Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase
Garvie, Colin W., Wu, Xiaoyun, Papanastasiou, Malvina, Lee, Sooncheol, Fuller, James, Schnitzler, Gavin R., Horner, Steven W., Baker, Andrew, Zhang, Terry, Mullahoo, James P., Westlake, Lindsay, Hoyt, Stephanie H., Toetzl, Marcus, Ranaghan, Matthew J., de Waal, Luc, McGaunn, Joseph, Kaplan, Bethany, Piccioni, Federica, Yang, Xiaoping, Lange, Martin, Tersteegen, Adrian, Raymond, Donald, Lewis, Timothy A., Carr, Steven A., Cherniack, Andrew D., Lemke, Christopher T., Meyerson, Matthew, Greulich, Heidi
Published in Nature communications (16.07.2021)
Published in Nature communications (16.07.2021)
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Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling
Corsello, Steven M, Nagari, Rohith T, Spangler, Ryan D, Rossen, Jordan, Kocak, Mustafa, Bryan, Jordan G, Humeidi, Ranad, Peck, David, Wu, Xiaoyun, Tang, Andrew A, Wang, Vickie M, Bender, Samantha A, Lemire, Evan, Narayan, Rajiv, Montgomery, Philip, Ben-David, Uri, Garvie, Colin W, Chen, Yejia, Rees, Matthew G, Lyons, Nicholas J, McFarland, James M, Wong, Bang T, Wang, Li, Dumont, Nancy, O'Hearn, Patrick J, Stefan, Eric, Doench, John G, Harrington, Caitlin N, Greulich, Heidi, Meyerson, Matthew, Vazquez, Francisca, Subramanian, Aravind, Roth, Jennifer A, Bittker, Joshua A, Boehm, Jesse S, Mader, Christopher C, Tsherniak, Aviad, Golub, Todd R
Published in Nature cancer (01.02.2020)
Published in Nature cancer (01.02.2020)
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Assessing optimal: inequalities in codon optimization algorithms
Ranaghan, Matthew J, Li, Jeffrey J, Laprise, Dylan M, Garvie, Colin W
Published in BMC biology (19.02.2021)
Published in BMC biology (19.02.2021)
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Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state
Miller, Peter G, Sathappa, Murugappan, Moroco, Jamie A, Jiang, Wei, Qian, Yue, Iqbal, Sumaiya, Guo, Qi, Giacomelli, Andrew O, Shaw, Subrata, Vernier, Camille, Bajrami, Besnik, Yang, Xiaoping, Raffier, Cerise, Sperling, Adam S, Gibson, Christopher J, Kahn, Josephine, Jin, Cyrus, Ranaghan, Matthew, Caliman, Alisha, Brousseau, Merissa, Fischer, Eric S, Lintner, Robert, Piccioni, Federica, Campbell, Arthur J, Root, David E, Garvie, Colin W, Ebert, Benjamin L
Published in Nature communications (30.06.2022)
Published in Nature communications (30.06.2022)
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Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization
Graves, Bradford, Thompson, Thelma, Xia, Mingxuan, Janson, Cheryl, Lukacs, Christine, Deo, Dayanand, Di Lello, Paola, Fry, David, Garvie, Colin, Huang, Kuo-Sen, Gao, Lin, Tovar, Christian, Lovey, Allen, Wanner, Jutta, Vassilev, Lyubomir T
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2012)
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Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12
Wu, Xiaoyun, Schnitzler, Gavin R., Gao, Galen F., Diamond, Brett, Baker, Andrew R., Kaplan, Bethany, Williamson, Kaylyn, Westlake, Lindsay, Lorrey, Selena, Lewis, Timothy A., Garvie, Colin W., Lange, Martin, Hayat, Sikander, Seidel, Henrik, Doench, John, Cherniack, Andrew D., Kopitz, Charlotte, Meyerson, Matthew, Greulich, Heidi
Published in The Journal of biological chemistry (13.03.2020)
Published in The Journal of biological chemistry (13.03.2020)
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Mechanistic insights into RNase L through use of an MDMX-derived multi-functional protein domain
Garvie, Colin W., Vasanthavada, Keshav, Xiang, Qing
Published in Biochimica et biophysica acta (01.08.2013)
Published in Biochimica et biophysica acta (01.08.2013)
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The Autophagy-Related Beclin‑1 Protein Requires the Coiled-Coil and BARA Domains To Form a Homodimer with Submicromolar Affinity
Ranaghan, Matthew J, Durney, Michael A, Mesleh, Michael F, McCarren, Patrick R, Garvie, Colin W, Daniels, Douglas S, Carey, Kimberly L, Skepner, Adam P, Levine, Beth, Perez, Jose R
Published in Biochemistry (Easton) (26.12.2017)
Published in Biochemistry (Easton) (26.12.2017)
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Correction: Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12
Wu, Xiaoyun, Schnitzler, Gavin R., Gao, Galen F., Diamond, Brett, Baker, Andrew R., Kaplan, Bethany, Williamson, Kaylyn, Westlake, Lindsay, Lorrey, Selena, Lewis, Timothy A., Garvie, Colin W., Lange, Martin, Hayat, Sikander, Seidel, Henrik, Doench, John, Cherniack, Andrew D., Kopitz, Charlotte, Meyerson, Matthew, Greulich, Heidi
Published in The Journal of biological chemistry (27.11.2020)
Published in The Journal of biological chemistry (27.11.2020)
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A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein
Pop, Marius S, Stransky, Nicolas, Garvie, Colin W, Theurillat, Jean-Philippe, Hartman, Emily C, Lewis, Timothy A, Zhong, Cheng, Culyba, Elizabeth K, Lin, Fallon, Daniels, Douglas S, Pagliarini, Raymond, Ronco, Lucienne, Koehler, Angela N, Garraway, Levi A
Published in Molecular cancer therapeutics (01.06.2014)
Published in Molecular cancer therapeutics (01.06.2014)
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Development of a novel, sensitive cell-based corin assay
Lambertz, Pascal, Theisen, Laura, Längst, Natalie, Garvie, Colin W., MacDonald, Bryan T., Yu, John, Elowe, Nadine H., Zubov, Dmitry, Kaushik, Virendar K., Wunder, Frank
Published in Biochemical pharmacology (01.02.2019)
Published in Biochemical pharmacology (01.02.2019)
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Point mutations at the catalytic site of PCSK9 inhibit folding, autoprocessing, and interaction with the LDL receptor
Garvie, Colin W., Fraley, Cara V., Elowe, Nadine H., Culyba, Elizabeth K., Lemke, Christopher T., Hubbard, Brian K., Kaushik, Virendar K., Daniels, Douglas S.
Published in Protein science (01.11.2016)
Published in Protein science (01.11.2016)
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Highly Cooperative Recruitment of Ets-1 and Release of Autoinhibition by Pax5
Fitzsimmons, Daniel, Lukin, Kara, Lutz, Ryan, Garvie, Colin W., Wolberger, Cynthia, Hagman, James
Published in Journal of molecular biology (18.09.2009)
Published in Journal of molecular biology (18.09.2009)
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Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses
Wang, Minxian, Lee-Kim, Vivian S, Atri, Deepak S, Elowe, Nadine H, Yu, John, Garvie, Colin W, Won, Hong-Hee, Hadaya, Joseph E, MacDonald, Bryan T, Trindade, Kevin, Melander, Olle, Rader, Daniel J, Natarajan, Pradeep, Kathiresan, Sekar, Kaushik, Virendar K, Khera, Amit V, Gupta, Rajat M
Published in Circulation. Genomic and precision medicine (01.10.2021)
Published in Circulation. Genomic and precision medicine (01.10.2021)
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Structural Analysis of the Autoinhibition of Ets-1 and Its Role in Protein Partnerships
Garvie, Colin W, Pufall, Miles A, Graves, Barbara J, Wolberger, Cynthia
Published in The Journal of biological chemistry (22.11.2002)
Published in The Journal of biological chemistry (22.11.2002)
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Solution Structure of the Heterotrimeric Complex between the Interaction Domains of RFX5 and RFXAP from the RFX Gene Regulatory Complex
Laird, Kholiswa M., Briggs, LaTese L., Boss, Jeremy M., Summers, Michael F., Garvie, Colin W.
Published in Journal of molecular biology (15.10.2010)
Published in Journal of molecular biology (15.10.2010)
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