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Kim, Hyunho, Xu, Hangxue, Yao, Qin, Li, Weizhe, Huang, Qiong, Outeda, Patricia, Cebotaru, Valeriu, Chiaravalli, Marco, Boletta, Alessandra, Piontek, Klaus, Germino, Gregory G, Weinman, Edward J, Watnick, Terry, Qian, Feng
Published in Nature communications (18.11.2014)
Published in Nature communications (18.11.2014)
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Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease
Menezes, Luis F., Lin, Cheng-Chao, Zhou, Fang, Germino, Gregory G.
Published in EBioMedicine (01.03.2016)
Published in EBioMedicine (01.03.2016)
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In vivo Polycystin-1 interactome using a novel Pkd1 knock-in mouse model
Lin, Cheng-Chao, Menezes, Luis F, Qiu, Jiahe, Pearson, Elisabeth, Zhou, Fang, Ishimoto, Yu, Anderson, D Eric, Germino, Gregory G
Published in PloS one (04.08.2023)
Published in PloS one (04.08.2023)
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Polycystin Signaling Is Required for Directed Endothelial Cell Migration and Lymphatic Development
Outeda, Patricia, Huso, David L., Fisher, Steven A., Halushka, Marc K., Kim, Hyunho, Qian, Feng, Germino, Gregory G., Watnick, Terry
Published in Cell reports (Cambridge) (01.05.2014)
Published in Cell reports (Cambridge) (01.05.2014)
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TRPP2 and TRPV4 form a polymodal sensory channel complex
Köttgen, Michael, Buchholz, Björn, Garcia-Gonzalez, Miguel A, Kotsis, Fruzsina, Fu, Xiao, Doerken, Mara, Boehlke, Christopher, Steffl, Daniel, Tauber, Robert, Wegierski, Tomasz, Nitschke, Roland, Suzuki, Makoto, Kramer-Zucker, Albrecht, Germino, Gregory G, Watnick, Terry, Prenen, Jean, Nilius, Bernd, Kuehn, E. Wolfgang, Walz, Gerd
Published in The Journal of cell biology (11.08.2008)
Published in The Journal of cell biology (11.08.2008)
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Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1
Distefano, Gianfranco, Boca, Manila, Rowe, Isaline, Wodarczyk, Claas, Ma, Li, Piontek, Klaus B., Germino, Gregory G., Pandolfi, Pier Paolo, Boletta, Alessandra
Published in Molecular and Cellular Biology (01.05.2009)
Published in Molecular and Cellular Biology (01.05.2009)
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The mTOR Pathway Is Regulated by Polycystin-1, and Its Inhibition Reverses Renal Cystogenesis in Polycystic Kidney Disease
Shillingford, Jonathan M., Murcia, Noel S., Larson, Claire H., Low, Seng Hui, Hedgepeth, Ryan, Brown, Nicole, Flask, Chris A., Novick, Andrew C., Goldfarb, David A., Kramer-Zucker, Albrecht, Walz, Gerd, Piontek, Klaus B., Germino, Gregory G., Weimbs, Thomas
Published in Proceedings of the National Academy of Sciences - PNAS (04.04.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (04.04.2006)
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Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier
Menezes, Luis F, Zhou, Fang, Patterson, Andrew D, Piontek, Klaus B, Krausz, Kristopher W, Gonzalez, Frank J, Germino, Gregory G
Published in PLoS genetics (01.11.2012)
Published in PLoS genetics (01.11.2012)
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Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function
Lee, Yin Loon, Santé, Joshua, Comerci, Colin J, Cyge, Benjamin, Menezes, Luis F, Li, Feng-Qian, Germino, Gregory G, Moerner, W E, Takemaru, Ken-Ichi, Stearns, Tim
Published in Molecular biology of the cell (01.10.2014)
Published in Molecular biology of the cell (01.10.2014)
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Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure
Yu, Shengqiang, Hackmann, Karl, Gao, Jianggang, He, Xiaobing, Piontek, Klaus, García González, Miguel A, Menezes, Luis F, Xu, Hangxue, Germino, Gregory G, Zuo, Jian, Qian, Feng
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2007)
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Intragenic motifs regulate the transcriptional complexity of Pkhd1/PKHD1
Boddu, Ravindra, Yang, Chaozhe, O’Connor, Amber K., Hendrickson, Robert Curtis, Boone, Braden, Cui, Xiangqin, Garcia-Gonzalez, Miguel, Igarashi, Peter, Onuchic, Luiz F., Germino, Gregory G., Guay-Woodford, Lisa M.
Published in Journal of molecular medicine (Berlin, Germany) (01.10.2014)
Published in Journal of molecular medicine (Berlin, Germany) (01.10.2014)
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Pkd1 and Pkd2 are required for normal placental development
Garcia-Gonzalez, Miguel A, Outeda, Patricia, Zhou, Qin, Zhou, Fang, Menezes, Luis F, Qian, Feng, Huso, David L, Germino, Gregory G, Piontek, Klaus B, Watnick, Terry
Published in PloS one (16.09.2010)
Published in PloS one (16.09.2010)
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NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology
Kaimori, Jun-Ya, Lin, Cheng-Chao, Outeda, Patricia, Garcia-Gonzalez, Miguel A, Menezes, Luis F, Hartung, Erum A, Li, Ao, Wu, Guanqing, Fujita, Hideaki, Sato, Yasunori, Nakanuma, Yasuni, Yamamoto, Satoko, Ichimaru, Naotsugu, Takahara, Shiro, Isaka, Yoshitaka, Watnick, Terry, Onuchic, Luiz F, Guay-Woodford, Lisa M, Germino, Gregory G
Published in Scientific reports (10.08.2017)
Published in Scientific reports (10.08.2017)
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Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents
Guggino, William B, Germino, Gregory G, Hanaoka, Kazushige, Qian, Feng, Boletta, Alessandra, Bhunia, Anil K, Piontek, Klaus, Tsiokas, Leonidas, Sukhatme, Vikas P
Published in Nature (London) (21.12.2000)
Published in Nature (London) (21.12.2000)
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Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway
Garcia-Gonzalez, Miguel A., Menezes, Luis F., Piontek, Klaus B., Kaimori, Junya, Huso, David L., Watnick, Terry, Onuchic, Luiz F., Guay-Woodford, Lisa M., Germino, Gregory G.
Published in Human molecular genetics (15.08.2007)
Published in Human molecular genetics (15.08.2007)
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Journal Article
PKHD1, the Polycystic Kidney and Hepatic Disease 1 Gene, Encodes a Novel Large Protein Containing Multiple Immunoglobulin-Like Plexin-Transcription–Factor Domains and Parallel Beta-Helix 1 Repeats
Onuchic, Luiz F., Furu, Laszlo, Nagasawa, Yasuyuki, Hou, Xiaoying, Eggermann, Thomas, Ren, Zhiyong, Bergmann, Carsten, Senderek, Jan, Esquivel, Ernie, Zeltner, Raoul, Rudnik-Schöneborn, Sabine, Mrug, Michael, Sweeney, William, Avner, Ellis D., Zerres, Klaus, Guay-Woodford, Lisa M., Somlo, Stefan, Germino, Gregory G.
Published in American journal of human genetics (01.05.2002)
Published in American journal of human genetics (01.05.2002)
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