Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling
Fan, Mengyang, Lu, Wenchao, Che, Jianwei, Kwiatkowski, Nicholas P, Gao, Yang, Seo, Hyuk-Soo, Ficarro, Scott B, Gokhale, Prafulla C, Liu, Yao, Geffken, Ezekiel A, Lakhani, Jimit, Song, Kijun, Kuljanin, Miljan, Ji, Wenzhi, Jiang, Jie, He, Zhixiang, Tse, Jason, Boghossian, Andrew S, Rees, Matthew G, Ronan, Melissa M, Roth, Jennifer A, Mancias, Joseph D, Marto, Jarrod A, Dhe-Paganon, Sirano, Zhang, Tinghu, Gray, Nathanael S
Published in eLife (27.10.2022)
Published in eLife (27.10.2022)
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Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy
Jiang, Liwei, Wang, Yi-Jun, Zhao, Jing, Uehara, Mayuko, Hou, Qingming, Kasinath, Vivek, Ichimura, Takaharu, Banouni, Naima, Dai, Li, Li, Xiaofei, Greiner, Dale L., Shultz, Leonard D., Zhang, Xiaolong, Sun, Zhen-Yu Jim, Curtin, Ian, Vangos, Nicholas E., Yeoh, Zoe C., Geffken, Ezekiel A., Seo, Hyuk-Soo, Liu, Ze-Xian, Heffron, Gregory J., Shah, Khalid, Dhe-Paganon, Sirano, Abdi, Reza
Published in Cell (25.11.2020)
Published in Cell (25.11.2020)
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Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival
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Published in The Journal of cell biology (04.01.2021)
Published in The Journal of cell biology (04.01.2021)
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Identification of a potent and selective covalent Pin1 inhibitor
Pinch, Benika J., Doctor, Zainab M., Nabet, Behnam, Browne, Christopher M., Seo, Hyuk-Soo, Mohardt, Mikaela L., Kozono, Shingo, Lian, Xiaolan, Manz, Theresa D., Chun, Yujin, Kibe, Shin, Zaidman, Daniel, Daitchman, Dina, Yeoh, Zoe C., Vangos, Nicholas E., Geffken, Ezekiel A., Tan, Li, Ficarro, Scott B., London, Nir, Marto, Jarrod A., Buratowski, Stephen, Dhe-Paganon, Sirano, Zhou, Xiao Zhen, Lu, Kun Ping, Gray, Nathanael S.
Published in Nature chemical biology (01.09.2020)
Published in Nature chemical biology (01.09.2020)
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Journal Article
Regulation of GTPase function by autophosphorylation
Johnson, Christian W., Seo, Hyuk-Soo, Terrell, Elizabeth M., Yang, Moon-Hee, KleinJan, Fenneke, Gebregiworgis, Teklab, Gasmi-Seabrook, Genevieve M.C., Geffken, Ezekiel A., Lakhani, Jimit, Song, Kijun, Bashyal, Puspalata, Popow, Olesja, Paulo, Joao A., Liu, Andrea, Mattos, Carla, Marshall, Christopher B., Ikura, Mitsuhiko, Morrison, Deborah K., Dhe-Paganon, Sirano, Haigis, Kevin M.
Published in Molecular cell (03.03.2022)
Published in Molecular cell (03.03.2022)
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Journal Article
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo
Dubiella, Christian, Pinch, Benika J., Koikawa, Kazuhiro, Zaidman, Daniel, Poon, Evon, Manz, Theresa D., Nabet, Behnam, He, Shuning, Resnick, Efrat, Rogel, Adi, Langer, Ellen M., Daniel, Colin J., Seo, Hyuk-Soo, Chen, Ying, Adelmant, Guillaume, Sharifzadeh, Shabnam, Ficarro, Scott B., Jamin, Yann, Martins da Costa, Barbara, Zimmerman, Mark W., Lian, Xiaolan, Kibe, Shin, Kozono, Shingo, Doctor, Zainab M., Browne, Christopher M., Yang, Annan, Stoler-Barak, Liat, Shah, Richa B., Vangos, Nicholas E., Geffken, Ezekiel A., Oren, Roni, Koide, Eriko, Sidi, Samuel, Shulman, Ziv, Wang, Chu, Marto, Jarrod A., Dhe-Paganon, Sirano, Look, Thomas, Zhou, Xiao Zhen, Lu, Kun Ping, Sears, Rosalie C., Chesler, Louis, Gray, Nathanael S., London, Nir
Published in Nature chemical biology (01.09.2021)
Published in Nature chemical biology (01.09.2021)
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Journal Article
Fast transport of RNA granules by direct interactions with KIF5A/KLC1 motors prevents axon degeneration
Segal, Rosalind A, Hyuk-Soo Seo, Adelmant, Guillaume, Walensky, Loren, Marto, Jarrod A, Dhe-Paganon, Sirano, Fukuda, Yusuke, Pazyra-Murphy, Maria F, Tasdemir-Yilmaz, Ozge E, Li, Yihang, Rose, Lillian, Yeoh, Zoe C, Vangos, Nicholas E, Geffken, Ezekiel A, Bird, Gregory H
Published in bioRxiv (03.02.2020)
Published in bioRxiv (03.02.2020)
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Paper
Covalent Disruptor of YAP-TEAD Association Suppresses Defective Hippo Signaling
Fan, Mengyang, Lu, Wenchao, Che, Jianwei, Kwiatkowski, Nicholas P, Gao, Yang, Hyuk-Soo Seo, Ficarro, Scott B, Gokhale, Prafulla C, Liu, Yao, Geffken, Ezekiel A, Lakhani, Jimit, Song, Kijun, Miljan Kuljanin, Ji, Wenzhi, Jiang, Jie, He, Zhixiang, Tse, Jason, Boghossian, Andrew S, Rees, Matthew G, Ronan, Melissa M, Roth, Jennifer A, Mancias, Joseph D, Marto, Jarrod A, Dhe-Paganon, Sirano, Zhang, Tinghu, Gray, Nathanael
Published in bioRxiv (11.05.2022)
Published in bioRxiv (11.05.2022)
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Paper
Expanding the HDAC druggable landscape beyond enzymatic activity
Olivet, Julien, Choi, Soon Gang, Sierra, Salvador, O'grady, Tina M, Mario De La Fuente Revenga, Laval, Florent, Botchkarev, Vladimir V, Gorgulla, Christoph, Coote, Paul W, Blavier, Jeremy, Geffken, Ezekiel A, Lakhani, Jimit, Song, Kijun, Yeoh, Zoe C, Hu, Bin, Varca, Anthony C, Bruyr, Jonathan, Ibrahim, Samira, Jivanjee, Tasneem, Bromley, Joshua D, Nyquist, Sarah K, Richardson, Aaron, Hong, Yue, Wang, Yang, Calonghi, Natalia, Stephan, Alessandra, Spirohn, Kerstin, Vertommen, Didier, Baietti, Maria F, Lemmens, Irma, Hyuk-Soo Seo, Dozmorov, Mikhail G, Willems, Luc, Tavernier, Jan, Das, Kalyan, Leucci, Eleonora, Hochkoeppler, Alejandro, Zhen-Yu, Jim Sun, Calderwood, Michael A, Tong, Hao, Shalek, Alex K, Hill, David E, Boeszoermenyi, Andras, Arthanari, Haribabu, Buhrlage, Sara J, Dhe-Paganon, Sirano, Gonzalez-Maeso, Javier, Dequiedt, Franck, Twizere, Jean-Claude, Vidal, Marc
Published in bioRxiv (14.01.2023)
Published in bioRxiv (14.01.2023)
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Paper
Regulation of GTPase function by autophosphorylation
Johnson, Christian W, Hyuk-Soo Seo, Terrell, Elizabeth M, Kleinjan, Fenneke, Gebregiworgis, Teklab, Gasmi-Seabrook, Genevieve M C, Geffken, Ezekiel A, Lakhani, Jimit, Song, Kijun, Popow, Olesja, Paulo, Joao A, Liu, Andrea, Mattos, Carla, Marshall, Christopher B, Ikura, Mitsuhiko, Morrison, Deborah K, Dhe-Paganon, Sirano, Haigis, Kevin M
Published in bioRxiv (23.06.2021)
Published in bioRxiv (23.06.2021)
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Paper
Sulfopin, a selective covalent inhibitor of Pin1, blocks Myc-driven tumor initiation and growth in vivo
Dubiella, Christian, Pinch, Benika J, Zaidman, Daniel, Manz, Theresa D, Poon, Evon, He, Shuning, Resnick, Efrat, Langer, Ellen M, Daniel, Colin J, Hyuk-Soo Seo, Chen, Ying, Ficarro, Scott B, Jamin, Yann, Lian, Xiaolan, Kibe, Shin, Kozono, Shingo, Koikawa, Kazuhiro, Doctor, Zainab M, Nabet, Behnam, Browne, Christopher M, Annan Yang, Stoler-Barak, Liat, Shah, Richa B, Vangos, Nicholas E, Geffken, Ezekiel A, Oren, Roni, Sidi, Samuel, Shulman, Ziv, Chu, Wang, Marto, Jarrod A, Dhe-Paganon, Sirano, Look, Thomas, Zhou, Xiao Zhen, Lu, Kun Ping, Sears, Rosalie C, Chesler, Louis, Gray, Nathanael S, London, Nir
Published in bioRxiv (21.03.2020)
Published in bioRxiv (21.03.2020)
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