An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway
Garner, Thomas P., Reyna, Denis E., Priyadarshi, Amit, Chen, Hui-Chen, Li, Sheng, Wu, Yang, Ganesan, Yogesh Tengarai, Malashkevich, Vladimir N., Cheng, Emily H., Gavathiotis, Evripidis
Published in Molecular cell (04.08.2016)
Published in Molecular cell (04.08.2016)
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Journal Article
Eltrombopag directly inhibits BAX and prevents cell death
Spitz, Adam Z, Zacharioudakis, Emmanouil, Reyna, Denis E, Garner, Thomas P, Gavathiotis, Evripidis
Published in Nature communications (18.02.2021)
Published in Nature communications (18.02.2021)
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Journal Article
Inhibition of Pro-Apoptotic BAX by a Noncanonical Interaction Mechanism
Barclay, Lauren A., Wales, Thomas E., Garner, Thomas P., Wachter, Franziska, Lee, Susan, Guerra, Rachel M., Stewart, Michelle L., Braun, Craig R., Bird, Gregory H., Gavathiotis, Evripidis, Engen, John R., Walensky, Loren D.
Published in Molecular cell (05.03.2015)
Published in Molecular cell (05.03.2015)
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Journal Article
Modulating mitofusins to control mitochondrial function and signaling
Zacharioudakis, Emmanouil, Agianian, Bogos, Kumar Mv, Vasantha, Biris, Nikolaos, Garner, Thomas P, Rabinovich-Nikitin, Inna, Ouchida, Amanda T, Margulets, Victoria, Nordstrøm, Lars Ulrik, Riley, Joel S, Dolgalev, Igor, Chen, Yun, Wittig, Andre J H, Pekson, Ryan, Mathew, Chris, Wei, Peter, Tsirigos, Aristotelis, Tait, Stephen W G, Kirshenbaum, Lorrie A, Kitsis, Richard N, Gavathiotis, Evripidis
Published in Nature communications (07.07.2022)
Published in Nature communications (07.07.2022)
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Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration
Gomez-Sintes, Raquel, Xin, Qisheng, Jimenez-Loygorri, Juan Ignacio, McCabe, Mericka, Diaz, Antonio, Garner, Thomas P, Cotto-Rios, Xiomaris M, Wu, Yang, Dong, Shuxian, Reynolds, Cara A, Patel, Bindi, de la Villa, Pedro, Macian, Fernando, Boya, Patricia, Gavathiotis, Evripidis, Cuervo, Ana Maria
Published in Nature communications (21.07.2022)
Published in Nature communications (21.07.2022)
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Journal Article
An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway
Garner, Thomas P., Reyna, Denis E., Priyadarshi, Amit, Chen, Hui-Chen, Li, Sheng, Wu, Yang, Ganesan, Yogesh Tengarai, Malashkevich, Vladimir N., Cheng, Emily H., Gavathiotis, Evripidis
Published in Molecular cell (20.10.2016)
Published in Molecular cell (20.10.2016)
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Journal Article
Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase
Takeuchi, Hideyuki, Fernández-Valdivia, Rodrigo C, Caswell, Devin S, Nita-Lazar, Aleksandra, Rana, Nadia A, Garner, Thomas P, Weldeghiorghis, Thomas K, Macnaughtan, Megan A, Jafar-Nejad, Hamed, Haltiwanger, Robert S
Published in Proceedings of the National Academy of Sciences - PNAS (04.10.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (04.10.2011)
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A Kazal-Type Serine Protease Inhibitor from the Defense Gland Secretion of the Subterranean Termite Coptotermes formosanus Shiraki
Negulescu, Horia, Guo, Youzhong, Garner, Thomas P, Goodwin, Octavia Y, Henderson, Gregg, Laine, Roger A, Macnaughtan, Megan A
Published in PloS one (15.05.2015)
Published in PloS one (15.05.2015)
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Journal Article
Impact of p62/SQSTM1 UBA Domain Mutations Linked to Paget’s Disease of Bone on Ubiquitin Recognition
Garner, Thomas P, Long, Jed, Layfield, Robert, Searle, Mark S
Published in Biochemistry (Easton) (31.05.2011)
Published in Biochemistry (Easton) (31.05.2011)
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Journal Article
Independent Interactions of Ubiquitin-Binding Domains in a Ubiquitin-Mediated Ternary Complex
Garner, Thomas P, Strachan, Joanna, Shedden, Elizabeth C, Long, Jed E, Cavey, James R, Shaw, Barry, Layfield, Robert, Searle, Mark S
Published in Biochemistry (Easton) (25.10.2011)
Published in Biochemistry (Easton) (25.10.2011)
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Journal Article
Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains
Searle, Mark S, Garner, Thomas P, Strachan, Joanna, Long, Jed, Adlington, Jennifer, Cavey, James R, Shaw, Barry, Layfield, Robert
Published in Biochemical Society transactions (01.04.2012)
Published in Biochemical Society transactions (01.04.2012)
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Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures
Garner, Thomas P, Williams, Huw E L, Gluszyk, Katarzyna I, Roe, Stephen, Oldham, Neil J, Stevens, Malcolm F G, Moses, John E, Searle, Mark S
Published in Organic & biomolecular chemistry (01.01.2009)
Published in Organic & biomolecular chemistry (01.01.2009)
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Journal Article
Small-molecule allosteric inhibitors of BAX
Garner, Thomas P, Amgalan, Dulguun, Reyna, Denis E, Li, Sheng, Kitsis, Richard N, Gavathiotis, Evripidis
Published in Nature chemical biology (01.04.2019)
Published in Nature chemical biology (01.04.2019)
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Journal Article
Progress in targeting the BCL-2 family of proteins
Garner, Thomas P, Lopez, Andrea, Reyna, Denis E, Spitz, Adam Z, Gavathiotis, Evripidis
Published in Current opinion in chemical biology (01.08.2017)
Published in Current opinion in chemical biology (01.08.2017)
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Journal Article
Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia
Reyna, Denis E., Garner, Thomas P., Lopez, Andrea, Kopp, Felix, Choudhary, Gaurav S., Sridharan, Ashwin, Narayanagari, Swathi-Rao, Mitchell, Kelly, Dong, Baoxia, Bartholdy, Boris A., Walensky, Loren D., Verma, Amit, Steidl, Ulrich, Gavathiotis, Evripidis
Published in Cancer cell (09.10.2017)
Published in Cancer cell (09.10.2017)
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Journal Article
Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim
Cheng, Chunwei, Liu, Yan, Balasis, Maria E, Garner, Thomas P, Li, Jerry, Simmons, Nicholas L, Berndt, Norbert, Song, Hao, Pan, Lili, Qin, Yong, Nicolaou, K C, Gavathiotis, Evripidis, Sebti, Said M, Li, Rongshi
Published in Marine drugs (29.07.2014)
Published in Marine drugs (29.07.2014)
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Journal Article
A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy
Amgalan, Dulguun, Garner, Thomas P, Pekson, Ryan, Jia, Xiaotong F, Yanamandala, Mounica, Paulino, Victor, Liang, Felix G, Corbalan, J Jose, Lee, Jaehoon, Chen, Yun, Karagiannis, George S, Sanchez, Luis Rivera, Liang, Huizhi, Narayanagari, Swathi-Rao, Mitchell, Kelly, Lopez, Andrea, Margulets, Victoria, Scarlata, Marco, Santulli, Gaetano, Asnani, Aarti, Peterson, Randall T, Hazan, Rachel B, Condeelis, John S, Oktay, Maja H, Steidl, Ulrich, Kirshenbaum, Lorrie A, Gavathiotis, Evripidis, Kitsis, Richard N
Published in Nature cancer (01.03.2020)
Published in Nature cancer (01.03.2020)
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