Identifying transcriptional programs underlying cancer drug response with TraCe-seq
Chang, Matthew T., Shanahan, Frances, Nguyen, Thi Thu Thao, Staben, Steven T., Gazzard, Lewis, Yamazoe, Sayumi, Wertz, Ingrid E., Piskol, Robert, Yang, Yeqing Angela, Modrusan, Zora, Haley, Benjamin, Evangelista, Marie, Malek, Shiva, Foster, Scott A., Ye, Xin
Published in Nature biotechnology (01.01.2022)
Published in Nature biotechnology (01.01.2022)
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Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation
Rosenberg, Scott C., Shanahan, Frances, Yamazoe, Sayumi, Kschonsak, Marc, Zeng, Yi J., Lee, James, Plise, Emile, Yen, Ivana, Rose, Christopher M., Quinn, John G., Gazzard, Lewis J., Walters, Benjamin T., Kirkpatrick, Donald S., Staben, Steven T., Foster, Scott A., Malek, Shiva
Published in Cell chemical biology (16.02.2023)
Published in Cell chemical biology (16.02.2023)
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Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)
Flygare, John A, Beresini, Maureen, Budha, Nageshwar, Chan, Helen, Chan, Iris T, Cheeti, Sravanthi, Cohen, Frederick, Deshayes, Kurt, Doerner, Karl, Eckhardt, S. Gail, Elliott, Linda O, Feng, Bainian, Franklin, Matthew C, Reisner, Stacy Frankovitz, Gazzard, Lewis, Halladay, Jason, Hymowitz, Sarah G, La, Hank, LoRusso, Patricia, Maurer, Brigitte, Murray, Lesley, Plise, Emile, Quan, Clifford, Stephan, Jean-Philippe, Young, Shin G, Tom, Jeffrey, Tsui, Vickie, Um, Joanne, Varfolomeev, Eugene, Vucic, Domagoj, Wagner, Andrew J, Wallweber, Heidi J. A, Wang, Lan, Ware, Joseph, Wen, Zhaoyang, Wong, Harvey, Wong, Jonathan M, Wong, Melisa, Wong, Susan, Yu, Ron, Zobel, Kerry, Fairbrother, Wayne J
Published in Journal of medicinal chemistry (10.05.2012)
Published in Journal of medicinal chemistry (10.05.2012)
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Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors
Davies, Christopher W., Oh, Angela J., Mroue, Rana, Steffek, Micah, Bruning, John M., Xiao, Yang, Feng, Siyu, Jayakar, Sangeeta, Chan, Emily, Arumugam, Vidhyalakshmi, Uribe, Sean Carlo, Drummond, Jake, Frommlet, Alexandra, Lu, Cheng, Franke, Yvonne, Merchant, Mark, Koeppen, Hartmut, Quinn, John G., Malhotra, Sushant, Do, Steve, Gazzard, Lewis, Purkey, Hans E., Rudolph, Joachim, Mulvihill, Melinda M., Koerber, James T., Wang, Weiru, Evangelista, Marie
Published in Nature biotechnology (01.05.2022)
Published in Nature biotechnology (01.05.2022)
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Oxidizing Potential of Endosomes and Lysosomes Limits Intracellular Cleavage of Disulfide-Based Antibody-Drug Conjugates
Austin, Cary D., Xiaohui Wen, Lewis Gazzard, Nelson, Christopher, Scheller, Richard H., Scales, Suzie J.
Published in Proceedings of the National Academy of Sciences - PNAS (13.12.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (13.12.2005)
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Synthesis of the Kopsia alkaloids (±)-pauciflorine B, (±)-lahadinine B, (±)-kopsidasine, (±)-kopsidasine- N-oxide, (±)-kopsijasminilam and (±)-11-methoxykopsilongine
Magnus, Philip, Gazzard, Lewis, Hobson, Lindsay, Payne, Andrew H., Rainey, Trevor J., Westlund, Neil, Lynch, Vince
Published in Tetrahedron (22.04.2002)
Published in Tetrahedron (22.04.2002)
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Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres
Cohen, Frederick, Koehler, Michael F.T., Bergeron, Philippe, Elliott, Linda O., Flygare, John A., Franklin, Matthew C., Gazzard, Lewis, Keteltas, Stephen F., Lau, Kevin, Ly, Cuong Q., Tsui, Vickie, Fairbrother, Wayne J.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Structure-Based Design and Evaluation of Reversible KRAS G13D Inhibitors
Nilewski, Christian, Labadie, Sharada, Wei, Binqing, Malhotra, Sushant, Do, Steven, Gazzard, Lewis, Liu, Li, Shao, Cheng, Murray, Jeremy, Izrayelit, Yevgeniy, Gustafson, Amy, Endres, Nicholas F., Ma, Fang, Ye, Xin, Zou, Jun, Evangelista, Marie
Published in ACS medicinal chemistry letters (11.01.2024)
Published in ACS medicinal chemistry letters (11.01.2024)
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Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window
Rudolph, Joachim, Murray, Lesley J, Ndubaku, Chudi O, O’Brien, Thomas, Blackwood, Elizabeth, Wang, Weiru, Aliagas, Ignacio, Gazzard, Lewis, Crawford, James J, Drobnick, Joy, Lee, Wendy, Zhao, Xianrui, Hoeflich, Klaus P, Favor, David A, Dong, Ping, Zhang, Haiming, Heise, Christopher E, Oh, Angela, Ong, Christy C, La, Hank, Chakravarty, Paroma, Chan, Connie, Jakubiak, Diana, Epler, Jennifer, Ramaswamy, Sreemathy, Vega, Roxanne, Cain, Gary, Diaz, Dolores, Zhong, Yu
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
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Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2)
Pei, Zhonghua, Mendonca, Rohan, Gazzard, Lewis, Pastor, Richard, Goon, Leanne, Gustafson, Amy, VanderPorten, Erica, Hatzivassiliou, Georgia, Dement, Kevin, Cass, Robert, Yuen, Po-wai, Zhang, Yamin, Wu, Guosheng, Lin, Xingyu, Liu, Yichin, Sellers, Benjamin D
Published in ACS medicinal chemistry letters (10.05.2018)
Published in ACS medicinal chemistry letters (10.05.2018)
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Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1
Tellis, John C, Wei, BinQing, Siu, Michael, An, Le, Chan, Grace Kayan, Chen, Yong, Du, Xiangnan, Gazzard, Lewis, Hu, Baihua, Kiefer, James, Kakiuchi-Kiyota, Satoko, Lainchbury, Michael, Linehan, Jonathan L, Luo, Xifeng, Malhotra, Sushant, Mendonca, Rohan, Pang, Jodie, Ran, Yinqing, Sethuraman, Vijay, Seward, Eileen, Sneeringer, Chris, Su, Dian, Wang, Weiru, Wu, Ping, Moffat, John G, Heffron, Timothy P, Choo, Edna F, Chan, Bryan K
Published in ACS medicinal chemistry letters (12.09.2024)
Published in ACS medicinal chemistry letters (12.09.2024)
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Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pKa Polar Moiety
Ndubaku, Chudi O., Crawford, James J., Drobnick, Joy, Aliagas, Ignacio, Campbell, David, Dong, Ping, Dornan, Laura M., Duron, Sergio, Epler, Jennifer, Gazzard, Lewis, Heise, Christopher E., Hoeflich, Klaus P., Jakubiak, Diana, La, Hank, Lee, Wendy, Lin, Baiwei, Lyssikatos, Joseph P., Maksimoska, Jasna, Marmorstein, Ronen, Murray, Lesley J., O’Brien, Thomas, Oh, Angela, Ramaswamy, Sreemathy, Wang, Weiru, Zhao, Xianrui, Zhong, Yu, Blackwood, Elizabeth, Rudolph, Joachim
Published in ACS medicinal chemistry letters (31.10.2015)
Published in ACS medicinal chemistry letters (31.10.2015)
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Development of an Expedient Process for the Multi-Kilogram Synthesis of Chk1 Inhibitor GDC-0425
Stumpf, Andreas, Cheng, Zhigang Ken, Wong, Brian, Reynolds, Mark, Angelaud, Remy, Girotti, James, Deese, Alan, Gu, Christine, Gazzard, Lewis
Published in Organic process research & development (19.06.2015)
Published in Organic process research & development (19.06.2015)
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Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1)
Chan, Bryan K, Seward, Eileen, Lainchbury, Michael, Brewer, Thomas F, An, Le, Blench, Toby, Cartwright, Matthew W, Chan, Grace Ka Yan, Choo, Edna F, Drummond, Jason, Elliott, Richard L, Gancia, Emanuela, Gazzard, Lewis, Hu, Baihua, Jones, Graham E, Luo, Xifeng, Madin, Andrew, Malhotra, Sushant, Moffat, John G, Pang, Jodie, Salphati, Laurent, Sneeringer, Christopher J, Stivala, Craig E, Wei, Binqing, Wang, Weiru, Wu, Ping, Heffron, Timothy P
Published in ACS medicinal chemistry letters (13.01.2022)
Published in ACS medicinal chemistry letters (13.01.2022)
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테트라시클릭 옥사제핀 화합물 및 이의 용도
LANDRY MATTHEW LEO, CHENG YUN XING, DO STEVEN, XIN JIANFENG, CHENG LIMIN, GAZZARD LEWIS J, GREEN SAMANTHA ALYSON, MALHOTRA SUSHANT, SIU MICHAEL, HE MINGTAO
Year of Publication 17.10.2023
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Year of Publication 17.10.2023
Patent
Design of Selective PAK1 Inhibitor G‑5555: Improving Properties by Employing an Unorthodox Low‑pK a Polar Moiety
Ndubaku, Chudi O, Crawford, James J, Drobnick, Joy, Aliagas, Ignacio, Campbell, David, Dong, Ping, Dornan, Laura M, Duron, Sergio, Epler, Jennifer, Gazzard, Lewis, Heise, Christopher E, Hoeflich, Klaus P, Jakubiak, Diana, La, Hank, Lee, Wendy, Lin, Baiwei, Lyssikatos, Joseph P, Maksimoska, Jasna, Marmorstein, Ronen, Murray, Lesley J, O’Brien, Thomas, Oh, Angela, Ramaswamy, Sreemathy, Wang, Weiru, Zhao, Xianrui, Zhong, Yu, Blackwood, Elizabeth, Rudolph, Joachim
Published in ACS medicinal chemistry letters (10.12.2015)
Published in ACS medicinal chemistry letters (10.12.2015)
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Journal Article
Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1
Gazzard, Lewis, Appleton, Brent, Chapman, Kerry, Chen, Huifen, Clark, Kevin, Drobnick, Joy, Goodacre, Simon, Halladay, Jason, Lyssikatos, Joseph, Schmidt, Stephen, Sideris, Steve, Wiesmann, Christian, Williams, Karen, Wu, Ping, Yen, Ivana, Malek, Shiva
Published in Bioorganic & medicinal chemistry letters (15.12.2014)
Published in Bioorganic & medicinal chemistry letters (15.12.2014)
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Journal Article
Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1
Gazzard, Lewis, Williams, Karen, Chen, Huifen, Axford, Lorraine, Blackwood, Elizabeth, Burton, Brenda, Chapman, Kerry, Crackett, Peter, Drobnick, Joy, Ellwood, Charles, Epler, Jennifer, Flagella, Michael, Gancia, Emanuela, Gill, Matthew, Goodacre, Simon, Halladay, Jason, Hewitt, Joanne, Hunt, Hazel, Kintz, Samuel, Lyssikatos, Joseph, Macleod, Calum, Major, Sarah, Médard, Guillaume, Narukulla, Raman, Ramiscal, Judi, Schmidt, Stephen, Seward, Eileen, Wiesmann, Christian, Wu, Ping, Yee, Sharon, Yen, Ivana, Malek, Shiva
Published in Journal of medicinal chemistry (25.06.2015)
Published in Journal of medicinal chemistry (25.06.2015)
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Combination drug scheduling defines a "window of opportunity" for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900
Blackwood, Elizabeth, Epler, Jennifer, Yen, Ivana, Flagella, Michael, O'Brien, Tom, Evangelista, Marie, Schmidt, Stephen, Xiao, Yang, Choi, Jonathan, Kowanetz, Kaska, Ramiscal, Judi, Wong, Kenton, Jakubiak, Diana, Yee, Sharon, Cain, Gary, Gazzard, Lewis, Williams, Karen, Halladay, Jason, Jackson, Peter K, Malek, Shiva
Published in Molecular cancer therapeutics (01.10.2013)
Published in Molecular cancer therapeutics (01.10.2013)
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