Single and multiple ascending-dose study of glucagon-receptor antagonist RN909 in type 2 diabetes: a phase 1, randomized, double-blind, placebo-controlled trial
Gumbiner, Barry, Esteves, Brooke, Dell, Vanessa, Joh, Tenshang, Garzone, Pamela D., Forgie, Alison, Udata, Chandrasekhar
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Published in Endocrine (01.11.2018)
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Effects of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibition with Bococizumab on Lipoprotein Particles in Hypercholesterolemic Subjects
Wan, Hong, Gumbiner, Barry, Joh, Tenshang, Riel, Tom, Udata, Chandrasekhar, Forgues, Philippe, Garzone, Pamela D.
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Model-Based Characterization of the Pharmacokinetics, Target Engagement Biomarkers, and Immunomodulatory Activity of PF-06342674, a Humanized mAb Against IL-7 Receptor-α, in Adults with Type 1 Diabetes
Williams, Jason H., Udata, Chandrasekhar, Ganguly, Bishu J., Bucktrout, Samantha L., Joh, Tenshang, Shannon, Megan, Wong, Gilbert Y., Levisetti, Matteo, Garzone, Pamela D., Meng, Xu
Published in The AAPS journal (03.01.2020)
Published in The AAPS journal (03.01.2020)
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A Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for Bococizumab, a Humanized Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9, and Its Application in Early Clinical Development
Udata, Chandrasekhar, Garzone, Pamela D, Gumbiner, Barry, Joh, Tenshang, Liang, Hong, Liao, Kai-Hsin, Williams, Jason H, Meng, Xu
Published in Journal of clinical pharmacology (01.07.2017)
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Lemur tail kinase 3 serves as a predictor of patient outcomes and a target for the treatment of ovarian cancer
Saed, Ghassan M, Fletcher, Nicole M, Sharma, Harvey, Tullberg, Axel Stenmark, Ittner, Ella, Parris, Toshima Z, Pettersson, Daniella, Kovács, Anikó, Rönnerman, Elisabeth Werner, Dahm-Kähler, Pernilla, Portela, Anna, Garzone, Pamela D, Morris, Robert, Helou, Khalil
Published in Molecular Therapy: Oncology (19.09.2024)
Published in Molecular Therapy: Oncology (19.09.2024)
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EFFECTS OF RN316 (PF-04950615), A HUMANIZED IGG2ΔA MONOCLONAL ANTIBODY BINDING PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9, ON LIPOPROTEIN PARTICLES IN HYPERCHOLESTEROLEMIC SUBJECTS
Wan, Hong, Gumbiner, Barry, Joh, Tenshang, Udata, Chandrasekhar, Forgues, Philippe, Garzone, Pamela D
Published in Journal of the American College of Cardiology (12.03.2013)
Published in Journal of the American College of Cardiology (12.03.2013)
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Immunomodulatory activity of humanized anti-IL-7R monoclonal antibody RN168 in subjects with type 1 diabetes
Herold, Kevan C, Bucktrout, Samantha L, Wang, Xiao, Bode, Bruce W, Gitelman, Stephen E, Gottlieb, Peter A, Hughes, Jing, Joh, Tenshang, McGill, Janet B, Pettus, Jeremy H, Potluri, Shobha, Schatz, Desmond, Shannon, Megan, Udata, Chandrasekhar, Wong, Gilbert, Levisetti, Matteo, Ganguly, Bishu J, Garzone, Pamela D
Published in JCI insight (19.12.2019)
Published in JCI insight (19.12.2019)
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Molecular Characterization of Familial Hypercholesterolemia in a North American Cohort
Garg, Abhimanyu, Fazio, Sergio, Duell, P Barton, Baass, Alexis, Udata, Chandrasekhar, Joh, Tenshang, Riel, Tom, Sirota, Marina, Dettling, Danielle, Liang, Hong, Garzone, Pamela D, Gumbiner, Barry, Wan, Hong
Published in Journal of the Endocrine Society (01.01.2020)
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Effects of 12 weeks of treatment with intravenously administered bococizumab, a humanized monoclonal antibody blocking proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects on high‐dose statin
Fazio, Sergio, Robertson, David G., Joh, Tenshang, Wan, Hong, Riel, Tom, Forgues, Philippe, Baum, Charles M., Garzone, Pamela D., Gumbiner, Barry
Published in Cardiovascular therapeutics (01.02.2018)
Published in Cardiovascular therapeutics (01.02.2018)
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The effects of single‐ and multiple‐dose administration of bococizumab (RN316/PF‐04950615), a humanized IgG2Δa monoclonal antibody binding proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects treated with and without atorvastatin: Results from four phase I studies
Gumbiner, Barry, Joh, Tenshang, Liang, Hong, Wan, Hong, Levisetti, Matteo, Vana, Alicia M., Shelton, David L., Forgues, Philippe, Billotte, Stephan, Pons, Jaume, Baum, Charles M., Garzone, Pamela D.
Published in Cardiovascular therapeutics (01.02.2018)
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Safety and tolerability of LBR-101, a humanized monoclonal antibody that blocks the binding of CGRP to its receptor: Results of the Phase 1 program
Bigal, Marcelo E, Escandon, Rafael, Bronson, Michele, Walter, Sarah, Sudworth, Maria, Huggins, John P, Garzone, Pamela
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Published in Cephalalgia (01.06.2014)
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Phase I study of CCW702, a bispecific small molecule-antibody conjugate targeting PSMA and CD3 in patients with metastatic castration-resistant prostate cancer (mCRPC)
Markowski, Mark Christopher, Kilari, Deepak, Eisenberger, Mario A., McKay, Rana R., Dreicer, Robert, Trikha, Mohit, Heath, Elisabeth I., Li, Jing, Garzone, Pamela D., Young, Travis S.
Published in Journal of clinical oncology (20.05.2021)
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Enhancement of the efficacy of an antagonist of an extracellular receptor by attachment to the surface of a biocompatible carrier
Wartchow, Charles A, Alters, Susan E, Garzone, Pamela D, Li, Lingyun, Choi, Steven, DeChene, Neal E, Doede, Tina, Huang, Linong, Pease, John S, Shen, Zhimin, Knox, Susan J, Cleland, Jeffrey L
Published in Pharmaceutical research (01.10.2004)
Published in Pharmaceutical research (01.10.2004)
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Increasing Serum Half-life and Extending Cholesterol Lowering in Vivo by Engineering Antibody with pH-sensitive Binding to PCSK9
Chaparro-Riggers, Javier, Liang, Hong, DeVay, Rachel M., Bai, Lanfang, Sutton, Janette E., Chen, Wei, Geng, Tao, Lindquist, Kevin, Casas, Meritxell Galindo, Boustany, Leila M., Brown, Colleen L., Chabot, Jeffrey, Gomes, Bruce, Garzone, Pamela, Rossi, Andrea, Strop, Pavel, Shelton, Dave, Pons, Jaume, Rajpal, Arvind
Published in The Journal of biological chemistry (30.03.2012)
Published in The Journal of biological chemistry (30.03.2012)
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Clinical pharmacology assessment of PF-06647020 (PF-7020), an antibody-drug conjugate (ADC) targeting protein tyrosine kinase 7 (PTK7), in adult patients (pts) with advanced solid tumors
Xuan, Dawei, Xin, Xiaohua (Robert), Gibson, Brenda, Joh, Tenshang, Yin, Hequn, Garzone, Pamela D., Sachdev, Jasgit C., Maitland, Michael L., Sharma, Manish, Moreno, Victor, Calvo, Emiliano, Kummar, Shivaani, Stringer-Reasor, Erica Michelle, Lakhani, Nehal J., Tolcher, Anthony W., Beaupre, Darrin M.
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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ROBUST GLUCOSE AND HBA1C LOWERING AFTER A SINGLE DOSE OF RN909 (PF-06293620) IN TYPE 2 DIABETES (T2D) SUBJECTS
Gumbiner, Barry, Esteves, Brooke, Dell, Vanessa, Joh, Tenshang, Garzone, Pamela D, gie, Alison, Udata, Chandrasekhar
Published in Endocrine practice (01.12.2016)
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Published in Endocrine practice (01.12.2016)
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Abstract # P-6: Robust Glucose and HbA1c Lowering After a Single Dose of Rn909 (Pf-06293620) in Type 2 Diabetes (T2D) SUBJECTS
Gumbiner, Barry, Esteves, Brooke, Dell, Vanessa, Joh, Tenshang, Garzone, Pamela D., Forgie, Alison, Udata, Chandrasekhar
Published in Endocrine practice (01.12.2016)
Published in Endocrine practice (01.12.2016)
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Journal Article
EFFECTS OF RN316 (PF-04950615), A HUMANIZED IGG2[delta]A MONOCLONAL ANTIBODY BINDING PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9, ON LIPOPROTEIN PARTICLES IN HYPERCHOLESTEROLEMIC SUBJECTS
Wan, Hong, Gumbiner, Barry, Joh, Tenshang, Udata, Chandrasekhar, gues, Philippe, Garzone, Pamela D
Published in Journal of the American College of Cardiology (12.03.2013)
Published in Journal of the American College of Cardiology (12.03.2013)
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Journal Article
The effects of single- and multiple-dose administration of bococizumab (RN316/PF-04950615), a humanized IgG2[Delta]a monoclonal antibody binding proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects treated with and without atorvastatin: Results from four phase I studies
Gumbiner, Barry, Joh, Tenshang, Liang, Hong, Wan, Hong, Levisetti, Matteo, Vana, Alicia M, Shelton, David L, gues, Philippe, Billotte, Stephan, Pons, Jaume, Baum, Charles M, Garzone, Pamela D
Published in Cardiovascular therapeutics (01.02.2018)
Published in Cardiovascular therapeutics (01.02.2018)
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Journal Article
Effects of 12ￂ weeks of treatment with intravenously administered bococizumab, a humanized monoclonal antibody blocking proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects on high-dose statin
Fazio, Sergio, Robertson, David G, Joh, Tenshang, Wan, Hong, Riel, Tom, gues, Philippe, Baum, Charles M, Garzone, Pamela D, Gumbiner, Barry
Published in Cardiovascular therapeutics (01.02.2018)
Published in Cardiovascular therapeutics (01.02.2018)
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