Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen
Pontel, Lucas B., Rosado, Ivan V., Burgos-Barragan, Guillermo, Garaycoechea, Juan I., Yu, Rui, Arends, Mark J., Chandrasekaran, Gayathri, Broecker, Verena, Wei, Wei, Liu, Limin, Swenberg, James A., Crossan, Gerry P., Patel, Ketan J.
Published in Molecular cell (01.10.2015)
Published in Molecular cell (01.10.2015)
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Journal Article
Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells
Garaycoechea, Juan I., Crossan, Gerry P., Langevin, Frédéric, Mulderrig, Lee, Louzada, Sandra, Yang, Fentang, Guilbaud, Guillaume, Park, Naomi, Roerink, Sophie, Nik-Zainal, Serena, Stratton, Michael R., Patel, Ketan J.
Published in Nature (London) (11.01.2018)
Published in Nature (London) (11.01.2018)
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Journal Article
Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function
Garaycoechea, Juan I., Crossan, Gerry P., Langevin, Frederic, Daly, Maria, Arends, Mark J., Patel, Ketan J.
Published in Nature (London) (27.09.2012)
Published in Nature (London) (27.09.2012)
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Journal Article
Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements
Luquette, Lovelace J., Miller, Michael B., Zhou, Zinan, Bohrson, Craig L., Zhao, Yifan, Jin, Hu, Gulhan, Doga, Ganz, Javier, Bizzotto, Sara, Kirkham, Samantha, Hochepied, Tino, Libert, Claude, Galor, Alon, Kim, Junho, Lodato, Michael A., Garaycoechea, Juan I., Gawad, Charles, West, Jay, Walsh, Christopher A., Park, Peter J.
Published in Nature genetics (01.10.2022)
Published in Nature genetics (01.10.2022)
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Journal Article
Pathological consequences of DNA damage in the kidney
Garaycoechea, Juan I., Quinlan, Catherine, Luijsterburg, Martijn S.
Published in Nature reviews. Nephrology (01.04.2023)
Published in Nature reviews. Nephrology (01.04.2023)
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Journal Article
Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response
Mulderrig, Lee, Garaycoechea, Juan I., Tuong, Zewen K., Millington, Christopher L., Dingler, Felix A., Ferdinand, John R., Gaul, Liam, Tadross, John A., Arends, Mark J., O’Rahilly, Stephen, Crossan, Gerry P., Clatworthy, Menna R., Patel, Ketan J.
Published in Nature (London) (02.12.2021)
Published in Nature (London) (02.12.2021)
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Journal Article
Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair
Hodskinson, Michael R.G., Silhan, Jan, Crossan, Gerry P., Garaycoechea, Juan I., Mukherjee, Shivam, Johnson, Christopher M., Schärer, Orlando D., Patel, Ketan J.
Published in Molecular cell (08.05.2014)
Published in Molecular cell (08.05.2014)
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Journal Article
p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice
Hill, Ross J., Bona, Nazareno, Smink, Job, Webb, Hannah K., Crisp, Alastair, Garaycoechea, Juan I., Crossan, Gerry P.
Published in Nature communications (21.03.2024)
Published in Nature communications (21.03.2024)
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Journal Article
Primordial germ cell DNA demethylation and development require DNA translesion synthesis
Shah, Pranay, Hill, Ross, Dion, Camille, Clark, Stephen J., Abakir, Abdulkadir, Willems, Jeroen, Arends, Mark J., Garaycoechea, Juan I., Leitch, Harry G., Reik, Wolf, Crossan, Gerry P.
Published in Nature communications (03.05.2024)
Published in Nature communications (03.05.2024)
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Journal Article
Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases
Rajendra, Eeson, Garaycoechea, Juan I, Patel, Ketan J, Passmore, Lori A
Published in Nucleic acids research (16.12.2014)
Published in Nucleic acids research (16.12.2014)
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Journal Article
Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner
Wang, Meng, Brandt, Laura T.L., Wang, Xiaonan, Russell, Holly, Mitchell, Emily, Kamimae-Lanning, Ashley N., Brown, Jill M., Dingler, Felix A., Garaycoechea, Juan I., Isobe, Tomoya, Kinston, Sarah J., Gu, Muxin, Vassiliou, George S., Wilson, Nicola K., Göttgens, Berthold, Patel, Ketan J.
Published in Molecular cell (20.07.2023)
Published in Molecular cell (20.07.2023)
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Journal Article
Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function
GARAYCOECHEA, Juan I, CROSSAN, Gerry P, LANGEVIN, Frederic, DALY, Maria, ARENDS, Mark J, PATEL, Ketan J
Published in Nature (London) (26.08.2012)
Published in Nature (London) (26.08.2012)
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Journal Article
A comparative study on phosphotransferase activity of acid phosphatases from Raoultella planticola and Enterobacter aerogenes on nucleosides, sugars, and related compounds
Médici, Rosario, Garaycoechea, Juan I., Valino, Ana L., Pereira, Claudio A., Lewkowicz, Elizabeth S., Iribarren, Adolfo M.
Published in Applied microbiology and biotechnology (01.04.2014)
Published in Applied microbiology and biotechnology (01.04.2014)
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Journal Article
Biocatalysed halogenation of nucleobase analogues
Médici, Rosario, Garaycoechea, Juan Ignacio, Dettorre, Lucas Andrés, Iribarren, Adolfo Marcelo, Lewkowicz, Elizabeth Sandra
Published in Biotechnology letters (01.10.2011)
Published in Biotechnology letters (01.10.2011)
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Journal Article
Aldehydes and Fanconi anaemia: the enemy within
Langevin, Frédéric P M, Garaycoechea, Juan I, Crossan, Gerry P, Patel, Ketan J
Published in M.S. Médecine sciences (01.04.2013)
Published in M.S. Médecine sciences (01.04.2013)
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Journal Article
3216 – GENOTOXIC FORMALDEHYDE ACCELERATES AGEING IN HEMATOPOIETIC STEM CELLS IN A P53-DRIVEN MANNER
Wang, Meng, Brandt, Laura, Wang, Xiaonan, Russell, Holly, Mitchell, Emily, Kamimae-Lanning, Ashley, Brown, Jill, Dingler, Felix, Garaycoechea, Juan, Isobe, Tomoya, Kinston, Sarah, Gu, Muxin, Vassiliou, George, Wilson, Nicola, Gottgens, Berthold, Patel, Ketan
Published in Experimental hematology (2023)
Published in Experimental hematology (2023)
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Journal Article
Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function
Garaycoechea, Juan I, Crossan, Gerry P, Langevin, Frederic, Daly, Maria, Arends, Mark J, Patel, Ketan J
Published in Nature (London) (27.09.2012)
Published in Nature (London) (27.09.2012)
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Journal Article