Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily
Wrigley, Jonathan D, Gavory, Gerald, Simpson, Iain, Preston, Marian, Plant, Helen, Bradley, Jenna, Goeppert, Anne U, Rozycka, Ewelina, Davies, Gareth, Walsh, Jarrod, Valentine, Andrea, McClelland, Keeva, Odrzywol, Krzysztofa Ewa, Renshaw, Jonathan, Boros, Joanna, Tart, Jonathan, Leach, Lindsey, Nowak, Thorsten, Ward, Richard A, Harrison, Timothy, Andrews, David M
Published in ACS chemical biology (15.12.2017)
Published in ACS chemical biology (15.12.2017)
Get full text
Journal Article
Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development
Page, Natalie, Wappett, Mark, O’Dowd, Colin R., O’Rourke, Martin, Gavory, Gerald, Zhang, Lixin, Rountree, J. S. Shane, Jordan, Linda, Barker, Oliver, Gibson, Hayley, Boyd, Caroline, Feutren-Burton, Stephanie, McLean, Estelle, Trevitt, Graham, Harrison, Timothy
Published in Scientific reports (20.09.2022)
Published in Scientific reports (20.09.2022)
Get full text
Journal Article
USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF
Jurisic, Anamarija, Sung, Pei‐Ju, Wappett, Mark, Daubriac, Julien, Lobb, Ian T., Kung, Wei‐Wei, Crawford, Nyree, Page, Natalie, Cassidy, Eamon, Feutren‐Burton, Stephanie, Rountree, J. S. Shane, Helm, Matthew D., O'Dowd, Colin R., Kennedy, Richard D., Gavory, Gerald, Cranston, Aaron N., Longley, Daniel B., Jacq, Xavier, Harrison, Timothy
Published in Clinical and translational medicine (01.04.2024)
Published in Clinical and translational medicine (01.04.2024)
Get full text
Journal Article
Discovery and characterization of highly potent and selective allosteric USP7 inhibitors
Gavory, Gerald, O'Dowd, Colin R, Helm, Matthew D, Flasz, Jakub, Arkoudis, Elias, Dossang, Anthony, Hughes, Caroline, Cassidy, Eamon, McClelland, Keeva, Odrzywol, Ewa, Page, Natalie, Barker, Oliver, Miel, Hugues, Harrison, Timothy
Published in Nature chemical biology (01.02.2018)
Published in Nature chemical biology (01.02.2018)
Get full text
Journal Article
Identification of a new RNA·RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenita point mutation
Ren, Xiaojun, Gavory, Gérald, Li, Haitao, Ying, Liming, Klenerman, David, Balasubramanian, Shankar
Published in Nucleic acids research (15.11.2003)
Published in Nucleic acids research (15.11.2003)
Get full text
Journal Article
Abstract 6057: Discovery of a novel function for USP7 inhibitors: Reprogramming the tumor microenvironment
Jacq, Xavier, Jurisic, Anamarija, Daubriac, Julien, Lobb, Ian T., Wappett, Mark, Cranston, Aaron, Sung, Peggy, Gavory, Gerald, O'Dowd, Colin, Harisson, Tim
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Get full text
Journal Article
Abstract 4869: Discovery and characterization of highly potent and selective USP7 inhibitors and benchmarking against clinical MDM2 antagonists
Gavory, Gerald, O'Dowd, Colin, Arkoudis, Elias, Barker, Oliver, Cassidy, Eamon, Dossang, Anthony, Flasz, Jakub, Helm, Matt, Hughes, Caroline, McClelland, Keeva, Miel, Hugues, Odrzywol, Ewa, Page, Natalie, Harrison, Tim
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Abstract 4423: Antitumor activity of the novel oral highly selective Wee1 inhibitor Debio 0123
O'Dowd, Colin, Gavory, Gerald, Burkamp, Frank, Treder, Adam, Boyd, Caroline, Harrison, Tim, Massière, Frederic, Glück, Astrid, Chardonnens, Christophe, Zaffalon, Andrea, Rigotti, Stefania, Mader, Robert, Vuagniaux, Grégoire, Chessex, Anne Vaslin
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Get full text
Journal Article
Abstract LB-049: Targeting the ubiquitin-proteasome system by small molecule inhibition of the DUBome
Harrison, Tim, Jacq, Xavier, O'Dowd, Colin, Gavory, Gerald, Barker, Oliver, Bell, Christina, Burkamp, Frank, Burton, Stephanie, Cassidy, Eamon, Helm, Matthew, Hewitt, Peter, Page, Natalie, Rountree, Shane, Rozycka, Ewelina, Shepherd, Steven, Whitehead, Steven, Wappett, Mark
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Get full text
Journal Article
Abstract LBA004: Identification of GSPT1-directed molecular glue degrader (MGD) for the treatment of Myc-driven breast cancer
Gavory, Gerald, Fasching, Bernhard, Bonenfant, Debora, Sadok, Amine, Singh, Ambika, Schillo, Martin, Massafra, Vittoria, d’Alessandro, Anne-Cecile, Castle, John, Ghandi, Mahmoud, Chicas, Agustin, Delobel, Frederic, Flohr, Alexander, Ottaviani, Giorgio, Ryckmans, Thomas, Laine, Anne-Laure, Eidam, Oliv, Wang, Hannah, Bernett, Ilona, Chan, Laura, Gorrini, Chiara, Roumiliotis, Theo, Choudhary, Jyoti, LeBihan, Yann-Vai, Cabry, Marc, Stubbs, Mark, Burke, Rosemary, Van Montfort, Rob, Caldwell, John, Chopra, Rajesh, Collins, Ian, Buonamici, Silvia
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
Get full text
Journal Article
Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors
O’Dowd, Colin R, Helm, Matthew D, Rountree, J. S. Shane, Flasz, Jakub T, Arkoudis, Elias, Miel, Hugues, Hewitt, Peter R, Jordan, Linda, Barker, Oliver, Hughes, Caroline, Rozycka, Ewelina, Cassidy, Eamon, McClelland, Keeva, Odrzywol, Ewa, Page, Natalie, Feutren-Burton, Stephanie, Dvorkin, Scarlett, Gavory, Gerald, Harrison, Timothy
Published in ACS medicinal chemistry letters (08.03.2018)
Published in ACS medicinal chemistry letters (08.03.2018)
Get full text
Journal Article
Abstract 1181: Discovery and development of novel highly potent and selective inhibitors of USP19 using UbiPlex
Gavory, Gerald, O'Dowd, Colin, Rozycka, Ewelina, Dossang, Anthony, Henderson, Ashling, Hughes, Caroline, Miel, Hugues, Barker, Oliver, Costa, Joana, Hewitt, Peter, McFarland, Mary, Proctor, Lauren, Harrison, Tim
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article
Abstract LB-087: Discovery and development of first-in-class orally bioavailable USP19 inhibitors
Jacq, Xavier, Gavory, Gerald, O'Dowd, Colin, Cranston, Aaron, Baker, Oliver, Bell, Christina, Burton, Stephanie, Cassidy, Eamon, Costa, Joana, Henderson, Ashling, Helm, Matthew, Hewitt, Peter, Hughes, Caroline, McFarland, Mary, Miel, Hugues, Proctor, Lauren, Roundtree, Shane, Church, Rachel, Rozycka, Ewelina, Wappett, Mark, Whitehead, Steven, Harrison, Tim, Bedard, Nathalie, Wing, Simon S.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Get full text
Journal Article
Abstract LB-159: A novel, potent and selective inhibitor of Wee1 with robust antitumor activity in various cancer xenograph models
Gavory, Gerald, O’Dowd, Colin, Burkamp, Frank, Rountree, Shane, Rozycka, Ewelina, Boyd, Caroline, Gorges, Beronia, Burton, Stephanie, Wilkinson, Andy, Shepherd, Steven, Janssen, Dominic, McFarland, Mary, Harrison, Tim
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Get full text
Journal Article
Abstract LB-319: Development and characterization of ADC999 : A novel, potent orally available Wee1 inhibitor with robust antitumor efficacy in vivo
Gavory, Gerald, O'Dowd, Colin, Rozycka, Ewelina, Boyd, Caroline, Gorges, Beronia, McLean, Estelle, Daubriac, Julien, Rountree, Shane, Shepherd, Steven, Burton, Stephanie, McFarland, Mary, Treder, Adam, Wilkinson, Andy, Burkamp, Frank, Harrison, Tim
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article
Abstract 1935: Accessing the cancer DUBome with UbiPlex: A bespoke drug discovery platform for deubiquitinase enzymes
Gavory, Gerald, O'Dowd, Colin, Barker, Oliver, Bell, Christina, Burkamp, Frank, Burton, Stephanie, Cassidy, Eamon, Costa, Joana, Dossang, Anthony, Helm, Matt, Henderson, Ashling, Hewitt, Peter, Hughes, Caroline, McFarland, Mary, Miel, Hugues, Page, Natalie, Proctor, Lauren, Rountree, Shane, Rozycka, Ewelina, Shepherd, Steven, Treder, Adam, Wappett, Mark, Whitehead, Steven, Harrison, Tim
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Abstract LB-257: Discovery and characterization of novel, highly potent and selective USP7 inhibitors
Gavory, Gerald, O'dowd, Colin, McClelland, Keeva, Odrzywol, Ewa, Brown, Alan, Burton, Stephanie, Barker, Oliver, Burkamp, Frank, Helm, Matt, James, Iain, Flasz, Jakub, Arkoudis, Elias, Harrison, Tim
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Get full text
Journal Article
Abstract B17: Development of novel, potent orally available Wee1 inhibitors with robust antitumor efficacy in vivo
Gavory, Gerald, O'Dowd, Colin, Rozycka, Ewelina, Boyd, Caroline, Gorges, Beronia, McLean, Estelle, Rountree, Shane, Sheperd, Steven, Burton, Stephanie, McFarland, Mary, Janssen, Dominic, Treder, Adam, Wilkinson, Andy, Burkamp, Frank, Harrison, Tim
Published in Molecular cancer research (01.04.2017)
Published in Molecular cancer research (01.04.2017)
Get full text
Journal Article