Search Results - "García-Molina, Aránzazu" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

1,4-Oxazine β‑Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads

1,4-Oxazine β‑Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads

by Rombouts, Frederik J. R, Tresadern, Gary, Delgado, Oscar, Martínez-Lamenca, Carolina, Van Gool, Michiel, García-Molina, Aránzazu, Alonso de Diego, Sergio A, Oehlrich, Daniel, Prokopcova, Hana, Alonso, José Manuel, Austin, Nigel, Borghys, Herman, Van Brandt, Sven, Surkyn, Michel, De Cleyn, Michel, Vos, Ann, Alexander, Richard, Macdonald, Gregor, Moechars, Dieder, Gijsen, Harrie, Trabanco, Andrés A
Published in Journal of medicinal chemistry (22.10.2015)

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Diazaspirononane Nonsaccharide Inhibitors of O‑GlcNAcase (OGA) for the Treatment of Neurodegenerative Disorders

Diazaspirononane Nonsaccharide Inhibitors of O‑GlcNAcase (OGA) for the Treatment of Neurodegenerative Disorders

by Martínez-Viturro, Carlos M, Trabanco, Andrés A, Royes, Jordi, Fernández, Elena, Tresadern, Gary, Vega, Juan A, del Cerro, Alcira, Delgado, Francisca, García Molina, Aránzazu, Tovar, Fulgencio, Shaffer, Paul, Ebneth, Andreas, Bretteville, Alexis, Mertens, Liesbeth, Somers, Marijke, Alonso, Jose M, Bartolomé-Nebreda, José M
Published in Journal of medicinal chemistry (25.11.2020)

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Optimization of 1,4-Oxazine β‑Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate

Optimization of 1,4-Oxazine β‑Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate

by Gijsen, Harrie J. M, Alonso de Diego, Sergio A, De Cleyn, Michel, García-Molina, Aránzazu, Macdonald, Gregor J, Martínez-Lamenca, Carolina, Oehlrich, Daniel, Prokopcova, Hana, Rombouts, Frederik J. R, Surkyn, Michel, Trabanco, Andrés A, Van Brandt, Sven, Van den Bossche, Dries, Van Gool, Michiel, Austin, Nigel, Borghys, Herman, Dhuyvetter, Deborah, Moechars, Diederik
Published in Journal of medicinal chemistry (28.06.2018)

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Scaffold Hopping to Imidazo[1,2‑a]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptor

Scaffold Hopping to Imidazo[1,2‑a]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptor

by de Lucas, Ana I, Vega, Juan A, García Molina, Aránzazu, Linares, María Lourdes, Tresadern, Gary, Lavreysen, Hilde, Oehlrich, Daniel, Trabanco, Andrés A, Cid, José M
Published in ACS omega (07.09.2021)

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Correction to Optimization of 1,4-Oxazine β‑Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate

Correction to Optimization of 1,4-Oxazine β‑Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate

by Gijsen, Harrie J. M, Alonso de Diego, Sergio A, De Cleyn, Michel, García-Molina, Aránzazu, Macdonald, Gregor J, Martinez-Lamenca, Carolina, Oehlrich, Daniel, Prokopcova, Hana, Rombouts, Frederik J. R, Surkyn, Michel, Trabanco, Andrés A, Van Brandt, Sven, Van den Bossche, Dries, Van Gool, Michiel, Austin, Nigel, Borghys, Herman, Dhuyvetter, Deborah, Urmaliya, Vijay, Teisman, Ard, Moechars, Diederik
Published in Journal of medicinal chemistry (27.12.2018)

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Spiro-oxindole Piperidines and 3‑(Azetidin-3-yl)‑1H‑benzimidazol-2-ones as mGlu2 Receptor PAMs

Spiro-oxindole Piperidines and 3‑(Azetidin-3-yl)‑1H‑benzimidazol-2-ones as mGlu2 Receptor PAMs

by de Lucas, Ana Isabel, Vega, Juan Antonio, Matesanz, Encarnación, Linares, María Lourdes, García Molina, Aránzazu, Tresadern, Gary, Lavreysen, Hilde, Trabanco, Andrés A, Cid, José María
Published in ACS medicinal chemistry letters (12.03.2020)

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Discovery of 6,7-Dihydropyrazolo1,5-apyrazin-4(5H)-one Derivatives as mGluR2 Negative Allosteric Modulators with In Vivo Activity in a Rodent's Model of Cognition

Discovery of 6,7-Dihydropyrazolo1,5-apyrazin-4(5H)-one Derivatives as mGluR2 Negative Allosteric Modulators with In Vivo Activity in a Rodent's Model of Cognition

by Alonso de Diego, Sergio A, Linares, María Lourdes, García Molina, Aránzazu, de Lucas, Ana Isabel, Del Cerro, Alcira, Alonso, Jose Manuel, Ver Donck, Luc, Cid, Jose María, Trabanco, Andrés A, Van Gool, Michiel
Published in Journal of medicinal chemistry (12.09.2024)

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Discovery of 6,7-Dihydropyrazolo[1,5- a ]pyrazin-4(5 H )-one Derivatives as mGluR 2 Negative Allosteric Modulators with In Vivo Activity in a Rodent’s Model of Cognition

Discovery of 6,7-Dihydropyrazolo[1,5- a ]pyrazin-4(5 H )-one Derivatives as mGluR 2 Negative Allosteric Modulators with In Vivo Activity in a Rodent’s Model of Cognition

by Alonso de Diego, Sergio A., Linares, María Lourdes, García Molina, Aránzazu, de Lucas, Ana Isabel, del Cerro, Alcira, Alonso, Jose Manuel, Ver Donck, Luc, Cid, Jose María, Trabanco, Andrés A., Van Gool, Michiel
Published in Journal of medicinal chemistry (12.09.2024)

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Inhibition of the Alanine-Serine-Cysteine‑1 Transporter by BMS-466442

Inhibition of the Alanine-Serine-Cysteine‑1 Transporter by BMS-466442

by Torrecillas, Ivan R, Conde-Ceide, Susana, de Lucas, Ana Isabel, Garcı́a Molina, Aránzazu, Trabanco, Andrés A, Lavreysen, Hilde, Pardo, Leonardo, Tresadern, Gary
Published in ACS chemical neuroscience (15.05.2019)

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Spiro-oxindole Piperidines and 3-(Azetidin-3-yl)-1 H -benzimidazol-2-ones as mGlu 2 Receptor PAMs

Spiro-oxindole Piperidines and 3-(Azetidin-3-yl)-1 H -benzimidazol-2-ones as mGlu 2 Receptor PAMs

by de Lucas, Ana Isabel, Vega, Juan Antonio, Matesanz, Encarnación, Linares, María Lourdes, García Molina, Aránzazu, Tresadern, Gary, Lavreysen, Hilde, Trabanco, Andrés A, Cid, José María
Published in ACS medicinal chemistry letters (12.03.2020)

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Journal Article

6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglur2 receptors

6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglur2 receptors

by Trabanco-Suárez, Andrés, Delgado-González, Óscar, Megens, Antonius, Van Gool, Michiel, Decorte, Annelies, Andrés-Gil, José, Macdonald, Gregor, Alonso-De Diego, Sergio-Alvar, García-Molina, Aránzazu, Cid-Núñez, José
Year of Publication 25.06.2021

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Patent

Substituted 6,7-dihydropyrazolo[1,5-a]pyrazines as negative allosteric modulators of mGluR2 receptors

Substituted 6,7-dihydropyrazolo[1,5-a]pyrazines as negative allosteric modulators of mGluR2 receptors

by Alonso-de Diego, Sergio-Alvar, Delgado-González, Óscar, MacDonald, Gregor James, García-Molina, Aránzazu, Van Gool, Michiel Luc Maria, Andrés-Gil, José Ignacio, Cid-Núñez, José Maria, Decorte, Annelies Marie Antonius, Megens, Antonius Adrianus Hendrikus Petrus, Trabanco-Suárez, Andrés Avelino
Year of Publication 10.03.2020

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Patent

SUBSTITUTED 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINES AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

SUBSTITUTED 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINES AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

by Alonso-de Diego, Sergio-Alvar, Delgado-González, Óscar, MacDonald, Gregor James, García-Molina, Aránzazu, Van Gool, Michiel Luc Maria, Andrés-Gil, José Ignacio, Cid-Núñez, José Maria, Decorte, Annelies Marie Antonius, Megens, Antonius Adrianus Hendrikus Petrus, Trabanco-Suárez, Andrés Avelino
Year of Publication 21.02.2019

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Patent

6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

by Cid-Núnez, José Maria, Decorte, Annelies, Marie, Antonius, Delgado-González, Óscar, MacDonald, Gregor James, Alonso-De Diego, Sergio-Alvar, García-Molina, Aránzazu, Andrés-Gil, José, Ignacio, Van Gool, Michiel Luc Maria, Megens, Antonius Adrianus Hendrikus, Trabanco-Suárez, Andrés Avelino
Year of Publication 06.10.2017

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Patent

6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

by CID-NÚÑEZ, José Maria, ANDRÉS-GIL, José Ignacio, ALONSO-DE DIEGO, Sergio-Alvar, DELGADO-GONZÁLEZ, Óscar, GARCÍA-MOLINA, Aránzazu, MEGENS, Antonius Adrianus Hendrikus Petrus, MACDONALD, Gregor James, VAN GOOL, Michiel Luc Maria, TRABANCO-SUÁREZ, Andrés Avelino, DECORTE, Annelies Marie Antonius
Year of Publication 20.07.2018

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Patent

6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

by MACDONALD, GREGOR JAMES, CID-NÚÑEZ, JOSÉ MARIA, DELGADO-GONZÁLEZ, ÓSCAR, GARCÍA-MOLINA, ARÁNZAZU, MEGENS, ANTONIUS ADRIANUS HENDRIKUS PETRUS, DECORTE, ANNELIES MARIE ANTONIUS, ALONSO-DE DIEGO, SERGIO-ALVAR, TRABANCO-SUÁREZ, ANDRÉS AVELINO, ANDRÉS-GIL, JOSÉ IGNACIO, VAN GOOL, MICHIEL LUC MARIA
Year of Publication 31.10.2017

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Patent

6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

by TRABANCO-SUÁREZ, ANDRÉS, AVELINO, DELGADO-GONZÁLEZ, ÓSCAR, MEGENS, ANTONIUS, ADRIANUS, HENDRIKUS, PETRUS, DECORTE, ANNELIES, MARIE, ANTONIUS, GARCÍA-MOLINA, ARÁNZAZU, CID-NÚÑEZ, JOSÉ, MARIA, VAN GOOL, MICHIEL, LUC, MARIA, ANDRÉS-GIL, JOSÉ, IGNACIO, ALONSO-DE DIEGO, SERGIO-ALVAR, MACDONALD, GREGOR, JAMES
Year of Publication 31.10.2017

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Patent

6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONFORBINDELSER OG DERES ANVENDELSE SOM NEGATIVE ALLOSTERISKE MODULATORER AF MGLUR2-RECEPTORER

6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONFORBINDELSER OG DERES ANVENDELSE SOM NEGATIVE ALLOSTERISKE MODULATORER AF MGLUR2-RECEPTORER

by DECORTE, Annelies, Marie, Antonius, TRABANCO-SUÁREZ, Andrés, Avelino, VAN GOOL, Michiel, Luc, Maria, ALONSO-DE DIEGO, Sergio-Alvar, DELGADO-GONZÁLEZ, Óscar, CID-NÚÑEZ, José, Maria, MACDONALD, Gregor, James, GARCÍA-MOLINA, Aránzazu, ANDRÉS-GIL, José, Ignacio, MEGENS, Antonius, Adrianus, Hendrikus, Petrus
Year of Publication 28.08.2017

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Patent

6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

by GREGOR JAMES MACDONALD, JOSÉ, IGNACIO ANDRÉS-GIL, MICHIEL, LUC, MARIA VAN GOOL, ANDRÉS AVELINO TRABANCO-SUÁREZ, ARÁNZAZU GARCÍA-MOLINA, SERGIO-ALVAR ALONSO-DE DIEGO, JOSÉ, MARIA CID-NÚÑEZ, ÓSCAR DELGADO-GONZÁLEZ, ANNELIES, MARIE, ANTONIUS DECORTE, ANTONIUS ADRIANUS HENDRIKUS PETRUS MEGENS
Year of Publication 16.08.2017

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Patent

6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

by DECORTE, Annelies, Marie, Antonius, TRABANCO-SUÁREZ, Andrés, Avelino, VAN GOOL, Michiel, Luc, Maria, ALONSO-DE DIEGO, Sergio-Alvar, DELGADO-GONZÁLEZ, Óscar, CID-NÚÑEZ, José, Maria, MACDONALD, Gregor, James, GARCÍA-MOLINA, Aránzazu, ANDRÉS-GIL, José, Ignacio, MEGENS, Antonius, Adrianus, Hendrikus, Petrus
Year of Publication 10.05.2017

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Patent