Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site
Mazhab-Jafari, Mohammad T., Marshall, Christopher B., Smith, Matthew J., Gasmi-Seabrook, Geneviève M. C., Stathopulos, Peter B., Inagaki, Fuyuhiko, Kay, Lewis E., Neel, Benjamin G., Ikura, Mitsuhiko
Published in Proceedings of the National Academy of Sciences - PNAS (26.05.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (26.05.2015)
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Journal Article
Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization
Lee, Ki-Young, Enomoto, Masahiro, Gebregiworgis, Teklab, Gasmi-Seabrook, Geneviève M. C, Ikura, Mitsuhiko, Marshall, Christopher B
Published in Chemical science (Cambridge) (06.10.2021)
Published in Chemical science (Cambridge) (06.10.2021)
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Journal Article
Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment
Wang, Feng, Marshall, Christopher B, Yamamoto, Kazuo, Li, Guang-Yao, Gasmi-Seabrook, Geneviève M. C, Okada, Hitoshi, Mak, Tak W, Ikura, Mitsuhiko
Published in Proceedings of the National Academy of Sciences - PNAS (17.04.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (17.04.2012)
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Journal Article
NMR in integrated biophysical drug discovery for RAS: past, present, and future
Marshall, Christopher B., KleinJan, Fenneke, Gebregiworgis, Teklab, Lee, Ki-Young, Fang, Zhenhao, Eves, Ben J., Liu, Ningdi F., Gasmi-Seabrook, Geneviève M. C., Enomoto, Masahiro, Ikura, Mitsuhiko
Published in Journal of biomolecular NMR (01.11.2020)
Published in Journal of biomolecular NMR (01.11.2020)
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Journal Article
Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1)
Fang, Zhenhao, Marshall, Christopher B., Yin, Jiani C., Mazhab-Jafari, Mohammad T., Gasmi-Seabrook, Geneviève M.C., Smith, Matthew J., Nishikawa, Tadateru, Xu, Yang, Neel, Benjamin G., Ikura, Mitsuhiko
Published in The Journal of biological chemistry (22.07.2016)
Published in The Journal of biological chemistry (22.07.2016)
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Journal Article
Real-time NMR Study of Three Small GTPases Reveals That Fluorescent 2′(3′)-O-(N-Methylanthraniloyl)-tagged Nucleotides Alter Hydrolysis and Exchange Kinetics
Mazhab-Jafari, Mohammad T., Marshall, Christopher B., Smith, Matthew, Gasmi-Seabrook, Geneviève M.C., Stambolic, Vuk, Rottapel, Robert, Neel, Benjamin G., Ikura, Mitsuhiko
Published in The Journal of biological chemistry (19.02.2010)
Published in The Journal of biological chemistry (19.02.2010)
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Journal Article
Real-time NMR Study of Guanine Nucleotide Exchange and Activation of RhoA by PDZ-RhoGEF
Gasmi-Seabrook, Geneviève M.C., Marshall, Christopher B., Cheung, Melissa, Kim, Bryan, Wang, Feng, Jang, Ying Ju, Mak, Tak W., Stambolic, Vuk, Ikura, Mitsuhiko
Published in The Journal of biological chemistry (19.02.2010)
Published in The Journal of biological chemistry (19.02.2010)
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Journal Article
Time-resolved NMR detection of prolyl-hydroxylation in intrinsically disordered region of HIF-1α
He, Wenguang, Gasmi-Seabrook, Geneviève M. C., Ikura, Mitsuhiko, Lee, Jeffrey E., Ohh, Michael
Published in Proceedings of the National Academy of Sciences - PNAS (10.09.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (10.09.2024)
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Journal Article
Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant
Eves, Ben J., Gebregiworgis, Teklab, Gasmi-Seabrook, Geneviève M.C., Kuntz, Douglas A., Privé, Gilbert G., Marshall, Christopher B., Ikura, Mitsuhiko
Published in Journal of molecular biology (15.05.2022)
Published in Journal of molecular biology (15.05.2022)
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Journal Article
Biochemical and biophysical characterization of the RAS family small GTPase protein DiRAS3
Saitoh, Takashi, Kim, Ha-Neul, Narita, Riku, Ohtsuka, Ibuki, Mo, Weiyu, Lee, Ki-Young, Enomoto, Masahiro, Gasmi-Seabrook, Geneviève M.C., Marshall, Christopher B., Ikura, Mitsuhiko
Published in Protein expression and purification (01.12.2023)
Published in Protein expression and purification (01.12.2023)
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Journal Article
Type 2 Ryanodine Receptor Domain A Contains a Unique and Dynamic α-Helix That Transitions to a β-Strand in a Mutant Linked with a Heritable Cardiomyopathy
Amador, Fernando J., Kimlicka, Lynn, Stathopulos, Peter B., Gasmi-Seabrook, Geneviève M.C., MacLennan, David H., Van Petegem, Filip, Ikura, Mitsuhiko
Published in Journal of molecular biology (01.11.2013)
Published in Journal of molecular biology (01.11.2013)
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Journal Article
Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts
Marshall, Christopher B., Meiri, David, Smith, Matthew J., Mazhab-Jafari, Mohammad T., Gasmi-Seabrook, Geneviève M.C., Rottapel, Robert, Stambolic, Vuk, Ikura, Mitsuhiko
Published in Methods (San Diego, Calif.) (01.08.2012)
Published in Methods (San Diego, Calif.) (01.08.2012)
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Journal Article
The Solution Structure of the C-Terminal Ig-like Domain of the Bacteriophage λ Tail Tube Protein
Pell, Lisa G., Gasmi-Seabrook, Genevieve M.C., Morais, Marc, Neudecker, Philipp, Kanelis, Voula, Bona, Diane, Donaldson, Logan W., Edwards, Aled M., Howell, P. Lynne, Davidson, Alan R., Maxwell, Karen L.
Published in Journal of molecular biology (29.10.2010)
Published in Journal of molecular biology (29.10.2010)
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Journal Article
Regulation of GTPase function by autophosphorylation
Johnson, Christian W., Seo, Hyuk-Soo, Terrell, Elizabeth M., Yang, Moon-Hee, KleinJan, Fenneke, Gebregiworgis, Teklab, Gasmi-Seabrook, Genevieve M.C., Geffken, Ezekiel A., Lakhani, Jimit, Song, Kijun, Bashyal, Puspalata, Popow, Olesja, Paulo, Joao A., Liu, Andrea, Mattos, Carla, Marshall, Christopher B., Ikura, Mitsuhiko, Morrison, Deborah K., Dhe-Paganon, Sirano, Haigis, Kevin M.
Published in Molecular cell (03.03.2022)
Published in Molecular cell (03.03.2022)
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Journal Article
Solution Structures of the C-Terminal Domain of Cardiac Troponin C Free and Bound to the N-Terminal Domain of Cardiac Troponin I
Gasmi-Seabrook, Geneviève M. C, Howarth, Jack W, Finley, Natosha, Abusamhadneh, Ekram, Gaponenko, Vadim, Brito, Rui M. M, Solaro, R. John, Rosevear, Paul R
Published in Biochemistry (Easton) (29.06.1999)
Published in Biochemistry (Easton) (29.06.1999)
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Journal Article
Solution Structures of the C-Terminal Domain of Cardiac Troponin C Free and Bound to the N-Terminal Domain of Cardiac Troponin I
Gasmi-Seabrook, Geneviève M. C, Howarth, Jack W, Finley, Natosha, Abusamhadneh, Ekram, Gaponenko, Vadim, Brito, Rui M. M, Solaro, R. John, Rosevear, Paul R
Published in Biochemistry (Easton) (26.10.1999)
Published in Biochemistry (Easton) (26.10.1999)
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Journal Article
Regulation of GTPase function by autophosphorylation
Johnson, Christian W, Hyuk-Soo Seo, Terrell, Elizabeth M, Kleinjan, Fenneke, Gebregiworgis, Teklab, Gasmi-Seabrook, Genevieve M C, Geffken, Ezekiel A, Lakhani, Jimit, Song, Kijun, Popow, Olesja, Paulo, Joao A, Liu, Andrea, Mattos, Carla, Marshall, Christopher B, Ikura, Mitsuhiko, Morrison, Deborah K, Dhe-Paganon, Sirano, Haigis, Kevin M
Published in bioRxiv (23.06.2021)
Published in bioRxiv (23.06.2021)
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