Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
Weaver, Richard J., Blomme, Eric A., Chadwick, Amy E., Copple, Ian M., Gerets, Helga H. J., Goldring, Christopher E., Guillouzo, Andre, Hewitt, Philip G., Ingelman-Sundberg, Magnus, Jensen, Klaus Gjervig, Juhila, Satu, Klingmüller, Ursula, Labbe, Gilles, Liguori, Michael J., Lovatt, Cerys A., Morgan, Paul, Naisbitt, Dean J., Pieters, Raymond H. H., Snoeys, Jan, van de Water, Bob, Williams, Dominic P., Park, B. Kevin
Published in Nature reviews. Drug discovery (01.02.2020)
Published in Nature reviews. Drug discovery (01.02.2020)
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A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
Sison-Young, Rowena L., Lauschke, Volker M., Johann, Esther, Alexandre, Eliane, Antherieu, Sébastien, Aerts, Hélène, Gerets, Helga H. J., Labbe, Gilles, Hoët, Delphine, Dorau, Martina, Schofield, Christopher A., Lovatt, Cerys A., Holder, Julie C., Stahl, Simone H., Richert, Lysiane, Kitteringham, Neil R., Jones, Robert P., Elmasry, Mohamed, Weaver, Richard J., Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Chris E., Park, B. Kevin
Published in Archives of toxicology (01.03.2017)
Published in Archives of toxicology (01.03.2017)
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Journal Article
Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats
Richert, Lysiane, Baze, Audrey, Parmentier, Céline, Gerets, Helga H.J., Sison-Young, Rowena, Dorau, Martina, Lovatt, Cerys, Czich, Andreas, Goldring, Christopher, Park, B. Kevin, Juhila, Satu, Foster, Alison J., Williams, Dominic P.
Published in Toxicology letters (06.09.2016)
Published in Toxicology letters (06.09.2016)
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Assessing the interplay between off-target promiscuity, cytotoxicity, and tolerability in rodents to improve the safety profile of novel anti-malarial plasmepsin X inhibitors
Gerets, Helga H J, Delaunois, Annie, Cardenas, Alvaro, Class, Reiner, Fleurance, Renaud, de Haro, Teresa, Laleu, Benoît, Lowe, Martin A, Rosseels, Marie-Luce, Valentin, Jean-Pierre
Published in Toxicological sciences (01.10.2024)
Published in Toxicological sciences (01.10.2024)
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Deconvoluting and derisking QRS complex widening to improve cardiac safety profile of novel plasmepsin X antimalarials
Delaunois, Annie, Cardenas, Alvaro, de Haro, Teresa, Gerets, Helga H J, Gryshkova, Vitalina, Hebeisen, Simon, Korlowski, Chloé, Laleu, Benoit, Lowe, Martin A, Valentin, Jean-Pierre
Published in Toxicological sciences (01.10.2024)
Published in Toxicological sciences (01.10.2024)
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A cross-industry survey on photosafety evaluation of pharmaceuticals after implementation of ICH S10
Bauer, Daniel, Buckley, Lorrene A., Delafoy, Laure, Ellinger-Ziegelbauer, Heidrun, Fellows, Mick D., Gerets, Helga H.J., Howe, Jonathan, Kaijser, Gerry, Nicolette, John, Pettersen, Betty A., Schimpf, Brian
Published in Regulatory toxicology and pharmacology (01.10.2021)
Published in Regulatory toxicology and pharmacology (01.10.2021)
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Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury
Weaver, Richard J, Betts, Catherine, Blomme, Eric A G, Gerets, Helga H J, Gjervig Jensen, Klaus, Hewitt, Philip G, Juhila, Satu, Labbe, Gilles, Liguori, Michael J, Mesens, Natalie, Ogese, Monday O, Persson, Mikael, Snoeys, Jan, Stevens, James L, Walker, Tracy, Park, B Kevin
Published in Expert opinion on drug metabolism & toxicology (01.07.2017)
Published in Expert opinion on drug metabolism & toxicology (01.07.2017)
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In silico approaches in carcinogenicity hazard assessment: Current status and future needs
Tice, Raymond R., Bassan, Arianna, Amberg, Alexander, Anger, Lennart T., Beal, Marc A., Bellion, Phillip, Benigni, Romualdo, Birmingham, Jeffrey, Brigo, Alessandro, Bringezu, Frank, Ceriani, Lidia, Crooks, Ian, Cross, Kevin, Elespuru, Rosalie, Faulkner, David M., Fortin, Marie C., Fowler, Paul, Frericks, Markus, Gerets, Helga H.J., Jahnke, Gloria D., Jones, David R., Kruhlak, Naomi L., Piparo, Elena Lo, Lopez-Belmonte, Juan, Luniwal, Amarjit, Luu, Alice, Madia, Federica, Manganelli, Serena, Manickam, Balasubramanian, Mestres, Jordi, Mihalchik-Burhans, Amy L., Neilson, Louise, Pandiri, Arun, Pavan, Manuela, Rider, Cynthia V., Rooney, John P., Trejo-Martin, Alejandra, Watanabe-Sailor, Karen H., White, Angela T., Woolley, David, Myatt, Glenn J.
Published in Computational toxicology (01.11.2021)
Published in Computational toxicology (01.11.2021)
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Journal Article
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
Sison-Young, Rowena L., Lauschke, Volker M., Johann, Esther, Alexandre, Eliane, Antherieu, Sébastien, Aerts, Hélène, Gerets, Helga H. J., Labbe, Gilles, Hoët, Delphine, Dorau, Martina, Schofield, Christopher A., Lovatt, Cerys A., Holder, Julie C., Stahl, Simone H., Richert, Lysiane, Kitteringham, Neil R., Jones, Robert P., Elmasry, Mohamed, Weaver, Richard J., Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Chris E., Park, B. Kevin
Published in Archives of toxicology (01.03.2017)
Published in Archives of toxicology (01.03.2017)
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Journal Article
Multiplexing cell viability assays
Gerets, Helga H J, Dhalluin, Stéphane, Atienzar, Franck A
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2011)
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2011)
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Molecular cloning and differential expression of the cat immediate early gene c-fos
Van der Gucht, Estel, Massie, Ann, De Klerck, Bert, Peeters, Kristel, Winters, Kurt, Gerets, Helga H.J, Clerens, Stefan, Vandesande, Frans, Arckens, Lutgarde
Published in Brain research. Molecular brain research. (17.03.2003)
Published in Brain research. Molecular brain research. (17.03.2003)
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