, Kulkarni, Chaitanya, Bhagwat, Shankar, Chaudhari, Vinod D, Sayyed, Majid, Pachpute, Vipul, Phadtare, Ramesh, Gole, Gopal, Phukan, Samiron, Sunkara, Brahmam, Samant, Charudatt, Shingare, Manisha, Naik, Aditya, Trivedi, Sneha, Marisetti, Ajit Kumar, Reddy, Madhusudhan, Gholve, Milind, Mahajan, Nilesh, Sabde, Sudeep, Patil, Vinod, Modi, Dipak, Mehta, Maneesh, Nigade, Prashant, Tamane, Kaustubh, Tota, Swati, Goyal, Hemant, Volam, Harish, Pawar, Shashikant, Ahirrao, Prajakta, Dinchhana, Lal, Mallurwar, Sadanand, Akarte, Atul, Bokare, Anand, Kanhere, Rupesh, Reddy, Neetinkumar, Koul, Sarita, Dandekar, Manoj, Singh, Minakshi, Bernstein, Peter R, Narasimham, Lakshmi, Bhonde, Mandar, Gundu, Jayasagar, Goel, Rajan, Kulkarni, Sanjeev, Sharma, Sharad, Kamboj, Rajender Kumar, Palle, Venkata P
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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Journal Article
Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro‑N‑(2′-methyl-3′-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1′-biphenyl]-4-yl)benzamide. Structure–Activity Relationship and Preclinical Characterization
Khedkar, Nilesh Raghunath, Irlapatti, Nageswara Rao, Dadke, Disha, Kanoje, Vijay, Shaikh, Zubair, Karche, Vijay, Shinde, Vikas, Deshmukh, Gokul, Patil, Amit, Jachak, Santosh, Phukan, Samiron, Kizhakinagath, Praveenkumar Anidil, Gholve, Milind, Bhankhede, Trupti, Daler, Jagadeesh, Nemade, Harshal Narendra, Budhe, Sagar, Pareek, Himani, Yeshodharan, Rajesh, Gupta, Rajesh, Kalia, Anil, Pandey, Dilip, Wagh, Akshaya, Kumar, Swaroop, Patil, Vinod, Modi, Dipak, Sharma, Nidhi, Ahirrao, Prajakta, Mehta, Maneesh, Kumar, Hemant, Nigade, Prashant, Tamane, Kaustubh, Mallurwar, Sadanand, Kuldharan, Sandip, Pawar, Shashikant, Vishwase, Gururaj, Bokan, Sanjay, Singh, Minakshi, Naik, Kumar, Ingawale, Sachin, Shankar, Rajesh, Kamalakannan, Prabakaran, Venugopal, Spinvin, George, Shaji K, Padiya, Kamlesh J, Nemmani, Kumar V. S, Gundu, Jaysagar, Bhonde, Mandar, Narasimham, Lakshmi, Sindkhedkar, Milind, Shah, Chirag, Sinha, Neelima, Sharma, Sharad, Bakhle, Dhananjay, Kamboj, Rajender Kumar, Palle, Venkata P
Published in Journal of medicinal chemistry (09.12.2021)
Published in Journal of medicinal chemistry (09.12.2021)
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