Synthesis and biological evaluation of novel ferrocene–naphthoquinones as antiplasmodial agents
García-Barrantes, Pedro M., Lamoureux, Guy V., Pérez, Alice L., García-Sánchez, Rory N., Martínez, Antonio R., San Feliciano, Arturo
Published in European journal of medicinal chemistry (01.12.2013)
Published in European journal of medicinal chemistry (01.12.2013)
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Journal Article
Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design
Friberg, Anders, Vigil, Dominico, Zhao, Bin, Daniels, R. Nathan, Burke, Jason P, Garcia-Barrantes, Pedro M, Camper, DeMarco, Chauder, Brian A, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W
Published in Journal of medicinal chemistry (10.01.2013)
Published in Journal of medicinal chemistry (10.01.2013)
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Journal Article
Hypoglycemic and antihyperglycemic effect of Witheringia solanacea in normal and alloxan-induced hyperglycemic rats
Herrera, Cristina, García-Barrantes, Pedro M., Binns, Franklin, Vargas, Marianela, Poveda, Luis, Badilla, Sandra
Published in Journal of ethnopharmacology (27.01.2011)
Published in Journal of ethnopharmacology (27.01.2011)
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Journal Article
Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulators
Yohn, Samantha E., Foster, Daniel J., Covey, Dan P., Moehle, Mark S., Galbraith, Jordan, Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Bubser, Michael, Blobaum, Anna L., Joffe, Max E., Cheer, Joseph F., Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey
Published in Molecular psychiatry (01.11.2020)
Published in Molecular psychiatry (01.11.2020)
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Journal Article
A Novel M 1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity
Rook, Jerri M, Bertron, Jeanette L, Cho, Hyekyung P, Garcia-Barrantes, Pedro M, Moran, Sean P, Maksymetz, James T, Nance, Kellie D, Dickerson, Jonathan W, Remke, Daniel H, Chang, Sichen, Harp, Joel M, Blobaum, Anna L, Niswender, Colleen M, Jones, Carrie K, Stauffer, Shaun R, Conn, P Jeffrey, Lindsley, Craig W
Published in ACS chemical neuroscience (19.09.2018)
Published in ACS chemical neuroscience (19.09.2018)
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Journal Article
The discovery of VU0486846: steep SAR from a series of M-1 PAMs based on a novel benzomorpholine core
Bertron, Jeanette L., Cho, Hyekyung P., Garcia-Barrantes, Pedro M., Panarese, Joseph D., Salovich, James M., Nance, Kellie D., Engers, Darren W., Rook, Jerri M., Blobaum, Anna L., Niswender, Colleen M., Stauffer, Shaun R., Conn, P. Jeffrey, Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (01.07.2018)
Published in Bioorganic & medicinal chemistry letters (01.07.2018)
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Journal Article
Chemical Modulation of Mutant mGlu1 Receptors Derived from Deleterious GRM1 Mutations Found in Schizophrenics
Cho, Hyekyung P, Garcia-Barrantes, Pedro M, Brogan, John T, Hopkins, Corey R, Niswender, Colleen M, Rodriguez, Alice L, Venable, Daryl F, Morrison, Ryan D, Bubser, Michael, Daniels, J. Scott, Jones, Carrie K, Conn, P. Jeffrey, Lindsley, Craig W
Published in ACS chemical biology (17.10.2014)
Published in ACS chemical biology (17.10.2014)
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Journal Article
Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N‑(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in Schizophrenics
Garcia-Barrantes, Pedro M, Cho, Hyekyung P, Niswender, Colleen M, Byers, Frank W, Locuson, Charles W, Blobaum, Anna L, Xiang, Zixiu, Rook, Jerri M, Conn, P. Jeffrey, Lindsley, Craig W
Published in Journal of medicinal chemistry (22.10.2015)
Published in Journal of medicinal chemistry (22.10.2015)
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Journal Article
The discovery of VU0486846: steep SAR from a series of M1 PAMs based on a novel benzomorpholine core
Bertron, Jeanette L., Cho, Hyekyung P., Garcia-Barrantes, Pedro M., Panarese, Joseph D., Salovich, James M., Nance, Kellie D., Engers, Darren W., Rook, Jerri M., Blobaum, Anna L., Niswender, Colleen M., Stauffer, Shaun R., Conn, P. Jeffrey, Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (01.07.2018)
Published in Bioorganic & medicinal chemistry letters (01.07.2018)
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Journal Article
Lead optimization of the VU0486321 series of mGlu(1) PAMs. Part 2: SAR of alternative 3-methyl heterocycles and progress towards an in vivo tool
Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Metts, Adam M., Blobaum, Anna L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (01.02.2016)
Published in Bioorganic & medicinal chemistry letters (01.02.2016)
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Journal Article
Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 1: SAR of modifications to the central aryl core
Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Blobaum, Anna L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
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Journal Article
Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs
Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Blobaum, Anna L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (15.04.2016)
Published in Bioorganic & medicinal chemistry letters (15.04.2016)
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Journal Article
Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs
Rook, Jerri M, Abe, Masahito, Cho, Hyekyung P, Nance, Kellie D, Luscombe, Vincent B, Adams, Jeffrey J, Dickerson, Jonathan W, Remke, Daniel H, Garcia-Barrantes, Pedro M, Engers, Darren W, Engers, Julie L, Chang, Sichen, Foster, Jarrett J, Blobaum, Anna L, Niswender, Colleen M, Jones, Carrie K, Conn, P. Jeffrey, Lindsley, Craig W
Published in ACS chemical neuroscience (19.04.2017)
Published in ACS chemical neuroscience (19.04.2017)
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Journal Article
Discovery, Synthesis, and Preclinical Characterization of N‑(3-Chloro-4-fluorophenyl)‑1H‑pyrazolo[4,3‑b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4)
Engers, Darren W, Blobaum, Anna L, Gogliotti, Rocco D, Cheung, Yiu-Yin, Salovich, James M, Garcia-Barrantes, Pedro M, Daniels, J. Scott, Morrison, Ryan, Jones, Carrie K, Soars, Matthew G, Zhuo, Xiaoliang, Hurley, Jeremy, Macor, John E, Bronson, Joanne J, Conn, P. Jeffrey, Lindsley, Craig W, Niswender, Colleen M, Hopkins, Corey R
Published in ACS chemical neuroscience (21.09.2016)
Published in ACS chemical neuroscience (21.09.2016)
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Journal Article
Re-exploration of the mGlu1 PAM Ro 07-11401 scaffold: Discovery of analogs with improved CNS penetration despite steep SAR
Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Starr, Tahj M., Blobaum, Anna L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
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Journal Article
Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia
Conde-Ceide, Susana, Martínez-Viturro, Carlos M., Alcázar, Jesús, Garcia-Barrantes, Pedro M., Lavreysen, Hilde, Mackie, Claire, Vinson, Paige N., Rook, Jerri M., Bridges, Thomas M., Daniels, J. Scott, Megens, Anton, Langlois, Xavier, Drinkenburg, Wilhelmus H., Ahnaou, Abdellah, Niswender, Colleen M., Jones, Carrie K., Macdonald, Gregor J., Steckler, Thomas, Conn, P. Jeffrey, Stauffer, Shaun R., Bartolomé-Nebreda, José Manuel, Lindsley, Craig W.
Published in ACS medicinal chemistry letters (11.06.2015)
Published in ACS medicinal chemistry letters (11.06.2015)
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Journal Article
Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration
Panarese, Joseph D., Cho, Hykeyung P., Adams, Jeffrey J., Nance, Kellie D., Garcia-Barrantes, Pedro M., Chang, Sichen, Morrison, Ryan D., Blobaum, Anna L., Niswender, Colleen M., Stauffer, Shaun R., Conn, P. Jeffrey, Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (01.08.2016)
Published in Bioorganic & medicinal chemistry letters (01.08.2016)
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