The retinamide VNLG‐152 inhibits f‐AR/AR‐V7 and MNK–eIF4E signaling pathways to suppress EMT and castration‐resistant prostate cancer xenograft growth
Ramamurthy, Vidya P., Ramalingam, Senthilmurugan, Gediya, Lalji K., Njar, Vincent C. O.
Published in The FEBS journal (01.03.2018)
Published in The FEBS journal (01.03.2018)
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Systematic Structure Modifications of Multitarget Prostate Cancer Drug Candidate Galeterone To Produce Novel Androgen Receptor Down-Regulating Agents as an Approach to Treatment of Advanced Prostate Cancer
Purushottamachar, Puranik, Godbole, Abhijit M, Gediya, Lalji K, Martin, Marlena S, Vasaitis, Tadas S, Kwegyir-Afful, Andrew K, Ramalingam, Senthilmurugan, Ates-Alagoz, Zeynep, Njar, Vincent C. O
Published in Journal of medicinal chemistry (27.06.2013)
Published in Journal of medicinal chemistry (27.06.2013)
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Journal Article
The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis
Ramalingam, Senthilmurugan, Ramamurthy, Vidya P, Gediya, Lalji K, Murigi, Francis N, Purushottamachar, Puranik, Huang, Weiliang, Choi, Eun Yong, Zhang, Yuji, Vasaitis, Tadas S, Kane, Maureen A, Lapidus, Rena G, Njar, Vincent C O
Published in Cancers (03.03.2019)
Published in Cancers (03.03.2019)
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Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens: Synthesis, in Vitro Biological Activity, Pharmacokinetics, and Antitumor Activity in the LAPC4 Human Prostate Cancer Xenograft Model
Handratta, Venkatesh D, Vasaitis, Tadas S, Njar, Vincent C. O, Gediya, Lalji K, Kataria, Ritesh, Chopra, Pankaj, Newman, Donnell, Farquhar, Rena, Guo, Zhiyong, Qiu, Yun, Brodie, Angela M. H
Published in Journal of medicinal chemistry (21.04.2005)
Published in Journal of medicinal chemistry (21.04.2005)
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The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer
Tran, Kim, Risingsong, Renee, Royce, Darlene B, Williams, Charlotte R, Sporn, Michael B, Pioli, Patricia A, Gediya, Lalji K, Njar, Vincent C, Liby, Karen T
Published in Carcinogenesis (New York) (01.01.2013)
Published in Carcinogenesis (New York) (01.01.2013)
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Journal Article
Novel galeterone analogs act independently of AR and AR-V7 for the activation of the unfolded protein response and induction of apoptosis in the CWR22Rv1 prostate cancer cell model
McCarty, David J, Huang, Weiliang, Kane, Maureen A, Purushottamachar, Puranik, Gediya, Lalji K, Njar, Vincent C O
Published in Oncotarget (24.10.2017)
Published in Oncotarget (24.10.2017)
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Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): Head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model
Bruno, Robert D., Vasaitis, Tadas S., Gediya, Lalji K., Purushottamachar, Puranik, Godbole, Abhijit M., Ates-Alagoz, Zeynep, Brodie, Angela M.H., Njar, Vincent C.O.
Published in Steroids (01.11.2011)
Published in Steroids (01.11.2011)
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Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts
Gediya, Lalji K., Belosay, Aashvini, Khandelwal, Aakanksha, Purushottamachar, Puranik, Njar, Vincent C.O.
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
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Journal Article
Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases
Njar, Vincent C.O., Gediya, Lalji, Purushottamachar, Puranik, Chopra, Pankaj, Vasaitis, Tadas Sean, Khandelwal, Aakanksha, Mehta, Jhalak, Huynh, Carlic, Belosay, Aashvini, Patel, Jyoti
Published in Bioorganic & medicinal chemistry (01.07.2006)
Published in Bioorganic & medicinal chemistry (01.07.2006)
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Journal Article
4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate) (NSC 88915) and Related Novel Steroid Derivatives as Tyrosyl-DNA Phosphodiesterase (Tdp1) Inhibitors
Dexheimer, Thomas S, Gediya, Lalji K, Stephen, Andrew G, Weidlich, Iwona, Antony, Smitha, Marchand, Christophe, Interthal, Heidrun, Nicklaus, Marc, Fisher, Robert J, Njar, Vincent C, Pommier, Yves
Published in Journal of medicinal chemistry (26.11.2009)
Published in Journal of medicinal chemistry (26.11.2009)
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Journal Article
A New Simple and High-Yield Synthesis of Suberoylanilide Hydroxamic Acid and Its Inhibitory Effect Alone or in Combination with Retinoids on Proliferation of Human Prostate Cancer Cells
Gediya, Lalji K, Chopra, Pankaj, Purushottamachar, Puranik, Maheshwari, Neha, Njar, Vincent C. O
Published in Journal of medicinal chemistry (28.07.2005)
Published in Journal of medicinal chemistry (28.07.2005)
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VN/14-1 induces ER stress and autophagy in HP-LTLC human breast cancer cells and has excellent oral pharmacokinetic profile in female Sprague Dawley rats
Godbole, Abhijit M., Ramalingam, Senthilmurugan, Ramamurthy, Vidya P., Khandelwal, Aakanksha, Bruno, Robert D., Upreti, Vijay V., Gediya, Lalji K., Purushottamachar, Puranik, Mbatia, Hannah W., Addya, Sankar, Ambulos, Nicholas, Njar, Vincent C.O.
Published in European journal of pharmacology (05.07.2014)
Published in European journal of pharmacology (05.07.2014)
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Journal Article
Design, Synthesis, and Evaluation of Novel Mutual Prodrugs (Hybrid Drugs) of All-trans-Retinoic Acid and Histone Deacetylase Inhibitors with Enhanced Anticancer Activities in Breast and Prostate Cancer Cells in Vitro
Gediya, Lalji K, Khandelwal, Aakanksha, Patel, Jyoti, Belosay, Aashvini, Sabnis, Gauri, Mehta, Jhalak, Purushottamachar, Puranik, Njar, Vincent C. O
Published in Journal of medicinal chemistry (10.07.2008)
Published in Journal of medicinal chemistry (10.07.2008)
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Journal Article
First chemical feature-based pharmacophore modeling of potent retinoidal retinoic acid metabolism blocking agents (RAMBAs): Identification of novel RAMBA scaffolds
Purushottamachar, Puranik, Patel, Jyoti B., Gediya, Lalji K., Clement, Omoshile O., Njar, Vincent C.O.
Published in European journal of medicinal chemistry (01.01.2012)
Published in European journal of medicinal chemistry (01.01.2012)
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Journal Article
Androgen receptor inactivation contributes to antitumor efficacy of 17α-hydroxylase/17,20-lyase inhibitor 3β-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer
Vasaitis, Tadas, Belosay, Aashvini, Schayowitz, Adam, Khandelwal, Aakanksha, Chopra, Pankaj, Gediya, Lalji K., Guo, Zhiyong, Fang, Hong-Bin, Njar, Vincent C.O., Brodie, Angela M.H.
Published in Molecular cancer therapeutics (01.08.2008)
Published in Molecular cancer therapeutics (01.08.2008)
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Journal Article
Potent anti-prostate cancer agents derived from a novel androgen receptor down-regulating agent
Purushottamachar, Puranik, Khandelwal, Aakanksha, Vasaitis, Tadas S., Bruno, Robert D., Gediya, Lalji K., Njar, Vincent C.O.
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
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Journal Article
Anti-tumor effects of a novel retinoic acid metabolism blocking agent VN/14-1 in the N-methyl-N-nitrosourea-induced rat mammary carcinoma model and its effects on the uterus
Goss, Paul E., Qi, Shangle, Hu, Haiqing, Gediya, Lalji K., Purushottamachar, Puranik, Godbole, Abhijit M., Njar, Vincent C. O.
Published in Breast cancer research and treatment (01.05.2012)
Published in Breast cancer research and treatment (01.05.2012)
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Journal Article
First pharmacophore-based identification of androgen receptor down-regulating agents: Discovery of potent anti-prostate cancer agents
Purushottamachar, Puranik, Khandelwal, Aakanksha, Chopra, Pankaj, Maheshwari, Neha, Gediya, Lalji K., Vasaitis, Tadas S., Bruno, Robert D., Clement, Omoshile O., Njar, Vincent C.O.
Published in Bioorganic & medicinal chemistry (15.05.2007)
Published in Bioorganic & medicinal chemistry (15.05.2007)
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Journal Article
Novel Retinoic Acid Metabolism Blocking Agents Endowed with Multiple Biological Activities Are Efficient Growth Inhibitors of Human Breast and Prostate Cancer Cells in Vitro and a Human Breast Tumor Xenograft in Nude Mice
Patel, Jyoti B, Huynh, Carlic K, Handratta, Venkatesh D, Gediya, Lalji K, Brodie, Angela M. H, Goloubeva, Olga G, Clement, Omoshile O, Nanne, Ivo P, Soprano, Dianne Robert, Njar, Vincent C. O
Published in Journal of medicinal chemistry (30.12.2004)
Published in Journal of medicinal chemistry (30.12.2004)
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