Two Distinct Structures of Membrane‐Associated Homodimers of GTP‐ and GDP‐Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement
Lee, Ki‐Young, Fang, Zhenhao, Enomoto, Masahiro, Gasmi‐Seabrook, Genevieve, Zheng, Le, Koide, Shohei, Ikura, Mitsuhiko, Marshall, Christopher B.
Published in Angewandte Chemie International Edition (26.06.2020)
Published in Angewandte Chemie International Edition (26.06.2020)
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Regulation of GTPase function by autophosphorylation
Johnson, Christian W., Seo, Hyuk-Soo, Terrell, Elizabeth M., Yang, Moon-Hee, KleinJan, Fenneke, Gebregiworgis, Teklab, Gasmi-Seabrook, Genevieve M.C., Geffken, Ezekiel A., Lakhani, Jimit, Song, Kijun, Bashyal, Puspalata, Popow, Olesja, Paulo, Joao A., Liu, Andrea, Mattos, Carla, Marshall, Christopher B., Ikura, Mitsuhiko, Morrison, Deborah K., Dhe-Paganon, Sirano, Haigis, Kevin M.
Published in Molecular cell (03.03.2022)
Published in Molecular cell (03.03.2022)
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The Solution Structure of the C-Terminal Ig-like Domain of the Bacteriophage λ Tail Tube Protein
Pell, Lisa G., Gasmi-Seabrook, Genevieve M.C., Morais, Marc, Neudecker, Philipp, Kanelis, Voula, Bona, Diane, Donaldson, Logan W., Edwards, Aled M., Howell, P. Lynne, Davidson, Alan R., Maxwell, Karen L.
Published in Journal of molecular biology (29.10.2010)
Published in Journal of molecular biology (29.10.2010)
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Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site
Mazhab-Jafari, Mohammad T., Marshall, Christopher B., Smith, Matthew J., Gasmi-Seabrook, Geneviève M. C., Stathopulos, Peter B., Inagaki, Fuyuhiko, Kay, Lewis E., Neel, Benjamin G., Ikura, Mitsuhiko
Published in Proceedings of the National Academy of Sciences - PNAS (26.05.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (26.05.2015)
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Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization
Lee, Ki-Young, Enomoto, Masahiro, Gebregiworgis, Teklab, Gasmi-Seabrook, Geneviève M. C, Ikura, Mitsuhiko, Marshall, Christopher B
Published in Chemical science (Cambridge) (06.10.2021)
Published in Chemical science (Cambridge) (06.10.2021)
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STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry
Stathopulos, Peter B., Schindl, Rainer, Fahrner, Marc, Zheng, Le, Gasmi-Seabrook, Geneviève M., Muik, Martin, Romanin, Christoph, Ikura, Mitsuhiko
Published in Nature communications (19.12.2013)
Published in Nature communications (19.12.2013)
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Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment
Wang, Feng, Marshall, Christopher B, Yamamoto, Kazuo, Li, Guang-Yao, Gasmi-Seabrook, Geneviève M. C, Okada, Hitoshi, Mak, Tak W, Ikura, Mitsuhiko
Published in Proceedings of the National Academy of Sciences - PNAS (17.04.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (17.04.2012)
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NMR in integrated biophysical drug discovery for RAS: past, present, and future
Marshall, Christopher B., KleinJan, Fenneke, Gebregiworgis, Teklab, Lee, Ki-Young, Fang, Zhenhao, Eves, Ben J., Liu, Ningdi F., Gasmi-Seabrook, Geneviève M. C., Enomoto, Masahiro, Ikura, Mitsuhiko
Published in Journal of biomolecular NMR (01.11.2020)
Published in Journal of biomolecular NMR (01.11.2020)
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Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant
Eves, Ben J., Gebregiworgis, Teklab, Gasmi-Seabrook, Geneviève M.C., Kuntz, Douglas A., Privé, Gilbert G., Marshall, Christopher B., Ikura, Mitsuhiko
Published in Journal of molecular biology (15.05.2022)
Published in Journal of molecular biology (15.05.2022)
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Biochemical and biophysical characterization of the RAS family small GTPase protein DiRAS3
Saitoh, Takashi, Kim, Ha-Neul, Narita, Riku, Ohtsuka, Ibuki, Mo, Weiyu, Lee, Ki-Young, Enomoto, Masahiro, Gasmi-Seabrook, Geneviève M.C., Marshall, Christopher B., Ikura, Mitsuhiko
Published in Protein expression and purification (01.12.2023)
Published in Protein expression and purification (01.12.2023)
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Type 2 Ryanodine Receptor Domain A Contains a Unique and Dynamic α-Helix That Transitions to a β-Strand in a Mutant Linked with a Heritable Cardiomyopathy
Amador, Fernando J., Kimlicka, Lynn, Stathopulos, Peter B., Gasmi-Seabrook, Geneviève M.C., MacLennan, David H., Van Petegem, Filip, Ikura, Mitsuhiko
Published in Journal of molecular biology (01.11.2013)
Published in Journal of molecular biology (01.11.2013)
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Protein global fold determination using site-directed spin and isotope labeling
GAPONENKO, VADIM, HOWARTH, JACK W., COLUMBUS, LINDA, GASMI-SEABROOK, GENEVIEVE, YUAN, JIE, HUBBELL, WAYNE L., ROSEVEAR, PAUL R.
Published in Protein science (01.02.2000)
Published in Protein science (01.02.2000)
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Evolution of AF6-RAS association and its implications in mixed-lineage leukemia
Smith, Matthew J., Ottoni, Elizabeth, Ishiyama, Noboru, Goudreault, Marilyn, Haman, André, Meyer, Claus, Tucholska, Monika, Gasmi-Seabrook, Genevieve, Menezes, Serena, Laister, Rob C., Minden, Mark D., Marschalek, Rolf, Gingras, Anne-Claude, Hoang, Trang, Ikura, Mitsuhiko
Published in Nature communications (23.10.2017)
Published in Nature communications (23.10.2017)
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Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1)
Fang, Zhenhao, Marshall, Christopher B., Yin, Jiani C., Mazhab-Jafari, Mohammad T., Gasmi-Seabrook, Geneviève M.C., Smith, Matthew J., Nishikawa, Tadateru, Xu, Yang, Neel, Benjamin G., Ikura, Mitsuhiko
Published in The Journal of biological chemistry (22.07.2016)
Published in The Journal of biological chemistry (22.07.2016)
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Real-time NMR Study of Three Small GTPases Reveals That Fluorescent 2′(3′)-O-(N-Methylanthraniloyl)-tagged Nucleotides Alter Hydrolysis and Exchange Kinetics
Mazhab-Jafari, Mohammad T., Marshall, Christopher B., Smith, Matthew, Gasmi-Seabrook, Geneviève M.C., Stambolic, Vuk, Rottapel, Robert, Neel, Benjamin G., Ikura, Mitsuhiko
Published in The Journal of biological chemistry (19.02.2010)
Published in The Journal of biological chemistry (19.02.2010)
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Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts
Marshall, Christopher B., Meiri, David, Smith, Matthew J., Mazhab-Jafari, Mohammad T., Gasmi-Seabrook, Geneviève M.C., Rottapel, Robert, Stambolic, Vuk, Ikura, Mitsuhiko
Published in Methods (San Diego, Calif.) (01.08.2012)
Published in Methods (San Diego, Calif.) (01.08.2012)
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Journal Article
Two Distinct Structures of Membrane‐Associated Homodimers of GTP‐ and GDP‐Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement
Lee, Ki‐Young, Fang, Zhenhao, Enomoto, Masahiro, Gasmi‐Seabrook, Genevieve, Zheng, Le, Koide, Shohei, Ikura, Mitsuhiko, Marshall, Christopher B.
Published in Angewandte Chemie (26.06.2020)
Published in Angewandte Chemie (26.06.2020)
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Journal Article
Real-time NMR Study of Guanine Nucleotide Exchange and Activation of RhoA by PDZ-RhoGEF
Gasmi-Seabrook, Geneviève M.C., Marshall, Christopher B., Cheung, Melissa, Kim, Bryan, Wang, Feng, Jang, Ying Ju, Mak, Tak W., Stambolic, Vuk, Ikura, Mitsuhiko
Published in The Journal of biological chemistry (19.02.2010)
Published in The Journal of biological chemistry (19.02.2010)
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Journal Article
Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane
Fang, Zhenhao, Lee, Ki-Young, Huo, Ku-Geng, Gasmi-Seabrook, Geneviève, Zheng, Le, Moghal, Nadeem, Tsao, Ming-Sound, Ikura, Mitsuhiko, Marshall, Christopher B.
Published in Proceedings of the National Academy of Sciences - PNAS (02.06.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (02.06.2020)
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