Selexipag: An Oral and Selective IP Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension
Asaki, Tetsuo, Kuwano, Keiichi, Morrison, Keith, Gatfield, John, Hamamoto, Taisuke, Clozel, Martine
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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The Antifibrotic Activity of Prostacyclin Receptor Agonism Is Mediated through Inhibition of YAP/TAZ
Zmajkovicova, Katarina, Menyhart, Katalin, Bauer, Yasmina, Studer, Rolf, Renault, Berengere, Schnoebelen, Marie, Bolinger, Matthias, Nayler, Oliver, Gatfield, John
Published in American journal of respiratory cell and molecular biology (01.05.2019)
Published in American journal of respiratory cell and molecular biology (01.05.2019)
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The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468
Treiber, Alexander, de Kanter, Ruben, Roch, Catherine, Gatfield, John, Boss, Christoph, von Raumer, Markus, Schindelholz, Benno, Muehlan, Clemens, van Gerven, Joop, Jenck, Francois
Published in The Journal of pharmacology and experimental therapeutics (01.09.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2017)
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Journal Article
Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist
Iglarz, Marc, Binkert, Christoph, Morrison, Keith, Fischli, Walter, Gatfield, John, Treiber, Alexander, Weller, Thomas, Bolli, Martin H, Boss, Christoph, Buchmann, Stephan, Capeleto, Bruno, Hess, Patrick, Qiu, Changbin, Clozel, Martine
Published in The Journal of pharmacology and experimental therapeutics (01.12.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2008)
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Journal Article
From bosentan (Tracleer®) to macitentan (Opsumit®): The medicinal chemistry perspective
Boss, Christoph, Bolli, Martin H., Gatfield, John
Published in Bioorganic & medicinal chemistry letters (01.08.2016)
Published in Bioorganic & medicinal chemistry letters (01.08.2016)
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Journal Article
GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1
Zmajkovicova, Katarina, Bauer, Yasmina, Menyhart, Katalin, Schnoebelen, Marie, Freti, Diego, Boucher, Maxime, Renault, Bérengère, Studer, Rolf, Birker-Robaczewska, Magdalena, Klenk, Axel, Nayler, Oliver, Gatfield, John
Published in PloS one (13.02.2020)
Published in PloS one (13.02.2020)
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Journal Article
FTY720 Phosphate Activates Sphingosine-1-Phosphate Receptor 2 and Selectively Couples to Gα12/13/Rho/ROCK to Induce Myofibroblast Contraction
Sobel, Katrin, Monnier, Lucile, Menyhart, Katalin, Bolinger, Matthias, Studer, Rolf, Nayler, Oliver, Gatfield, John
Published in Molecular pharmacology (01.06.2015)
Published in Molecular pharmacology (01.06.2015)
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Journal Article
Novel high-throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP2 and EP4 receptors
Sieber, Patrick, Schäfer, Anny, Lieberherr, Raphael, Le Goff, François, Stritt, Manuel, Welford, Richard W D, Gatfield, John, Peter, Oliver, Nayler, Oliver, Lüthi, Urs
Published in PloS one (28.11.2018)
Published in PloS one (28.11.2018)
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Journal Article
Distinct ETA receptor binding mode of macitentan as determined by site directed mutagenesis
Gatfield, John, Mueller Grandjean, Celia, Bur, Daniel, Bolli, Martin H, Nayler, Oliver
Published in PloS one (16.09.2014)
Published in PloS one (16.09.2014)
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Journal Article
Ancestral Antibiotic Resistance in Mycobacterium tuberculosis
Morris, Rowan P, Nguyen, Liem, Gatfield, John, Visconti, Kevin, Nguyen, Kien, Schnappinger, Dirk, Ehrt, Sabine, Liu, Yang, Heifets, Leonid, Pieters, Jean, Schoolnik, Gary, Thompson, Charles J
Published in Proceedings of the National Academy of Sciences - PNAS (23.08.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (23.08.2005)
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Journal Article
Desensitization by progressive up-titration prevents first-dose effects on the heart: guinea pig study with ponesimod, a selective S1P1 receptor modulator
Rey, Markus, Hess, Patrick, Clozel, Martine, Delahaye, Stéphane, Gatfield, John, Nayler, Oliver, Steiner, Beat
Published in PloS one (12.09.2013)
Published in PloS one (12.09.2013)
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Journal Article
Orexin Receptor Antagonists: A New Concept In CNS Disorders?
Gatfield, John, Brisbare-Roch, Catherine, Jenck, Francois, Boss, Christoph
Published in ChemMedChem (02.08.2010)
Published in ChemMedChem (02.08.2010)
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Journal Article
Structure-Activity Relationship, Biological, and Pharmacological Characterization of the Proline Sulfonamide ACT-462206: a Potent, Brain-Penetrant Dual Orexin 1/Orexin 2 Receptor Antagonist
Boss, Christoph, Roch-Brisbare, Catherine, Steiner, Michel A., Treiber, Alexander, Dietrich, Hendrik, Jenck, Francois, von Raumer, Markus, Sifferlen, Thierry, Brotschi, Christine, Heidmann, Bibia, Williams, Jodi T., Aissaoui, Hamed, Siegrist, Romain, Gatfield, John
Published in ChemMedChem (01.11.2014)
Published in ChemMedChem (01.11.2014)
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Structure–activity relationship studies and sleep-promoting activity of novel 1-chloro-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 2
Sifferlen, Thierry, Koberstein, Ralf, Cottreel, Emmanuelle, Boller, Amandine, Weller, Thomas, Gatfield, John, Brisbare-Roch, Catherine, Jenck, Francois, Boss, Christoph
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
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Journal Article
Hijacking the host: survival of pathogenic mycobacteria inside macrophages
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Book Review
Journal Article
Synthesis, structure–activity relationship studies, and identification of novel 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 1
Sifferlen, Thierry, Koberstein, Ralf, Cottreel, Emmanuelle, Boller, Amandine, Weller, Thomas, Gatfield, John, Brisbare-Roch, Catherine, Jenck, Francois, Boss, Christoph
Published in Bioorganic & medicinal chemistry letters (01.04.2013)
Published in Bioorganic & medicinal chemistry letters (01.04.2013)
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Journal Article
Sphingosine 1-Phosphate (S1P) Receptor Agonists Mediate Pro-fibrotic Responses in Normal Human Lung Fibroblasts via S1P2 and S1P3 Receptors and Smad-independent Signaling
Sobel, Katrin, Menyhart, Katalin, Killer, Nina, Renault, Bérengère, Bauer, Yasmina, Studer, Rolf, Steiner, Beat, Bolli, Martin H., Nayler, Oliver, Gatfield, John
Published in The Journal of biological chemistry (24.05.2013)
Published in The Journal of biological chemistry (24.05.2013)
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Journal Article
Milestones to the Discovery of T-type Calcium Channel Blockers for the Treatment of Generalized Epilepsies
Bezençon, Olivier, Siegrist, Romain, Heidmann, Bibia, Pozzi, Davide, Stamm, Simon, Remeň, Luboš, Richard, Sylvia, Simons, Lloyd, Gaston, Rick, Downing, Dennis, Grisostomi, Corinna, Roch, Catherine, Kessler, Melanie, Gatfield, John, Moon, Richard, Pfeifer, Thomas, Mosbacher, Johannes, Reymond, Isabelle, Ertel, Eric A, de Kanter, Ruben, Capeleto, Bruno, Fournier, Elvire, Rey, Markus, Moccia, Luca, Toeroek-Schafroth, Michael, Roscher, René, Schindelholz, Benno
Published in Chimia (25.10.2017)
Published in Chimia (25.10.2017)
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