Micro-pharmacokinetics: Quantifying local drug concentration at live cell membranes
Gherbi, Karolina, Briddon, Stephen J, Charlton, Steven J
Published in Scientific reports (22.02.2018)
Published in Scientific reports (22.02.2018)
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Journal Article
Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs
Bradley, Sophie J, Molloy, Colin, Valuskova, Paulina, Dwomoh, Louis, Scarpa, Miriam, Rossi, Mario, Finlayson, Lisa, Svensson, Kjell A, Chernet, Eyassu, Barth, Vanessa N, Gherbi, Karolina, Sykes, David A, Wilson, Caroline A, Mistry, Rajendra, Sexton, Patrick M, Christopoulos, Arthur, Mogg, Adrian J, Rosethorne, Elizabeth M, Sakata, Shuzo, John Challiss, R A, Broad, Lisa M, Tobin, Andrew B
Published in Nature chemical biology (01.03.2020)
Published in Nature chemical biology (01.03.2020)
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Journal Article
A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A3 Receptor in Living Cells
Arruda, Maria Augusta, Stoddart, Leigh A., Gherbi, Karolina, Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.
Published in Frontiers in pharmacology (13.12.2017)
Published in Frontiers in pharmacology (13.12.2017)
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Journal Article
Long Receptor Residence Time of C26 Contributes to Super Agonist Activity at the Human β2 Adrenoceptor
Rosethorne, Elizabeth M, Bradley, Michelle E, Gherbi, Karolina, Sykes, David A, Sattikar, Afrah, Wright, John D, Renard, Emilie, Trifilieff, Alex, Fairhurst, Robin A, Charlton, Steven J
Published in Molecular pharmacology (01.04.2016)
Published in Molecular pharmacology (01.04.2016)
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Journal Article
Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor
Yen, Hsin-Yung, Liko, Idlir, Song, Wanling, Kapoor, Parth, Almeida, Fernando, Toporowska, Joanna, Gherbi, Karolina, Hopper, Jonathan T S, Charlton, Steven J, Politis, Argyris, Sansom, Mark S P, Jazayeri, Ali, Robinson, Carol V
Published in Nature chemistry (01.12.2022)
Published in Nature chemistry (01.12.2022)
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Journal Article
Negative cooperativity across β1‐adrenoceptor homodimers provides insights into the nature of the secondary low‐affinity CGP 12177 β1‐adrenoceptor binding conformation
Gherbi, Karolina, May, Lauren T., Baker, Jillian G., Briddon, Stephen J., Hill, Stephen J.
Published in The FASEB journal (01.07.2015)
Published in The FASEB journal (01.07.2015)
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Journal Article
Abstract 5014: Profile of ARX001822, a highly potent, selective and orally bioavailable A2a antagonist effective in preventing adenosinergic suppression of T cell activation
Finan, Peter M., Pettipher, Roy, White, Jonathan, Patel, Viral, Moulton, Ben, Porres, Soraya, Gherbi, Karolina, Rosethorne, Elizabeth M., Charlton, Steven J., McCarthy, Clive
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Long Receptor Residence Time of C26 Contributes to Super Agonist Activity at the Human β 2 Adrenoceptor
Rosethorne, Elizabeth M., Bradley, Michelle E., Gherbi, Karolina, Sykes, David A., Sattikar, Afrah, Wright, John D., Renard, Emilie, Trifilieff, Alex, Fairhurst, Robin A., Charlton, Steven J.
Published in Molecular pharmacology (01.04.2016)
Published in Molecular pharmacology (01.04.2016)
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Journal Article
A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A 3 Receptor in Living Cells
Arruda, Maria Augusta, Stoddart, Leigh A, Gherbi, Karolina, Briddon, Stephen J, Kellam, Barrie, Hill, Stephen J
Published in Frontiers in pharmacology (2017)
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Published in Frontiers in pharmacology (2017)
Journal Article
Ligand-induced conformational changes in the β1-Adrenergic Receptor Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry
Toporowska, Joanna, Kapoor, Parth, Musgaard, Maria, Gherbi, Karolina, Sengmany, Kathy, Qu, Feng, Soave, Mark, Hsin-Yung Yen, Hansen, Kjetil, Jazayeri, Ali, Hopper, Jonathan Ts, Politis, Argyris
Published in bioRxiv (09.02.2024)
Published in bioRxiv (09.02.2024)
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