Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain
García-Cuesta, Eva M, Martínez, Pablo, Selvaraju, Karthik, Ulltjärn, Gabriel, Gómez Pozo, Adrián Miguel, D'Agostino, Gianluca, Gardeta, Sofia, Quijada-Freire, Adriana, Blanco Gabella, Patricia, Roca, Carlos, Hoyo, Daniel Del, Jiménez-Saiz, Rodrigo, García-Rubia, Alfonso, Soler Palacios, Blanca, Lucas, Pilar, Ayala-Bueno, Rosa, Santander Acerete, Noelia, Carrasco, Yolanda, Oscar Sorzano, Carlos, Martinez, Ana, Campillo, Nuria E, Jensen, Lasse D, Rodriguez Frade, Jose Miguel, Santiago, César, Mellado, Mario
Published in eLife (09.09.2024)
Published in eLife (09.09.2024)
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The inhibition of NCS-1 binding to Ric8a rescues fragile X syndrome mice model phenotypes
Cogram, Patricia, Fernández-Beltrán, Luis C., Casarejos, María José, Sánchez-Yepes, Sonia, Rodríguez-Martín, Eulalia, García-Rubia, Alfonso, Sánchez-Barrena, María José, Gil, Carmen, Martínez, Ana, Mansilla, Alicia
Published in Frontiers in neuroscience (16.11.2022)
Published in Frontiers in neuroscience (16.11.2022)
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Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools
Sebastian-Perez, Victor, García-Rubia, Alfonso, Seif el-Din, Sayed H., Sabra, Abdel-Nasser A., El-Lakkany, Naglaa M., William, Samia, Blundell, Tom L., Maes, Louis, Martinez, Ana, Campillo, Nuria E., Botros, Sanaa S., Gil, Carmen
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2020)
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2020)
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Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity
Botros, Sanaa S., William, Samia, Sabra, Abdel-Nasser A., El-Lakkany, Naglaa M., Seif el-Din, Sayed H., García-Rubia, Alfonso, Sebastián-Pérez, Victor, Blaazer, Antoni R., de Heuvel, Erik, Sijm, Maarten, Zheng, Yang, Salado, Irene G., Munday, Jane C., Maes, Louis, de Esch, Iwan J.P., Sterk, Geert J., Augustyns, Koen, Leurs, Rob, Gil, Carmen, De Koning, Harry P.
Published in International journal for parasitology -- drugs and drug resistance (01.04.2019)
Published in International journal for parasitology -- drugs and drug resistance (01.04.2019)
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From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein‐Templated Synthesis
Nozal, Vanesa, García‐Rubia, Alfonso, Cuevas, Eva P., Pérez, Concepción, Tosat‐Bitrián, Carlota, Bartolomé, Fernando, Carro, Eva, Ramírez, David, Palomo, Valle, Martínez, Ana
Published in Angewandte Chemie International Edition (23.08.2021)
Published in Angewandte Chemie International Edition (23.08.2021)
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PdII-Catalysed CH Functionalisation of Indoles and Pyrroles Assisted by the Removable N-(2-Pyridyl)sulfonyl Group: C2-Alkenylation and Dehydrogenative Homocoupling
García-Rubia, Alfonso, Urones, Beatriz, Gómez Arrayás, Ramón, Carretero, Juan Carlos
Published in Chemistry : a European journal (16.08.2010)
Published in Chemistry : a European journal (16.08.2010)
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Cu-Catalyzed Silylation of Alkynes: A Traceless 2‑Pyridylsulfonyl Controller Allows Access to Either Regioisomer on Demand
García-Rubia, Alfonso, Romero-Revilla, Jose A, Mauleón, Pablo, Gómez Arrayás, Ramón, Carretero, Juan C
Published in Journal of the American Chemical Society (03.06.2015)
Published in Journal of the American Chemical Society (03.06.2015)
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Discovery of new antimicrobial thiophene derivatives with activity against drug-resistant Gram negative-bacteria
Molina-Panadero, Irene, Morales-Tenorio, Marcos, García-Rubia, Alfonso, Ginex, Tiziana, Eskandari, Khalil, Martinez, Ana, Gil, Carmen, Smani, Younes
Published in Frontiers in pharmacology (20.08.2024)
Published in Frontiers in pharmacology (20.08.2024)
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Designing multitarget ligands for neurodegenerative diseases with improved permeability trough PLGA nanoencapsulation
Nozal, Vanesa, Fernández-Gómez, Paula, García-Rubia, Alfonso, Martínez-González, Loreto, Cuevas, Eva P., Carro, Eva, Palomo, Valle, Martínez, Ana
Published in Biomedicine & pharmacotherapy (01.06.2024)
Published in Biomedicine & pharmacotherapy (01.06.2024)
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Efficacy of a benzothiazole‐based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis
Benítez‐Fernández, Rocío, Josa‐Prado, Fernando, Sánchez, Estefanía, Lao, Yolanda, García‐Rubia, Alfonso, Cumella, José, Martínez, Ana, Palomo, Valle, Castro, Fernando
Published in CNS neuroscience & therapeutics (01.01.2024)
Published in CNS neuroscience & therapeutics (01.01.2024)
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Palladium-Catalyzed Coupling of Arene C–H Bonds with Methyl- and Arylboron Reagents Assisted by the Removable 2-Pyridylsulfinyl Group
Romero-Revilla, José A, Garcı́a-Rubia, Alfonso, Goméz Arrayás, Ramón, Fernández-Ibáñez, M. Ángeles, Carretero, Juan C
Published in Journal of organic chemistry (18.11.2011)
Published in Journal of organic chemistry (18.11.2011)
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PdII-Catalyzed CH Olefination of N-(2-Pyridyl)sulfonyl Anilines and Arylalkylamines
García-Rubia, Alfonso, Urones, Beatriz, Gómez Arrayás, Ramón, Carretero, Juan C.
Published in Angewandte Chemie (11.11.2011)
Published in Angewandte Chemie (11.11.2011)
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Journal Article
From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein‐Templated Synthesis
Nozal, Vanesa, García‐Rubia, Alfonso, Cuevas, Eva P., Pérez, Concepción, Tosat‐Bitrián, Carlota, Bartolomé, Fernando, Carro, Eva, Ramírez, David, Palomo, Valle, Martínez, Ana
Published in Angewandte Chemie (23.08.2021)
Published in Angewandte Chemie (23.08.2021)
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Journal Article
Identification of potential inhibitors of protein-protein interaction useful to fight against Ebola and other highly pathogenic viruses
Lasala, Fátima, García-Rubia, Alfonso, Requena, Carlos, Galindo, Inmaculada, Cuesta-Geijo, Miguel Angel, García-Dorival, Isabel, Bueno, Paula, Labiod, Nuria, Luczkowiak, Joanna, Martinez, Ana, Campillo, Nuria E., Alonso, Covadonga, Delgado, Rafael, Gil, Carmen
Published in Antiviral research (01.02.2021)
Published in Antiviral research (01.02.2021)
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