Interpreting type 1 diabetes risk with genetics and single-cell epigenomics
Chiou, Joshua, Geusz, Ryan J, Okino, Mei-Lin, Han, Jee Yun, Miller, Michael, Melton, Rebecca, Beebe, Elisha, Benaglio, Paola, Huang, Serina, Korgaonkar, Katha, Heller, Sandra, Kleger, Alexander, Preissl, Sebastian, Gorkin, David U, Sander, Maike, Gaulton, Kyle J
Published in Nature (London) (17.06.2021)
Published in Nature (London) (17.06.2021)
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Journal Article
Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors
Geusz, Ryan J, Wang, Allen, Lam, Dieter K, Vinckier, Nicholas K, Alysandratos, Konstantinos-Dionysios, Roberts, David A, Wang, Jinzhao, Kefalopoulou, Samy, Ramirez, Araceli, Qiu, Yunjiang, Chiou, Joshua, Gaulton, Kyle J, Ren, Bing, Kotton, Darrell N, Sander, Maike
Published in Nature communications (17.11.2021)
Published in Nature communications (17.11.2021)
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Journal Article
LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development
Vinckier, Nicholas K, Patel, Nisha A, Geusz, Ryan J, Wang, Allen, Wang, Jinzhao, Matta, Ileana, Harrington, Austin R, Wortham, Matthew, Wetton, Nichole, Wang, Jianxun, Jhala, Ulupi S, Rosenfeld, Michael G, Benner, Christopher W, Shih, Hung-Ping, Sander, Maike
Published in Nature communications (29.04.2020)
Published in Nature communications (29.04.2020)
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Journal Article
Mutations and variants of ONECUT1 in diabetes
Philippi, Anne, Heller, Sandra, Costa, Ivan G, Senée, Valérie, Breunig, Markus, Li, Zhijian, Kwon, Gino, Russell, Ronan, Illing, Anett, Lin, Qiong, Hohwieler, Meike, Degavre, Anne, Zalloua, Pierre, Liebau, Stefan, Schuster, Michael, Krumm, Johannes, Zhang, Xi, Geusz, Ryan, Benthuysen, Jacqueline R, Wang, Allen, Chiou, Joshua, Gaulton, Kyle, Neubauer, Heike, Simon, Eric, Klein, Thomas, Wagner, Martin, Nair, Gopika, Besse, Céline, Dandine-Roulland, Claire, Olaso, Robert, Deleuze, Jean-François, Kuster, Bernhard, Hebrok, Matthias, Seufferlein, Thomas, Sander, Maike, Boehm, Bernhard O, Oswald, Franz, Nicolino, Marc, Julier, Cécile, Kleger, Alexander
Published in Nature medicine (01.11.2021)
Published in Nature medicine (01.11.2021)
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Journal Article
Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development
Geusz, Ryan J, Wang, Allen, Chiou, Joshua, Lancman, Joseph J, Wetton, Nichole, Kefalopoulou, Samy, Wang, Jinzhao, Qiu, Yunjiang, Yan, Jian, Aylward, Anthony, Ren, Bing, Dong, P Duc Si, Gaulton, Kyle J, Sander, Maike
Published in eLife (05.02.2021)
Published in eLife (05.02.2021)
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Journal Article
Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation
Heller, Sandra, Li, Zhijian, Lin, Qiong, Geusz, Ryan, Breunig, Markus, Hohwieler, Meike, Zhang, Xi, Nair, Gopika G, Seufferlein, Thomas, Hebrok, Matthias, Sander, Maike, Julier, Cécile, Kleger, Alexander, Costa, Ivan G
Published in Communications biology (17.11.2021)
Published in Communications biology (17.11.2021)
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Journal Article
ONECUT1 mutations and variants in diabetes
Philippi, Anne, Heller, Sandra, Costa, Ivan G., Senée, Valérie, Breunig, Markus, Li, Zhijian, Kwon, Gino, Russell, Ronan, Illing, Anett, Lin, Qiong, Hohwieler, Meike, Degavre, Anne, Zalloua, Pierre, Liebau, Stefan, Schuster, Michael, Krumm, Johannes, Zhang, Xi, Geusz, Ryan, Benthuysen, Jacqueline R., Wang, Allen, Chiou, Joshua, Gaulton, Kyle, Neubauer, Heike, Simon, Eric, Klein, Thomas, Wagner, Martin, Nair, Gopika, Besse, Céline, Dandine-Roulland, Claire, Olaso, Robert, Deleuze, Jean-François, Kuster, Bernhard, Hebrok, Matthias, Seufferlein, Thomas, Sander, Maike, Boehm, Bernhard O., Oswald, Franz, Nicolino, Marc, Julier, Cécile, Kleger, Alexander
Published in Nature medicine (18.10.2021)
Published in Nature medicine (18.10.2021)
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Journal Article
Large-scale genetic association and single cell accessible chromatin mapping defines cell type-specific mechanisms of type 1 diabetes risk
Chiou, Joshua, Geusz, Ryan J, Mei-Lin Okino, Jee Yun Han, Miller, Michael, Benaglio, Paola, Huang, Serina, Korgaonkar, Katha, Heller, Sandra, Kleger, Alexander, Preissl, Sebastian, Gorkin, David U, Sander, Maike, Gaulton, Kyle J
Published in bioRxiv (15.01.2021)
Published in bioRxiv (15.01.2021)
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Paper
A dual mechanism of enhancer activation by FOXA pioneer factors induces endodermal organ fates
Geusz, Ryan J, Wang, Allen, Lam, Dieter K, Vinckier, Nicholas K, Konstantinos-Dionysios Alysandratos, Roberts, David A, Wang, Jinzhao, Kefalopoulou, Samy, Qiu, Yunjiang, Chiou, Joshua, Gaulton, Kyle J, Ren, Bing, Kotton, Darrell N, Sander, Maike
Published in bioRxiv (29.08.2020)
Published in bioRxiv (29.08.2020)
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Paper
Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development
Geusz, Ryan J, Wang, Allen, Chiou, Joshua, Lancman, Joseph J, Wetton, Nichole, Kefalopoulou, Samy, Wang, Jinzhao, Qiu, Yunjiang, Yan, Jian, Aylward, Anthony, Ren, Bing, Si Dong, P Duc, Gaulton, Kyle J, Sander, Maike
Published in bioRxiv (19.05.2020)
Published in bioRxiv (19.05.2020)
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Paper