Targeting MET in cancer: rationale and progress
Gherardi, Ermanno, Birchmeier, Walter, Birchmeier, Carmen, Woude, George Vande
Published in Nature reviews. Cancer (01.02.2012)
Published in Nature reviews. Cancer (01.02.2012)
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Journal Article
Inhibition of the MET Kinase Activity and Cell Growth in MET-Addicted Cancer Cells by Bi-Paratopic Linking
Andres, Fabio, Iamele, Luisa, Meyer, Timo, Stüber, Jakob C., Kast, Florian, Gherardi, Ermanno, Niemann, Hartmut H., Plückthun, Andreas
Published in Journal of molecular biology (03.05.2019)
Published in Journal of molecular biology (03.05.2019)
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Journal Article
Human Nonalcoholic Steatohepatitis on a Chip
Freag, May S., Namgung, Bumseok, Reyna Fernandez, Maria E., Gherardi, Ermanno, Sengupta, Shiladitya, Jang, Hae Lin
Published in Hepatology communications (01.02.2021)
Published in Hepatology communications (01.02.2021)
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Journal Article
A Novel HGF/SF Receptor (MET) Agonist Transiently Delays the Disease Progression in an Amyotrophic Lateral Sclerosis Mouse Model by Promoting Neuronal Survival and Dampening the Immune Dysregulation
Vallarola, Antonio, Tortarolo, Massimo, De Gioia, Roberta, Iamele, Luisa, de Jonge, Hugo, de Nola, Giovanni, Bovio, Enrica, Pasetto, Laura, Bonetto, Valentina, Freschi, Mattia, Bendotti, Caterina, Gherardi, Ermanno
Published in International journal of molecular sciences (12.11.2020)
Published in International journal of molecular sciences (12.11.2020)
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Journal Article
Structural basis for agonism and antagonism of hepatocyte growth factor
Tolbert, W. David, Daugherty-Holtrop, Jennifer, Gherardi, Ermanno, Woude, George Vande, Xu, H. Eric, Schlessinger, Joseph
Published in Proceedings of the National Academy of Sciences - PNAS (27.07.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (27.07.2010)
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Journal Article
Structural Basis of Hepatocyte Growth Factor/Scatter Factor and MET Signalling
Gherardi, Ermanno, Sandin, Sara, Petoukhov, Maxim V., Finch, John, Youles, Mark E., Öfverstedt, Lars-Göran, Miguel, Ricardo N., Blundell, Tom L., Vande Woude, George F., Skoglund, UIf, Svergun, Dmitri I.
Published in Proceedings of the National Academy of Sciences - PNAS (14.03.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (14.03.2006)
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Journal Article
Interactions of Hepatocyte Growth Factor/Scatter Factor with Various Glycosaminoglycans Reveal an Important Interplay between the Presence of Iduronate and Sulfate Density
Catlow, Krista R., Deakin, Jon A., Wei, Zheng, Delehedde, Maryse, Fernig, David G., Gherardi, Ermanno, Gallagher, John T., Pavão, Mauro S.G., Lyon, Malcolm
Published in The Journal of biological chemistry (29.02.2008)
Published in The Journal of biological chemistry (29.02.2008)
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Journal Article
Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain
DiCara, Danielle M., Chirgadze, Dimitri Y., Pope, Anthony R., Karatt-Vellatt, Aneesh, Winter, Anja, Slavny, Peter, van den Heuvel, Joop, Parthiban, Kothai, Holland, Jane, Packman, Len C., Mavria, Georgia, Hoffmann, Jens, Birchmeier, Walter, Gherardi, Ermanno, McCafferty, John
Published in Scientific reports (21.08.2017)
Published in Scientific reports (21.08.2017)
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Journal Article
Diverse and potent activities of HGF/SF in skin wound repair
Bevan, Damon, Gherardi, Ermanno, Fan, Tai-Ping, Edwards, Dylan, Warn, Richard
Published in The Journal of pathology (01.07.2004)
Published in The Journal of pathology (01.07.2004)
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Journal Article
Protein Engineered Variants of Hepatocyte Growth Factor/Scatter Factor Promote Proliferation of Primary Human Hepatocytes and in Rodent Liver
Ross, Jacob, Gherardi, Ermanno, Mallorqui–Fernandez, Noemi, Bocci, Marco, Sobkowicz, Anna, Rees, Myrrdin, Rowe, Arthur, Ellmerich, Stephan, Massie, Isobel, Soeda, Junpei, Selden, Clare, Hodgson, Humphrey
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2012)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2012)
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Journal Article
Non-agonistic bivalent antibodies that promote c-MET degradation and inhibit tumor growth and others specific for tumor related c-MET
Greenall, Sameer A, Gherardi, Ermanno, Liu, Zhanqi, Donoghue, Jacqueline F, Vitali, Angela A, Li, Qian, Murphy, Roger, Iamele, Luisa, Scott, Andrew M, Johns, Terrance G
Published in PloS one (12.04.2012)
Published in PloS one (12.04.2012)
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Journal Article
Functional Map and Domain Structure of MET, the Product of the c-met Protooncogene and Receptor for Hepatocyte Growth Factor/Scatter Factor
Gherardi, Ermanno, Youles, Mark E., Miguel, Ricardo N., Blundell, Tom L., Iamele, Luisa, Gough, Julian, Bandyopadhyay, Abhishek, Hartmann, Guido, P. Jonathan G. Butler
Published in Proceedings of the National Academy of Sciences - PNAS (14.10.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (14.10.2003)
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Journal Article
mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
Tolbert, W. David, Daugherty, Jennifer, Gao, ChongFeng, Xie, Qian, Miranti, Cindy, Gherardi, Ermanno, Vande Woude, George, Xu, H. Eric
Published in Proceedings of the National Academy of Sciences - PNAS (11.09.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (11.09.2007)
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Journal Article
Coupling growth-factor engineering with nanotechnology for therapeutic angiogenesis
Roy, Rituparna Sinha, Soni, Shivani, Harfouche, Rania, Vasudevan, Pooja R., Holmes, Oliver, de Jonge, Hugo, Rowe, Arthur, Paraskar, Abhimanyu, Hentschel, Dirk M., Chirgadze, Dimitri, Blundell, Tom L., Gherardi, Ermanno, Mashelkar, Raghunath A., Sengupta, Shiladitya
Published in Proceedings of the National Academy of Sciences - PNAS (03.08.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (03.08.2010)
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Journal Article
Engineering the NK1 Fragment of Hepatocyte Growth Factor/Scatter Factor as a MET Receptor Antagonist
Youles, Mark, Holmes, Oliver, Petoukhov, Maxim V., Nessen, Merel A., Stivala, Simona, Svergun, Dmitri I., Gherardi, Ermanno
Published in Journal of molecular biology (28.03.2008)
Published in Journal of molecular biology (28.03.2008)
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Journal Article
Hepatocyte Growth Factor/Scatter Factor Can Induce Angiogenesis Independently of Vascular Endothelial Growth Factor
Sengupta, Shiladitya, Gherardi, Ermanno, Sellers, Lynda A, Wood, Jeanette M, Sasisekharan, Ram, Fan, Tai-Ping D
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2003)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2003)
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Journal Article
X-ray and Neutron Small-Angle Scattering Analysis of the Complex Formed by the Met Receptor and the Listeria monocytogenes Invasion Protein InlB
Niemann, Hartmut H., Petoukhov, Maxim V., Härtlein, Michael, Moulin, Martine, Gherardi, Ermanno, Timmins, Peter, Heinz, Dirk W., Svergun, Dmitri I.
Published in Journal of molecular biology (21.03.2008)
Published in Journal of molecular biology (21.03.2008)
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Journal Article
Eotaxin-1/CC Chemokine Ligand 11: A Novel Eosinophil Survival Factor Secreted by Human Pulmonary Artery Endothelial Cells
Farahi, Neda, Cowburn, Andrew S, Upton, Paul D, Deighton, John, Sobolewski, Anastasia, Gherardi, Ermanno, Morrell, Nicholas W, Chilvers, Edwin R
Published in Journal of Immunology (15.07.2007)
Published in Journal of Immunology (15.07.2007)
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