Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists
Song, Fengbin, Xu, Guozhang, Gaul, Michael D., Zhao, Baoping, Lu, Tianbao, Zhang, Rui, DesJarlais, Renee L., DiLoreto, Karen, Huebert, Norman, Shook, Brian, Rentzeperis, Dennis, Santulli, Rosie, Eckardt, Annette, Demarest, Keith
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
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Journal Article
The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2
Qi, Jenson, Lang, Wensheng, Geisler, John G., Wang, Ping, Petrounia, Ioanna, Mai, Selyna, Smith, Charles, Askari, Hossein, Struble, Geoffrey T., Williams, Robyn, Bhanot, Sanjay, Monia, Brett P., Bayoumy, Shariff, Grant, Eugene, Caldwell, Gary W., Todd, Matthew J., Liang, Yin, Gaul, Micheal D., Demarest, Keith T., Connelly, Margery A.
Published in Journal of lipid research (01.06.2012)
Published in Journal of lipid research (01.06.2012)
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Journal Article
Investigating flow mechanisms in a forest soil by mixed‐effects modelling
Bogner, C, Gaul, D, Kolb, A, Schmiedinger, I, Huwe, B
Published in European journal of soil science (01.12.2010)
Published in European journal of soil science (01.12.2010)
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Journal Article
TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate responses to particle-mediated MPLA-CpG co-presentation
Pradhan, P, Toy, R, Jhita, N, Atalis, A, Pandey, B, Beach, A, Blanchard, E L, Moore, S G, Gaul, D A, Santangelo, P J, Shayakhmetov, D M, Roy, K
Published in Science advances (01.01.2021)
Published in Science advances (01.01.2021)
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Journal Article
5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors
Xu, Guozhang, Du, Fuyong, Kuo, Gee-Hong, Xu, June Zhi, Liang, Yin, Demarest, Keith, Gaul, Michael D.
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
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Journal Article
Discovery of Potent and Orally Bioavailable Pyridine N‑Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions
Xu, Guozhang, Liu, Zhijie, Wang, Xinkang, Lu, Tianbao, DesJarlais, Renee L., Thieu, Tho, Zhang, Jing, Devine, Zheng Huang, Du, Fuyong, Li, Qiu, Milligan, Cynthia M., Shaffer, Paul, Cedervall, Peder E., Spurlino, John C., Stratton, Christopher F., Pietrak, Beth, Szewczuk, Lawrence M., Wong, Victoria, Steele, Ruth A., Bruinzeel, Wouter, Chintala, Madhu, Silva, Jose, Gaul, Michael D., Macielag, Mark J., Nargund, Ravi
Published in Journal of medicinal chemistry (11.08.2022)
Published in Journal of medicinal chemistry (11.08.2022)
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Journal Article
Potent Sodium/Glucose Cotransporter SGLT1/2 Dual Inhibition Improves Glycemic Control Without Marked Gastrointestinal Adaptation or Colonic Microbiota Changes in Rodents
Du, Fuyong, Hinke, Simon A., Cavanaugh, Cassandre, Polidori, David, Wallace, Nathanial, Kirchner, Thomas, Jennis, Matthew, Lang, Wensheng, Kuo, Gee-Hong, Gaul, Micheal D., Lenhard, James, Demarest, Keith, Ajami, Nadim J., Liang, Yin, Hornby, Pamela J.
Published in The Journal of pharmacology and experimental therapeutics (01.06.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2018)
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Journal Article
Synthesis and biological evaluation of benzocyclobutane-C-glycosides as potent and orally active SGLT1/SGLT2 dual inhibitors
Kuo, Gee-Hong, Gaul, Micheal D., Liang, Yin, Xu, June Z., Du, Fuyong, Hornby, Pamela, Xu, Guozhang, Qi, Jenson, Wallace, Nathaniel, Lee, Seunghun, Grant, Eugene, Murray, William V., Demarest, Keith
Published in Bioorganic & medicinal chemistry letters (15.04.2018)
Published in Bioorganic & medicinal chemistry letters (15.04.2018)
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Journal Article
Indazole-based ligands for estrogen-related receptor α as potential anti-diabetic agents
Patch, Raymond J., Huang, Hui, Patel, Sharmila, Cheung, Wing, Xu, Guozhang, Zhao, Bao-Ping, Beauchamp, Derek A., Rentzeperis, Dionisios, Geisler, John G., Askari, Hossein B., Liu, Jianying, Kasturi, Jyotsna, Towers, Meghan, Gaul, Micheal D., Player, Mark R.
Published in European journal of medicinal chemistry (29.09.2017)
Published in European journal of medicinal chemistry (29.09.2017)
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Journal Article
Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors
Xu, Guozhang, Gaul, Michael D., Kuo, Gee-Hong, Du, Fuyong, Xu, June Zhi, Wallace, Nathaniel, Hinke, Simon, Kirchner, Thomas, Silva, Jose, Huebert, Norman D., Lee, Seunghun, Murray, William, Liang, Yin, Demarest, Keith
Published in Bioorganic & medicinal chemistry letters (15.11.2018)
Published in Bioorganic & medicinal chemistry letters (15.11.2018)
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Journal Article
Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes
Xu, Guozhang, Gaul, Michael D., Song, Fengbin, Du, Fuyong, Liang, Yin, DesJarlais, Renee L., DiLoreto, Karen, Shook, Brian, Rentzeperis, Dennis, Santulli, Rosie, Eckardt, Annette, Demarest, Keith
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
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Journal Article
Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor
Xu, Guozhang, Gaul, Michael D., Liu, Zhijie, DesJarlais, Renee L., Qi, Jenson, Wang, Weixue, Krosky, Daniel, Petrounia, Ioanna, Milligan, Cynthia M., Hermans, An, Lu, Hua-Rong, Huang, Devine Zheng, Xu, June Zhi, Spurlino, John C.
Published in Bioorganic & medicinal chemistry letters (01.12.2020)
Published in Bioorganic & medicinal chemistry letters (01.12.2020)
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Journal Article
Identification of Diaryl Ether-Based Ligands for Estrogen-Related Receptor α as Potential Antidiabetic Agents
Patch, Raymond J, Searle, Lily L, Kim, Alexander J, De, Debyendu, Zhu, Xizhen, Askari, Hossein B, O’Neill, John C, Abad, Marta C, Rentzeperis, Dionisios, Liu, Jianying, Kemmerer, Michael, Lin, Ling, Kasturi, Jyotsna, Geisler, John G, Lenhard, James M, Player, Mark R, Gaul, Micheal D
Published in Journal of medicinal chemistry (10.02.2011)
Published in Journal of medicinal chemistry (10.02.2011)
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Journal Article
Metabolic tracing of monoacylglycerol acyltransferase-2 activity in vitro and in vivo
Qi, Jenson, Lang, Wensheng, Connelly, Margery A, Du, Fuyong, Liang, Yin, Caldwell, Gary W, Martin, Tonya, Hansen, Michael K, Kuo, Gee-Hong, Gaul, Michael D, Pocai, Alessandro, Lee, Seunghun
Published in Analytical biochemistry (01.05.2017)
Published in Analytical biochemistry (01.05.2017)
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Journal Article
Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors
Rheault, Tara R., Caferro, Thomas R., Dickerson, Scott H., Donaldson, Kelly H., Gaul, Michael D., Goetz, Aaron S., Mullin, Robert J., McDonald, Octerloney B., Petrov, Kimberly G., Rusnak, David W., Shewchuk, Lisa M., Spehar, Glenn M., Truesdale, Anne T., Vanderwall, Dana E., Wood, Edgar R., Uehling, David E.
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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