OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis
Mevissen, Tycho E.T., Hospenthal, Manuela K., Geurink, Paul P., Elliott, Paul R., Akutsu, Masato, Arnaudo, Nadia, Ekkebus, Reggy, Kulathu, Yogesh, Wauer, Tobias, El Oualid, Farid, Freund, Stefan M.V., Ovaa, Huib, Komander, David
Published in Cell (03.07.2013)
Published in Cell (03.07.2013)
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Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
Shin, Donghyuk, Mukherjee, Rukmini, Grewe, Diana, Bojkova, Denisa, Baek, Kheewoong, Bhattacharya, Anshu, Schulz, Laura, Widera, Marek, Mehdipour, Ahmad Reza, Tascher, Georg, Geurink, Paul P, Wilhelm, Alexander, van der Heden van Noort, Gerbrand J, Ovaa, Huib, Müller, Stefan, Knobeloch, Klaus-Peter, Rajalingam, Krishnaraj, Schulman, Brenda A, Cinatl, Jindrich, Hummer, Gerhard, Ciesek, Sandra, Dikic, Ivan
Published in Nature (London) (26.11.2020)
Published in Nature (London) (26.11.2020)
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Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
Klemm, Theresa, Ebert, Gregor, Calleja, Dale J, Allison, Cody C, Richardson, Lachlan W, Bernardini, Jonathan P, Lu, Bernadine GC, Kuchel, Nathan W, Grohmann, Christoph, Shibata, Yuri, Gan, Zhong Yan, Cooney, James P, Doerflinger, Marcel, Au, Amanda E, Blackmore, Timothy R, Heden van Noort, Gerbrand J, Geurink, Paul P, Ovaa, Huib, Newman, Janet, Riboldi‐Tunnicliffe, Alan, Czabotar, Peter E, Mitchell, Jeffrey P, Feltham, Rebecca, Lechtenberg, Bernhard C, Lowes, Kym N, Dewson, Grant, Pellegrini, Marc, Lessene, Guillaume, Komander, David
Published in The EMBO journal (15.09.2020)
Published in The EMBO journal (15.09.2020)
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Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput
Jia, Yuqing, Kim, Robbert Q., Kooij, Raymond, Ovaa, Huib, Sapmaz, Aysegul, Geurink, Paul P.
Published in Journal of medicinal chemistry (13.10.2022)
Published in Journal of medicinal chemistry (13.10.2022)
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Journal Article
Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets
Flierman, Dennis, van der Heden van Noort, Gerbrand J., Ekkebus, Reggy, Geurink, Paul P., Mevissen, Tycho E.T., Hospenthal, Manuela K., Komander, David, Ovaa, Huib
Published in Cell chemical biology (21.04.2016)
Published in Cell chemical biology (21.04.2016)
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Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening
Resnick, Efrat, Bradley, Anthony, Gan, Jinrui, Douangamath, Alice, Krojer, Tobias, Sethi, Ritika, Geurink, Paul P, Aimon, Anthony, Amitai, Gabriel, Bellini, Dom, Bennett, James, Fairhead, Michael, Fedorov, Oleg, Gabizon, Ronen, Gan, Jin, Guo, Jingxu, Plotnikov, Alexander, Reznik, Nava, Ruda, Gian Filippo, Díaz-Sáez, Laura, Straub, Verena M, Szommer, Tamas, Velupillai, Srikannathasan, Zaidman, Daniel, Zhang, Yanling, Coker, Alun R, Dowson, Christopher G, Barr, Haim M, Wang, Chu, Huber, Kilian V.M, Brennan, Paul E, Ovaa, Huib, von Delft, Frank, London, Nir
Published in Journal of the American Chemical Society (05.06.2019)
Published in Journal of the American Chemical Society (05.06.2019)
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Structural basis of the specificity of USP18 toward ISG15
Basters, Anja, Geurink, Paul P, Röcker, Annika, Witting, Katharina F, Tadayon, Roya, Hess, Sandra, Semrau, Marta S, Storici, Paola, Ovaa, Huib, Knobeloch, Klaus-Peter, Fritz, Günter
Published in Nature structural & molecular biology (01.03.2017)
Published in Nature structural & molecular biology (01.03.2017)
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Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection
Mukherjee, Rukmini, Bhattacharya, Anshu, Bojkova, Denisa, Mehdipour, Ahmad Reza, Shin, Donghyuk, Khan, Khadija Shahed, Hei-Yin Cheung, Hayley, Wong, Kam-Bo, Ng, Wai-Lung, Cinatl, Jindrich, Geurink, Paul P., van der Heden van Noort, Gerbrand J., Rajalingam, Krishnaraj, Ciesek, Sandra, Hummer, Gerhard, Dikic, Ivan
Published in The Journal of biological chemistry (01.08.2021)
Published in The Journal of biological chemistry (01.08.2021)
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Journal Article
Identification and characterization of diverse OTU deubiquitinases in bacteria
Schubert, Alexander F, Nguyen, Justine V, Franklin, Tyler G, Geurink, Paul P, Roberts, Cameron G, Sanderson, Daniel J, Miller, Lauren N, Ovaa, Huib, Hofmann, Kay, Pruneda, Jonathan N, Komander, David
Published in The EMBO journal (03.08.2020)
Published in The EMBO journal (03.08.2020)
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Journal Article
Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne
Mevissen, Tycho E T, Kulathu, Yogesh, Mulder, Monique P C, Geurink, Paul P, Maslen, Sarah L, Gersch, Malte, Elliott, Paul R, Burke, John E, van Tol, Bianca D M, Akutsu, Masato, Oualid, Farid El, Kawasaki, Masato, Freund, Stefan M V, Ovaa, Huib, Komander, David
Published in Nature (London) (20.10.2016)
Published in Nature (London) (20.10.2016)
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Journal Article
On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases
Ekkebus, Reggy, van Kasteren, Sander I, Kulathu, Yogesh, Scholten, Arjen, Berlin, Ilana, Geurink, Paul P, de Jong, Annemieke, Goerdayal, Soenita, Neefjes, Jacques, Heck, Albert J. R, Komander, David, Ovaa, Huib
Published in Journal of the American Chemical Society (27.02.2013)
Published in Journal of the American Chemical Society (27.02.2013)
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Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis
Liu, Sijia, González-Prieto, Román, Zhang, Mengdi, Geurink, Paul P, Kooij, Raymond, Iyengar, Prasanna Vasudevan, van Dinther, Maarten, Bos, Erik, Zhang, Xiaobing, Le Dévédec, Sylvia E, van de Water, Bob, Koning, Roman I, Zhu, Hong-Jian, Mesker, Wilma E, Vertegaal, Alfred C O, Ovaa, Huib, Zhang, Long, Martens, John W M, Ten Dijke, Peter
Published in Clinical cancer research (15.03.2020)
Published in Clinical cancer research (15.03.2020)
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Journal Article
Catching a DUB in the act: novel ubiquitin-based active site directed probes
Ekkebus, Reggy, Flierman, Dennis, Geurink, Paul P, Ovaa, Huib
Published in Current opinion in chemical biology (01.12.2014)
Published in Current opinion in chemical biology (01.12.2014)
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Journal Article
Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C‑Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos
Kooij, Raymond, Liu, Sijia, Sapmaz, Aysegul, Xin, Bo-Tao, Janssen, George M. C, van Veelen, Peter A, Ovaa, Huib, Dijke, Peter ten, Geurink, Paul P
Published in Journal of the American Chemical Society (30.09.2020)
Published in Journal of the American Chemical Society (30.09.2020)
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Journal Article
Bacterial esterases reverse lipopolysaccharide ubiquitylation to block host immunity
Szczesna, Magdalena, Huang, Yizhou, Lacoursiere, Rachel E., Bonini, Francesca, Pol, Vito, Koc, Fulya, Ward, Beatrice, Geurink, Paul P., Pruneda, Jonathan N., Thurston, Teresa L.M.
Published in Cell host & microbe (12.06.2024)
Published in Cell host & microbe (12.06.2024)
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Journal Article
Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies
Swatek, Kirby N., Aumayr, Martina, Pruneda, Jonathan N., Visser, Linda J., Berryman, Stephen, Kueck, Anja F., Geurink, Paul P., Ovaa, Huib, van Kuppeveld, Frank J. M., Tuthill, Tobias J., Skern, Tim, Komander, David
Published in Proceedings of the National Academy of Sciences - PNAS (06.03.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (06.03.2018)
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Journal Article
USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism
Gan, Jin, Pinto-Fernández, Adán, Flierman, Dennis, Akkermans, Jimmy J L L, O'Brien, Darragh P, Greenwood, Helene, Scott, Hannah Claire, Fritz, Günter, Knobeloch, Klaus-Peter, Neefjes, Jacques, van Dam, Hans, Ovaa, Huib, Ploegh, Hidde L, Kessler, Benedikt M, Geurink, Paul P, Sapmaz, Aysegul
Published in Proceedings of the National Academy of Sciences - PNAS (12.12.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (12.12.2023)
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Journal Article
Development of Inhibitors, Probes, and PROTAC Provides a Complete Toolbox to Study PARK7 in the Living Cell
Jia, Yuqing, Oyken, Merve, Kim, Robbert Q., Tjokrodirijo, Rayman T.N., de Ru, Arnoud H., Janssen, Antonius P. A., Hacker, Stephan M., van Veelen, Peter A., Geurink, Paul P., Sapmaz, Aysegul
Published in Journal of medicinal chemistry (23.05.2024)
Published in Journal of medicinal chemistry (23.05.2024)
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