Notch1 Receptor Regulates AKT Protein Activation Loop (Thr308) Dephosphorylation through Modulation of the PP2A Phosphatase in Phosphatase and Tensin Homolog (PTEN)-null T-cell Acute Lymphoblastic Leukemia Cells
Hales, Eric C., Orr, Steven M., Larson Gedman, Amanda, Taub, Jeffrey W., Matherly, Larry H.
Published in The Journal of biological chemistry (02.08.2013)
Published in The Journal of biological chemistry (02.08.2013)
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Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss
Medyouf, Hind, Gao, Xiuhua, Armstrong, Florence, Gusscott, Samuel, Liu, Qing, Gedman, Amanda Larson, Matherly, Larry H., Schultz, Kirk R., Pflumio, Francoise, You, Mingjian James, Weng, Andrew P.
Published in Blood (11.02.2010)
Published in Blood (11.02.2010)
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Journal Article
The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias
Andersson, Anna K, Ma, Jing, Wang, Jianmin, Chen, Xiang, Gedman, Amanda Larson, Dang, Jinjun, Nakitandwe, Joy, Holmfeldt, Linda, Parker, Matthew, Easton, John, Huether, Robert, Kriwacki, Richard, Rusch, Michael, Wu, Gang, Li, Yongjin, Mulder, Heather, Raimondi, Susana, Pounds, Stanley, Kang, Guolian, Shi, Lei, Becksfort, Jared, Gupta, Pankaj, Payne-Turner, Debbie, Vadodaria, Bhavin, Boggs, Kristy, Yergeau, Donald, Manne, Jayanthi, Song, Guangchun, Edmonson, Michael, Nagahawatte, Panduka, Wei, Lei, Cheng, Cheng, Pei, Deqing, Sutton, Rosemary, Venn, Nicola C, Chetcuti, Albert, Rush, Amanda, Catchpoole, Daniel, Heldrup, Jesper, Fioretos, Thoas, Lu, Charles, Ding, Li, Pui, Ching-Hon, Shurtleff, Sheila, Mullighan, Charles G, Mardis, Elaine R, Wilson, Richard K, Gruber, Tanja A, Zhang, Jinghui, Downing, James R
Published in Nature genetics (01.04.2015)
Published in Nature genetics (01.04.2015)
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Journal Article
The genomic landscape of core-binding factor acute myeloid leukemias
Faber, Zachary J, Chen, Xiang, Gedman, Amanda Larson, Boggs, Kristy, Cheng, Jinjun, Ma, Jing, Radtke, Ina, Chao, Jyh-Rong, Walsh, Michael P, Song, Guangchun, Andersson, Anna K, Dang, Jinjun, Dong, Li, Liu, Yu, Huether, Robert, Cai, Zhongling, Mulder, Heather, Wu, Gang, Edmonson, Michael, Rusch, Michael, Qu, Chunxu, Li, Yongjin, Vadodaria, Bhavin, Wang, Jianmin, Hedlund, Erin, Cao, Xueyuan, Yergeau, Donald, Nakitandwe, Joy, Pounds, Stanley B, Shurtleff, Sheila, Fulton, Robert S, Fulton, Lucinda L, Easton, John, Parganas, Evan, Pui, Ching-Hon, Rubnitz, Jeffrey E, Ding, Li, Mardis, Elaine R, Wilson, Richard K, Gruber, Tanja A, Mullighan, Charles G, Schlenk, Richard F, Paschka, Peter, Döhner, Konstanze, Döhner, Hartmut, Bullinger, Lars, Zhang, Jinghui, Klco, Jeffery M, Downing, James R
Published in Nature genetics (01.12.2016)
Published in Nature genetics (01.12.2016)
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An Inv(16)(p13.3q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein Defines an Aggressive Subtype of Pediatric Acute Megakaryoblastic Leukemia
Gruber, Tanja A., Larson Gedman, Amanda, Zhang, Jinghui, Koss, Cary S., Marada, Suresh, Ta, Huy Q., Chen, Shann-Ching, Su, Xiaoping, Ogden, Stacey K., Dang, Jinjun, Wu, Gang, Gupta, Vedant, Andersson, Anna K., Pounds, Stanley, Shi, Lei, Easton, John, Barbato, Michael I., Mulder, Heather L., Manne, Jayanthi, Wang, Jianmin, Rusch, Michael, Ranade, Swati, Ganti, Ramapriya, Parker, Matthew, Ma, Jing, Radtke, Ina, Ding, Li, Cazzaniga, Giovanni, Biondi, Andrea, Kornblau, Steven M., Ravandi, Farhad, Kantarjian, Hagop, Nimer, Stephen D., Döhner, Konstanze, Döhner, Hartmut, Ley, Timothy J., Ballerini, Paola, Shurtleff, Sheila, Tomizawa, Daisuke, Adachi, Souichi, Hayashi, Yasuhide, Tawa, Akio, Shih, Lee-Yung, Liang, Der-Cherng, Rubnitz, Jeffrey E., Pui, Ching-Hon, Mardis, Elaine R., Wilson, Richard K., Downing, James R.
Published in Cancer cell (13.11.2012)
Published in Cancer cell (13.11.2012)
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AMKL chimeric transcription factors are potent inducers of leukemia
Dang, J, Nance, S, Ma, J, Cheng, J, Walsh, M P, Vogel, P, Easton, J, Song, G, Rusch, M, Gedman, A L, Koss, C, Downing, J R, Gruber, T A
Published in Leukemia (01.10.2017)
Published in Leukemia (01.10.2017)
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The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group
Larson Gedman, A, Chen, Q, Kugel Desmoulin, S, Ge, Y, LaFiura, K, Haska, C L, Cherian, C, Devidas, M, Linda, S B, Taub, J W, Matherly, L H
Published in Leukemia (01.08.2009)
Published in Leukemia (01.08.2009)
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Journal Article
Abstract 4116: Notch1 regulates AKT-T308 dephosphorylation through modulation of the PP2A phosphatase in GSI-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells
Hales, Eric Christopher, Orr, Steven M., Larson Gedman, Amanda, Taub, Jeffrey W., Matherly, Larry H.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Journal Article
Novel AMKL Chimeric Transcription Factors Are Potent Inducers of Leukemia with Unique Mechanisms of Leukemogenesis
Dang, Jinjun, Nance, Stephanie, Gedman, Amanda Larson, Cheng, Jinjun, Ma, Jing, Walsh, Michael P, Koss, Cary, Vogel, Peter, Downing, James R, Gruber, Tanja A
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Journal Article
Abstract A15: The landscape of somatic mutations in the core-binding factor acute myeloid leukemias
Gedman, Amanda Larson, Cheng, Jinjun, Chen, Xiang, Radtke, Ina, Andersson, Anna, Mulder, Heather, Boggs, Kristy, Vadodaria, Bhavin, Yergeau, Donald, Nakitandwe, Joy, Bullinger, Lars, Kuehn, Michael, Doehner, Hartmut, Doehner, Konstanze, Shurtleff, Sheila, Easton, John, Wilson, Richard, Zhang, Jinghui, Downing, James R.
Published in Cancer research (Chicago, Ill.) (15.10.2014)
Published in Cancer research (Chicago, Ill.) (15.10.2014)
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Journal Article
Incidence of Germline Mutations in Cancer-Predisposition Genes in Children with Hematologic Malignancies: a Report from the Pediatric Cancer Genome Project
Walsh, Michael, Wu, Gang, Edmonson, Michael, Gruber, Tanja A, Easton, John, Yergeau, Donald, Vadodaria, Bhavin, Ma, Xiaotu, Chen, Xiang, McGee, Rose, Odom, Christine, Shurtleff, Sheila A, Parker, Matthew, Rusch, Michael, Hedlund, Erin, Huether, Robert, Lemmon, Gordon, Nakitandwe, Joy, Becksfort, Jared, Nagahawatte, Panduka, Dong, Li, Gedman, Amanda Larson, Faber, Zachary J, Cheng, Jinjun, Dang, Jinjun, Pui, Ching-Hon, Nichols, Kim E, Gajjar, Amar, Ellison, David W, Pappo, Alberto, Mullighan, Charles G., Mardis, Elaine R, Wilson, Richard K, Zhang, Jinghui, Downing, James R
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Analysis of Clonal T-Cell Receptor Gamma Gene Rearrangements, NOTCH1, FBW7 and PTEN Mutations in Paired Pediatric T-Cell Acute Lymphoblastic Leukemia Samples at Diagnosis and Relapse Reveals Evidence of Relapse in New Leukemic Clones
Chen, Qing, Gedman, Amanda Larson, Matherly, Larry H., Taub, Jeffrey W.
Published in Blood (16.11.2008)
Published in Blood (16.11.2008)
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Journal Article
Identification and Characterization of Novel Fusion Proteins in Pediatric Acute Megakaryoblastic Leukemia
Dang, Jinjun, Gedman, Amanda Larson, Koss, Cary S, Marada, Suresh, Ogden, Stacey K, Pounds, Stanley, Chen, Shann-Ching, Ma, Jing, Zhang, Jinghui, Downing, James R, Gruber, Tanja A
Published in Clinical lymphoma, myeloma and leukemia (01.09.2014)
Published in Clinical lymphoma, myeloma and leukemia (01.09.2014)
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Journal Article
Acute T-Cell Leukemias Remain Dependent On Notch Signaling Despite PTEN and INK4A/ARF Loss
Medyouf, Hind, Gao, Xiuhua, Armstrong, Florence, Gusscott, Samuel, Liu, Qing, Gedman, Amanda Larson, Matherly, Larry, Schultz, Kirk R., Pflumio, Francoise, You, M. James, Weng, Andrew P.
Published in Blood (20.11.2009)
Published in Blood (20.11.2009)
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Journal Article
Transcriptome Sequence Analysis of Pediatric Acute Megakaryoblastic Leukemia Identifies An Inv(16)(p13.3;q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein As a Recurrent Lesion in 39% of Non-Infant Cases: A Report From the St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project
Gruber, Tanja A, Gedman, Amanda Larson, Ta, Huy Q., Zhang, Jinghui, Koss, Cary, Chen, Shann-Ching, Su, Xiaoping, Gupta, Vedant, Ogden, Stacey, Andersson, Anna K., Easton, John, Wang, Jianmin, Rusch, Michael, Ding, Li, Cazzaniga, Giovanni, Biondi, Andrea, Kornblau, Steven M., Ravandi, Farhad, Kantarjian, Hagop M., Nimer, Stephen D., Doehner, Konstanze, Doehner, Hartmut, Ley, Timothy J, Shurtleff, Sheila, Rubnitz, Jeffrey, Pui, Ching-Hon, Mardis, Elaine R., Wilson, Richard K., Downing, James R.
Published in Blood (18.11.2011)
Published in Blood (18.11.2011)
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Journal Article
Whole Genome Sequence Analysis of 22 MLL Rearranged Infant Acute Lymphoblastic Leukemias Reveals Remarkably Few Somatic Mutations: A Report From the St Jude Children‘s Research Hospital - Washington University Pediatric Cancer Genome Project
Andersson, Anna K., Ma, Jing, Wang, Jianmin, Chen, Xiang, Rusch, Michael, Wu, Gang, Easton, John, Parker, Matthew, Raimondi, Susana C., Holmfeldt, Linda, Gedman, Amanda Larson, Song, Guanchun, Becksfort, Jared, Gupta, Pankaj, Ulyanov, Anatoly, Payne-Turner, Debbie, Sutton, Rosemary, Venn, Nicola V, Chetcuti, Albert, Rush, Amanda, Catchpoole, Daniel, Heldrup, Jesper, Fioretos, Thoas, Hong, Xin, Lu, Charles, Ding, Li, Pui, Ching-Hon, Shurtleff, Sheila A, Gruber, Tanja A, Mullighan, Charles G, Mardis, Elaine R, Wilson, Richard K., Zhang, Jinghui, Downing, James R.
Published in Blood (18.11.2011)
Published in Blood (18.11.2011)
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Journal Article
Abstract 4360: Loss of NOTCH1 is associated with decreased expression of hsa-miR-125a-5p in T-cell acute lymphoblastic leukemia: Implications for using NOTCH1 inhibition in chemotherapy
Gedman, Amanda L. Larson, Dombkowski, Alan, Ge, Yubin, Taub, Jeffrey W., Matherly, Larry H.
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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