High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites
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Published in Scientific reports (07.05.2019)
Published in Scientific reports (07.05.2019)
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Transgenic Mouse Proteomics Identifies New 14-3-3-associated Proteins Involved in Cytoskeletal Rearrangements and Cell Signaling
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Published in Molecular & cellular proteomics (01.12.2006)
Published in Molecular & cellular proteomics (01.12.2006)
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Identification of KasA as the cellular target of an anti-tubercular scaffold
Abrahams, Katherine A., Chung, Chun-wa, Ghidelli-Disse, Sonja, Rullas, Joaquín, Rebollo-López, María José, Gurcha, Sudagar S., Cox, Jonathan A. G., Mendoza, Alfonso, Jiménez-Navarro, Elena, Martínez-Martínez, María Santos, Neu, Margarete, Shillings, Anthony, Homes, Paul, Argyrou, Argyrides, Casanueva, Ruth, Loman, Nicholas J., Moynihan, Patrick J., Lelièvre, Joël, Selenski, Carolyn, Axtman, Matthew, Kremer, Laurent, Bantscheff, Marcus, Angulo-Barturen, Iñigo, Izquierdo, Mónica Cacho, Cammack, Nicholas C., Drewes, Gerard, Ballell, Lluis, Barros, David, Besra, Gurdyal S., Bates, Robert H.
Published in Nature communications (01.09.2016)
Published in Nature communications (01.09.2016)
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Patient-derived gene and protein expression signatures of NGLY1 deficiency
Rauscher, Benedikt, Mueller, William F, Clauder-Münster, Sandra, Jakob, Petra, Islam, M Saiful, Sun, Han, Ghidelli-Disse, Sonja, Boesche, Markus, Bantscheff, Marcus, Pflaumer, Hannah, Collier, Paul, Haase, Bettina, Chen, Songjie, Hoffman, Rene, Wang, Guangwen, Benes, Vladimir, Drewes, Gerard, Snyder, Michael, Steinmetz, Lars M
Published in Journal of biochemistry (Tokyo) (21.02.2022)
Published in Journal of biochemistry (Tokyo) (21.02.2022)
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Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds
Crowther, Gregory J, Hillesland, Heidi K, Keyloun, Katelyn R, Reid, Molly C, Lafuente-Monasterio, Maria Jose, Ghidelli-Disse, Sonja, Leonard, Stephen E, He, Panqing, Jones, Jackson C, Krahn, Mallory M, Mo, Jack S, Dasari, Kartheek S, Fox, Anna M W, Boesche, Markus, El Bakkouri, Majida, Rivas, Kasey L, Leroy, Didier, Hui, Raymond, Drewes, Gerard, Maly, Dustin J, Van Voorhis, Wesley C, Ojo, Kayode K
Published in PloS one (02.03.2016)
Published in PloS one (02.03.2016)
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Loss of N-Glycanase 1 Alters Transcriptional and Translational Regulation in K562 Cell Lines
Mueller, William F, Jakob, Petra, Sun, Han, Clauder-Münster, Sandra, Ghidelli-Disse, Sonja, Ordonez, Diana, Boesche, Markus, Bantscheff, Marcus, Collier, Paul, Haase, Bettina, Benes, Vladimir, Paulsen, Malte, Sehr, Peter, Lewis, Joe, Drewes, Gerard, Steinmetz, Lars M
Published in G3 : genes - genomes - genetics (01.05.2020)
Published in G3 : genes - genomes - genetics (01.05.2020)
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The multi-target aspect of an MmpL3 inhibitor: The BM212 series of compounds bind EthR2, a transcriptional regulator of ethionamide activation
Moorey, Alice R., Cabanillas, Alejandro, Batt, Sarah M., Ghidelli-Disse, Sonja, Urones, Beatriz, Sanz, Olalla, Lelievre, Joel, Bantscheff, Marcus, Cox, Liam R., Besra, Gurdyal S.
Published in Cell surface (Amsterdam) (01.12.2021)
Published in Cell surface (Amsterdam) (01.12.2021)
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Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome
Webster, Lauren A., Thomas, Michael, Urbaniak, Michael, Wyllie, Susan, Ong, Han, Tinti, Michele, Fairlamb, Alan H., Boesche, Markus, Ghidelli-Disse, Sonja, Drewes, Gerard, Gilbert, Ian H.
Published in ACS infectious diseases (12.10.2018)
Published in ACS infectious diseases (12.10.2018)
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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
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Published in Nature (01.10.2009)
Published in Nature (01.10.2009)
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A physical and functional map of the human TNF-α/NF-κB signal transduction pathway
Bouwmeester, Tewis, Superti-Furga, Giulio, Bauch, Angela, Ruffner, Heinz, Angrand, Pierre-Olivier, Bergamini, Giovanna, Croughton, Karen, Cruciat, Cristina, Eberhard, Dirk, Gagneur, Julien, Ghidelli, Sonja, Hopf, Carsten, Huhse, Bettina, Mangano, Raffaella, Michon, Anne-Marie, Schirle, Markus, Schlegl, Judith, Schwab, Markus, Stein, Martin A, Bauer, Andreas, Casari, Georg, Drewes, Gerard, Gavin, Anne-Claude, Jackson, David B, Joberty, Gerard, Neubauer, Gitte, Rick, Jens, Kuster, Bernhard
Published in Nature cell biology (01.02.2004)
Published in Nature cell biology (01.02.2004)
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Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum
Hoeijmakers, Wieteke Anna Maria, Miao, Jun, Schmidt, Sabine, Toenhake, Christa Geeke, Shrestha, Sony, Venhuizen, Jeron, Henderson, Rob, Birnbaum, Jakob, Ghidelli-Disse, Sonja, Drewes, Gerard, Cui, Liwang, Stunnenberg, Hendrik Gerard, Spielmann, Tobias, Bártfai, Richárd
Published in Nucleic acids research (16.12.2019)
Published in Nucleic acids research (16.12.2019)
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Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
Paquet, Tanya, Le Manach, Claire, Cabrera, Diego González, Younis, Yassir, Henrich, Philipp P, Abraham, Tara S, Lee, Marcus C S, Basak, Rajshekhar, Ghidelli-Disse, Sonja, Lafuente-Monasterio, María José, Bantscheff, Marcus, Ruecker, Andrea, Blagborough, Andrew M, Zakutansky, Sara E, Zeeman, Anne-Marie, White, Karen L, Shackleford, David M, Mannila, Janne, Morizzi, Julia, Scheurer, Christian, Angulo-Barturen, Iñigo, Martínez, María Santos, Ferrer, Santiago, Sanz, Laura María, Gamo, Francisco Javier, Reader, Janette, Botha, Mariette, Dechering, Koen J, Sauerwein, Robert W, Tungtaeng, Anchalee, Vanachayangkul, Pattaraporn, Lim, Chek Shik, Burrows, Jeremy, Witty, Michael J, Marsh, Kennan C, Bodenreider, Christophe, Rochford, Rosemary, Solapure, Suresh M, Jiménez-Díaz, María Belén, Wittlin, Sergio, Charman, Susan A, Donini, Cristina, Campo, Brice, Birkholtz, Lyn-Marie, Hanson, Kirsten K, Drewes, Gerard, Kocken, Clemens H M, Delves, Michael J, Leroy, Didier, Fidock, David A, Waterson, David, Street, Leslie J, Chibale, Kelly
Published in Science translational medicine (26.04.2017)
Published in Science translational medicine (26.04.2017)
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Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis
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Published in Nature (London) (01.08.2018)
Published in Nature (London) (01.08.2018)
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Sir2p exists in two nucleosome-binding complexes with distinct deacetylase activities
Ghidelli, Sonja, Donze, David, Dhillon, Namrita, Kamakaka, Rohinton T.
Published in The EMBO journal (15.08.2001)
Published in The EMBO journal (15.08.2001)
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SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
Yan, Bingyu, Freiwald, Tilo, Chauss, Daniel, Wang, Luopin, West, Erin, Mirabelli, Carmen, Zhang, Charles J, Nichols, Eva-Maria, Malik, Nazish, Gregory, Richard, Bantscheff, Marcus, Ghidelli-Disse, Sonja, Kolev, Martin, Frum, Tristan, Spence, Jason R, Sexton, Jonathan Z, Alysandratos, Konstantinos D, Kotton, Darrell N, Pittaluga, Stefania, Bibby, Jack, Niyonzima, Nathalie, Olson, Matthew R, Kordasti, Shahram, Portilla, Didier, Wobus, Christiane E, Laurence, Arian, Lionakis, Michail S, Kemper, Claudia, Afzali, Behdad, Kazemian, Majid
Published in Science Immunology (07.04.2021)
Published in Science Immunology (07.04.2021)
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Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity
Vanaerschot, Manu, Murithi, James M., Pasaje, Charisse Flerida A., Ghidelli-Disse, Sonja, Dwomoh, Louis, Bird, Megan, Spottiswoode, Natasha, Mittal, Nimisha, Arendse, Lauren B., Owen, Edward S., Wicht, Kathryn J., Siciliano, Giulia, Bösche, Markus, Yeo, Tomas, Kumar, T.R. Santha, Mok, Sachel, Carpenter, Emma F., Giddins, Marla J., Sanz, Olalla, Ottilie, Sabine, Alano, Pietro, Chibale, Kelly, Llinás, Manuel, Uhlemann, Anne-Catrin, Delves, Michael, Tobin, Andrew B., Doerig, Christian, Winzeler, Elizabeth A., Lee, Marcus C.S., Niles, Jacquin C., Fidock, David A.
Published in Cell chemical biology (16.07.2020)
Published in Cell chemical biology (16.07.2020)
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Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites
Matralis, Alexios N, Malik, Adnan, Penzo, Maria, Moreno, Inmaculada, Almela, Maria J, Camino, Isabel, Crespo, Benigno, Saadeddin, Anas, Ghidelli-Disse, Sonja, Rueda, Lourdes, Calderon, Felix, Osborne, Simon A, Drewes, Gerard, Böesche, Markus, Fernández-Álvaro, Elena, Martin Hernando, Jose Ignacio, Baker, David A
Published in Journal of medicinal chemistry (24.10.2019)
Published in Journal of medicinal chemistry (24.10.2019)
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The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages
Arendse, Lauren B, Murithi, James M, Qahash, Tarrick, Pasaje, Charisse Flerida A, Godoy, Luiz C, Dey, Sumanta, Gibhard, Liezl, Ghidelli-Disse, Sonja, Drewes, Gerard, Bantscheff, Marcus, Lafuente-Monasterio, Maria J, Fienberg, Stephen, Wambua, Lynn, Gachuhi, Samuel, Coertzen, Dina, van der Watt, Mariëtte, Reader, Janette, Aswat, Ayesha S, Erlank, Erica, Venter, Nelius, Mittal, Nimisha, Luth, Madeline R, Ottilie, Sabine, Winzeler, Elizabeth A, Koekemoer, Lizette L, Birkholtz, Lyn-Marie, Niles, Jacquin C, Llinás, Manuel, Fidock, David A, Chibale, Kelly
Published in Science translational medicine (19.10.2022)
Published in Science translational medicine (19.10.2022)
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Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency
Guantay, Laura, Garro, Cintia, Siri, Sebastián, Pansa, María Florencia, Ghidelli-Disse, Sonja, Paviolo, Natalia, Racca, Ana, Nicotra, Viviana, Radu, Caius, Bocco, José Luis, Felice, Rosana, Jansson, Keith H., Remlinger, Katja, Amador, Alejandro, Stronach, Euan, Coleman, Kevin, Muelbaier, Marcel, Drewes, Gerard, Gloger, Isro, Madauss, Kevin, García, Manuela, Gottifredi, Vanesa, Soria, Gastón
Published in Drug resistance updates (01.03.2023)
Published in Drug resistance updates (01.03.2023)
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Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis
Wyllie, Susan, Thomas, Michael, Patterson, Stephen, Crouch, Sabrinia, De Rycker, Manu, Lowe, Rhiannon, Gresham, Stephanie, Urbaniak, Michael D., Otto, Thomas D., Stojanovski, Laste, Simeons, Frederick R. C., Manthri, Sujatha, MacLean, Lorna M., Zuccotto, Fabio, Homeyer, Nadine, Pflaumer, Hannah, Boesche, Markus, Sastry, Lalitha, Connolly, Paul, Albrecht, Sebastian, Berriman, Matt, Drewes, Gerard, Gray, David W., Ghidelli-Disse, Sonja, Dixon, Susan, Fiandor, Jose M., Wyatt, Paul G., Ferguson, Michael A. J., Fairlamb, Alan H., Miles, Timothy J., Read, Kevin D., Gilbert, Ian H.
Published in Nature (London) (20.07.2023)
Published in Nature (London) (20.07.2023)
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