In Vivo Induction of P‑Glycoprotein Function can be Measured with [18F]MC225 and PET
García-Varela, Lara, Rodríguez-Pérez, Manuel, Custodia, Antía, Moraga-Amaro, Rodrigo, Colabufo, Nicola A, Aguiar, Pablo, Sobrino, Tomás, Dierckx, Rudi A.J.O, van Waarde, Aren, Elsinga, Philip H, Luurtsema, Gert
Published in Molecular pharmaceutics (02.08.2021)
Published in Molecular pharmaceutics (02.08.2021)
Get full text
Journal Article
Pharmacokinetic Modeling of [18F]MC225 for Quantification of the P‑Glycoprotein Function at the Blood–Brain Barrier in Non-Human Primates with PET
García-Varela, Lara, Arif, Wejdan M, Vállez García, David, Kakiuchi, Takeharu, Ohba, Hiroyuki, Harada, Norihiro, Tago, Tetsuro, Elsinga, Philip H, Tsukada, Hideo, Colabufo, Nicola Antonio, Dierckx, Rudi A. J. O, van Waarde, Aren, Toyohara, Jun, Boellaard, Ronald, Luurtsema, Gert
Published in Molecular pharmaceutics (08.09.2020)
Published in Molecular pharmaceutics (08.09.2020)
Get full text
Journal Article
Biodistribution and pharmacokinetics of [89Zr]-anti-VEGF mAbs using PET in glioblastoma rat models
García-Varela, Lara, Codesido, Jessica, Perez-Pedrosa, Alberto, Muñoz-González, María, Ramos-Docampo, Emma, Rey-Bretal, David, García-Otero, Xurxo, Gómez-Lado, Noemí, Turrero, Angela, Beiroa, Daniel, Rodríguez-Perez, Ana Isabel, Vidal, Anxo, Fernández-Ferreiro, Anxo, Pubul, Virginia, Aguiar, Pablo
Published in International journal of pharmaceutics (05.03.2024)
Published in International journal of pharmaceutics (05.03.2024)
Get full text
Journal Article
Quantitative PET tracking of intra-articularly administered 89Zr-peptide-decorated nanoemulsions
Díez-Villares, Sandra, García-Varela, Lara, Antas, Soraya Groba-de, Caeiro, José Ramón, Carpintero-Fernandez, Paula, Mayán, María D., Aguiar, Pablo, de la Fuente, María
Published in Journal of controlled release (01.04.2023)
Published in Journal of controlled release (01.04.2023)
Get full text
Journal Article
Quantitative brain [18F]FDG PET beyond normal blood glucose levels
Rey-Bretal, David, García-Varela, Lara, Gómez-Lado, Noemí, Moscoso, Alexis, Piñeiro-Fiel, Manuel, Díaz-Platas, Lucía, Medin, Santiago, Fernández-Ferreiro, Anxo, Ruibal, Álvaro, Sobrino, Tomás, Silva-Rodríguez, Jesús, Aguiar, Pablo
Published in NeuroImage (Orlando, Fla.) (15.10.2024)
Published in NeuroImage (Orlando, Fla.) (15.10.2024)
Get full text
Journal Article
Vaginal residence and pharmacokinetic preclinical study of topical vaginal mucoadhesive W/S emulsions containing ciprofloxacin
Campaña-Seoane, Maria, Pérez-Gago, Ana, Vázquez, Gonzalo, Conde, Nerea, González, Paula, Martinez, Ariana, Martínez, Xurxo, García Varela, Lara, Herranz, Michel, Aguiar, Pablo, Fernández-Ferreiro, Anxo, Laguna, Reyes, Otero-Espinar, Francisco J.
Published in International journal of pharmaceutics (10.01.2019)
Published in International journal of pharmaceutics (10.01.2019)
Get full text
Journal Article
A murine model of BSCL2-associated Celia's encephalopathy
Cobelo-Gómez, Silvia, Sánchez-Iglesias, Sofía, Rábano, Alberto, Senra, Ana, Aguiar, Pablo, Gómez-Lado, Noemí, García-Varela, Lara, Burgueño-García, Iván, Lampón-Fernández, Laura, Fernández-Pombo, Antía, Díaz-López, Everardo Josué, Prado-Moraña, Teresa, San Millán, Beatriz, Araújo-Vilar, David
Published in Neurobiology of disease (15.10.2023)
Published in Neurobiology of disease (15.10.2023)
Get full text
Journal Article
Head-to-head comparison of (R)-[11C]verapamil and [18F]MC225 in non-human primates, tracers for measuring P-glycoprotein function
García-Varela, Lara, Vállez García, David, Aguiar, Pablo, Kakiuchi, Takeharu, Ohba, Hiroyuki, Harada, Norihiro, Nishiyama, Shingo, Tago, Tetsuro, Elsinga, Philip H., Tsukada, Hideo, Colabufo, Nicola A., Dierckx, Rudi A. J. O., van Waarde, Aren, Toyohara, Jun, Boellaard, Ronald, Luurtsema, Gert
Published in European journal of nuclear medicine and molecular imaging (01.12.2021)
Published in European journal of nuclear medicine and molecular imaging (01.12.2021)
Get full text
Journal Article
Evaluation of P-glycoprotein function at the blood–brain barrier using [18F]MC225-PET
Mossel, Pascalle, Garcia Varela, Lara, Arif, Wejdan M., van der Weijden, Chris W. J., Boersma, Hendrikus H., Willemsen, Antoon T. M., Boellaard, Ronald, Elsinga, Philip H., Borra, Ronald J. H., Colabufo, Nicola A., Toyohara, Jun, de Deyn, Peter Paul, Dierckx, Rudi A. J. O., Lammertsma, Adriaan A., Bartels, Anna L., Luurtsema, Gert
Published in European journal of nuclear medicine and molecular imaging (01.11.2021)
Published in European journal of nuclear medicine and molecular imaging (01.11.2021)
Get full text
Journal Article
[18F]-FMISO PET/MRI Imaging Shows Ischemic Tissue around Hematoma in Intracerebral Hemorrhage
Gómez-Lado, Noemí, López-Arias, Esteban, Iglesias-Rey, Ramón, Díaz-Platas, Lucía, Medín-Aguerre, Santiago, Fernández-Ferreiro, Anxo, Posado-Fernández, Adrián, García-Varela, Lara, Rodríguez-Pérez, Manuel, Campos, Francisco, Del Pino, Pablo, Ruibal, Álvaro, Pardo-Montero, Juan, Castillo, José, Aguiar, Pablo, Sobrino, Tomás
Published in Molecular pharmaceutics (07.12.2020)
Published in Molecular pharmaceutics (07.12.2020)
Get full text
Journal Article
Pharmacokinetic Modeling of ( R )-[ 11 C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates
García-Varela, Lara, García, David Vállez, Kakiuchi, Takeharu, Ohba, Hiroyuki, Nishiyama, Shingo, Tago, Tetsuro, Elsinga, Philip H, Tsukada, Hideo, Colabufo, Nicola A, Dierckx, Rudi A J O, van Waarde, Aren, Toyohara, Jun, Boellaard, Ronald, Luurtsema, Gert
Published in Molecular pharmaceutics (04.01.2021)
Published in Molecular pharmaceutics (04.01.2021)
Get full text
Journal Article
Test–Retest Repeatability of [18F]MC225-PET in Rodents: A Tracer for Imaging of P‑gp Function
García-Varela, Lara, Vállez García, David, Rodríguez-Pérez, Manuel, van Waarde, Aren, Sijbesma, Jürgen W. A, Schildt, Anna, Kwizera, Chantal, Aguiar, Pablo, Sobrino, Tomás, Dierckx, Rudi A. J. O, Elsinga, Philip H, Luurtsema, Gert
Published in ACS chemical neuroscience (19.02.2020)
Published in ACS chemical neuroscience (19.02.2020)
Get full text
Journal Article
Impact of benzodiazepines on brain FDG-PET quantification after single-dose and chronic administration in rats
Silva-Rodríguez, Jesús, García-Varela, Lara, López-Arias, Esteban, Domínguez-Prado, Inés, Cortés, Julia, Pardo-Montero, Juan, Fernández-Ferreiro, Anxo, Ruibal, Álvaro, Sobrino, Tomás, Aguiar, Pablo
Published in Nuclear medicine and biology (01.12.2016)
Published in Nuclear medicine and biology (01.12.2016)
Get full text
Journal Article
Impact of an Adenosine A2A Receptor Agonist and Antagonist on Binding of the Dopamine D2 Receptor Ligand [11C]raclopride in the Rodent Striatum
Prasad, Kavya, de Vries, Erik F. J., Sijbesma, Jürgen W. A., Garcia-Varela, Lara, Vazquez-Matias, Daniel A., Moraga-Amaro, Rodrigo, Willemsen, Antoon T. M., Dierckx, Rudi A. J. O., van Waarde, Aren
Published in Molecular pharmaceutics (18.07.2022)
Published in Molecular pharmaceutics (18.07.2022)
Get full text
Journal Article
Positron Emission Tomography for the Development and Characterization of Corneal Permanence of Ophthalmic Pharmaceutical Formulations
Fernández-Ferreiro, Anxo, Silva-Rodríguez, Jesús, Otero-Espinar, Francisco Javier, González-Barcia, Miguel, Lamas, María Jesús, Ruibal, Alvaro, Luaces-Rodriguez, Andrea, Vieites-Prado, Alba, Sobrino, Tomas, Herranz, Michel, García-Varela, Lara, Blanco-Mendez, José, Gil-Martínez, María, Pardo, María, Moscoso, Alexis, Medín-Aguerre, Santiago, Pardo-Montero, Juan, Aguiar, Pablo
Published in Investigative ophthalmology & visual science (01.02.2017)
Published in Investigative ophthalmology & visual science (01.02.2017)
Get full text
Journal Article
Preclinical PET Study of Intravitreal Injections
Fernández-Ferreiro, Anxo, Luaces-Rodríguez, Andrea, Aguiar, Pablo, Pardo-Montero, Juan, González-Barcia, Miguel, García-Varela, Lara, Herranz, Michel, Silva-Rodríguez, Jesús, Gil-Martínez, María, Bermúdez, María A, Vieites-Prado, Alba, Blanco-Méndez, José, Lamas, María Jesús, Gómez-Ulla, Francisco, Ruibal, Álvaro, Otero-Espinar, Francisco Javier, González, Francisco
Published in Investigative ophthalmology & visual science (01.06.2017)
Published in Investigative ophthalmology & visual science (01.06.2017)
Get full text
Journal Article
Quantitative brain 18FFDG PET beyond normal blood glucose levels
Rey-Bretal, David, García-Varela, Lara, Gómez-Lado, Noemí, Moscoso, Alexis, Piñeiro-Fiel, Manuel, Díaz-Platas, Lucía, Medin, Santiago, Fernández-Ferreiro, Anxo, Ruibal, Álvaro, Sobrino, Tomás, Silva-Rodríguez, Jesús, Aguiar, Pablo
Published in NeuroImage (Orlando, Fla.) (15.10.2024)
Published in NeuroImage (Orlando, Fla.) (15.10.2024)
Get full text
Journal Article
A new approach to produce [18F]MC225 via one-step synthesis, a PET radiotracer for measuring P-gp function
Garcia-Varela, Lara, Attia, Khaled, Sembrano, John Carlo, Jacquet, Olivier, Antunes, Inês F., Kwizera, Chantal, Visser, Ton J., Dierckx, Rudi A. J. O., Elsinga, Philip H., Luurtsema, Gert
Published in EJNMMI radiopharmacy and chemistry (15.07.2021)
Published in EJNMMI radiopharmacy and chemistry (15.07.2021)
Get full text
Journal Article
Quantitative PET tracking of intra-articularly administered 89 Zr-peptide-decorated nanoemulsions
Díez-Villares, Sandra, García-Varela, Lara, Antas, Soraya Groba-de, Caeiro, José Ramón, Carpintero-Fernandez, Paula, Mayán, María D, Aguiar, Pablo, de la Fuente, María
Published in Journal of controlled release (01.04.2023)
Get full text
Published in Journal of controlled release (01.04.2023)
Journal Article
Dose-response assessment of cerebral P-glycoprotein inhibition in vivo with [18F]MC225 and PET
Garcia-Varela, Lara, Mossel, Pascalle, Aguiar, Pablo, Vazquez-Matias, Daniel A., van Waarde, Aren, Willemsen, Antoon T.M., Bartels, Anna L., Colabufo, Nicola A., Dierckx, Rudi A.J.O., Elsinga, Philip H., Luurtsema, Gert
Published in Journal of controlled release (01.07.2022)
Published in Journal of controlled release (01.07.2022)
Get full text
Journal Article