Therapeutic inhibition of TRF1 impairs the growth of p53‐deficient K‐RasG12V‐induced lung cancer by induction of telomeric DNA damage
García‐Beccaria, María, Martínez, Paula, Méndez‐Pertuz, Marinela, Martínez, Sonia, Blanco‐Aparicio, Carmen, Cañamero, Marta, Mulero, Francisca, Ambrogio, Chiara, Flores, Juana M, Megias, Diego, Barbacid, Mariano, Pastor, Joaquín, Blasco, Maria A
Published in EMBO molecular medicine (01.07.2015)
Published in EMBO molecular medicine (01.07.2015)
Get full text
Journal Article
Mutant IDH Inhibits IFNγ-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma
Wu, Meng-Ju, Shi, Lei, Dubrot, Juan, Merritt, Joshua, Vijay, Vindhya, Wei, Ting-Yu, Kessler, Emily, Olander, Kira E, Adil, Ramzi, Pankaj, Amaya, Tummala, Krishna Seshu, Weeresekara, Vajira, Zhen, Yuanli, Wu, Qibiao, Luo, Meiqi, Shen, William, García-Beccaria, María, Fernández-Vaquero, Mirian, Hudson, Christine, Ronseaux, Sebastien, Sun, Yi, Saad-Berreta, Rodrigo, Jenkins, Russell W, Wang, Tong, Heikenwälder, Mathias, Ferrone, Cristina R, Goyal, Lipika, Nicolay, Brandon, Deshpande, Vikram, Kohli, Rahul M, Zheng, Hongwu, Manguso, Robert T, Bardeesy, Nabeel
Published in Cancer discovery (01.03.2022)
Published in Cancer discovery (01.03.2022)
Get full text
Journal Article
Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis
Reich, Maria, Spomer, Lina, Klindt, Caroline, Fuchs, Katharina, Stindt, Jan, Deutschmann, Kathleen, Höhne, Johanna, Liaskou, Evaggelia, Hov, Johannes R., Karlsen, Tom H., Beuers, Ulrich, Verheij, Joanne, Ferreira-Gonzalez, Sofia, Hirschfield, Gideon, Forbes, Stuart J., Schramm, Christoph, Esposito, Irene, Nierhoff, Dirk, Fickert, Peter, Fuchs, Claudia Daniela, Trauner, Michael, García-Beccaria, María, Gabernet, Gisela, Nahnsen, Sven, Mallm, Jan-Philipp, Vogel, Marina, Schoonjans, Kristina, Lautwein, Tobias, Köhrer, Karl, Häussinger, Dieter, Luedde, Tom, Heikenwalder, Mathias, Keitel, Verena
Published in Journal of hepatology (01.09.2021)
Published in Journal of hepatology (01.09.2021)
Get full text
Journal Article
Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling
Rosenberg, Nofar, Van Haele, Matthias, Lanton, Tali, Brashi, Neta, Bromberg, Zohar, Adler, Hanan, Giladi, Hilla, Peled, Amnon, Goldenberg, Daniel S., Axelrod, Jonathan H., Simerzin, Alina, Chai, Chofit, Paldor, Mor, Markezana, Auerlia, Yaish, Dayana, Shemulian, Zohar, Gross, Dvora, Barnoy, Shanny, Gefen, Maytal, Amran, Osher, Claerhout, Sofie, Fernández-Vaquero, Mirian, García-Beccaria, María, Heide, Danijela, Shoshkes-Carmel, Michal, Schmidt Arras, Dirk, Elgavish, Sharona, Nevo, Yuval, Benyamini, Hadar, Tirnitz-Parker, Janina E.E., Sanchez, Aranzazu, Herrera, Blanca, Safadi, Rifaat, Kaestner, Klaus H., Rose-John, Stefan, Roskams, Tania, Heikenwalder, Mathias, Galun, Eithan
Published in Journal of hepatology (01.12.2022)
Published in Journal of hepatology (01.12.2022)
Get full text
Journal Article
The therapeutic landscape of hepatocellular carcinoma
Gallage, Suchira, García-Beccaria, María, Szydlowska, Marta, Rahbari, Mohammad, Mohr, Raphael, Tacke, Frank, Heikenwalder, Mathias
Published in Med (New York, N.Y. : Online) (14.05.2021)
Published in Med (New York, N.Y. : Online) (14.05.2021)
Get full text
Journal Article
Nuclear Translocation of RELB Is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice
Elßner, Christin, Goeppert, Benjamin, Longerich, Thomas, Scherr, Anna-Lena, Stindt, Jan, Nanduri, Lahiri Kanth, Rupp, Christian, Kather, Jakob Nikolas, Schmitt, Nathalie, Kautz, Nicole, Breuhahn, Kai, Ismail, Lars, Heide, Danijela, Hetzer, Jenny, García-Beccaria, María, Hövelmeyer, Nadine, Waisman, Ari, Urbanik, Toni, Mueller, Sebastian, Gdynia, Georg, Banales, Jesus M., Roessler, Stephanie, Schirmacher, Peter, Jäger, Dirk, Schölch, Sebastian, Keitel, Verena, Heikenwalder, Mathias, Schulze-Bergkamen, Henning, Köhler, Bruno Christian
Published in Gastroenterology (New York, N.Y. 1943) (01.03.2019)
Published in Gastroenterology (New York, N.Y. 1943) (01.03.2019)
Get full text
Journal Article
In vivo role of checkpoint kinase 2 in signaling telomere dysfunction
García‐Beccaria, María, Martínez, Paula, Flores, Juana M., Blasco, Maria A.
Published in Aging cell (01.10.2014)
Published in Aging cell (01.10.2014)
Get full text
Journal Article
Therapeutic inhibition of TRF 1 impairs the growth of p53 ‐deficient K‐Ras G12V ‐ induced lung cancer by induction of telomeric DNA damage
García‐Beccaria, María, Martínez, Paula, Méndez‐Pertuz, Marinela, Martínez, Sonia, Blanco‐Aparicio, Carmen, Cañamero, Marta, Mulero, Francisca, Ambrogio, Chiara, Flores, Juana M, Megias, Diego, Barbacid, Mariano, Pastor, Joaquín, Blasco, Maria A
Published in EMBO molecular medicine (01.07.2015)
Published in EMBO molecular medicine (01.07.2015)
Get full text
Journal Article
Lymphotoxin beta-activated LTBR/NIK/RELB axis drives proliferation in cholangiocarcinoma
Xu, Kaiyu, Kessler, Annika, Nichetti, Federico, Hoffmeister-Wittmann, Paula, Scherr, Anna-Lena, Nader, Luisa, Kelmendi, Eblina, Schmitt, Nathalie, Schwab, Maximilian, García-Beccaria, María, Sobol, Benjamin, Nieto, Osama Azzam, Isele, Hanna, Gärtner, Ulrike, Vaquero-Siguero, Nuria, Volk, Julia, Korell, Felix, Mock, Andreas, Heide, Danijela, Ramadori, Pierluigi, Lenoir, Bénédicte, Albrecht, Thomas, Hüllein, Jennifer, Jäger, Dirk, Fröhling, Stefan, Springfeld, Christoph, Jackstadt, Rene, Heikenwälder, Mathias, Dill, Michael T, Roessler, Stephanie, Goeppert, Benjamin, Köhler, Bruno C
Published in Liver international (01.11.2024)
Published in Liver international (01.11.2024)
Get full text
Journal Article
Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention
O'Connor, Tracy, Zhou, Xiaolan, Kosla, Jan, Adili, Arlind, Garcia Beccaria, Maria, Kotsiliti, Elena, Pfister, Dominik, Johlke, Anna-Lena, Sinha, Ankit, Sankowski, Roman, Schick, Markus, Lewis, Richard, Dokalis, Nikolaos, Seubert, Bastian, Höchst, Bastian, Inverso, Donato, Heide, Danijela, Zhang, Wenlong, Weihrich, Petra, Manske, Katrin, Wohlleber, Dirk, Anton, Martina, Hoellein, Alexander, Seleznik, Gitta, Bremer, Juliane, Bleul, Sabine, Augustin, Hellmut G., Scherer, Florian, Koedel, Uwe, Weber, Achim, Protzer, Ulrike, Förster, Reinhold, Wirth, Thomas, Aguzzi, Adriano, Meissner, Felix, Prinz, Marco, Baumann, Bernd, Höpken, Uta E., Knolle, Percy A., von Baumgarten, Louisa, Keller, Ulrich, Heikenwalder, Mathias
Published in Cancer cell (16.09.2019)
Published in Cancer cell (16.09.2019)
Get full text
Journal Article
Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma
Wu, Meng-Ju, Shi, Lei, Dubrot, Juan, Merritt, Joshua, Vijay, Vindhya, Wei, Ting-Yu, Kessler, Emily, Olander, Kira E., Adil, Ramzi, Pankaj, Amaya, Tummala, Krishna Seshu, Weeresekara, Vajira, Zhen, Yuanli, Wu, Qibiao, Luo, Meiqi, Shen, William, García-Beccaria, María, Fernández-Vaquero, Mirian, Hudson, Christine, Ronseaux, Sebastien, Sun, Yi, Saad-Berreta, Rodrigo, Jenkins, Russell W., Wang, Tong, Heikenwälder, Mathias, Ferrone, Cristina R., Goyal, Lipika, Nicolay, Brandon, Deshpande, Vikram, Kohli, Rahul M., Zheng, Hongwu, Manguso, Robert T., Bardeesy, Nabeel
Published in Cancer discovery (01.03.2022)
Published in Cancer discovery (01.03.2022)
Get full text
Journal Article
Abstract PO026: Bile acid signaling remodels the iCCA immune microenvironment
García-Beccaria, María, Fernández-Vaquero, Mirian, Reich, Maria, Pfister, Dominik, Herebian, Diran, Goeppert, Benjamin, Tschaharganeh, Darjus Felix, Keitel, Verena, Heikenwälder, Mathias
Published in Clinical cancer research (01.09.2022)
Published in Clinical cancer research (01.09.2022)
Get full text
Journal Article
Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling
Kotsiliti, Elena, Leone, Valentina, Schuehle, Svenja, Govaere, Olivier, Li, Hai, Wolf, Monika J., Horvatic, Helena, Bierwirth, Sandra, Hundertmark, Jana, Inverso, Donato, Zizmare, Laimdota, Sarusi-Portuguez, Avital, Gupta, Revant, O’Connor, Tracy, Giannou, Anastasios D., Shiri, Ahmad Mustafa, Schlesinger, Yehuda, Beccaria, Maria Garcia, Rennert, Charlotte, Pfister, Dominik, Öllinger, Rupert, Gadjalova, Iana, Ramadori, Pierluigi, Rahbari, Mohammad, Rahbari, Nuh, Healy, Marc E., Fernández-Vaquero, Mirian, Yahoo, Neda, Janzen, Jakob, Singh, Indrabahadur, Fan, Chaofan, Liu, Xinyuan, Rau, Monika, Feuchtenberger, Martin, Schwaneck, Eva, Wallace, Sebastian J., Cockell, Simon, Wilson-Kanamori, John, Ramachandran, Prakash, Kho, Celia, Kendall, Timothy J., Leblond, Anne-Laure, Keppler, Selina J., Bielecki, Piotr, Steiger, Katja, Hofmann, Maike, Rippe, Karsten, Zitzelsberger, Horst, Weber, Achim, Malek, Nisar, Luedde, Tom, Vucur, Mihael, Augustin, Hellmut G., Flavell, Richard, Parnas, Oren, Rad, Roland, Pabst, Olivier, Henderson, Neil C., Huber, Samuel, Macpherson, Andrew, Knolle, Percy, Claassen, Manfred, Geier, Andreas, Trautwein, Christoph, Unger, Kristian, Elinav, Eran, Waisman, Ari, Abdullah, Zeinab, Haller, Dirk, Tacke, Frank, Anstee, Quentin M., Heikenwalder, Mathias
Published in Journal of hepatology (01.08.2023)
Published in Journal of hepatology (01.08.2023)
Get full text
Journal Article
Mixed HCC-CCA originates from hepatic progenitor cells, is dependent on IL6 singling and is ablated by senolytic agents
Rosenberg, Nofar, Van Haele, Matthias, Beccaria, Maria Garcia, Fernández-Vaquero, Mirian, Heide, Danijela, Barashi, Neta, Peled, Amnon, Nevo, Yuval, Elgavish, Shrona, Schmist-Arras, Dirk, Edler, Hanan, Simerzin, Alina, Shoshkes-Carmel, Michal, Kaestner, Klaus, Giladi, Hilla, Rose-John, Stefan, Roskams, Tania, Heikenwälder, Mathias, Galun, Eithan
Published in Journal of hepatology (01.07.2022)
Published in Journal of hepatology (01.07.2022)
Get full text
Journal Article
MODULATION OF TRF1 FOR BRAIN CANCER TREATMENT
BEJARANO BOSQUE, Leire, PASTOR FERNANDEZ, Joaquin Angel, BLASCO MARHUENDA, Maria Antonia, BLANCO-APARICIO, Carmen, GOMEZ-CASERO ESTEBAN, Elena, GARCIA-BECCARIA, Maria, MARTINEZ RODRIGUEZ, Paula, MENDEZ PERTUZ, Marinela
Year of Publication 24.02.2022
Get full text
Year of Publication 24.02.2022
Patent
MODULATION OF TRF1 FOR BRAIN CANCER TREATMENT
BEJARANO BOSQUE, Leire, PASTOR FERNANDEZ, Joaquin Angel, BLASCO MARHUENDA, Maria Antonia, BLANCO-APARICIO, Carmen, GOMEZ-CASERO ESTEBAN, Elena, GARCIA-BECCARIA, Maria, MARTINEZ RODRIGUEZ, Paula, MENDEZ PERTUZ, Marinela
Year of Publication 21.07.2021
Get full text
Year of Publication 21.07.2021
Patent
MODULATION OF TRF1 FOR BRAIN CANCER TREATMENT
BEJARANO BOSQUE, Leire, PASTOR FERNANDEZ, Joaquin Angel, BLASCO MARHUENDA, Maria Antonia, BLANCO-APARICIO, Carmen, GOMEZ-CASERO ESTEBAN, Elena, GARCIA-BECCARIA, Maria, MARTINEZ RODRIGUEZ, Paula, MENDEZ PERTUZ, Marinela
Year of Publication 19.03.2020
Get full text
Year of Publication 19.03.2020
Patent
MODULATION OF TRF1 FOR BRAIN CANCER TREATMENT
BLASCO MARHUENDA, MARIA ANTONIA, MENDEZ PERTUZ, MARINELA, PASTOR FERNANDEZ, JOAQUIN ANGEL, GOMEZ-CASERO ESTEBAN, ELENA, GARCIA-BECCARIA, MARIA, MARTINEZ RODRIGUEZ, PAULA, BLANCO-APARICIO, CARMEN, BEJARANO BOSQUE, LEIRE
Year of Publication 19.03.2020
Get full text
Year of Publication 19.03.2020
Patent
MODULATION OF TRF1 FOR BRAIN CANCER TREATMENT
BEJARANO BOSQUE, Leire, PASTOR FERNANDEZ, Joaquin Angel, BLASCO MARHUENDA, Maria Antonia, BLANCO-APARICIO, Carmen, GOMEZ-CASERO ESTEBAN, Elena, GARCIA-BECCARIA, Maria, MARTINEZ RODRIGUEZ, Paula, MENDEZ PERTUZ, Marinela
Year of Publication 18.03.2020
Get full text
Year of Publication 18.03.2020
Patent