Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1
Geier, Ethan G., Schlessinger, Avner, Fan, Hao, Gable, Jonathan E., Irwin, John J., Sali, Andrej, Giacomini, Kathleen M.
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2013)
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Journal Article
Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study
Steele, Natasha Z R, Carr, Jessie S, Bonham, Luke W, Geier, Ethan G, Damotte, Vincent, Miller, Zachary A, Desikan, Rahul S, Boehme, Kevin L, Mukherjee, Shubhabrata, Crane, Paul K, Kauwe, John S K, Kramer, Joel H, Miller, Bruce L, Coppola, Giovanni, Hollenbach, Jill A, Huang, Yadong, Yokoyama, Jennifer S
Published in PLoS medicine (28.03.2017)
Published in PLoS medicine (28.03.2017)
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Journal Article
SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan
Johnson, Alyssa E., Orr, Brian O., Fetter, Richard D., Moughamian, Armen J., Primeaux, Logan A., Geier, Ethan G., Yokoyama, Jennifer S., Miller, Bruce L., Davis, Graeme W.
Published in Nature communications (21.01.2021)
Published in Nature communications (21.01.2021)
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Journal Article
Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases
Cochran, J. Nicholas, Geier, Ethan G., Bonham, Luke W., Newberry, J. Scott, Amaral, Michelle D., Thompson, Michelle L., Lasseigne, Brittany N., Karydas, Anna M., Roberson, Erik D., Cooper, Gregory M., Rabinovici, Gil D., Miller, Bruce L., Myers, Richard M., Yokoyama, Jennifer S.
Published in American journal of human genetics (07.05.2020)
Published in American journal of human genetics (07.05.2020)
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Journal Article
Expansion of highly interferon‐responsive T cells in early‐onset Alzheimer's disease
Sirkis, Daniel W., Warly Solsberg, Caroline, Johnson, Taylor P., Bonham, Luke W., Oddi, Alexis P., Geier, Ethan G., Miller, Bruce L., Rabinovici, Gil D., Yokoyama, Jennifer S.
Published in Alzheimer's & dementia (01.07.2024)
Published in Alzheimer's & dementia (01.07.2024)
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Journal Article
Role of the copper transporter, CTR1, in platinum-induced ototoxicity
More, Swati S, Akil, Omar, Ianculescu, Alexandra G, Geier, Ethan G, Lustig, Lawrence R, Giacomini, Kathleen M
Published in The Journal of neuroscience (14.07.2010)
Published in The Journal of neuroscience (14.07.2010)
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Journal Article
Exchange of Apolipoprotein A-I between Lipid-associated and Lipid-free States: A POTENTIAL TARGET FOR OXIDATIVE GENERATION OF DYSFUNCTIONAL HIGH DENSITY LIPOPROTEINS
Cavigiolio, Giorgio, Geier, Ethan G, Shao, Baohai, Heinecke, Jay W, Oda, Michael N
Published in The Journal of biological chemistry (11.06.2010)
Published in The Journal of biological chemistry (11.06.2010)
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Journal Article
Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET
Schlessinger, Avner, Geier, Ethan, Fan, Hao, Irwin, John J, Shoichet, Brian K, Giacomini, Kathleen M, Sali, Andrej
Published in Proceedings of the National Academy of Sciences - PNAS (20.09.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (20.09.2011)
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Journal Article
Radiogenomics of C9orf72 Expansion Carriers Reveals Global Transposable Element Derepression and Enables Prediction of Thalamic Atrophy and Clinical Impairment
Bonham, Luke W, Geier, Ethan G, Sirkis, Daniel W, Leong, Josiah K, Ramos, Eliana Marisa, Wang, Qing, Karydas, Anna, Lee, Suzee E, Sturm, Virginia E, Sawyer, Russell P, Friedberg, Adit, Ichida, Justin K, Gitler, Aaron D, Sugrue, Leo, Cordingley, Michael, Bee, Walter, Weber, Eckard, Kramer, Joel H, Rankin, Katherine P, Rosen, Howard J, Boxer, Adam L, Seeley, William W, Ravits, John, Miller, Bruce L, Yokoyama, Jennifer S
Published in The Journal of neuroscience (11.01.2023)
Published in The Journal of neuroscience (11.01.2023)
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Journal Article
Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer's Disease Pathology and Shows Differential Expression in Transgenic Mice
Bonham, Luke W, Geier, Ethan G, Steele, Natasha Z R, Holland, Dominic, Miller, Bruce L, Dale, Anders M, Desikan, Rahul S, Yokoyama, Jennifer S
Published in Frontiers in neuroscience (16.07.2018)
Published in Frontiers in neuroscience (16.07.2018)
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Journal Article
Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy
Sirkis, Daniel W, Warly Solsberg, Caroline, Johnson, Taylor P, Bonham, Luke W, Sturm, Virginia E, Lee, Suzee E, Rankin, Katherine P, Rosen, Howard J, Boxer, Adam L, Seeley, William W, Miller, Bruce L, Geier, Ethan G, Yokoyama, Jennifer S
Published in Genome medicine (18.07.2023)
Published in Genome medicine (18.07.2023)
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Journal Article
Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr)
Ramirez Aguilar, Laura, Acosta-Uribe, Juliana, Giraldo, Margarita M., Moreno, Sonia, Baena, Ana, Alzate, Diana, Cuastumal, Rosario, Aguillón, David, Madrigal, Lucía, Saldarriaga, Amanda, Navarro, Alexander, Garcia, Gloria P., Aguirre-Acevedo, Daniel C., Geier, Ethan G., Cochran, J. Nicholas, Quiroz, Yakeel T., Myers, Richard M., Yokoyama, Jennifer S., Kosik, Kenneth S., Lopera, Francisco
Published in Alzheimer's & dementia (01.05.2019)
Published in Alzheimer's & dementia (01.05.2019)
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Journal Article
Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins
Salphati, Laurent, Chu, Xiaoyan, Chen, Liangfu, Prasad, Bhagwat, Dallas, Shannon, Evers, Raymond, Mamaril-Fishman, Donna, Geier, Ethan G, Kehler, Jonathan, Kunta, Jeevan, Mezler, Mario, Laplanche, Loic, Pang, Jodie, Rode, Anja, Soars, Matthew G, Unadkat, Jashvant D, van Waterschoot, Robert A B, Yabut, Jocelyn, Schinkel, Alfred H, Scheer, Nico
Published in Drug metabolism and disposition (01.08.2014)
Published in Drug metabolism and disposition (01.08.2014)
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Journal Article
Recent Advances in the Genetics of Frontotemporal Dementia
Sirkis, Daniel W., Geier, Ethan G., Bonham, Luke W., Karch, Celeste M., Yokoyama, Jennifer S.
Published in Current genetic medicine reports (01.03.2019)
Published in Current genetic medicine reports (01.03.2019)
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Journal Article
Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia
Geier, Ethan G., Bourdenx, Mathieu, Storm, Nadia J., Cochran, J. Nicholas, Sirkis, Daniel W., Hwang, Ji-Hye, Bonham, Luke W., Ramos, Eliana Marisa, Diaz, Antonio, Van Berlo, Victoria, Dokuru, Deepika, Nana, Alissa L., Karydas, Anna, Balestra, Maureen E., Huang, Yadong, Russo, Silvia P., Spina, Salvatore, Grinberg, Lea T., Seeley, William W., Myers, Richard M., Miller, Bruce L., Coppola, Giovanni, Lee, Suzee E., Cuervo, Ana Maria, Yokoyama, Jennifer S.
Published in Acta neuropathologica (01.01.2019)
Published in Acta neuropathologica (01.01.2019)
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Journal Article
TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy
Alquezar, Carolina, Schoch, Kathleen M, Geier, Ethan G, Ramos, Eliana Marisa, Scrivo, Aurora, Li, Kathy H, Argouarch, Andrea R, Mlynarski, Elisabeth E, Dombroski, Beth, DeTure, Michael, Dickson, Dennis W, Yokoyama, Jennifer S, Cuervo, Ana M, Burlingame, Alma L, Schellenberg, Gerard D, Miller, Timothy M, Miller, Bruce L, Kao, Aimee W
Published in Science advances (05.11.2021)
Published in Science advances (05.11.2021)
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Journal Article
Genetic Variation in the Androgen Receptor and Measures of Plasma Testosterone Levels Suggest Androgen Dysfunction in Alzheimer's Disease
Carr, Jessie S, Bonham, Luke W, Morgans, Alicia K, Ryan, Charles J, Yokoyama, Jennifer S, Geier, Ethan G
Published in Frontiers in neuroscience (07.08.2018)
Published in Frontiers in neuroscience (07.08.2018)
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