Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
Gerlinger, Marco, Rowan, Andrew J, Horswell, Stuart, Larkin, James, Endesfelder, David, Gronroos, Eva, Martinez, Pierre, Matthews, Nicholas, Stewart, Aengus, Tarpey, Patrick, Varela, Ignacio, Phillimore, Benjamin, Begum, Sharmin, McDonald, Neil Q, Butler, Adam, Jones, David, Raine, Keiran, Latimer, Calli, Santos, Claudio R, Nohadani, Mahrokh, Eklund, Aron C, Spencer-Dene, Bradley, Clark, Graham, Pickering, Lisa, Stamp, Gordon, Gore, Martin, Szallasi, Zoltan, Downward, Julian, Futreal, P. Andrew, Swanton, Charles
Published in The New England journal of medicine (08.03.2012)
Published in The New England journal of medicine (08.03.2012)
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Journal Article
Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
von Loga, Katharina, Woolston, Andrew, Punta, Marco, Barber, Louise J., Griffiths, Beatrice, Semiannikova, Maria, Spain, Georgia, Challoner, Benjamin, Fenwick, Kerry, Simon, Ronald, Marx, Andreas, Sauter, Guido, Lise, Stefano, Matthews, Nik, Gerlinger, Marco
Published in Nature communications (16.01.2020)
Published in Nature communications (16.01.2020)
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Journal Article
Classifying the evolutionary and ecological features of neoplasms
Maley, Carlo C., Aktipis, Athena, Graham, Trevor A., Sottoriva, Andrea, Boddy, Amy M., Janiszewska, Michalina, Silva, Ariosto S., Gerlinger, Marco, Yuan, Yinyin, Pienta, Kenneth J., Anderson, Karen S., Gatenby, Robert, Swanton, Charles, Posada, David, Wu, Chung-I, Schiffman, Joshua D., Hwang, E. Shelley, Polyak, Kornelia, Anderson, Alexander R. A., Brown, Joel S., Greaves, Mel, Shibata, Darryl
Published in Nature reviews. Cancer (01.10.2017)
Published in Nature reviews. Cancer (01.10.2017)
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Journal Article
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
Gerlinger, Marco, Horswell, Stuart, Larkin, James, Rowan, Andrew J, Salm, Max P, Varela, Ignacio, Fisher, Rosalie, McGranahan, Nicholas, Matthews, Nicholas, Santos, Claudio R, Martinez, Pierre, Phillimore, Benjamin, Begum, Sharmin, Rabinowitz, Adam, Spencer-Dene, Bradley, Gulati, Sakshi, Bates, Paul A, Stamp, Gordon, Pickering, Lisa, Gore, Martin, Nicol, David L, Hazell, Steven, Futreal, P Andrew, Stewart, Aengus, Swanton, Charles
Published in Nature genetics (01.03.2014)
Published in Nature genetics (01.03.2014)
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Journal Article
Cancer: evolution within a lifetime
Gerlinger, Marco, McGranahan, Nicholas, Dewhurst, Sally M, Burrell, Rebecca A, Tomlinson, Ian, Swanton, Charles
Published in Annual review of genetics (01.01.2014)
Published in Annual review of genetics (01.01.2014)
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Journal Article
Systematic Evaluation of the Prognostic Impact and Intratumour Heterogeneity of Clear Cell Renal Cell Carcinoma Biomarkers
Gulati, Sakshi, Martinez, Pierre, Joshi, Tejal, Birkbak, Nicolai Juul, Santos, Claudio R, Rowan, Andrew J, Pickering, Lisa, Gore, Martin, Larkin, James, Szallasi, Zoltan, Bates, Paul A, Swanton, Charles, Gerlinger, Marco
Published in European urology (01.11.2014)
Published in European urology (01.11.2014)
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Journal Article
Comparison of a coaxial versus non-coaxial liver biopsy technique in an oncological setting: diagnostic yield, complications and seeding risk
Fotiadis, Nicos, De Paepe, Katja N., Bonne, Lawrence, Khan, Nasir, Riddell, Angela, Turner, Nicholas, Starling, Naureen, Gerlinger, Marco, Rao, Sheela, Chau, Ian, Cunningham, David, Koh, Dow-Mu
Published in European radiology (01.12.2020)
Published in European radiology (01.12.2020)
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Journal Article
The promise of circulating tumor cell analysis in cancer management
Mateo, Joaquin, Gerlinger, Marco, Rodrigues, Daniel Nava, de Bono, Johann S
Published in Genome biology (30.08.2014)
Published in Genome biology (30.08.2014)
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Journal Article
Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment
Newey, Alice, Griffiths, Beatrice, Michaux, Justine, Pak, Hui Song, Stevenson, Brian J., Woolston, Andrew, Semiannikova, Maria, Spain, Georgia, Barber, Louise J., Matthews, Nik, Rao, Sheela, Watkins, David, Chau, Ian, Coukos, George, Racle, Julien, Gfeller, David, Starling, Naureen, Cunningham, David, Bassani-Sternberg, Michal, Gerlinger, Marco
Published in Journal for immunotherapy of cancer (18.11.2019)
Published in Journal for immunotherapy of cancer (18.11.2019)
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Journal Article
Author Correction: Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
von Loga, Katharina, Woolston, Andrew, Punta, Marco, Barber, Louise J., Griffiths, Beatrice, Semiannikova, Maria, Spain, Georgia, Challoner, Benjamin, Fenwick, Kerry, Simon, Ronald, Marx, Andreas, Sauter, Guido, Lise, Stefano, Matthews, Nik, Gerlinger, Marco
Published in Nature communications (29.01.2020)
Published in Nature communications (29.01.2020)
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Journal Article
Treatment and Survival Outcome of BRAF-Mutated Metastatic Colorectal Cancer: A Retrospective Matched Case-Control Study
Kayhanian, Hamzeh, Goode, Emily, Sclafani, Francesco, Ang, Joo Ern, Gerlinger, Marco, Gonzalez de Castro, David, Shepherd, Scott, Peckitt, Clare, Rao, Sheela, Watkins, David, Chau, Ian, Cunningham, David, Starling, Naureen
Published in Clinical colorectal cancer (01.03.2018)
Published in Clinical colorectal cancer (01.03.2018)
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Journal Article
Mutational signatures impact the evolution of anti-EGFR antibody resistance in colorectal cancer
Woolston, Andrew, Barber, Louise J., Griffiths, Beatrice, Pich, Oriol, Lopez-Bigas, Nuria, Matthews, Nik, Rao, Sheela, Watkins, David, Chau, Ian, Starling, Naureen, Cunningham, David, Gerlinger, Marco
Published in Nature ecology & evolution (01.07.2021)
Published in Nature ecology & evolution (01.07.2021)
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Journal Article
A novel molecular signature identifies mixed subtypes in renal cell carcinoma with poor prognosis and independent response to immunotherapy
Büttner, Florian A, Winter, Stefan, Stühler, Viktoria, Rausch, Steffen, Hennenlotter, Jörg, Füssel, Susanne, Zastrow, Stefan, Meinhardt, Matthias, Toma, Marieta, Jerónimo, Carmen, Henrique, Rui, Miranda-Gonçalves, Vera, Kröger, Nils, Ribback, Silvia, Hartmann, Arndt, Agaimy, Abbas, Stöhr, Christine, Polifka, Iris, Fend, Falko, Scharpf, Marcus, Comperat, Eva, Wasinger, Gabriel, Moch, Holger, Stenzl, Arnulf, Gerlinger, Marco, Bedke, Jens, Schwab, Matthias, Schaeffeler, Elke
Published in Genome medicine (15.09.2022)
Published in Genome medicine (15.09.2022)
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Journal Article
Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target
Gerlinger, Marco, Santos, Claudio R, Spencer-Dene, Bradley, Martinez, Pierre, Endesfelder, David, Burrell, Rebecca A, Vetter, Marcus, Jiang, Ming, Saunders, Rebecca E, Kelly, Gavin, Dykema, Karl, Rioux-Leclercq, Nathalie, Stamp, Gordon, Patard, Jean Jacques, Larkin, James, Howell, Michael, Swanton, Charles
Published in The Journal of pathology (01.06.2012)
Published in The Journal of pathology (01.06.2012)
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Journal Article
CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids
Gonzalez-Exposito, Reyes, Semiannikova, Maria, Griffiths, Beatrice, Khan, Khurum, Barber, Louise J, Woolston, Andrew, Spain, Georgia, von Loga, Katharina, Challoner, Ben, Patel, Radhika, Ranes, Michael, Swain, Amanda, Thomas, Janet, Bryant, Annette, Saffery, Claire, Fotiadis, Nicos, Guettler, Sebastian, Mansfield, David, Melcher, Alan, Powles, Thomas, Rao, Sheela, Watkins, David, Chau, Ian, Matthews, Nik, Wallberg, Fredrik, Starling, Naureen, Cunningham, David, Gerlinger, Marco
Published in Journal for immunotherapy of cancer (15.04.2019)
Published in Journal for immunotherapy of cancer (15.04.2019)
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Journal Article
Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: a retrospective analysis of five clinical trials
Juul, Nicolai, MSc, Szallasi, Zoltan, Prof, Eklund, Aron C, MSc, Li, Qiyuan, MSc, Burrell, Rebecca A, BA, Gerlinger, Marco, MD, Valero, Vicente, MD, Andreopoulou, Eleni, MD, Esteva, Francisco J, Prof, Symmans, W Fraser, Prof, Desmedt, Christine, PhD, Haibe-Kains, Benjamin, PhD, Sotiriou, Christos, MD, Pusztai, Lajos, Prof, Swanton, Charles, Dr
Published in The lancet oncology (01.04.2010)
Published in The lancet oncology (01.04.2010)
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Journal Article
Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer
Alexander, James L, Posma, Joram M, Scott, Alasdair, Poynter, Liam, Mason, Sam E, Doria, M Luisa, Herendi, Lili, Roberts, Lauren, McDonald, Julie A K, Cameron, Simon, Hughes, David J, Liska, Vaclav, Susova, Simona, Soucek, Pavel, der Sluis, Verena Horneffer-van, Gomez-Romero, Maria, Lewis, Matthew R, Hoyles, Lesley, Woolston, Andrew, Cunningham, David, Darzi, Ara, Gerlinger, Marco, Goldin, Robert, Takats, Zoltan, Marchesi, Julian R, Teare, Julian, Kinross, James
Published in Microbiome (08.05.2023)
Published in Microbiome (08.05.2023)
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Journal Article
Acquired Resistance to Crizotinib from a Mutation in CD74–ROS1
Gerlinger, Marco, Norton, Larry, Swanton, Charles, Awad, Mark M, Engelman, Jeffrey A, Shaw, Alice T
Published in The New England journal of medicine (19.09.2013)
Published in The New England journal of medicine (19.09.2013)
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Journal Article