Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists
Song, Fengbin, Xu, Guozhang, Gaul, Michael D., Zhao, Baoping, Lu, Tianbao, Zhang, Rui, DesJarlais, Renee L., DiLoreto, Karen, Huebert, Norman, Shook, Brian, Rentzeperis, Dennis, Santulli, Rosie, Eckardt, Annette, Demarest, Keith
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
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5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors
Xu, Guozhang, Du, Fuyong, Kuo, Gee-Hong, Xu, June Zhi, Liang, Yin, Demarest, Keith, Gaul, Michael D.
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
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Discovery of Potent and Orally Bioavailable Pyridine N‑Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions
Xu, Guozhang, Liu, Zhijie, Wang, Xinkang, Lu, Tianbao, DesJarlais, Renee L., Thieu, Tho, Zhang, Jing, Devine, Zheng Huang, Du, Fuyong, Li, Qiu, Milligan, Cynthia M., Shaffer, Paul, Cedervall, Peder E., Spurlino, John C., Stratton, Christopher F., Pietrak, Beth, Szewczuk, Lawrence M., Wong, Victoria, Steele, Ruth A., Bruinzeel, Wouter, Chintala, Madhu, Silva, Jose, Gaul, Michael D., Macielag, Mark J., Nargund, Ravi
Published in Journal of medicinal chemistry (11.08.2022)
Published in Journal of medicinal chemistry (11.08.2022)
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Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors
Xu, Guozhang, Gaul, Michael D., Kuo, Gee-Hong, Du, Fuyong, Xu, June Zhi, Wallace, Nathaniel, Hinke, Simon, Kirchner, Thomas, Silva, Jose, Huebert, Norman D., Lee, Seunghun, Murray, William, Liang, Yin, Demarest, Keith
Published in Bioorganic & medicinal chemistry letters (15.11.2018)
Published in Bioorganic & medicinal chemistry letters (15.11.2018)
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Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes
Xu, Guozhang, Gaul, Michael D., Song, Fengbin, Du, Fuyong, Liang, Yin, DesJarlais, Renee L., DiLoreto, Karen, Shook, Brian, Rentzeperis, Dennis, Santulli, Rosie, Eckardt, Annette, Demarest, Keith
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
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Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor
Xu, Guozhang, Gaul, Michael D., Liu, Zhijie, DesJarlais, Renee L., Qi, Jenson, Wang, Weixue, Krosky, Daniel, Petrounia, Ioanna, Milligan, Cynthia M., Hermans, An, Lu, Hua-Rong, Huang, Devine Zheng, Xu, June Zhi, Spurlino, John C.
Published in Bioorganic & medicinal chemistry letters (01.12.2020)
Published in Bioorganic & medicinal chemistry letters (01.12.2020)
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Metabolic tracing of monoacylglycerol acyltransferase-2 activity in vitro and in vivo
Qi, Jenson, Lang, Wensheng, Connelly, Margery A, Du, Fuyong, Liang, Yin, Caldwell, Gary W, Martin, Tonya, Hansen, Michael K, Kuo, Gee-Hong, Gaul, Michael D, Pocai, Alessandro, Lee, Seunghun
Published in Analytical biochemistry (01.05.2017)
Published in Analytical biochemistry (01.05.2017)
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Journal Article
Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors
Rheault, Tara R., Caferro, Thomas R., Dickerson, Scott H., Donaldson, Kelly H., Gaul, Michael D., Goetz, Aaron S., Mullin, Robert J., McDonald, Octerloney B., Petrov, Kimberly G., Rusnak, David W., Shewchuk, Lisa M., Spehar, Glenn M., Truesdale, Anne T., Vanderwall, Dana E., Wood, Edgar R., Uehling, David E.
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: Part 2. Pyridazine-based analogs
Yang, Shyh-Ming, Tang, Yuting, Rano, Thomas, Lu, Huajun, Kuo, Gee-Hong, Gaul, Michael D., Li, Yaxin, Ho, George, Lang, Wensheng, Conway, James G., Liang, Yin, Lenhard, James M., Demarest, Keith T., Murray, William V.
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
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Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s
Subasinghe, Nalin L., Khalil, Ehab, Travins, Jeremy M., Ali, Farah, Ballentine, Shelley K., Hufnagel, Heather R., Pan, Wenxi, Leonard, Kristi, Bone, Roger F., Soll, Richard M., Crysler, Carl S., Ninan, Nisha, Kirkpatrick, Jennifer, Kolpak, Michael X., Diloreto, Karen A., Eisennagel, Stephen H., Huebert, Norman D., Molloy, Christopher J., Tomczuk, Bruce E., Gaul, Michael D.
Published in Bioorganic & medicinal chemistry letters (15.08.2012)
Published in Bioorganic & medicinal chemistry letters (15.08.2012)
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Synthesis and biological study of 4-aminopyrimidine-5-carboxaldehyde oximes as antiproliferative VEGFR-2 inhibitors
Huang, Shenlin, Li, Ronghua, Connolly, Peter J., Xu, Guozhang, Gaul, Michael D., Emanuel, Stuart L., LaMontagne, Kenneth R., Greenberger, Lee M.
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
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CYP3A induction by n-hydroxyformamide tumor necrosis factor-α converting enzyme/matrix metalloproteinase inhibitors: Use of a pregnane X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans
TIPPIN, Timothy K, HAMILTON, Geraldine, HOIVIK, Debie J, MELLON-KUSIBAB, Kathy, LEHMANN, Jurgen, KLIEWER, Steven, NOVICK, Steven, LAETHEM, Ron, ZHIYANG ZHAO, LECLUYSE, Edward L, MOORE, Linda, BEAUDET, Elizabeth J, JOLLEY, Summer, BRODIE, Thomas A, ANDREWS, Robert C, BECHERER, J. David, MCDOUGALD, Darryl L, GAUL, Michael D
Published in Drug metabolism and disposition (01.07.2003)
Published in Drug metabolism and disposition (01.07.2003)
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N-Hydroxyformamide peptidomimetics as TACE/Matrix metalloprotease inhibitors: oral activity via P1′ isobutyl substitution
Musso, David L., Andersen, Marc W., Andrews, Robert C., Austin, Richard, Beaudet, Elizabeth J., Becherer, J.David, Bubacz, Dulce G., Bickett, D.Mark, Chan, Joseph H., Conway, James G., Cowan, David J., Gaul, Michael D., Glennon, Kimberly C., Hedeen, Kevin M., Lambert, Millard H., Leesnitzer, M.Anthony, McDougald, Darryl L., Mitchell, Justin L., Moss, Marcia L., Rabinowitz, Michael H., Rizzolio, Michele C., Schaller, Lee T., Stanford, Jennifer B., Tippin, Timothy K., Warner, Janet R., Whitesell, L.Graham, Wiethe, Robert W.
Published in Bioorganic & medicinal chemistry letters (20.08.2001)
Published in Bioorganic & medicinal chemistry letters (20.08.2001)
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Toward the development of a general chiral auxiliary. 1. Preparation of a new class of camphor lactam imides and their application to the construction of quaternary centers via Diels-Alder cycloaddition
Boeckman, Robert K, Nelson, Scott G, Gaul, Michael D
Published in Journal of the American Chemical Society (01.03.1992)
Published in Journal of the American Chemical Society (01.03.1992)
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Aqueous ozonolysis products of methyl- and dimethylnaphthalenes
Gaul, Michael D, Junk, Gregor A, Svec, Harry J
Published in Environmental science & technology (01.08.1987)
Published in Environmental science & technology (01.08.1987)
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Substrate specificity and novel selective inhibitors of TNF-alpha converting enzyme (TACE) from two-dimensional substrate mapping
Lambert, Millard H, Blackburn, R Kevin, Seaton, Theresa D, Kassel, Daniel B, Kinder, Daniel S, Leesnitzer, M Anthony, Bickett, D Mark, Warner, Janet R, Andersen, Marc W, Badiang, Jennifer G, Cowan, David J, Gaul, Michael D, Petrov, Kimberly G, Rabinowitz, Michael H, Wiethe, Robert W, Becherer, J David, McDougald, Darryl L, Musso, David L, Andrews, Robert C, Moss, Marcia L
Published in Combinatorial chemistry & high throughput screening (01.06.2005)
Published in Combinatorial chemistry & high throughput screening (01.06.2005)
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