Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity
Gaudet, Ryan G., Sintsova, Anna, Buckwalter, Carolyn M., Leung, Nelly, Cochrane, Alan, Li, Jianjun, Cox, Andrew D., Moffat, Jason, Gray-Owen, Scott D.
Published in Science (American Association for the Advancement of Science) (12.06.2015)
Published in Science (American Association for the Advancement of Science) (12.06.2015)
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Journal Article
Innate Recognition of Intracellular Bacterial Growth Is Driven by the TIFA-Dependent Cytosolic Surveillance Pathway
Gaudet, Ryan G., Guo, Cynthia X., Molinaro, Raphael, Kottwitz, Haila, Rohde, John R., Dangeard, Anne-Sophie, Arrieumerlou, Cécile, Girardin, Stephen E., Gray-Owen, Scott D.
Published in Cell reports (Cambridge) (16.05.2017)
Published in Cell reports (Cambridge) (16.05.2017)
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Journal Article
Neisseria gonorrhoeae-derived heptose elicits an innate immune response and drives HIV-1 expression
Malott, Rebecca J., Keller, Bernd O., Gaudet, Ryan G., McCaw, Shannon E., Lai, Christine C. L., Dobson-Belaire, Wendy N., Hobbs, J. Leigh, St. Michael, Frank, Cox, Andrew D., Moraes, Trevor F., Gray-Owen, Scott D.
Published in Proceedings of the National Academy of Sciences - PNAS (18.06.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (18.06.2013)
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Journal Article
A human apolipoprotein L with detergent-like activity kills intracellular pathogens
Gaudet, Ryan G, Zhu, Shiwei, Halder, Anushka, Kim, Bae-Hoon, Bradfield, Clinton J, Huang, Shuai, Xu, Dijin, Mamiñska, Agnieszka, Nguyen, Thanh Ngoc, Lazarou, Michael, Karatekin, Erdem, Gupta, Kallol, MacMicking, John D
Published in Science (American Association for the Advancement of Science) (16.07.2021)
Published in Science (American Association for the Advancement of Science) (16.07.2021)
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The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling
Abdel-Nour, Mena, Carneiro, Leticia A M, Downey, Jeffrey, Tsalikis, Jessica, Outlioua, Ahmed, Prescott, Dave, Da Costa, Leandro Silva, Hovingh, Elise S, Farahvash, Armin, Gaudet, Ryan G, Molinaro, Raphael, van Dalen, Rob, Lau, Charles C Y, Azimi, Farshad C, Escalante, Nichole K, Trotman-Grant, Aaron, Lee, Jeffrey E, Gray-Owen, Scott D, Divangahi, Maziar, Chen, Jane-Jane, Philpott, Dana J, Arnoult, Damien, Girardin, Stephen E
Published in Science (American Association for the Advancement of Science) (05.07.2019)
Published in Science (American Association for the Advancement of Science) (05.07.2019)
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PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection
Xu, Dijin, Jiang, Weiqian, Wu, Lizhen, Gaudet, Ryan G, Park, Eui-Soon, Su, Maohan, Cheppali, Sudheer Kumar, Cheemarla, Nagarjuna R, Kumar, Pradeep, Uchil, Pradeep D, Grover, Jonathan R, Foxman, Ellen F, Brown, Chelsea M, Stansfeld, Phillip J, Bewersdorf, Joerg, Mothes, Walther, Karatekin, Erdem, Wilen, Craig B, MacMicking, John D
Published in Nature (London) (27.07.2023)
Published in Nature (London) (27.07.2023)
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High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis
O'Meara, Teresa R, Duah, Kwamaa, Guo, Cynthia X, Maxson, Michelle E, Gaudet, Ryan G, Koselny, Kristy, Wellington, Melanie, Powers, Michael E, MacAlpine, Jessie, O'Meara, Matthew J, Veri, Amanda O, Grinstein, Sergio, Noble, Suzanne M, Krysan, Damian, Gray-Owen, Scott D, Cowen, Leah E
Published in mBio (21.08.2018)
Published in mBio (21.08.2018)
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Evolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune Cells
Gaudet, Ryan G, Bradfield, Clinton J, MacMicking, John D
Published in Microbiology spectrum (01.12.2016)
Published in Microbiology spectrum (01.12.2016)
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Journal Article
High-Throughput Screening Identifies Genes Required for italic toggle="yes">Candida albicans /italic> Induction of Macrophage Pyroptosis
Teresa R. O’Meara, Kwamaa Duah, Cynthia X. Guo, Michelle E. Maxson, Ryan G. Gaudet, Kristy Koselny, Melanie Wellington, Michael E. Powers, Jessie MacAlpine, Matthew J. O’Meara, Amanda O. Veri, Sergio Grinstein, Suzanne M. Noble, Damian Krysan, Scott D. Gray-Owen, Leah E. Cowen
Published in mBio (01.09.2018)
Published in mBio (01.09.2018)
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Journal Article
INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity
Gaudet, Ryan G, Sintsova, Anna, Buckwalter, Carolyn M, Leung, Nelly, Cochrane, Alan, Li, Jianjun, Cox, Andrew D, Moffat, Jason, Gray-Owen, Scott D
Published in Science (American Association for the Advancement of Science) (12.06.2015)
Published in Science (American Association for the Advancement of Science) (12.06.2015)
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Journal Article