Search Results - "Gharat, Laxmikant A" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy

Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy

by Banerjee, Abhisek, Velagaleti, Ranganadh, Patil, Sandip, Pawar, Mahesh, Yadav, Pravin, Kadam, Pradip, Qadri, Mohammad Mohsin, Chakraborti, Samitabh, Saini, Jagmohan S., Behera, Dayanidhi B., Karanjai, Keya, Iyer, Pravin S., Gharat, Laxmikant A., Das, Sanjib
Published in Bioorganic & medicinal chemistry letters (01.09.2021)

Get full text

Journal Article

Discovery of 5-(2-chloro-4′-(1H-imidazol-1-yl)-[1,1′-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD

Discovery of 5-(2-chloro-4′-(1H-imidazol-1-yl)-[1,1′-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD

by Muthukaman, Nagarajan, Deshmukh, Sanjay, Tondlekar, Shital, Tambe, Macchindra, Pisal, Dnyandeo, Sarode, Neelam, Mhatre, Siddharth, Chakraborti, Samitabh, Shah, Daisy, Bhosale, Vikram M., Kulkarni, Abhay, Mahat, Mahamad Yunnus A., Jadhav, Satyawan B., Gudi, Girish S., Khairatkar-Joshi, Neelima, Gharat, Laxmikant A.
Published in Bioorganic & medicinal chemistry letters (15.12.2018)

Get full text

Journal Article

Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[d]imidazole series – Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2

Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[d]imidazole series – Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2

by Muthukaman, Nagarajan, Deshmukh, Sanjay, Tambe, Macchindra, Pisal, Dnyandeo, Tondlekar, Shital, Shaikh, Mahamadhanif, Sarode, Neelam, Kattige, Vidya G., Sawant, Pooja, Pisat, Monali, Karande, Vikas, Honnegowda, Srinivasa, Kulkarni, Abhay, Behera, Dayanidhi, Jadhav, Satyawan B., Sangana, Ramchandra R., Gudi, Girish S., Khairatkar-Joshi, Neelima, Gharat, Laxmikant A.
Published in Bioorganic & medicinal chemistry letters (15.04.2018)

Get full text

Journal Article

Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1

Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1

by Muthukaman, Nagarajan, Tambe, Macchindra, Deshmukh, Sanjay, Pisal, Dnyandeo, Tondlekar, Shital, Shaikh, Mahamadhanif, Sarode, Neelam, Kattige, Vidya G., Pisat, Monali, Sawant, Pooja, Honnegowda, Srinivasa, Karande, Vikas, Kulkarni, Abhay, Behera, Dayanidhi, Jadhav, Satyawan B., Sangana, Ramchandra R., Gudi, Girish S., Khairatkar-Joshi, Neelima, Gharat, Laxmikant A.
Published in Bioorganic & medicinal chemistry letters (01.12.2017)

Get full text

Journal Article

Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E-2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model

Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E-2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model

by Muthukaman, Nagarajan, Tambe, Macchindra, Shaikh, Mahamadhanif, Pisal, Dnyandeo, Deshmukh, Sanjay, Tondlekar, Shital, Sarode, Neelam, Narayana, Lakshminarayana, Gajera, Jitendra M., Kattige, Vidya G., Honnegowda, Srinivasa, Karande, Vikas, Kulkarni, Abhay, Behera, Dayanidhi, Jadhav, Satyawan B., Gudi, Girish S., Khairatkar-Joshi, Neelima, Gharat, Laxmikant A.
Published in Bioorganic & medicinal chemistry letters (01.06.2017)

Get full text

Journal Article

Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model

Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model

by Muthukaman, Nagarajan, Tambe, Macchindra, Shaikh, Mahamadhanif, Pisal, Dnyandeo, Deshmukh, Sanjay, Tondlekar, Shital, Sarode, Neelam, Narayana, Lakshminarayana, Gajera, Jitendra M., Kattige, Vidya G., Honnegowda, Srinivasa, Karande, Vikas, Kulkarni, Abhay, Behera, Dayanidhi, Jadhav, Satyawan B., Gudi, Girish S., Khairatkar-Joshi, Neelima, Gharat, Laxmikant A.
Published in Bioorganic & medicinal chemistry letters (01.06.2017)

Get full text

Journal Article

Discovery of 2-(2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino [2 ',3 ':3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E-2 synthase-1 (mPGES-1) inhibitor

Discovery of 2-(2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino [2 ',3 ':3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E-2 synthase-1 (mPGES-1) inhibitor

by Muthukaman, Nagarajan, Deshmukh, Sanjay, Sarode, Neelam, Tondlekar, Shital, Tambe, Macchindra, Pisal, Dnyandeo, Shaikh, Mahamadhanif, Kattige, Vidya G., Honnegowda, Srinivasa, Karande, Vikas, Kulkarni, Abhay, Jadhav, Satyawan B., Mahat, Mahamad Yunnus A., Gudi, Girish S., Khairatkar-Joshi, Neelima, Gharat, Laxmikant A.
Published in Bioorganic & medicinal chemistry letters (15.12.2016)

Get full text

Journal Article

Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson’s disease model

Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson’s disease model

by Banerjee, Abhisek, Patil, Sandip, Pawar, Mahesh Y., Gullapalli, Srinivas, Gupta, Praveen K., Gandhi, Maulik N., Bhateja, Deepak K., Bajpai, Malini, Sangana, Ramachandra Rao, Gudi, Girish S., Khairatkar-Joshi, Neelima, Gharat, Laxmikant A.
Published in Bioorganic & medicinal chemistry letters (01.10.2012)

Get full text

Journal Article

Discovery of benzo[d]imidazo[5,1-b]thiazole as a new class of phosphodiesterase 10A inhibitors

Discovery of benzo[d]imidazo[5,1-b]thiazole as a new class of phosphodiesterase 10A inhibitors

by Banerjee, Abhisek, Narayana, Lakshminarayana, Raje, Firoj A., Pisal, Dnyandeo V., Kadam, Pradip A., Gullapalli, Srinivas, Kumar, Hemant, More, Sandeep V., Bajpai, Malini, Sangana, Ramachandra Rao, Jadhav, Satyawan, Gudi, Girish S., Khairatkar-Joshi, Neelima, Merugu, Ravi R.T., Voleti, Sreedhara R., Gharat, Laxmikant A.
Published in Bioorganic & medicinal chemistry letters (15.12.2013)

Get full text

Journal Article

Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor

Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor

by Muthukaman, Nagarajan, Deshmukh, Sanjay, Sarode, Neelam, Tondlekar, Shital, Tambe, Macchindra, Pisal, Dnyandeo, Shaikh, Mahamadhanif, Kattige, Vidya G., Honnegowda, Srinivasa, Karande, Vikas, Kulkarni, Abhay, Jadhav, Satyawan B., Mahat, Mahamad Yunnus A., Gudi, Girish S., Khairatkar-Joshi, Neelima, Gharat, Laxmikant A.
Published in Bioorganic & medicinal chemistry letters (15.12.2016)

Get full text

Journal Article

Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation

Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation

by Banerjee, Abhisek, Yadav, Pravin S., Bajpai, Malini, Sangana, Ramachandra Rao, Gullapalli, Srinivas, Gudi, Girish S., Gharat, Laxmikant A.
Published in Bioorganic & medicinal chemistry letters (01.05.2012)

Get full text

Journal Article

Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido [4,3-d]pyrimidin-4(3H)-one and pyrido [4,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E-2 synthase-1 inhibitors

Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido [4,3-d]pyrimidin-4(3H)-one and pyrido [4,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E-2 synthase-1 inhibitors

by Banerjee, Abhisek, Pawar, Mahesh Y., Patil, Sandip, Yadav, Pravin S., Kadam, Pradip A., Kattige, Vidya G., Deshpande, Durga S., Pednekar, Pallavi V., Pisat, Monali K., Gharat, Laxmikant A.
Published in Bioorganic & medicinal chemistry letters (15.10.2014)

Get full text

Journal Article

Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido[4,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E2 synthase-1 inhibitors

Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido[4,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E2 synthase-1 inhibitors

by Banerjee, Abhisek, Pawar, Mahesh Y., Patil, Sandip, Yadav, Pravin S., Kadam, Pradip A., Kattige, Vidya G., Deshpande, Durga S., Pednekar, Pallavi V., Pisat, Monali K., Gharat, Laxmikant A.
Published in Bioorganic & medicinal chemistry letters (15.10.2014)

Get full text

Journal Article

5-(alpha-fluorovinyl)-N-tosylindole

5-(alpha-fluorovinyl)-N-tosylindole

by Gharat, LA, Martin, AR
Published in Heterocycles (01.01.1996)

Get more information

Journal Article

Discovery of 2-((2-chloro-6-fluorophenyl)amino)- N -(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1 H -[1,4]dioxino[2′,3′:3,4]benzo[1,2- d ]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E 2 synthase-1 (mPGES-1) inhibitor

Discovery of 2-((2-chloro-6-fluorophenyl)amino)- N -(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1 H -[1,4]dioxino[2′,3′:3,4]benzo[1,2- d ]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E 2 synthase-1 (mPGES-1) inhibitor

by Muthukaman, Nagarajan, Deshmukh, Sanjay, Sarode, Neelam, Tondlekar, Shital, Tambe, Macchindra, Pisal, Dnyandeo, Shaikh, Mahamadhanif, Kattige, Vidya G., Honnegowda, Srinivasa, Karande, Vikas, Kulkarni, Abhay, Jadhav, Satyawan B., Mahat, Mahamad Yunnus A., Gudi, Girish S., Khairatkar-Joshi, Neelima, Gharat, Laxmikant A.
Published in Bioorganic & medicinal chemistry letters (01.12.2016)

Get full text

Journal Article

Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido[4,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E sub(2) synthase-1 inhibitors

Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido[4,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E sub(2) synthase-1 inhibitors

by Banerjee, Abhisek, Pawar, Mahesh Y, Patil, Sandip, Yadav, Pravin S, Kadam, Pradip A, Kattige, Vidya G, Deshpande, Durga S, Pednekar, Pallavi V, Pisat, Monali K, Gharat, Laxmikant A
Published in Bioorganic & medicinal chemistry letters (15.10.2014)

Get full text

Journal Article

Cyclopentyl: A Novel Protective Group for Phenols

Cyclopentyl: A Novel Protective Group for Phenols

by Gajera, Jitendra M., Gharat, Laxmikant A., Farande, Aniket V.
Published in Synthetic communications (01.11.2007)

Get full text

Journal Article

Cyclopentyl: A Novel Protective Group for Phenols

Cyclopentyl: A Novel Protective Group for Phenols

by Gajera, Jitendra M., Gharat, Laxmikant A., Farande, Aniket V.
Published in Synthetic communications (01.08.2007)

Get full text

Journal Article

Synthesis of multi-substituted dibenzo[b,d]furan

Synthesis of multi-substituted dibenzo[b,d]furan

by Gajera, Jitendra M., Gopalan, Balasubramanian, Yadav, Pravin S., Patil, Sandip D., Gharat, Laxmikant A.
Published in Journal of heterocyclic chemistry (01.05.2008)

Get more information

Journal Article

Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido[4,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E(2) synthase-1 inhibitors

Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido[4,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E(2) synthase-1 inhibitors

by Banerjee, Abhisek, Pawar, Mahesh Y, Patil, Sandip, Yadav, Pravin S, Kadam, Pradip A, Kattige, Vidya G, Deshpande, Durga S, Pednekar, Pallavi V, Pisat, Monali K, Gharat, Laxmikant A
Published in Bioorganic & medicinal chemistry letters (15.10.2014)

Get full text

Journal Article