Preclinical development of a miR-132 inhibitor for heart failure treatment
Foinquinos, Ariana, Batkai, Sandor, Genschel, Celina, Viereck, Janika, Rump, Steffen, Gyöngyösi, Mariann, Traxler, Denise, Riesenhuber, Martin, Spannbauer, Andreas, Lukovic, Dominika, Weber, Natalie, Zlabinger, Katrin, Hašimbegović, Ena, Winkler, Johannes, Fiedler, Jan, Dangwal, Seema, Fischer, Martin, de la Roche, Jeanne, Wojciechowski, Daniel, Kraft, Theresia, Garamvölgyi, Rita, Neitzel, Sonja, Chatterjee, Shambhabi, Yin, Xiaoke, Bär, Christian, Mayr, Manuel, Xiao, Ke, Thum, Thomas
Published in Nature communications (31.01.2020)
Published in Nature communications (31.01.2020)
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Journal Article
Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis
Kenneweg, Franziska, Bang, Claudia, Xiao, Ke, Boulanger, Chantal M., Loyer, Xavier, Mazlan, Stephane, Schroen, Blanche, Hermans-Beijnsberger, Steffie, Foinquinos, Ariana, Hirt, Marc N., Eschenhagen, Thomas, Funcke, Sandra, Stojanovic, Stevan, Genschel, Celina, Schimmel, Katharina, Just, Annette, Pfanne, Angelika, Scherf, Kristian, Dehmel, Susann, Raemon-Buettner, Stella M., Fiedler, Jan, Thum, Thomas
Published in Molecular therapy. Nucleic acids (06.12.2019)
Published in Molecular therapy. Nucleic acids (06.12.2019)
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Journal Article
Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study
Täubel, Jörg, Hauke, Wilfried, Rump, Steffen, Viereck, Janika, Batkai, Sandor, Poetzsch, Jenny, Rode, Laura, Weigt, Henning, Genschel, Celina, Lorch, Ulrike, Theek, Carmen, Levin, Arthur A, Bauersachs, Johann, Solomon, Scott D, Thum, Thomas
Published in European heart journal (07.01.2021)
Published in European heart journal (07.01.2021)
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Journal Article
Abstract 15205: miR-132 Inhibition Improves Myocardial Strain in a Large Animal Model of Chronic Adverse Remodeling
Batkai, Sandor, Genschel, Celina, Viereck, Janika, Rump, Steffen, Traxler, Denise, Gyongyosi, Mariann, Thum, Thomas
Published in Circulation (New York, N.Y.) (07.11.2023)
Published in Circulation (New York, N.Y.) (07.11.2023)
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Journal Article
CDR132L improves systolic and diastolic function in a large animal model of chronic heart failure
Batkai, Sandor, Genschel, Celina, Viereck, Janika, Rump, Steffen, Bär, Christian, Borchert, Tobias, Traxler, Denise, Riesenhuber, Martin, Spannbauer, Andreas, Lukovic, Dominika, Zlabinger, Katrin, Hašimbegović, Ena, Winkler, Johannes, Garamvölgyi, Rita, Neitzel, Sonja, Gyöngyösi, Mariann, Thum, Thomas
Published in European heart journal (07.01.2021)
Published in European heart journal (07.01.2021)
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Journal Article
Abstract 15096: miR-132 Inhibition Shows Anti-Hypertrophic Effects in Preclinical Heart Failure Models and in Exploratory Pharmacodynamic Parameters of a First-in-Human Phase 1b Clinical Trial
Batkai, Sandor, Genschel, Celina, Viereck, Janika, Rump, Steffen, Hauke, Wilfried, Gyongyosi, Mariann, Traxler, Denise, Hinkel, Rabea, Kupatt, Christian, Levin, Arthur A, Thum, Thomas
Published in Circulation (New York, N.Y.) (07.11.2023)
Published in Circulation (New York, N.Y.) (07.11.2023)
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Journal Article
Abstract 15259: The Novel Antisense Oligonucleotide CDR132L Improves Cardiac Function in Heart Failure Across Different Species
Viereck, Janika, Batkai, Sandor, Genschel, Celina, Rump, Steffen, Hauke, Wilfried, Gyongyosi, Mariann, Traxler, Denise, Hinkel, Rabea, Kupatt, Christian, Levin, Arthur A, Thum, Thomas
Published in Circulation (New York, N.Y.) (07.11.2023)
Published in Circulation (New York, N.Y.) (07.11.2023)
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Journal Article
Abstract 15057: miR-132 Inhibitor CDR 132L Attenuates Cardiac Remodeling by Exhibiting Anti-Fibrotic Effects
Batkai, Sandor, Genschel, Celina, Viereck, Janika, Rump, Steffen, Hauke, Wilfried, Gyongyosi, Mariann, Traxler, Denise, Hinkel, Rabea, Kupatt, Christian, Levin, Arthur A, Thum, Thomas
Published in Circulation (New York, N.Y.) (07.11.2023)
Published in Circulation (New York, N.Y.) (07.11.2023)
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Journal Article
Hypoxia-induced long non-coding RNA Malat1 is dispensable for renal ischemia/reperfusion-injury
Kölling, Malte, Genschel, Celina, Kaucsar, Tamas, Hübner, Anika, Rong, Song, Schmitt, Roland, Sörensen-Zender, Inga, Haddad, George, Kistler, Andreas, Seeger, Harald, Kielstein, Jan T., Fliser, Danilo, Haller, Hermann, Wüthrich, Rudolf, Zörnig, Martin, Thum, Thomas, Lorenzen, Johan
Published in Scientific reports (21.02.2018)
Published in Scientific reports (21.02.2018)
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Journal Article
Abstract 114: Safety And Efficacy Of CDR132L, A Novel Antisense Therapeutic Which Targets MicroRNA-132 In Heart Failure Patients
Taubel, Jorg, Hauke, Wilfried, Rump, Steffen, Viereck, Janika, Batkai, Sandor, Jenny, Poetzsch, Laura, Rode, Weigt, Henning, Genschel, Celina, Lorch, Ulrike, Theek, Carmen, Levin, Arthur A, Bauersachs, Johann B, Solomon, Scott D, Thum, Thomas
Published in Circulation research (03.09.2021)
Published in Circulation research (03.09.2021)
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