Search Results - "Gavin C. Hirst" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of a Cyclic Boronic Acid β‑Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases

Discovery of a Cyclic Boronic Acid β‑Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases

by Hecker, Scott J, Reddy, K. Raja, Totrov, Maxim, Hirst, Gavin C, Lomovskaya, Olga, Griffith, David C, King, Paula, Tsivkovski, Ruslan, Sun, Dongxu, Sabet, Mojgan, Tarazi, Ziad, Clifton, Matthew C, Atkins, Kateri, Raymond, Amy, Potts, Kristy T, Abendroth, Jan, Boyer, Serge H, Loutit, Jeffrey S, Morgan, Elizabeth E, Durso, Stephanie, Dudley, Michael N
Published in Journal of medicinal chemistry (14.05.2015)

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A-770041, a Novel and Selective Small-Molecule Inhibitor of Lck, Prevents Heart Allograft Rejection

A-770041, a Novel and Selective Small-Molecule Inhibitor of Lck, Prevents Heart Allograft Rejection

by Stachlewitz, Robert F, Hart, Michelle A, Bettencourt, Brian, Kebede, Tegest, Schwartz, Annette, Ratnofsky, Sheldon E, Calderwood, David J, Waegell, Wendy O, Hirst, Gavin C
Published in The Journal of pharmacology and experimental therapeutics (01.10.2005)

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Journal Article

Pyrazolo[3,4- d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck — a selectivity insight

Pyrazolo[3,4- d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck — a selectivity insight

by Burchat, Andrew F., Calderwood, David J., Friedman, Michael M., Hirst, Gavin C., Li, Biqin, Rafferty, Paul, Ritter, Kurt, Skinner, Barbara S.
Published in Bioorganic & medicinal chemistry letters (17.06.2002)

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Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease

Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease

by Leonard, Kristi A, Madge, Lisa A, Krawczuk, Paul J, Wang, Aihua, Kreutter, Kevin D, Bacani, Genesis M, Chai, Wenying, Smith, Russell C, Tichenor, Mark S, Harris, Michael C, Malaviya, Ravi, Seierstad, Mark, Johnson, Marguerite E, Venable, Jennifer D, Kim, Suzie, Hirst, Gavin C, Mathur, Ashok S, Rao, Tadimeti S, Edwards, James P, Rizzolio, Michele C, Koudriakova, Tatiana
Published in Journal of medicinal chemistry (26.03.2020)

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First total synthesis of Lycopodium alkaloids of the magellanane group. Enantioselective total syntheses of (-)-magellanine and (+)-magellaninone

First total synthesis of Lycopodium alkaloids of the magellanane group. Enantioselective total syntheses of (-)-magellanine and (+)-magellaninone

by Hirst, Gavin C, Johnson, Theodore O, Overman, Larry E
Published in Journal of the American Chemical Society (01.04.1993)

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Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection

Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection

by Burchat, Andrew, Borhani, David W., Calderwood, David J., Hirst, Gavin C., Li, Biqin, Stachlewitz, Robert F.
Published in Bioorganic & medicinal chemistry letters (01.01.2006)

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Discovery of thienopyridines as Src-family selective Lck inhibitors

Discovery of thienopyridines as Src-family selective Lck inhibitors

by Abbott, Lily, Betschmann, Patrick, Burchat, Andrew, Calderwood, David J., Davis, Heather, Hrnciar, Peter, Hirst, Gavin C., Li, Biqin, Morytko, Michael, Mullen, Kelly, Yang, Bryant
Published in Bioorganic & medicinal chemistry letters (01.03.2007)

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A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection

A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection

by Borhani, David W., Calderwood, David J., Friedman, Michael M., Hirst, Gavin C., Li, Biqin, Leung, Adelaine K.W., McRae, Brad, Ratnofsky, Sheldon, Ritter, Kurt, Waegell, Wendy
Published in Bioorganic & medicinal chemistry letters (17.05.2004)

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Suppression of CD4 + T cell activation by a novel inhibitor of Src family kinases

Suppression of CD4 + T cell activation by a novel inhibitor of Src family kinases

by McRae, Bradford L., Wallace, Craig, Dixon, Kathleen Fitzgerald, Roux, Alyson, Mohan, Sukumari, Jia, Yong, Presky, David H., Tracey, Daniel E., Hirst, Gavin C.
Published in International immunopharmacology (01.04.2005)

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Discovery of 1,5-Benzodiazepines with Peripheral Cholecystokinin (CCK-A) Receptor Agonist Activity. 1. Optimization of the Agonist “Trigger”

Discovery of 1,5-Benzodiazepines with Peripheral Cholecystokinin (CCK-A) Receptor Agonist Activity. 1. Optimization of the Agonist “Trigger”

by Aquino, Christopher J, Armour, Duncan R, Berman, Judd M, Birkemo, Larry S, Carr, Robin A. E, Croom, Dallas K, Dezube, Milana, Dougherty, Robert W, Ervin, Gregory N, Grizzle, Mary K, Head, Julie E, Hirst, Gavin C, James, Michael K, Johnson, Michael F, Miller, Laurence J, Queen, Kennedy L, Rimele, Thomas J, Smith, David N, Sugg, Elizabeth E
Published in Journal of medicinal chemistry (19.01.1996)

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Utilization of microarrayed compound screening (microARCS) to identify inhibitors of p56lck tyrosine kinase

Utilization of microarrayed compound screening (microARCS) to identify inhibitors of p56lck tyrosine kinase

by Freiberg, Gail, Wilkins, Julie, David, Caroline, Kofron, James, Jia, Yong, Hirst, Gavin C, Burns, David J, Warrior, Usha
Published in Journal of biomolecular screening (01.02.2004)

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Stereocontrolled construction of carbocyclic rings by sequential cationic cyclization-pinacol rearrangements

Stereocontrolled construction of carbocyclic rings by sequential cationic cyclization-pinacol rearrangements

by Hirst, Gavin C, Howard, Paul N, Overman, Larry E
Published in Journal of the American Chemical Society (01.02.1989)

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Journal Article

Pyrrolo[2,3- d]pyrimidines Containing an Extended 5-Substituent as Potent and Selective Inhibitors of lck II

Pyrrolo[2,3- d]pyrimidines Containing an Extended 5-Substituent as Potent and Selective Inhibitors of lck II

by Burchat, Andrew F, Calderwood, David J, Hirst, Gavin C, Holman, Nicholas J, Johnston, David N, Munschauer, Rainer, Rafferty, Paul, Tometzki, Gerald B
Published in Bioorganic & medicinal chemistry letters (02.10.2000)

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Journal Article

INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR

INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR

by Kreutter, Kevin D, Becart, Stephane, Hirst, Gavin C, Damm-Ganamet, Kelly L, Lebsack, Alec D, Barbay, Joseph Kent
Year of Publication 18.05.2023

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Patent

INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR

INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR

by BECART, Stephane, DAMM-GANAMET, Kelly L, HIRST, Gavin C, LEBSACK, Alec D, BARBAY, J. Kent, KREUTTER, Kevin D
Year of Publication 08.02.2023

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Patent

INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION

INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION

by WEI, Jianmei, CHAI, Wenying, KUMMER, David A, VENABLE, Jennifer D, HIRST, Gavin C, MCCLURE, Kelly J, BARBAY, J. Kent, NISHIMURA, Rachel T, KREUTTER, Kevin D, SHIH, Amy Y, VENKATESAN, Hariharan
Year of Publication 04.09.2024

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Optimization of 3-(1H-Indazol-3-ylmethyl)-1,5-benzodiazepines as Potent, Orally Active CCK-A Agonists

Optimization of 3-(1H-Indazol-3-ylmethyl)-1,5-benzodiazepines as Potent, Orally Active CCK-A Agonists

by Henke, Brad R, Aquino, Christopher J, Birkemo, Larry S, Croom, Dallas K, Dougherty, Robert W, Ervin, Gregory N, Grizzle, Mary K, Hirst, Gavin C, James, Michael K, Johnson, Michael F, Queen, Kennedy L, Sherrill, Ronald G, Sugg, Elizabeth E, Suh, Edward M, Szewczyk, Jerzy W, Unwalla, Rayomand J, Yingling, Jeff, Willson, Timothy M
Published in Journal of medicinal chemistry (15.08.1997)

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Journal Article

INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION

INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION

by WEI, Jianmei, CHAI, Wenying, KUMMER, David A, VENABLE, Jennifer D, HIRST, Gavin C, MCCLURE, Kelly J, BARBAY, J. Kent, NISHIMURA, Rachel T, KREUTTER, Kevin D, SHIH, Amy Y, VENKATESAN, Hariharan
Year of Publication 28.05.2024

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Patent

INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION

INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION

by VENABLE, JENNIFER D, VENKATESAN, HARIHARAN, HIRST, GAVIN C, KUMMER, DAVID A, MCCLURE, KELLY J, SHIH, AMY Y, CHAI, WENYING, BARBAY, J. KENT, KREUTTER, KEVIN D, NISHIMURA, RACHEL T, WEI, JIANMEI
Year of Publication 13.05.2024

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Patent

INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION

INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION

by WEI, Jianmei, CHAI, Wenying, KUMMER, David A, VENABLE, Jennifer D, HIRST, Gavin C, MCCLURE, Kelly J, BARBAY, J. Kent, NISHIMURA, Rachel T, KREUTTER, Kevin D, SHIH, Amy Y, VENKATESAN, Hariharan
Year of Publication 08.05.2024

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Patent

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