Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2
Poncet-Montange, Guillaume, Zhan, Yanai, Bardenhagen, Jennifer P, Petrocchi, Alessia, Leo, Elisabetta, Shi, Xi, Lee, 4th, Gilbert R, Leonard, Paul G, Geck Do, Mary K, Cardozo, Mario G, Andersen, Jannik N, Palmer, Wylie S, Jones, Philip, Ladbury, John E
Published in Biochemical journal (01.03.2015)
Published in Biochemical journal (01.03.2015)
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PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma
Giuliani, Virginia, Miller, Meredith A, Liu, Chiu-Yi, Hartono, Stella R, Class, Caleb A, Bristow, Christopher A, Suzuki, Erika, Sanz, Lionel A, Gao, Guang, Gay, Jason P, Feng, Ningping, Rose, Johnathon L, Tomihara, Hideo, Daniele, Joseph R, Peoples, Michael D, Bardenhagen, Jennifer P, Geck Do, Mary K, Chang, Qing E, Vangamudi, Bhavatarini, Vellano, Christopher, Ying, Haoqiang, Deem, Angela K, Do, Kim-Anh, Genovese, Giannicola, Marszalek, Joseph R, Kovacs, Jeffrey J, Kim, Michael, Fleming, Jason B, Guccione, Ernesto, Viale, Andrea, Maitra, Anirban, Emilia Di Francesco, M, Yap, Timothy A, Jones, Philip, Draetta, Giulio, Carugo, Alessandro, Chedin, Frederic, Heffernan, Timothy P
Published in Nature communications (30.07.2021)
Published in Nature communications (30.07.2021)
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Spirocyclic β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species
Hunt, Kevin W, Cook, Adam W, Watts, Ryan J, Clark, Christopher T, Vigers, Guy, Smith, Darin, Metcalf, Andrew T, Gunawardana, Indrani W, Burkard, Michael, Cox, April A, Geck Do, Mary K, Dutcher, Darrin, Thomas, Allen A, Rana, Sumeet, Kallan, Nicholas C, DeLisle, Robert K, Rizzi, James P, Regal, Kelly, Sammond, Douglas, Groneberg, Robert, Siu, Michael, Purkey, Hans, Lyssikatos, Joseph P, Marlow, Allison, Liu, Xingrong, Tang, Tony P
Published in Journal of medicinal chemistry (25.04.2013)
Published in Journal of medicinal chemistry (25.04.2013)
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8‑Tetrahydropyran-2-yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors
Thomas, Allen A, Hunt, Kevin W, Newhouse, Brad, Watts, Ryan J, Liu, Xingrong, Vigers, Guy, Smith, Darin, Rhodes, Susan P, Brown, Karin D, Otten, Jennifer N, Burkard, Michael, Cox, April A, Geck Do, Mary K, Dutcher, Darrin, Rana, Sumeet, DeLisle, Robert K, Regal, Kelly, Wright, Albion D, Groneberg, Robert, Liao, Jiangpeng, Scearce-Levie, Kimberly, Siu, Michael, Purkey, Hans E, Lyssikatos, Joseph P
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery
Zhan, Yanai, Kost-Alimova, Maria, Shi, Xi, Leo, Elisabetta, Bardenhagen, Jennifer P, Shepard, Hannah E, Appikonda, Srikanth, Vangamudi, Bhavatarini, Zhao, Shuping, Tieu, Trang N, Jiang, Shiming, Heffernan, Timothy P, Marszalek, Joseph R, Toniatti, Carlo, Draetta, Giulio, Tyler, Jessica, Barton, Michelle, Jones, Philip, Palmer, Wylie S, Geck Do, Mary K, Andersen, Jannik N
Published in Epigenetics & chromatin (21.09.2015)
Published in Epigenetics & chromatin (21.09.2015)
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Discovery of IPN60090, a Clinical Stage Selective Glutaminase‑1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties
Soth, Michael J, Le, Kang, Di Francesco, Maria Emilia, Hamilton, Matthew M, Liu, Gang, Burke, Jason P, Carroll, Chris L, Kovacs, Jeffrey J, Bardenhagen, Jennifer P, Bristow, Christopher A, Cardozo, Mario, Czako, Barbara, de Stanchina, Elisa, Feng, Ningping, Garvey, Jill R, Gay, Jason P, Do, Mary K. Geck, Greer, Jennifer, Han, Michelle, Harris, Angela, Herrera, Zachary, Huang, Sha, Giuliani, Virginia, Jiang, Yongying, Johnson, Sarah B, Johnson, Troy A, Kang, Zhijun, Leonard, Paul G, Liu, Zhen, McAfoos, Timothy, Miller, Meredith, Morlacchi, Pietro, Mullinax, Robert A, Palmer, Wylie S, Pang, Jihai, Rogers, Norma, Rudin, Charles M, Shepard, Hannah E, Spencer, Nakia D, Theroff, Jay, Wu, Qi, Xu, Alan, Yau, Ju Anne, Draetta, Giulio, Toniatti, Carlo, Heffernan, Timothy P, Jones, Philip
Published in Journal of medicinal chemistry (12.11.2020)
Published in Journal of medicinal chemistry (12.11.2020)
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Discovery of 7‑Tetrahydropyran-2-yl Chromans: β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors That Reduce Amyloid β‑Protein (Aβ) in the Central Nervous System
Thomas, Allen A, Hunt, Kevin W, Volgraf, Matthew, Watts, Ryan J, Liu, Xingrong, Vigers, Guy, Smith, Darin, Sammond, Douglas, Tang, Tony P, Rhodes, Susan P, Metcalf, Andrew T, Brown, Karin D, Otten, Jennifer N, Burkard, Michael, Cox, April A, Do, Mary K. Geck, Dutcher, Darrin, Rana, Sumeet, DeLisle, Robert K, Regal, Kelly, Wright, Albion D, Groneberg, Robert, Scearce-Levie, Kimberly, Siu, Michael, Purkey, Hans E, Lyssikatos, Joseph P, Gunawardana, Indrani W
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
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Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types
Pilié, Patrick G, Giuliani, Virginia, Wang, Wei-Lien, McGrail, Daniel J, Bristow, Christopher A, Ngoi, Natalie Y L, Kyewalabye, Keith, Wani, Khalida M, Le, Hung, Campbell, Erick, Sanchez, Nora S, Yang, Dong, Gheeya, Jinesh S, Goswamy, Rohit Vivek, Holla, Vijaykumar, Shaw, Kenna Rael, Meric-Bernstam, Funda, Liu, Chiu-Yi, Ma, XiaoYan, Feng, Ningping, Machado, Annette A, Bardenhagen, Jennifer P, Vellano, Christopher P, Marszalek, Joseph R, Rajendra, Eeson, Piscitello, Desiree, Johnson, Timothy I, Likhatcheva, Maria, Elinati, Elias, Majithiya, Jayesh, Neves, Joana, Grinkevich, Vera, Ranzani, Marco, Luzarraga, Marina Roy, Boursier, Marie, Armstrong, Lucy, Geo, Lerin, Lillo, Giorgia, Tse, Wai Yiu, Lazar, Alexander J, Kopetz, Scott E, Geck Do, Mary K, Lively, Sarah, Johnson, Michael G, Robinson, Helen M R, Smith, Graeme C M, Carroll, Christopher L, Di Francesco, M Emilia, Jones, Philip, Heffernan, Timothy P, Yap, Timothy A
Published in Clinical cancer research (15.05.2024)
Published in Clinical cancer research (15.05.2024)
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Identification of residues of spinach thioredoxin f that influence interactions with target enzymes
Geck, M.K. (University of Tennessee-Oak Ridge Graduate School of Biomedical Sciences, Oak Ridge, TN.), Larimer, F.W, Hartman, F.C
Published in The Journal of biological chemistry (04.10.1996)
Published in The Journal of biological chemistry (04.10.1996)
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Aminotransferase Activity and Bioinformatic Analysis of 1-Aminocyclopropane-1-carboxylate Synthase
Feng, Liang, Geck, Mary K, Eliot, Andrew C, Kirsch, Jack F
Published in Biochemistry (Easton) (12.12.2000)
Published in Biochemistry (Easton) (12.12.2000)
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Abstract 1655: Discovery and development of IACS-010759, a novel inhibitor of Complex I currently in phase I studies to exploit oxidative phosphorylation dependency in acute myeloid leukemia and solid tumors
Francesco, Maria Emilia Di, Marszalek, Joseph R., McAfoos, Timothy, Carroll, Christopher L., Kang, Zhijun, Liu, Gang, Theroff, Jay P., Bardenhager, Jennifer P., Bandi, Madhavi L., Molina, Jennifer R., Gera, Sonal, Protopopova, Marina, Sun, Yuting, Do, Mary K. Geck, Feng, Ningping, Gay, Jason P., Muller, Florian, Konopleva, Marina, Meric-Bernstam, Funda, Toniatti, Carlo, Heffernan, Timothy P., Draetta, Giulio F., Jones, Philip
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract PR01: IACS-010759 a novel inhibitor of oxidative phosphorylation advancing into first-in-human studies to exploit metabolic vulnerabilities
Jones, Philip, Francesco, M Emilia Di, Molina, Jennifer M., Protopopova, Marina, Bandi, Madhavi, Bardenhagen, Jennifer, Bristow, Christopher A., Carroll, Christopher L., Feng, Ningping, Gay, Jason P., Do, Mary K. Geck, Greer, Jennifer M., Konopleva, Marina, Kang, Zhijun, Liu, Gang, McAfoos, Timothy, Morlacchi, Pietro, Smith, Melinda G., Fnu, Sonal, Theroff, Jay P., Draetta, Giulio, Toniatti, Carlo, Marszalek, Joseph R.
Published in Clinical cancer research (01.01.2017)
Published in Clinical cancer research (01.01.2017)
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Direct identification of the primary nucleophile of thioredoxin f
Brandes, H.K., Larimer, F.W., Geck, M.K., Stringer, C.D., Schürmann, P., Hartman, F.C.
Published in The Journal of biological chemistry (05.09.1993)
Published in The Journal of biological chemistry (05.09.1993)
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Cumulative effect of double-site mutations of human epidermal growth factor on receptor binding
CAMPION, S. R, GECK, M. K, NIYOGI, S. K
Published in The Journal of biological chemistry (25.01.1993)
Published in The Journal of biological chemistry (25.01.1993)
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