Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling
Samson, André L, Garnish, Sarah E, Hildebrand, Joanne M, Murphy, James M
Published in Science signaling (02.02.2021)
Published in Science signaling (02.02.2021)
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Journal Article
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis
Liu, Zikou, Dagley, Laura F, Shield‐Artin, Kristy, Young, Samuel N, Bankovacki, Aleksandra, Wang, Xiangyi, Tang, Michelle, Howitt, Jason, Stafford, Che A, Nachbur, Ueli, Fitzgibbon, Cheree, Garnish, Sarah E, Webb, Andrew I, Komander, David, Murphy, James M, Hildebrand, Joanne M, Silke, John
Published in The EMBO journal (01.12.2021)
Published in The EMBO journal (01.12.2021)
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Journal Article
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis
Garnish, Sarah E., Meng, Yanxiang, Koide, Akiko, Sandow, Jarrod J., Denbaum, Eric, Jacobsen, Annette V., Yeung, Wayland, Samson, Andre L., Horne, Christopher R., Fitzgibbon, Cheree, Young, Samuel N., Smith, Phoebe P. C., Webb, Andrew I., Petrie, Emma J., Hildebrand, Joanne M., Kannan, Natarajan, Czabotar, Peter E., Koide, Shohei, Murphy, James M.
Published in Nature communications (13.04.2021)
Published in Nature communications (13.04.2021)
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Journal Article
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
Meng, Yanxiang, Davies, Katherine A., Fitzgibbon, Cheree, Young, Samuel N., Garnish, Sarah E., Horne, Christopher R., Luo, Cindy, Garnier, Jean-Marc, Liang, Lung-Yu, Cowan, Angus D., Samson, Andre L., Lessene, Guillaume, Sandow, Jarrod J., Czabotar, Peter E., Murphy, James M.
Published in Nature communications (22.11.2021)
Published in Nature communications (22.11.2021)
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Journal Article
Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies
Petrie, Emma J., Birkinshaw, Richard W., Koide, Akiko, Denbaum, Eric, Hildebrand, Joanne M., Garnish, Sarah E., Davies, Katherine A., Sandow, Jarrod J., Samson, Andre L., Gavin, Xavier, Fitzgibbon, Cheree, Young, Samuel N., Hennessy, Patrick J., Smith, Phoebe P. C., Webb, Andrew I., Czabotar, Peter E., Koide, Shohei, Murphy, James M.
Published in Proceedings of the National Academy of Sciences - PNAS (14.04.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (14.04.2020)
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Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
Davies, Katherine A., Fitzgibbon, Cheree, Young, Samuel N., Garnish, Sarah E., Yeung, Wayland, Coursier, Diane, Birkinshaw, Richard W., Sandow, Jarrod J., Lehmann, Wil I. L., Liang, Lung-Yu, Lucet, Isabelle S., Chalmers, James D., Patrick, Wayne M., Kannan, Natarajan, Petrie, Emma J., Czabotar, Peter E., Murphy, James M.
Published in Nature communications (19.06.2020)
Published in Nature communications (19.06.2020)
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Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization
Meng, Yanxiang, Garnish, Sarah E., Davies, Katherine A., Black, Katrina A., Leis, Andrew P., Horne, Christopher R., Hildebrand, Joanne M., Hoblos, Hanadi, Fitzgibbon, Cheree, Young, Samuel N., Dite, Toby, Dagley, Laura F., Venkat, Aarya, Kannan, Natarajan, Koide, Akiko, Koide, Shohei, Glukhova, Alisa, Czabotar, Peter E., Murphy, James M.
Published in Nature communications (26.10.2023)
Published in Nature communications (26.10.2023)
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Journal Article
MLKL deficiency elevates testosterone production in male mice independently of necroptotic functions
Chiou, Shene, Cawthorne, Wayne, Soerianto, Thomas, Hofferek, Vinzenz, Patel, Komal M., Garnish, Sarah E., Tovey Crutchfield, Emma C., Hall, Cathrine, Hildebrand, Joanne M., McConville, Malcolm J., Lawlor, Kate E., Hawkins, Edwin D., Samson, Andre L., Murphy, James M.
Published in Cell death & disease (21.11.2024)
Published in Cell death & disease (21.11.2024)
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Journal Article
Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death
Frank, Daniel, Garnish, Sarah E., Sandow, Jarrod J., Weir, Ashley, Liu, Lin, Clayer, Elise, Meza, Lizeth, Rashidi, Maryam, Cobbold, Simon A., Scutts, Simon R., Doerflinger, Marcel, Anderton, Holly, Lawlor, Kate E., Lalaoui, Najoua, Kueh, Andrew J., Eng, Vik Ven, Ambrose, Rebecca L., Herold, Marco J., Samson, Andre L., Feltham, Rebecca, Murphy, James M., Ebert, Gregor, Pearson, Jaclyn S., Vince, James E.
Published in iScience (15.07.2022)
Published in iScience (15.07.2022)
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Journal Article
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
Samson, Andre L., Zhang, Ying, Geoghegan, Niall D., Gavin, Xavier J., Davies, Katherine A., Mlodzianoski, Michael J., Whitehead, Lachlan W., Frank, Daniel, Garnish, Sarah E., Fitzgibbon, Cheree, Hempel, Anne, Young, Samuel N., Jacobsen, Annette V., Cawthorne, Wayne, Petrie, Emma J., Faux, Maree C., Shield-Artin, Kristy, Lalaoui, Najoua, Hildebrand, Joanne M., Silke, John, Rogers, Kelly L., Lessene, Guillaume, Hawkins, Edwin D., Murphy, James M.
Published in Nature communications (19.06.2020)
Published in Nature communications (19.06.2020)
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Journal Article
Inhibitors identify an auxiliary role for mTOR signalling in necroptosis execution downstream of MLKL activation
Garnish, Sarah E, Horne, Christopher R, Meng, Yanxiang, Young, Samuel N, Jacobsen, Annette V, Hildebrand, Joanne M, Murphy, James M
Published in Biochemical journal (04.09.2024)
Published in Biochemical journal (04.09.2024)
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Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL
Sethi, Ashish, Horne, Christopher R., Fitzgibbon, Cheree, Wilde, Karyn, Davies, Katherine A., Garnish, Sarah E., Jacobsen, Annette V., Samson, André L., Hildebrand, Joanne M., Wardak, Ahmad, Czabotar, Peter E., Petrie, Emma J., Gooley, Paul R., Murphy, James M.
Published in Cell death and differentiation (01.09.2022)
Published in Cell death and differentiation (01.09.2022)
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Journal Article
Coxiella burnetii protein CBU2016 supports CCV expansion
Thomas, David R, Garnish, Sarah E, Khoo, Chen Ai, Padmanabhan, Bhavna, Scott, Nichollas E, Newton, Hayley J
Published in Pathogens and disease (07.02.2024)
Published in Pathogens and disease (07.02.2024)
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Journal Article
MLKL deficiency protects against low-grade, sterile inflammation in aged mice
Tovey Crutchfield, Emma C., Garnish, Sarah E., Day, Jessica, Anderton, Holly, Chiou, Shene, Hempel, Anne, Hall, Cathrine, Patel, Komal M., Gangatirkar, Pradnya, Martin, Katherine R., Li Wai Suen, Connie S. N., Garnham, Alexandra L., Kueh, Andrew J., Wicks, Ian P., Silke, John, Nachbur, Ueli, Samson, Andre L., Murphy, James M., Hildebrand, Joanne M.
Published in Cell death and differentiation (01.04.2023)
Published in Cell death and differentiation (01.04.2023)
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Journal Article
A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation
Garnish, Sarah E., Martin, Katherine R., Kauppi, Maria, Jackson, Victoria E., Ambrose, Rebecca, Eng, Vik Ven, Chiou, Shene, Meng, Yanxiang, Frank, Daniel, Tovey Crutchfield, Emma C., Patel, Komal M., Jacobsen, Annette V., Atkin-Smith, Georgia K., Di Rago, Ladina, Doerflinger, Marcel, Horne, Christopher R., Hall, Cathrine, Young, Samuel N., Cook, Matthew, Athanasopoulos, Vicki, Vinuesa, Carola G., Lawlor, Kate E., Wicks, Ian P., Ebert, Gregor, Ng, Ashley P., Slade, Charlotte A., Pearson, Jaclyn S., Samson, André L., Silke, John, Murphy, James M., Hildebrand, Joanne M.
Published in Nature communications (28.09.2023)
Published in Nature communications (28.09.2023)
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Journal Article
Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway
Pierotti, Catia L., Tanzer, Maria C., Jacobsen, Annette V., Hildebrand, Joanne M., Garnier, Jean-Marc, Sharma, Pooja, Lucet, Isabelle S., Cowan, Angus D., Kersten, Wilhelmus J. A., Luo, Meng-Xiao, Liang, Lung-Yu, Fitzgibbon, Cheree, Garnish, Sarah E., Hempel, Anne, Nachbur, Ueli, Huang, David C. S., Czabotar, Peter E., Silke, John, van Delft, Mark F., Murphy, James M., Lessene, Guillaume
Published in ACS chemical biology (16.10.2020)
Published in ACS chemical biology (16.10.2020)
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Journal Article
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
Hildebrand, Joanne M., Kauppi, Maria, Majewski, Ian J., Liu, Zikou, Cox, Allison J., Miyake, Sanae, Petrie, Emma J., Silk, Michael A., Li, Zhixiu, Tanzer, Maria C., Brumatti, Gabriela, Young, Samuel N., Hall, Cathrine, Garnish, Sarah E., Corbin, Jason, Stutz, Michael D., Di Rago, Ladina, Gangatirkar, Pradnya, Josefsson, Emma C., Rigbye, Kristin, Anderton, Holly, Rickard, James A., Tripaydonis, Anne, Sheridan, Julie, Scerri, Thomas S., Jackson, Victoria E., Czabotar, Peter E., Zhang, Jian-Guo, Varghese, Leila, Allison, Cody C., Pellegrini, Marc, Tannahill, Gillian M., Hatchell, Esme C., Willson, Tracy A., Stockwell, Dina, de Graaf, Carolyn A., Collinge, Janelle, Hilton, Adrienne, Silke, Natasha, Spall, Sukhdeep K., Chau, Diep, Athanasopoulos, Vicki, Metcalf, Donald, Laxer, Ronald M., Bassuk, Alexander G., Darbro, Benjamin W., Fiatarone Singh, Maria A., Vlahovich, Nicole, Hughes, David, Kozlovskaia, Maria, Ascher, David B., Warnatz, Klaus, Venhoff, Nils, Thiel, Jens, Biben, Christine, Blum, Stefan, Reveille, John, Hildebrand, Michael S., Vinuesa, Carola G., McCombe, Pamela, Brown, Matthew A., Kile, Benjamin T., McLean, Catriona, Bahlo, Melanie, Masters, Seth L., Nakano, Hiroyasu, Ferguson, Polly J., Murphy, James M., Alexander, Warren S., Silke, John
Published in Nature communications (19.06.2020)
Published in Nature communications (19.06.2020)
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Journal Article
MLKL deficiency protects against low-grade, sterile inflammation in aged mice
Tovey, Emma C, Garnish, Sarah E, Day, Jessica, Anderton, Holly, Chiou, Shene, Hempel, Anne, Hall, Cathrine, Patel, Komal, Gangatirkar, Pradnya, Connie Sn Li Wai Suen, Garnham, Alexandra, Kueh, Andrew J, Nachbur, Ueli, Samson, Andre L, Murphy, James M, Hildebrand, Joanne M
Published in bioRxiv (17.10.2022)
Published in bioRxiv (17.10.2022)
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