AKT mutant allele-specific activation dictates pharmacologic sensitivities
Shrestha Bhattarai, Tripti, Shamu, Tambudzai, Gorelick, Alexander N., Chang, Matthew T., Chakravarty, Debyani, Gavrila, Elena I., Donoghue, Mark T. A., Gao, JianJong, Patel, Swati, Gao, Sizhi Paul, Reynolds, Margaret H., Phillips, Sarah M., Soumerai, Tara, Abida, Wassim, Hyman, David M., Schram, Alison M., Solit, David B., Smyth, Lillian M., Taylor, Barry S.
Published in Nature communications (19.04.2022)
Published in Nature communications (19.04.2022)
Get full text
Journal Article
Leveraging Systematic Functional Analysis to Benchmark an In Silico Framework Distinguishes Driver from Passenger MEK Mutants in Cancer
Hanrahan, Aphrothiti J, Sylvester, Brooke E, Chang, Matthew T, Elzein, Arijh, Gao, Jianjiong, Han, Weiwei, Liu, Ye, Xu, Dong, Gao, Sizhi P, Gorelick, Alexander N, Jones, Alexis M, Kiliti, Amber J, Nissan, Moriah H, Nimura, Clare A, Poteshman, Abigail N, Yao, Zhan, Gao, Yijun, Hu, Wenhuo, Wise, Hannah C, Gavrila, Elena I, Shoushtari, Alexander N, Tiwari, Shakuntala, Viale, Agnes, Abdel-Wahab, Omar, Merghoub, Taha, Berger, Michael F, Rosen, Neal, Taylor, Barry S, Solit, David B
Published in Cancer research (Chicago, Ill.) (01.10.2020)
Published in Cancer research (Chicago, Ill.) (01.10.2020)
Get full text
Journal Article
Efficacy and Determinants of Response to HER Kinase Inhibition in HER2 -Mutant Metastatic Breast Cancer
Smyth, Lillian M, Piha-Paul, Sarina A, Won, Helen H, Schram, Alison M, Saura, Cristina, Loi, Sherene, Lu, Janice, Shapiro, Geoffrey I, Juric, Dejan, Mayer, Ingrid A, Arteaga, Carlos L, de la Fuente, Macarena I, Brufksy, Adam M, Spanggaard, Iben, Mau-Sørensen, Morten, Arnedos, Monica, Moreno, Victor, Boni, Valentina, Sohn, Joohyuk, Schwartzberg, Lee S, Gonzàlez-Farré, Xavier, Cervantes, Andrés, Bidard, François-Clement, Gorelick, Alexander N, Lanman, Richard B, Nagy, Rebecca J, Ulaner, Gary A, Chandarlapaty, Sarat, Jhaveri, Komal, Gavrila, Elena I, Zimel, Catherine, Selcuklu, S Duygu, Melcer, Myra, Samoila, Aliaksandra, Cai, Yanyan, Scaltriti, Maurizio, Mann, Grace, Xu, Feng, Eli, Lisa D, Dujka, Melanie, Lalani, Alshad S, Bryce, Richard, Baselga, José, Taylor, Barry S, Solit, David B, Meric-Bernstam, Funda, Hyman, David M
Published in Cancer discovery (01.02.2020)
Published in Cancer discovery (01.02.2020)
Get full text
Journal Article
Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis
Taylor, Justin, Sendino, Maria, Gorelick, Alexander N, Pastore, Alessandro, Chang, Matthew T, Penson, Alexander V, Gavrila, Elena I, Stewart, Connor, Melnik, Ella M, Herrejon Chavez, Florisela, Bitner, Lillian, Yoshimi, Akihide, Lee, Stanley Chun-Wei, Inoue, Daichi, Liu, Bo, Zhang, Xiao J, Mato, Anthony R, Dogan, Ahmet, Kharas, Michael G, Chen, Yuhong, Wang, Demin, Soni, Rajesh K, Hendrickson, Ronald C, Prieto, Gorka, Rodriguez, Jose A, Taylor, Barry S, Abdel-Wahab, Omar
Published in Cancer discovery (01.10.2019)
Published in Cancer discovery (01.10.2019)
Get full text
Journal Article
Exceptional response to cetuximab monotherapy after failure of immunotherapy with a checkpoint inhibitor in a patient with metastatic head and neck squamous cell cancer: case report and review of the literature
Bloomer, Chance H., Gavrila, Elena, Burcher, Kimberly M., Kalada, John M., Chang, Mark J., Gebeyehu, Rediet R., Asare, Elsabeth, Khoury, Lara M., Kinney, Rebecca, Frizzell, Bart, Sullivan, Christopher A., Bunch, Paul M., Porosnicu, Mercedes
Published in Therapeutic advances in medical oncology (01.01.2023)
Published in Therapeutic advances in medical oncology (01.01.2023)
Get full text
Journal Article
Acute Toxicity and Pharmacokinetic Profile of an EU-GMP-Certified Cannabis sativa L. in Rodents
Filipiuc, Leontina-Elena, Ştefănescu, Raluca, Solcan, Carmen, Ciorpac, Mitică, Szilagyi, Andrei, Cojocaru, Dana, Stanciu, Gabriela Dumitrita, Creangă, Ioana, Caratașu, Cătălin-Cezar, Ababei, Daniela-Carmen, Gavrila, Roxana-Elena, Timofte, Andrei-Daniel, Filipiuc, Silviu-Iulian, Bild, Veronica
Published in Pharmaceuticals (Basel, Switzerland) (03.05.2023)
Published in Pharmaceuticals (Basel, Switzerland) (03.05.2023)
Get full text
Journal Article
Serendipitous synergism – an exceptional response to treatment with pembrolizumab in the course of a natural immunovirotherapy: a case report and review of the literature
Khoury, Lara M., Burcher, Kimberly M., Ng, Ronald T., Song, Alexander H., Chang, Mark J., Gavrila, Elena, Bloomer, Chance H., Robinson, Mac B., Kouri, Brian E., Waltonen, Joshua D., Bunch, Paul M., Lauer, Ulrich M., Porosnicu, Mercedes
Published in Therapeutic advances in medical oncology (2022)
Published in Therapeutic advances in medical oncology (2022)
Get full text
Journal Article
Relationship between Tumor Mutational Burden, PD-L1, Patient Characteristics, and Response to Immune Checkpoint Inhibitors in Head and Neck Squamous Cell Carcinoma
Burcher, Kimberly M., Lantz, Jeffrey W., Gavrila, Elena, Abreu, Arianne, Burcher, Jack T., Faucheux, Andrew T., Xie, Amy, Jackson, Clayton, Song, Alexander H., Hughes, Ryan T., Lycan, Thomas, Bunch, Paul M., Furdui, Cristina M., Topaloglu, Umit, D’Agostino, Ralph B., Zhang, Wei, Porosnicu, Mercedes
Published in Cancers (16.11.2021)
Published in Cancers (16.11.2021)
Get full text
Journal Article
Study protocol: phase II study to evaluate the effect of cetuximab monotherapy after immunotherapy with PD-1 inhibitors in patients with head and neck squamous cell cancer
Burcher, Kimberly M, Bloomer, Chance H, Gavrila, Elena, Kalada, John M, Chang, Mark J, Gebeyehu, Rediet R, Song, Alexander H, Khoury, Lara M, Lycan, Thomas W, Kinney, Rebecca, D'Agostino, Jr, Ralph, Bunch, Paul M, Shukla, Kirtikar, Triozzi, Pierre, Furdui, Cristina M, Zhang, Wei, Porosnicu, Mercedes
Published in Therapeutic advances in medical oncology (2024)
Published in Therapeutic advances in medical oncology (2024)
Get full text
Journal Article
In Reply: TP53 Alteration Status and Tumor Mutational Burden Score: Prevalence and Prognosis in Head and Neck Squamous Cell Carcinoma
Burcher, Kimberly M, Wilson, Harper L, Gavrila, Elena, Abreu, Arianne, D'Agostino, Ralph B, Zhang, Wei, Porosnicu, Mercedes
Published in The oncologist (Dayton, Ohio) (05.07.2022)
Published in The oncologist (Dayton, Ohio) (05.07.2022)
Get full text
Journal Article
Abstract PR08: AKT mutant allele-specific activation dictates pharmacologic sensitivities
Bhattarai, Tripti Shrestha, Shamu, Tambudzai, Patel, Swati, Gorelick, Alexander, Chang, Matthew T., Gavrila, Elena I., Gao, JianJong, Donoghue, Mark T.A., Gao, Paul S., Soumerai, Tara, Abida, Wassim, Smyth, Lilian M., Hyman, David M., Solit, David B., Taylor, Barry S.
Published in Molecular cancer research (01.10.2020)
Published in Molecular cancer research (01.10.2020)
Get full text
Journal Article
Abstract 2934: AKT mutant allele-specific activation dictates pharmacologic sensitivities
Bhattarai, Tripti Shrestha, Shamu, Tambudzai, Patel, Swati, Gorelick, Alexander, Chang, Matthew T., Gavrila, Elena I., Gao, JianJong, Donoghue, Mark T., Gao, Paul S., Soumerai, Tara, Abida, Wassim, Smyth, Lilian M., Hyman, David M., Solit, David B., Taylor, Barry S.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Get full text
Journal Article
A TESTABLE MATHEMATICAL MODEL FOR ALZHEIMER’S DISEASE USING BIOCHEMICAL SYSTEMS THEORY (BST) PREDICTS THAT MITOCHONDRIAL DYSFUNCTION IS LINKED TO CHANGES IN EXPRESSION OF FIVE GENES IMPACTING MITOCHONDRIAL ROS AND APOPTOSIS
Coleman, Randolph A., Durmaz, Ceyda, Gavrila, Elena, Shelton, Morgan, Castora, Frank J.
Published in Alzheimer's & dementia (01.07.2017)
Published in Alzheimer's & dementia (01.07.2017)
Get full text
Journal Article
Bucureşti – centrul istoric. Campania 2007. Raport preliminar privind cercetările arheologice efectuate pe strada Smârdan
Mănucu-Adameşteanu, Gheorghe, Măgureanu, Andrei, Panait, Panait I, Boroneant, Adina, Gavrilă, Elena, Popescu, Raluca, Rădulescu, Maria Venera, Toderaș, Meda, Velter, Ana Maria, Tóth, Boglárka, Botár, István
Published in Materiale și cercetări arheologice (2007)
Get full text
Published in Materiale și cercetări arheologice (2007)
Journal Article
Acute Toxicity and Pharmacokinetic Profile of an EU-GMP-Certified ICannabis sativa/I L. in Rodents
Filipiuc, Leontina-Elena, Ştefănescu, Raluca, Solcan, Carmen, Ciorpac, Mitică, Szilagyi, Andrei, Cojocaru, Dana, Stanciu, Gabriela Dumitrita, Creangă, Ioana, Caratașu, Cătălin-Cezar, Ababei, Daniela-Carmen, Gavrila, Roxana-Elena, Timofte, Andrei-Daniel, Filipiuc, Silviu-Iulian, Bild, Veronica
Published in Pharmaceuticals (Basel, Switzerland) (01.05.2023)
Published in Pharmaceuticals (Basel, Switzerland) (01.05.2023)
Get full text
Journal Article
Exceptional response to cetuximab monotherapy after failure of immunotherapy with a checkpoint inhibitor in a patient with metastatic head and neck squamous cell cancer: case report and review of the literature
Bloomer, Chance H, Gavrila, Elena, Burcher, Kimberly M, Kalada, John M, Chang, Mark J, Gebeyehu, Rediet R, Asare, Elsabeth, Khoury, Lara M, Kinney, Rebecca, Frizzell, Bart, Sullivan, Christopher A, Bunch, Paul M, Porosnicu, Mercedes
Published in Therapeutic advances in medical oncology (01.01.2023)
Published in Therapeutic advances in medical oncology (01.01.2023)
Get full text
Report
Serendipitous synergism - an exceptional response to treatment with pembrolizumab in the course of a natural immunovirotherapy: a case report and review of the literature
Khoury, Lara M, Burcher, Kimberly M, Ng, Ronald T, Song, Alexander H, Chang, Mark J, Gavrila, Elena, Bloomer, Chance H, Robinson, Mac B, Kouri, Brian E, Waltonen, Joshua D, Bunch, Paul M, Lauer, Ulrich M, Porosnicu, Mercedes
Published in Therapeutic advances in medical oncology (01.01.2022)
Published in Therapeutic advances in medical oncology (01.01.2022)
Get full text
Report