Search Results - "Gediya, Lalji K." :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Systematic Structure Modifications of Multitarget Prostate Cancer Drug Candidate Galeterone To Produce Novel Androgen Receptor Down-Regulating Agents as an Approach to Treatment of Advanced Prostate Cancer

Systematic Structure Modifications of Multitarget Prostate Cancer Drug Candidate Galeterone To Produce Novel Androgen Receptor Down-Regulating Agents as an Approach to Treatment of Advanced Prostate Cancer

by Purushottamachar, Puranik, Godbole, Abhijit M, Gediya, Lalji K, Martin, Marlena S, Vasaitis, Tadas S, Kwegyir-Afful, Andrew K, Ramalingam, Senthilmurugan, Ates-Alagoz, Zeynep, Njar, Vincent C. O
Published in Journal of medicinal chemistry (27.06.2013)

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The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis

The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis

by Ramalingam, Senthilmurugan, Ramamurthy, Vidya P, Gediya, Lalji K, Murigi, Francis N, Purushottamachar, Puranik, Huang, Weiliang, Choi, Eun Yong, Zhang, Yuji, Vasaitis, Tadas S, Kane, Maureen A, Lapidus, Rena G, Njar, Vincent C O
Published in Cancers (03.03.2019)

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Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens: Synthesis, in Vitro Biological Activity, Pharmacokinetics, and Antitumor Activity in the LAPC4 Human Prostate Cancer Xenograft Model

Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens: Synthesis, in Vitro Biological Activity, Pharmacokinetics, and Antitumor Activity in the LAPC4 Human Prostate Cancer Xenograft Model

by Handratta, Venkatesh D, Vasaitis, Tadas S, Njar, Vincent C. O, Gediya, Lalji K, Kataria, Ritesh, Chopra, Pankaj, Newman, Donnell, Farquhar, Rena, Guo, Zhiyong, Qiu, Yun, Brodie, Angela M. H
Published in Journal of medicinal chemistry (21.04.2005)

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The retinamide VNLG‐152 inhibits f‐AR/AR‐V7 and MNK–eIF4E signaling pathways to suppress EMT and castration‐resistant prostate cancer xenograft growth

The retinamide VNLG‐152 inhibits f‐AR/AR‐V7 and MNK–eIF4E signaling pathways to suppress EMT and castration‐resistant prostate cancer xenograft growth

by Ramamurthy, Vidya P., Ramalingam, Senthilmurugan, Gediya, Lalji K., Njar, Vincent C. O.
Published in The FEBS journal (01.03.2018)

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Androgen receptor inactivation contributes to antitumor efficacy of 17α-hydroxylase/17,20-lyase inhibitor 3β-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer

Androgen receptor inactivation contributes to antitumor efficacy of 17α-hydroxylase/17,20-lyase inhibitor 3β-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer

by Vasaitis, Tadas, Belosay, Aashvini, Schayowitz, Adam, Khandelwal, Aakanksha, Chopra, Pankaj, Gediya, Lalji K., Guo, Zhiyong, Fang, Hong-Bin, Njar, Vincent C.O., Brodie, Angela M.H.
Published in Molecular cancer therapeutics (01.08.2008)

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The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer

The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer

by Tran, Kim, Risingsong, Renee, Royce, Darlene B, Williams, Charlotte R, Sporn, Michael B, Pioli, Patricia A, Gediya, Lalji K, Njar, Vincent C, Liby, Karen T
Published in Carcinogenesis (New York) (01.01.2013)

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Novel galeterone analogs act independently of AR and AR-V7 for the activation of the unfolded protein response and induction of apoptosis in the CWR22Rv1 prostate cancer cell model

Novel galeterone analogs act independently of AR and AR-V7 for the activation of the unfolded protein response and induction of apoptosis in the CWR22Rv1 prostate cancer cell model

by McCarty, David J, Huang, Weiliang, Kane, Maureen A, Purushottamachar, Puranik, Gediya, Lalji K, Njar, Vincent C O
Published in Oncotarget (24.10.2017)

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Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): Head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model

Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): Head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model

by Bruno, Robert D., Vasaitis, Tadas S., Gediya, Lalji K., Purushottamachar, Puranik, Godbole, Abhijit M., Ates-Alagoz, Zeynep, Brodie, Angela M.H., Njar, Vincent C.O.
Published in Steroids (01.11.2011)

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Promise and challenges in drug discovery and development of hybrid anticancer drugs

Promise and challenges in drug discovery and development of hybrid anticancer drugs

by Gediya, Lalji K, Njar, Vincent Co
Published in Expert opinion on drug discovery (01.11.2009)

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4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate) (NSC 88915) and Related Novel Steroid Derivatives as Tyrosyl-DNA Phosphodiesterase (Tdp1) Inhibitors

4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate) (NSC 88915) and Related Novel Steroid Derivatives as Tyrosyl-DNA Phosphodiesterase (Tdp1) Inhibitors

by Dexheimer, Thomas S, Gediya, Lalji K, Stephen, Andrew G, Weidlich, Iwona, Antony, Smitha, Marchand, Christophe, Interthal, Heidrun, Nicklaus, Marc, Fisher, Robert J, Njar, Vincent C, Pommier, Yves
Published in Journal of medicinal chemistry (26.11.2009)

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Three-dimensional quantitative structure activity relationships (3-D-QSAR) of antihyperglycemic agents

Three-dimensional quantitative structure activity relationships (3-D-QSAR) of antihyperglycemic agents

by KULKARNI, S. S, GEDIYA, L. K, KULKARNI, V. M
Published in Bioorganic & medicinal chemistry (01.07.1999)

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A New Simple and High-Yield Synthesis of Suberoylanilide Hydroxamic Acid and Its Inhibitory Effect Alone or in Combination with Retinoids on Proliferation of Human Prostate Cancer Cells

A New Simple and High-Yield Synthesis of Suberoylanilide Hydroxamic Acid and Its Inhibitory Effect Alone or in Combination with Retinoids on Proliferation of Human Prostate Cancer Cells

by Gediya, Lalji K, Chopra, Pankaj, Purushottamachar, Puranik, Maheshwari, Neha, Njar, Vincent C. O
Published in Journal of medicinal chemistry (28.07.2005)

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VN/14-1 induces ER stress and autophagy in HP-LTLC human breast cancer cells and has excellent oral pharmacokinetic profile in female Sprague Dawley rats

by Godbole, Abhijit M., Ramalingam, Senthilmurugan, Ramamurthy, Vidya P., Khandelwal, Aakanksha, Bruno, Robert D., Upreti, Vijay V., Gediya, Lalji K., Purushottamachar, Puranik, Mbatia, Hannah W., Addya, Sankar, Ambulos, Nicholas, Njar, Vincent C.O.
Published in European journal of pharmacology (05.07.2014)

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Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts

Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts

by Gediya, Lalji K., Belosay, Aashvini, Khandelwal, Aakanksha, Purushottamachar, Puranik, Njar, Vincent C.O.
Published in Bioorganic & medicinal chemistry (15.03.2008)

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Design, Synthesis, and Evaluation of Novel Mutual Prodrugs (Hybrid Drugs) of All-trans-Retinoic Acid and Histone Deacetylase Inhibitors with Enhanced Anticancer Activities in Breast and Prostate Cancer Cells in Vitro

Design, Synthesis, and Evaluation of Novel Mutual Prodrugs (Hybrid Drugs) of All-trans-Retinoic Acid and Histone Deacetylase Inhibitors with Enhanced Anticancer Activities in Breast and Prostate Cancer Cells in Vitro

by Gediya, Lalji K, Khandelwal, Aakanksha, Patel, Jyoti, Belosay, Aashvini, Sabnis, Gauri, Mehta, Jhalak, Purushottamachar, Puranik, Njar, Vincent C. O
Published in Journal of medicinal chemistry (10.07.2008)

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First chemical feature-based pharmacophore modeling of potent retinoidal retinoic acid metabolism blocking agents (RAMBAs): Identification of novel RAMBA scaffolds

First chemical feature-based pharmacophore modeling of potent retinoidal retinoic acid metabolism blocking agents (RAMBAs): Identification of novel RAMBA scaffolds

by Purushottamachar, Puranik, Patel, Jyoti B., Gediya, Lalji K., Clement, Omoshile O., Njar, Vincent C.O.
Published in European journal of medicinal chemistry (01.01.2012)

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Potent anti-prostate cancer agents derived from a novel androgen receptor down-regulating agent

Potent anti-prostate cancer agents derived from a novel androgen receptor down-regulating agent

by Purushottamachar, Puranik, Khandelwal, Aakanksha, Vasaitis, Tadas S., Bruno, Robert D., Gediya, Lalji K., Njar, Vincent C.O.
Published in Bioorganic & medicinal chemistry (01.04.2008)

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Anti-tumor effects of a novel retinoic acid metabolism blocking agent VN/14-1 in the N-methyl-N-nitrosourea-induced rat mammary carcinoma model and its effects on the uterus

Anti-tumor effects of a novel retinoic acid metabolism blocking agent VN/14-1 in the N-methyl-N-nitrosourea-induced rat mammary carcinoma model and its effects on the uterus

by Goss, Paul E., Qi, Shangle, Hu, Haiqing, Gediya, Lalji K., Purushottamachar, Puranik, Godbole, Abhijit M., Njar, Vincent C. O.
Published in Breast cancer research and treatment (01.05.2012)

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First pharmacophore-based identification of androgen receptor down-regulating agents: Discovery of potent anti-prostate cancer agents

First pharmacophore-based identification of androgen receptor down-regulating agents: Discovery of potent anti-prostate cancer agents

by Purushottamachar, Puranik, Khandelwal, Aakanksha, Chopra, Pankaj, Maheshwari, Neha, Gediya, Lalji K., Vasaitis, Tadas S., Bruno, Robert D., Clement, Omoshile O., Njar, Vincent C.O.
Published in Bioorganic & medicinal chemistry (15.05.2007)

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Novel Retinoic Acid Metabolism Blocking Agents Endowed with Multiple Biological Activities Are Efficient Growth Inhibitors of Human Breast and Prostate Cancer Cells in Vitro and a Human Breast Tumor Xenograft in Nude Mice

Novel Retinoic Acid Metabolism Blocking Agents Endowed with Multiple Biological Activities Are Efficient Growth Inhibitors of Human Breast and Prostate Cancer Cells in Vitro and a Human Breast Tumor Xenograft in Nude Mice

by Patel, Jyoti B, Huynh, Carlic K, Handratta, Venkatesh D, Gediya, Lalji K, Brodie, Angela M. H, Goloubeva, Olga G, Clement, Omoshile O, Nanne, Ivo P, Soprano, Dianne Robert, Njar, Vincent C. O
Published in Journal of medicinal chemistry (30.12.2004)

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