Structural Basis of Wnt Recognition by Frizzled
Janda, Claudia Y., Waghray, Deepa, Levin, Aron M., Thomas, Christoph, Garcia, K. Christopher
Published in Science (American Association for the Advancement of Science) (06.07.2012)
Published in Science (American Association for the Advancement of Science) (06.07.2012)
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Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation
Glassman, Caleb R, Tsutsumi, Naotaka, Saxton, Robert A, Lupardus, Patrick J, Jude, Kevin M, Garcia, K Christopher
Published in Science (American Association for the Advancement of Science) (08.04.2022)
Published in Science (American Association for the Advancement of Science) (08.04.2022)
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In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles
Zhong, Yeteng, Ma, Zhuoran, Wang, Feifei, Wang, Xi, Yang, Yijun, Liu, Yulai, Zhao, Xiang, Li, Jiachen, Du, Haotian, Zhang, Mingxi, Cui, Qiuhong, Zhu, Shoujun, Sun, Qinchao, Wan, Hao, Tian, Ye, Liu, Qiang, Wang, Weizhi, Garcia, K. Christopher, Dai, Hongjie
Published in Nature biotechnology (01.11.2019)
Published in Nature biotechnology (01.11.2019)
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Accurate prediction of protein structures and interactions using a three-track neural network
Baek, Minkyung, DiMaio, Frank, Anishchenko, Ivan, Dauparas, Justas, Ovchinnikov, Sergey, Lee, Gyu Rie, Wang, Jue, Cong, Qian, Kinch, Lisa N, Schaeffer, R Dustin, Millán, Claudia, Park, Hahnbeom, Adams, Carson, Glassman, Caleb R, DeGiovanni, Andy, Pereira, Jose H, Rodrigues, Andria V, van Dijk, Alberdina A, Ebrecht, Ana C, Opperman, Diederik J, Sagmeister, Theo, Buhlheller, Christoph, Pavkov-Keller, Tea, Rathinaswamy, Manoj K, Dalwadi, Udit, Yip, Calvin K, Burke, John E, Garcia, K Christopher, Grishin, Nick V, Adams, Paul D, Read, Randy J, Baker, David
Published in Science (American Association for the Advancement of Science) (20.08.2021)
Published in Science (American Association for the Advancement of Science) (20.08.2021)
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Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy
Chheda, Zinal S, Kohanbash, Gary, Okada, Kaori, Jahan, Naznin, Sidney, John, Pecoraro, Matteo, Yang, Xinbo, Carrera, Diego A, Downey, Kira M, Shrivastav, Shruti, Liu, Shuming, Lin, Yi, Lagisetti, Chetana, Chuntova, Pavlina, Watchmaker, Payal B, Mueller, Sabine, Pollack, Ian F, Rajalingam, Raja, Carcaboso, Angel M, Mann, Matthias, Sette, Alessandro, Garcia, K Christopher, Hou, Yafei, Okada, Hideho
Published in The Journal of experimental medicine (02.01.2018)
Published in The Journal of experimental medicine (02.01.2018)
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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations
Wilmes, Stephan, Hafer, Maximillian, Vuorio, Joni, Tucker, Julie A, Winkelmann, Hauke, Löchte, Sara, Stanly, Tess A, Pulgar Prieto, Katiuska D, Poojari, Chetan, Sharma, Vivek, Richter, Christian P, Kurre, Rainer, Hubbard, Stevan R, Garcia, K Christopher, Moraga, Ignacio, Vattulainen, Ilpo, Hitchcock, Ian S, Piehler, Jacob
Published in Science (American Association for the Advancement of Science) (07.02.2020)
Published in Science (American Association for the Advancement of Science) (07.02.2020)
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Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins
Carrillo, Robert A., Özkan, Engin, Menon, Kaushiki P., Nagarkar-Jaiswal, Sonal, Lee, Pei-Tseng, Jeon, Mili, Birnbaum, Michael E., Bellen, Hugo J., Garcia, K. Christopher, Zinn, Kai
Published in Cell (17.12.2015)
Published in Cell (17.12.2015)
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Screening and large-scale expression of membrane proteins in mammalian cells for structural studies
Goehring, April, Lee, Chia-Hsueh, Wang, Kevin H, Michel, Jennifer Carlisle, Claxton, Derek P, Baconguis, Isabelle, Althoff, Thorsten, Fischer, Suzanne, Garcia, K Christopher, Gouaux, Eric
Published in Nature protocols (01.11.2014)
Published in Nature protocols (01.11.2014)
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Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity
Luca, Vincent C., Kim, Byoung Choul, Ge, Chenghao, Kakuda, Shinako, Wu, Di, Roein-Peikar, Mehdi, Haltiwanger, Robert S., Zhu, Cheng, Ha, Taekjip, Garcia, K. Christopher
Published in Science (American Association for the Advancement of Science) (24.03.2017)
Published in Science (American Association for the Advancement of Science) (24.03.2017)
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Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms
Spangler, Jamie B., Tomala, Jakub, Luca, Vincent C., Jude, Kevin M., Dong, Shen, Ring, Aaron M., Votavova, Petra, Pepper, Marion, Kovar, Marek, Garcia, K. Christopher
Published in Immunity (Cambridge, Mass.) (19.05.2015)
Published in Immunity (Cambridge, Mass.) (19.05.2015)
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Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10
Saxton, Robert A, Tsutsumi, Naotaka, Su, Leon L, Abhiraman, Gita C, Mohan, Kritika, Henneberg, Lukas T, Aduri, Nanda G, Gati, Cornelius, Garcia, K Christopher
Published in Science (American Association for the Advancement of Science) (19.03.2021)
Published in Science (American Association for the Advancement of Science) (19.03.2021)
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Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’
Levin, Aron M., Bates, Darren L., Ring, Aaron M., Krieg, Carsten, Lin, Jack T., Su, Leon, Moraga, Ignacio, Raeber, Miro E., Bowman, Gregory R., Novick, Paul, Pande, Vijay S., Fathman, C. Garrison, Boyman, Onur, Garcia, K. Christopher
Published in Nature (London) (26.04.2012)
Published in Nature (London) (26.04.2012)
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Durable antitumor responses to CD47 blockade require adaptive immune stimulation
Sockolosky, Jonathan T., Dougan, Michael, Ingram, Jessica R., Ho, Chia Chi M., Kauke, Monique J., Almo, Steven C., Ploegh, Hidde L., Garcia, K. Christopher
Published in Proceedings of the National Academy of Sciences - PNAS (10.05.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (10.05.2016)
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Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
Sockolosky, Jonathan T, Trotta, Eleonora, Parisi, Giulia, Picton, Lora, Su, Leon L, Le, Alan C, Chhabra, Akanksha, Silveria, Stephanie L, George, Benson M, King, Indigo C, Tiffany, Matthew R, Jude, Kevin, Sibener, Leah V, Baker, David, Shizuru, Judith A, Ribas, Antoni, Bluestone, Jeffrey A, Garcia, K Christopher
Published in Science (American Association for the Advancement of Science) (02.03.2018)
Published in Science (American Association for the Advancement of Science) (02.03.2018)
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Genetic variation in MHC proteins is associated with T cell receptor expression biases
Sharon, Eilon, Sibener, Leah V, Battle, Alexis, Fraser, Hunter B, Garcia, K Christopher, Pritchard, Jonathan K
Published in Nature genetics (01.09.2016)
Published in Nature genetics (01.09.2016)
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Deconstructing the Peptide-MHC Specificity of T Cell Recognition
Birnbaum, Michael E., Mendoza, Juan L., Sethi, Dhruv K., Dong, Shen, Glanville, Jacob, Dobbins, Jessica, Özkan, Engin, Davis, Mark M., Wucherpfennig, Kai W., Garcia, K. Christopher
Published in Cell (22.05.2014)
Published in Cell (22.05.2014)
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Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
Mohan, Kritika, Ueda, George, Kim, Ah Ram, Jude, Kevin M, Fallas, Jorge A, Guo, Yu, Hafer, Maximillian, Miao, Yi, Saxton, Robert A, Piehler, Jacob, Sankaran, Vijay G, Baker, David, Garcia, K Christopher
Published in Science (American Association for the Advancement of Science) (24.05.2019)
Published in Science (American Association for the Advancement of Science) (24.05.2019)
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